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In addition, local bone quality was assessed by measuring the peak torque necessary to break out the trabecular bone along each separate hole of a locking compression plate (LCP) during its instrumentation. Finally, biomechanical testing was performed using cyclic axial loading until failure in an AO\/OTA 33 A3 fracture model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Local BMD was highest in the distal region. This was confirmed by the measurement of local bone quality using DensiProbe<jats:sup>\u2122<\/jats:sup>. The most distal holes represented locations with the highest breakaway torque resistance, with the holes on the posterior side of the plate indicating higher values than those on its anterior side. We demonstrated strong correlation between the cycles to failure and local bone strength (measured with DensiProbe<jats:sup>\u2122<\/jats:sup>) in the most distal posterior screw hole, having the highest peak torque.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The local bone quality at the distal femur indicates that in plated distal femur fractures the distal posterior screw holes seem to be the key ones and should be occupied. Measurement of the local bone strength with DensiProbe<jats:sup>\u2122<\/jats:sup> is one possibility to determine the risk of construct failure, therefore, thresholds need to be defined.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00402-021-03782-7","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T21:53:52Z","timestamp":1613685232000},"page":"1055-1061","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Local bone quality measure and construct failure prediction: a biomechanical study on distal femur fractures"],"prefix":"10.1007","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7148-9569","authenticated-orcid":false,"given":"Dominic","family":"Gehweiler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Styger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9795-115X","authenticated-orcid":false,"given":"Boyko","family":"Gueorguiev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Colcuc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Vordemvenne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2352-7951","authenticated-orcid":false,"given":"Dirk","family":"W\u00e4hnert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"3782_CR1","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1097\/00003086-198809000-00033","volume":"234","author":"TJ Arneson","year":"1988","unstructured":"Arneson TJ, Melton LJ 3rd, Lewallen DG, O\u2019Fallon WM (1988) Epidemiology of diaphyseal and distal femoral fractures in Rochester, Minnesota, 1965\u20131984. 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