{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:46:51Z","timestamp":1783036011497,"version":"3.54.6"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum M\u00fcnster"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Arthrogryposis multiplex congenita (AMC) is a rare congenital condition that leads to severe joint contractures and deformities. As painful joint dysplasia and degeneration might develop over time, total joint replacement (TJR) can be a potential treatment option for these patients. The aim of this study is to investigate functional results, implant survivorship and potential complications in patients with AMC who undergo hip or knee arthroplasty.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>We retrospectively identified six TJR in three patients at a single centre performed between 2006 and 2019. The median patient age at surgery was 23\u00a0years and the median follow-up period was 69 (IQR 55\u201399) months. We analysed surgical technique, implant survivorship and complications as well as functional outcome determined by pain reported on the Numerical Rating Scale (NRS), patient-reported outcome scores [Oxford Hip Score (OHS), Harris Hip score (HHS), Oxford Knee Score (OKS)], range of motion and ambulatory status. Depending on data distribution means with ranges and median with interquartile range were compared with the Wilcoxon signed rank test or Student\u2019s <jats:italic>t<\/jats:italic> test. The level of significance was defined at\u2009&lt;\u20090.05.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In hips, the mean range of motion in flexion\/extension (52\u00b0 vs. 85\u00b0, <jats:italic>p<\/jats:italic>\u2009=\u20090.014) and in rotation (28\u00b0 vs. 68\u00b0, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) as well as mean pain score on the NRS (8.5 vs. 0, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), OHS (9 vs. 26, <jats:italic>p<\/jats:italic>\u2009=\u20090.031) and HHS (17 vs. 52, <jats:italic>p<\/jats:italic>\u2009=\u20090.007) significantly improved. In knees, mean range of motion (55\u00b0 vs. 93\u00b0, <jats:italic>p<\/jats:italic>\u2009=\u20090.403), mean pain score on the NRS (0 vs. 7) and the OKS (2 vs. 21) also improved. While the ambulatory status did not change, the patients who were wheelchair dependent reported less problems with transfers to a bed or chair and the patient who ambulated reported an improved walking distance. One total knee arthroplasty (TKA) underwent revision for an acute, late infection 155\u00a0months following the initial surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>TJR is a safe procedure in patients with AMC that effectively improves function and reduces pain irrespective of preoperative ambulatory status.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00402-020-03611-3","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T17:02:42Z","timestamp":1602349362000},"page":"181-188","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Total joint replacement of the hip and knee in patients with arthrogryposis multiplex congenita: a report of six joints"],"prefix":"10.1007","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0563-4128","authenticated-orcid":false,"given":"Christoph","family":"Theil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Roedl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Gosheger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Moellenbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Frommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Dieckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,10]]},"reference":[{"issue":"3","key":"3611_CR1","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1002\/ajmg.c.31734","volume":"181","author":"RC Hamdy","year":"2019","unstructured":"Hamdy RC, van Bosse H, Altiok H, Abu-Dalu K, Kotlarsky P, Fafara A, Eidelman M (2019) Treatment and outcomes of arthrogryposis in the lower extremity. 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One author (BV) reports board membership of the GEVR without compensation and payment for travel, presentations and lectures by Merete medical and Nuvasive Specialized Orthopedics, outside the submitted work. One author (RR) declares personal fees from Nuvasive, Smith&Nephew, Merete medical, Kyowa Kirin and Biomarine outside the submitted work. The other authors (GG, RD, BM, AF) have nothing to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"We had an ethics approval of the local ethics committee, reference number 2020-200-F-s. (Ethikkommission der Aerztekammer Westfalen-Lippe und der Westfaelischen-Wilhelms Universitaet Muenster).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Consent was not deemed necessary by the ethics committee because this study is a retrospective analysis of routine clinical data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Consent for publication was not necessary because the manuscript does not contain individual data.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}