{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T23:39:00Z","timestamp":1775950740173,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s00402-020-03629-7","type":"journal-article","created":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T11:02:26Z","timestamp":1602414146000},"page":"2101-2107","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Is continuation of anti-platelet treatment safe for elective total hip arthroplasty patients?"],"prefix":"10.1007","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4524-9120","authenticated-orcid":false,"given":"Itay","family":"Ashkenazi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haggai","family":"Schermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aviram","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Gurel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofir","family":"Chechik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaniv","family":"Warschawski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Schwarzkopf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimrod","family":"Snir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,11]]},"reference":[{"key":"3629_CR1","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1177\/1076029618772337","volume":"24","author":"DE Lindquist","year":"2018","unstructured":"Lindquist DE, Stewart DW, Brewster A, Waldroup C, Odle BL, Burchette JE et al (2018) Comparison of postoperative bleeding in total hip and knee arthroplasty patients receiving rivaroxaban, enoxaparin, or aspirin for thromboprophylaxis. Clin Appl Thromb 24:1315\u20131321. https:\/\/doi.org\/10.1177\/1076029618772337","journal-title":"Clin Appl Thromb"},{"key":"3629_CR2","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.pmedr.2016.12.023","volume":"5","author":"M Stuntz","year":"2017","unstructured":"Stuntz M, Bernstein B (2017) Recent trends in the prevalence of low-dose aspirin use for primary and secondary prevention of cardiovascular disease in the United States, 2012\u20132015. Prev Med Rep 5:183\u2013186. https:\/\/doi.org\/10.1016\/j.pmedr.2016.12.023","journal-title":"Prev Med Rep"},{"key":"3629_CR3","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12900","author":"JJ van Veen","year":"2015","unstructured":"van Veen JJ, Makris M (2015) Management of peri-operative anti-thrombotic therapy. Anaesthesia. https:\/\/doi.org\/10.1111\/anae.12900","journal-title":"Anaesthesia"},{"key":"3629_CR4","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1007\/s00590-016-1830-7","volume":"26","author":"R Meier","year":"2016","unstructured":"Meier R, Marthy R, Saely CH, Kuster MS, Giesinger K, Rickli H (2016) Comparison of preoperative continuation and discontinuation of aspirin in patients undergoing total hip or knee arthroplasty. Eur J Orthop Surg Traumatol 26:921\u2013928. https:\/\/doi.org\/10.1007\/s00590-016-1830-7","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"3629_CR5","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1056\/NEJMoa1712746","volume":"378","author":"DR Anderson","year":"2018","unstructured":"Anderson DR, Dunbar M, Murnaghan J, Kahn SR, Gross P, Forsythe M et al (2018) Aspirin or rivaroxaban for VTE prophylaxis after hip or knee arthroplasty. N Engl J Med 378:699\u2013707. https:\/\/doi.org\/10.1056\/NEJMoa1712746","journal-title":"N Engl J Med"},{"key":"3629_CR6","doi-asserted-by":"publisher","first-page":"504","DOI":"10.2106\/JBJS.18.00143","volume":"101","author":"AJ Rondon","year":"2019","unstructured":"Rondon AJ, Shohat N, Tan TL, Goswami K, Huang RC, Parvizi J (2019) The use of aspirin for prophylaxis against venous thromboembolism decreases mortality following primary total joint arthroplasty. J Bone Jt Surg Am 101:504\u2013513. https:\/\/doi.org\/10.2106\/JBJS.18.00143","journal-title":"J Bone Jt Surg Am"},{"key":"3629_CR7","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1001\/jamainternmed.2019.6108","volume":"180","author":"GS Matharu","year":"2020","unstructured":"Matharu GS, Kunutsor SK, Judge A, Blom AW, Whitehouse MR (2020) Clinical effectiveness and safety of aspirin for venous thromboembolism prophylaxis after total hip and knee replacement: a systematic review and meta-analysis of randomized clinical trials. JAMA Intern Med 180:376\u2013384. https:\/\/doi.org\/10.1001\/jamainternmed.2019.6108","journal-title":"JAMA Intern Med"},{"key":"3629_CR8","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s00392-008-0718-x","volume":"98","author":"H M\u00f6llmann","year":"2009","unstructured":"M\u00f6llmann H, Nef HM, Hamm CW, Els\u00e4sser A (2009) How to manage patients with need for antiplatelet therapy in the setting of (un-)planned surgery. Clin Res Cardiol 98:8\u201315. https:\/\/doi.org\/10.1007\/s00392-008-0718-x","journal-title":"Clin Res Cardiol"},{"key":"3629_CR9","doi-asserted-by":"publisher","first-page":"931","DOI":"10.3928\/01477447-20071101-04","volume":"30","author":"JT Murphy","year":"2007","unstructured":"Murphy JT, Fahy BG (2007) Balancing perioperative risks in orthopedic surgery: the patient with a coronary stent. Orthopedics 30:931\u2013936. https:\/\/doi.org\/10.3928\/01477447-20071101-04","journal-title":"Orthopedics"},{"key":"3629_CR10","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.injury.2011.01.011","volume":"42","author":"O Chechik","year":"2011","unstructured":"Chechik O, Thein R, Fichman G, Haim A, Ben TT, Steinberg EL (2011) The effect of clopidogrel and aspirin on blood loss in hip fracture surgery. Injury 42:1277\u20131282. https:\/\/doi.org\/10.1016\/j.injury.2011.01.011","journal-title":"Injury"},{"key":"3629_CR11","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1007\/s00167-015-3824-0","volume":"25","author":"PE Schwab","year":"2017","unstructured":"Schwab PE, Lavand\u2019homme P, Yombi JC, Thienpont E (2017) Aspirin mono-therapy continuation does not result in more bleeding after knee arthroplasty. Knee Surg Sport Traumatol Arthrosc 25:2586\u20132593. https:\/\/doi.org\/10.1007\/s00167-015-3824-0","journal-title":"Knee Surg Sport Traumatol Arthrosc"},{"key":"3629_CR12","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.redar.2012.02.006","volume":"59","author":"J Castillo Monsegur","year":"2012","unstructured":"Castillo Monsegur J, Bisbe Vives E, Santiveri Papiol X, L\u00f3pez Bosque R, Ruiz A (2012) Low-dose aspirin doesn\u2019t increase surgical bleeding nor transfusion rate in total knee arthroplasty. Rev Esp Anestesiol Reanim 59:180\u2013186. https:\/\/doi.org\/10.1016\/j.redar.2012.02.006","journal-title":"Rev Esp Anestesiol Reanim"},{"key":"3629_CR13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/00000539-199601000-00004","volume":"82","author":"GJ Despotis","year":"1996","unstructured":"Despotis GJ, Filos KS, Zoys TN, Hogue CW, Spitznagel E, Lappas DG (1996) Factors associated with excessive postoperative blood loss and hemostatic transfusion requirements: a multivariate analysis in cardiac surgical patients. Anesth Analg 82:13\u201321. https:\/\/doi.org\/10.1097\/00000539-199601000-00004","journal-title":"Anesth Analg"},{"key":"3629_CR14","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1097\/00000658-200206000-00009","volume":"235","author":"VA Ferraris","year":"2002","unstructured":"Ferraris VA, Ferraris SP, Joseph O, Wehner P, Mentzer RM (2002) Aspirin and postoperative bleeding after coronary artery bypass grafting. Ann Surg 235:820\u2013827. https:\/\/doi.org\/10.1097\/00000658-200206000-00009","journal-title":"Ann Surg"},{"key":"3629_CR15","first-page":"224","volume":"14","author":"M Kamran","year":"2008","unstructured":"Kamran M, Ahmed A, Dar MI, Khan AB (2008) Effect of aspirin on postoperative bleeding in coronary artery bypass grafting. Ann Thorac Cardiovasc Surg 14:224\u2013229","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"3629_CR16","first-page":"2440","volume":"128","author":"B Hofstad","year":"2008","unstructured":"Hofstad B, Nesbakken A, Eritsland J, Br\u00f8rs O, Sandset PM (2008) Should platelet inhibitors be discontinued before gastrointestinal endoscopy? Tidsskr Den Nor Laegeforening 128:2440\u20132442","journal-title":"Tidsskr Den Nor Laegeforening"},{"key":"3629_CR17","doi-asserted-by":"publisher","first-page":"331","DOI":"10.14219\/jada.archive.2000.0176","volume":"131","author":"L Ardekian","year":"2000","unstructured":"Ardekian L, Gaspar R, Peled M, Brener B, Laufer D (2000) Does low-dose aspirin therapy complicate oral surgical procedures? J Am Dent Assoc 131:331\u2013335. https:\/\/doi.org\/10.14219\/jada.archive.2000.0176","journal-title":"J Am Dent Assoc"},{"key":"3629_CR18","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/S0886-3350(98)80020-5","volume":"24","author":"EI Assia","year":"1998","unstructured":"Assia EI, Raskin T, Kaiserman I, Rotenstreich Y, Segev F (1998) Effect of aspirin intake on bleeding during cataract surgery. J Cataract Refract Surg 24:1243\u20131246. https:\/\/doi.org\/10.1016\/S0886-3350(98)80020-5","journal-title":"J Cataract Refract Surg"},{"key":"3629_CR19","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1093\/bja\/aer274","volume":"107","author":"J Mantz","year":"2011","unstructured":"Mantz J, Samama CM, Tubach F, Devereaux PJ, Collet JP, Albaladejo P et al (2011) Impact of preoperative maintenance or interruption of aspirin on thrombotic and bleeding events after elective non-cardiac surgery: the multicentre, randomized, blinded, placebo-controlled STRATAGEM trial. Br J Anaesth 107:899\u2013910. https:\/\/doi.org\/10.1093\/bja\/aer274","journal-title":"Br J Anaesth"},{"key":"3629_CR20","doi-asserted-by":"publisher","first-page":"3070 3082.e1","DOI":"10.1016\/j.arth.2018.03.031","volume":"33","author":"YA Fillingham","year":"2018","unstructured":"Fillingham YA, Ramkumar DB, Jevsevar DS, Yates AJ, Shores P, Mullen K et al (2018a) The safety of tranexamic acid in total joint arthroplasty: a direct meta-analysis. J Arthroplasty 33:3070 3082.e1. https:\/\/doi.org\/10.1016\/j.arth.2018.03.031","journal-title":"J Arthroplasty"},{"key":"3629_CR21","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1097\/ALN.0000000000000113","volume":"120","author":"F Botto","year":"2014","unstructured":"Botto F, Alonso-Coello P, Chan MTV, Villar JC, Xavier D, Srinathan S et al (2014) Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes. Anesthesiology 120:564\u2013578. https:\/\/doi.org\/10.1097\/ALN.0000000000000113","journal-title":"Anesthesiology"},{"key":"3629_CR22","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1161\/CIRCULATIONAHA.113.002128","volume":"127","author":"JAR Van Waes","year":"2013","unstructured":"Van Waes JAR, Nathoe HM, De Graaff JC, Kemperman H, De Borst GJ, Peelen LM et al (2013) Myocardial injury after noncardiac surgery and its association with short-term mortality. Circulation 127:2264\u20132271. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.113.002128","journal-title":"Circulation"},{"key":"3629_CR23","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1258\/vasc.2011.oa0336","volume":"20","author":"O Chechik","year":"2012","unstructured":"Chechik O, Goldstein Y, Behrbalk E, Kaufman E, Rabinovich Y (2012) Blood loss and complications following carotid endarterectomy in patients treated with clopidogrel. Vascular 20:193\u2013197. https:\/\/doi.org\/10.1258\/vasc.2011.oa0336","journal-title":"Vascular"},{"key":"3629_CR24","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/j.ahj.2013.03.001","volume":"165","author":"JL Carson","year":"2013","unstructured":"Carson JL, Brooks MM, Abbott JD, Chaitman B, Kelsey SF, Triulzi DJ et al (2013) Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. Am Heart J 165:964","journal-title":"Am Heart J"},{"key":"3629_CR25","first-page":"B5221","volume":"63","author":"M Gregersen","year":"2016","unstructured":"Gregersen M (2016) Postoperative red blood cell transfusion strategy in frail anemic elderly with hip fracture: a randomized controlled trial. Dan Med J 63:B5221","journal-title":"Dan Med J"},{"key":"3629_CR26","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1007\/s11999-013-3135-z","volume":"472","author":"IJ Raphael","year":"2014","unstructured":"Raphael IJ, Tischler EH, Huang R, Rothman RH, Hozack WJ, Parvizi J (2014) Aspirin: an alternative for pulmonary embolism prophylaxis after arthroplasty? Clin Orthop Relat Res 472:482\u2013488. https:\/\/doi.org\/10.1007\/s11999-013-3135-z","journal-title":"Clin Orthop Relat Res"},{"key":"3629_CR27","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1302\/0301-620X.99B11.BJJ-2017-0337.R2","volume":"99B","author":"I Azboy","year":"2017","unstructured":"Azboy I, Barrack R, Thomas AM, Haddad FS, Parvizi J (2017) Aspirin and the prevention of venous thromboembolism following total joint arthroplasty: commonly asked questions. Bone Jt J 99B:1420\u20131430. https:\/\/doi.org\/10.1302\/0301-620X.99B11.BJJ-2017-0337.R2","journal-title":"Bone Jt J"},{"key":"3629_CR28","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1136\/bmj.316.7141.1337","volume":"316","author":"C Baigent","year":"1998","unstructured":"Baigent C, Collins R, Appleby P, Parish S, Sleight P, Peto R (1998) ISIS-2: 10 year survival among patients with suspected acute myocardial infarction in randomised comparison of intravenous streptokinase, oral aspirin, both, or neither. BMJ 316:1337. https:\/\/doi.org\/10.1136\/bmj.316.7141.1337","journal-title":"BMJ"},{"key":"3629_CR29","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1136\/bmj.324.7329.71","volume":"324","author":"C Baigent","year":"2002","unstructured":"Baigent C, Sudlow C, Collins R, Peto R (2002) Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. Br Med J 324:71\u201386. https:\/\/doi.org\/10.1136\/bmj.324.7329.71","journal-title":"Br Med J"},{"key":"3629_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.03.040","author":"A Tang","year":"2020","unstructured":"Tang A, Zak S, Iorio R, Slover J, Bosco J, Schwarzkopf R (2020) Low-dose aspirin is safe and effective for venous thromboembolism prevention in patients undergoing revision total hip arthroplasty: a retrospective cohort study. J Arthroplasty. https:\/\/doi.org\/10.1016\/j.arth.2020.03.040","journal-title":"J Arthroplasty"},{"key":"3629_CR31","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1136\/jech.56.7.510","volume":"56","author":"V Lorant","year":"2002","unstructured":"Lorant V, Boland B, Humblet P, Deli\u00e8ge D (2002) Equity in prevention and health care. J Epidemiol Community Health 56:510\u2013516. https:\/\/doi.org\/10.1136\/jech.56.7.510","journal-title":"J Epidemiol Community Health"},{"key":"3629_CR32","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2106\/JBJS.F.00163","volume":"89","author":"VP Patel","year":"2007","unstructured":"Patel VP, Walsh M, Sehgal B, Preston C, DeWal H, Di Cesare PE (2007) Factors associated with prolonged wound drainage after primary total hip and knee arthroplasty. J Bone Jt Surg Ser A 89:33\u201338. https:\/\/doi.org\/10.2106\/JBJS.F.00163","journal-title":"J Bone Jt Surg Ser A"},{"key":"3629_CR33","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1016\/j.arth.2018.06.023","volume":"33","author":"YA Fillingham","year":"2018","unstructured":"Fillingham YA, Ramkumar DB, Jevsevar DS, Yates AJ, Shores P, Mullen K et al (2018b) The efficacy of tranexamic acid in total hip arthroplasty: a network meta-analysis. J Arthroplasty 33:3083-3089.e4. https:\/\/doi.org\/10.1016\/j.arth.2018.06.023","journal-title":"J Arthroplasty"},{"key":"3629_CR34","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1213\/ANE.0000000000001159","volume":"122","author":"B Barrachina","year":"2016","unstructured":"Barrachina B, Lopez-Picado A, Remon M, Fondarella A, Iriarte I, Bastida R et al (2016) Tranexamic acid compared with placebo for reducing total blood loss in hip replacement surgery: a randomized clinical trial. Anesth Analg 122:986\u2013995. https:\/\/doi.org\/10.1213\/ANE.0000000000001159","journal-title":"Anesth Analg"},{"key":"3629_CR35","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.11.53","author":"JE Ollivier","year":"2016","unstructured":"Ollivier JE, Van Driessche S, Billuart F, Beldame J, Matsoukis J (2016) Tranexamic acid and total hip arthroplasty: optimizing the administration method. Ann Transl Med. https:\/\/doi.org\/10.21037\/atm.2016.11.53","journal-title":"Ann Transl Med"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-020-03629-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00402-020-03629-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-020-03629-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T05:36:07Z","timestamp":1633930567000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00402-020-03629-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,11]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["3629"],"URL":"https:\/\/doi.org\/10.1007\/s00402-020-03629-7","relation":{},"ISSN":["0936-8051","1434-3916"],"issn-type":[{"value":"0936-8051","type":"print"},{"value":"1434-3916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,11]]},"assertion":[{"value":"23 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the medical center\u2019s institutional review board that waived informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}