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Regarding the origin of the lesion, patients were divided into three groups. Chondral lesions were observed in the patella (cP group) in fifteen patients, whereas eight patients demonstrated a femoral condylar location (cF group). Eleven patients presented with osteochondritis dissecans of the femur (ocF group). Associated procedures involving realignment of the patella, osteotomy around the knee, or cancellous bone grafting were performed when necessary. The mean size of the lesions was 2.8\u2009\u00b1\u20091.6 cm<jats:sup>2<\/jats:sup>, and the mean patient age was 37.1\u2009\u00b1\u200911.9\u00a0years. To evaluate the clinical outcomes, the Lysholm score and the VAS pain score were imposed, as well as the reoperation rate.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After an average of 9.3\u2009\u00b1\u20091\u00a0years, follow-up was completed in 79% of the patients. Two patients from the cohort received a total knee prosthesis. The primary outcome measures (Lysolm and VAS pain) at 9-year follow-up were 85\u2009\u00b1\u200913 for the Lysholm score and 1.9\u2009\u00b1\u20091.6 for the VAS score in the entire analyzed population. Compared to the preoperative values (Lysholm 56\u2009\u00b1\u200919, VAS 5.8\u2009\u00b1\u20092.4) and the 2-year results (Lysholm 85\u2009\u00b1\u200916, VAS 2.0\u2009\u00b1\u20092.1), there was significant improvement in the first 2\u00a0years after intervention and a stable course in the long-term observation. The same was observed in the cP and ocF subgroups, whereas patients of the cF group showed even further improvement.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>AMIC showed durable results in aligned knees. The favorable outcome was maintained after an average of 9\u00a0years when malalignment of the lower limb and patellar maltracking were corrected. Such data are particularly encouraging for young adult patients who may benefit from a procedure that circumvents early arthroplasty.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00402-020-03564-7","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T16:10:19Z","timestamp":1597335019000},"page":"1845-1854","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Stable clinical long term results after AMIC in the aligned knee"],"prefix":"10.1007","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-5832","authenticated-orcid":false,"given":"Nadine","family":"Kaiser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland P.","family":"Jakob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Pagenstert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Tannast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Petek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"issue":"50","key":"3564_CR1","doi-asserted-by":"publisher","first-page":"39027","DOI":"10.1074\/jbc.M006700200","volume":"275","author":"N Verzijl","year":"2000","unstructured":"Verzijl N, DeGroot J, Thorpe SR, Bank RA, Shaw JN, Lyons TJ, Bijlsma JW, Lafeber FP, Baynes JW, TeKoppele JM (2000) Effect of collagen turnover on the accumulation of advanced glycation end products. 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N Kaiser received travel reimbursement from Geistlich Pharma. The other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article complies with the ethical principles. The form of therapy presented is an established method and does not represent experimental surgery.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}