{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:56:20Z","timestamp":1760885780456,"version":"3.37.3"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsmedizin Greifswald"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Aims<\/jats:title>\n                <jats:p>To compare the diagnostic accuracy of investigators from different specialities (radiologists and orthopaedic surgeons) with varying levels of experience of 1.5\u00a0T direct magnetic resonance arthrography (dMRA) against intraoperative findings in patients with femoroacetabular impingement syndrome (FAIS).\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 272 patients were evaluated with dMRA and subsequent hip arthroscopy. The dMRA images were evaluated independently by two non-hip-arthroscopy-trained orthopaedic surgeons, two fellowship-trained musculoskeletal radiologists, and two hip-arthroscopy-trained orthopaedic surgeons. The radiological diagnoses were compared with the intraoperative findings.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Hip arthroscopy revealed labral pathologies in 218 (79%) and acetabular chondral lesions in 190 (69%) hips. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy for evaluating the acetabular labral pathologies were 79%, 18%, 79%, 18%, and 66% (non-hip-arthroscopy trained orthopaedic surgeons), 83%, 36%, 83%, 36%, and 74% (fellowship-trained musculoskeletal radiologists), and 88%, 53%, 88%, 54% and 81% (hip-arthroscopy trained orthopaedic surgeons). The sensitivity, specificity, PPV, NPV and accuracy of dMRA for assessing the acetabular chondral damage were 81%, 36%, 71%, 50%, and 66% (non-hip-arthroscopy trained orthopaedic surgeons), 84%, 38%, 75%, 52%, and 70% (fellowship-trained musculoskeletal radiologists), and 91%, 51%, 81%, 73%, and 79% (hip-arthroscopy trained orthopaedic surgeons). The hip-arthroscopy trained orthopaedic surgeons displayed the highest percentage of correctly diagnosed labral pathologies and acetabular chondral lesions, which is significantly higher than the other two investigator groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The accuracy of dMRA on detecting labral pathologies or acetabular chondral lesions depends on the examiner and its level of experience in hip arthroscopy. The highest values are found for the hip-arthroscopy-trained orthopaedic surgeons.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Level of evidence<\/jats:title>\n                <jats:p>Retrospective cohort study; III.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00402-021-04071-z","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T12:03:18Z","timestamp":1626696198000},"page":"1563-1569","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of acetabular chondral damage and labral pathologies via direct MR arthrography: specialization matters"],"prefix":"10.1007","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5195-7529","authenticated-orcid":false,"given":"A.","family":"Zimmerer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MM.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Tramountanis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Janz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Miehlke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GI.","family":"Wassilew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sobau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"4071_CR1","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000096804.78689.c2","author":"R Ganz","year":"2003","unstructured":"Ganz R, Parvizi J, Beck M et al (2003) Femoroacetabular impingement: a cause for osteoarthritis of the hip. Clin Orthop Relat Res. https:\/\/doi.org\/10.1097\/01.blo.0000096804.78689.c2","journal-title":"Clin Orthop Relat Res"},{"issue":"3","key":"4071_CR2","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.csm.2016.02.001","volume":"35","author":"A Kandil","year":"2016","unstructured":"Kandil A, Safran MR (2016) Hip arthroscopy: a brief history. Clin Sports Med 35(3):321\u2013329. https:\/\/doi.org\/10.1016\/j.csm.2016.02.001","journal-title":"Clin Sports Med"},{"issue":"2","key":"4071_CR3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.arthro.2008.09.011","volume":"25","author":"R Mardones","year":"2009","unstructured":"Mardones R, Lara J, Donndorff A et al (2009) Surgical correction of \u201ccam-type\u201d femoroacetabular impingement: a cadaveric comparison of open versus arthroscopic debridement. Arthroscopy 25(2):175\u2013182. https:\/\/doi.org\/10.1016\/j.arthro.2008.09.011","journal-title":"Arthroscopy"},{"key":"4071_CR4","first-page":"337","volume":"55","author":"TG Sampson","year":"2006","unstructured":"Sampson TG (2006) Arthroscopic treatment of femoroacetabular impingement: a proposed technique with clinical experience. Instr Course Lect 55:337\u2013346","journal-title":"Instr Course Lect"},{"issue":"7","key":"4071_CR5","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1007\/s00167-007-0332-x","volume":"15","author":"M Philippon","year":"2007","unstructured":"Philippon M, Schenker M, Briggs K et al (2007) Femoroacetabular impingement in 45 professional athletes: associated pathologies and return to sport following arthroscopic decompression. Knee Surg Sports Traumatol Arthrosc 15(7):908\u2013914. https:\/\/doi.org\/10.1007\/s00167-007-0332-x","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"14","key":"4071_CR6","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1136\/bjsports-2012-091035","volume":"47","author":"MP Reiman","year":"2013","unstructured":"Reiman MP, Goode AP, Hegedus EJ et al (2013) Diagnostic accuracy of clinical tests of the hip: a systematic review with meta-analysis. Br J Sports Med 47(14):893\u2013902. https:\/\/doi.org\/10.1136\/bjsports-2012-091035","journal-title":"Br J Sports Med"},{"issue":"1","key":"4071_CR7","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.mric.2012.08.008","volume":"21","author":"I Botser","year":"2013","unstructured":"Botser I, Safran MR (2013) MR imaging of the hip: pathologies and morphologies of the hip joint, what the surgeon wants to know. Magn Reson Imaging Clin N Am 21(1):169\u2013182. https:\/\/doi.org\/10.1016\/j.mric.2012.08.008","journal-title":"Magn Reson Imaging Clin N Am"},{"issue":"1","key":"4071_CR8","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1148\/radiology.200.1.8657916","volume":"200","author":"C Czerny","year":"1996","unstructured":"Czerny C, Hofmann S, Neuhold A et al (1996) Lesions of the acetabular labrum: accuracy of MR imaging and MR arthrography in detection and staging. Radiology 200(1):225\u2013230. https:\/\/doi.org\/10.1148\/radiology.200.1.8657916","journal-title":"Radiology"},{"issue":"3","key":"4071_CR9","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1148\/radiol.12110357","volume":"264","author":"R Sutter","year":"2012","unstructured":"Sutter R, Zanetti M, Pfirrmann CWA (2012) New developments in hip imaging. Radiology 264(3):651\u2013667. https:\/\/doi.org\/10.1148\/radiol.12110357","journal-title":"Radiology"},{"issue":"1","key":"4071_CR10","doi-asserted-by":"publisher","first-page":"160","DOI":"10.2214\/AJR.12.10266","volume":"202","author":"R Sutter","year":"2014","unstructured":"Sutter R, Zubler V, Hoffmann A et al (2014) Hip MRI: how useful is intraarticular contrast material for evaluating surgically proven lesions of the labrum and articular cartilage? Am J Roentgenol 202(1):160\u2013169. https:\/\/doi.org\/10.2214\/AJR.12.10266","journal-title":"Am J Roentgenol"},{"issue":"7","key":"4071_CR11","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1177\/0363546504266480","volume":"32","author":"JWT Byrd","year":"2004","unstructured":"Byrd JWT, Jones KS (2004) Diagnostic accuracy of clinical assessment, magnetic resonance imaging, magnetic resonance arthrography, and intra-articular injection in hip arthroscopy patients. Am J Sports Med 32(7):1668\u20131674. https:\/\/doi.org\/10.1177\/0363546504266480","journal-title":"Am J Sports Med"},{"issue":"6","key":"4071_CR12","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1007\/s00264-011-1459-4","volume":"36","author":"EJ Griffiths","year":"2012","unstructured":"Griffiths EJ, Khanduja V (2012) Hip arthroscopy: evolution, current practice and future developments. Int Orthop 36(6):1115\u20131121. https:\/\/doi.org\/10.1007\/s00264-011-1459-4","journal-title":"Int Orthop"},{"issue":"9","key":"4071_CR13","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.arthro.2008.04.075","volume":"24","author":"RL Martin","year":"2008","unstructured":"Martin RL, Irrgang JJ, Sekiya JK (2008) The diagnostic accuracy of a clinical examination in determining intra-articular hip pain for potential hip arthroscopy candidates. Arthroscopy 24(9):1013\u20131018. https:\/\/doi.org\/10.1016\/j.arthro.2008.04.075","journal-title":"Arthroscopy"},{"issue":"1","key":"4071_CR14","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s13018-018-0832-z","volume":"13","author":"L Annabell","year":"2018","unstructured":"Annabell L, Master V, Rhodes A et al (2018) Hip pathology: the diagnostic accuracy of magnetic resonance imaging. J Orthop Surg Res 13(1):127. https:\/\/doi.org\/10.1186\/s13018-018-0832-z","journal-title":"J Orthop Surg Res"},{"issue":"4","key":"4071_CR15","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00330-010-1956-7","volume":"21","author":"TO Smith","year":"2011","unstructured":"Smith TO, Hilton G, Toms AP et al (2011) The diagnostic accuracy of acetabular labral tears using magnetic resonance imaging and magnetic resonance arthrography: a meta-analysis. Eur Radiol 21(4):863\u2013874. https:\/\/doi.org\/10.1007\/s00330-010-1956-7","journal-title":"Eur Radiol"},{"issue":"10","key":"4071_CR16","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1016\/j.ejrad.2014.05.034","volume":"83","author":"C-Y Tian","year":"2014","unstructured":"Tian C-Y, Wang J-Q, Zheng Z-Z et al (2014) 3.0 T conventional hip MR and hip MR arthrography for the acetabular labral tears confirmed by arthroscopy. Eur J Radiol 83(10):1822\u20131827. https:\/\/doi.org\/10.1016\/j.ejrad.2014.05.034","journal-title":"Eur J Radiol"},{"issue":"2","key":"4071_CR17","doi-asserted-by":"publisher","first-page":"449","DOI":"10.2214\/AJR.04.1809","volume":"186","author":"GA Toomayan","year":"2006","unstructured":"Toomayan GA, Holman WR, Major NM et al (2006) Sensitivity of MR arthrography in the evaluation of acetabular labral tears. Am J Roentgenol 186(2):449\u2013453. https:\/\/doi.org\/10.2214\/AJR.04.1809","journal-title":"Am J Roentgenol"},{"issue":"6","key":"4071_CR18","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00256-011-1266-4","volume":"41","author":"CM McGuire","year":"2012","unstructured":"McGuire CM, MacMahon P, Byrne DP et al (2012) Diagnostic accuracy of magnetic resonance imaging and magnetic resonance arthrography of the hip is dependent on specialist training of the radiologist. Skeletal Radiol 41(6):659\u2013665. https:\/\/doi.org\/10.1007\/s00256-011-1266-4","journal-title":"Skeletal Radiol"},{"issue":"9","key":"4071_CR19","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/j.jse.2015.05.050","volume":"24","author":"S van Grinsven","year":"2015","unstructured":"van Grinsven S, Nijenhuis TA, Konings PC et al (2015) Are radiologists superior to orthopaedic surgeons in diagnosing instability-related shoulder lesions on magnetic resonance arthrography? A multicenter reproducibility and accuracy study. J Shoulder Elbow Surg 24(9):1405\u20131412. https:\/\/doi.org\/10.1016\/j.jse.2015.05.050","journal-title":"J Shoulder Elbow Surg"},{"issue":"9","key":"4071_CR20","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.arthro.2008.05.008","volume":"24","author":"WJ Robertson","year":"2008","unstructured":"Robertson WJ, Kelly BT (2008) The safe zone for hip arthroscopy: a cadaveric assessment of central, peripheral, and lateral compartment portal placement. Arthroscopy 24(9):1019\u20131026. https:\/\/doi.org\/10.1016\/j.arthro.2008.05.008","journal-title":"Arthroscopy"},{"key":"4071_CR21","volume-title":"The adult hip","author":"JJ Callaghan","year":"2007","unstructured":"Callaghan JJ, Rosenberg AG, Rubash HE (2007) The adult hip. Lippincott Williams & Wilkins, Philadelphia"},{"issue":"7","key":"4071_CR22","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1302\/0301-620X.87B7.15203","volume":"87","author":"M Beck","year":"2005","unstructured":"Beck M, Kalhor M, Leunig M et al (2005) Hip morphology influences the pattern of damage to the acetabular cartilage: femoroacetabular impingement as a cause of early osteoarthritis of the hip. J Bone Joint Surg Br 87(7):1012\u20131018. https:\/\/doi.org\/10.1302\/0301-620X.87B7.15203","journal-title":"J Bone Joint Surg Br"},{"issue":"9 Suppl","key":"4071_CR23","doi-asserted-by":"publisher","first-page":"S81","DOI":"10.1016\/j.arthro.2010.01.021","volume":"26","author":"R Fry","year":"2010","unstructured":"Fry R, Domb B (2010) Labral base refixation in the hip: rationale and technique for an anatomic approach to labral repair. Arthroscopy 26(9 Suppl):S81\u2013S89. https:\/\/doi.org\/10.1016\/j.arthro.2010.01.021","journal-title":"Arthroscopy"},{"volume-title":"Articular cartilage lesions: a practical guide to assessment and treatment","year":"2004","unstructured":"Cole BJ, Malek MM (eds) (2004) Articular cartilage lesions: a practical guide to assessment and treatment. Springer, New York","key":"4071_CR24"},{"issue":"1","key":"4071_CR25","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1037\/1082-989X.1.1.30","volume":"1","author":"KO McGraw","year":"1996","unstructured":"McGraw KO, Wong SP (1996) Forming inferences about some intraclass correlation coefficients. Psychol Methods 1(1):30\u201346. https:\/\/doi.org\/10.1037\/1082-989X.1.1.30","journal-title":"Psychol Methods"},{"issue":"19","key":"4071_CR26","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1002\/(SICI)1097-0258(19981015)17:19<2207:AID-SIM920>3.0.CO;2-Y","volume":"17","author":"PA Lachenbruch","year":"1998","unstructured":"Lachenbruch PA, Lynch CJ (1998) Assessing screening tests: extensions of McNemar\u2019s test. Statist Med 17(19):2207\u20132217. https:\/\/doi.org\/10.1002\/(SICI)1097-0258(19981015)17:19%3c2207:AID-SIM920%3e3.0.CO;2-Y","journal-title":"Statist Med"},{"issue":"1","key":"4071_CR27","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s12891-017-1443-2","volume":"18","author":"AM Saied","year":"2017","unstructured":"Saied AM, Redant C, El-Batouty M et al (2017) Accuracy of magnetic resonance studies in the detection of chondral and labral lesions in femoroacetabular impingement: systematic review and meta-analysis. BMC Musculoskelet Disord 18(1):83. https:\/\/doi.org\/10.1186\/s12891-017-1443-2","journal-title":"BMC Musculoskelet Disord"},{"issue":"6","key":"4071_CR28","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1007\/s11999-010-1741-6","volume":"469","author":"CM Larson","year":"2011","unstructured":"Larson CM, Giveans MR, Taylor M (2011) Does arthroscopic FAI correction improve function with radiographic arthritis? Clin Orthop Relat Res 469(6):1667\u20131676. https:\/\/doi.org\/10.1007\/s11999-010-1741-6","journal-title":"Clin Orthop Relat Res"},{"issue":"10","key":"4071_CR29","doi-asserted-by":"publisher","first-page":"3110","DOI":"10.1007\/s00167-018-4941-3","volume":"27","author":"B Mygind-Klavsen","year":"2019","unstructured":"Mygind-Klavsen B, Lund B, Nielsen TG et al (2019) Danish hip arthroscopy registry: predictors of outcome in patients with femoroacetabular impingement (FAI). Knee Surg Sports Traumatol Arthrosc 27(10):3110\u20133120. https:\/\/doi.org\/10.1007\/s00167-018-4941-3","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"1","key":"4071_CR30","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1302\/0301-620X.91B1.21329","volume":"91-B","author":"MJ Philippon","year":"2009","unstructured":"Philippon MJ, Briggs KK, Yen YM et al (2009) Outcomes following hip arthroscopy for femoroacetabular impingement with associated chondrolabral dysfunction. J Bone Joint Surg Br 91-B(1):16\u201323. https:\/\/doi.org\/10.1302\/0301-620X.91B1.21329","journal-title":"J Bone Joint Surg Br"},{"issue":"7","key":"4071_CR31","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s00402-014-2012-x","volume":"134","author":"P Koenen","year":"2014","unstructured":"Koenen P, B\u00e4this H, Schneider MM et al (2014) How do we face patients\u2019 expectations in joint arthroplasty? Arch Orthop Trauma Surg 134(7):925\u2013931. https:\/\/doi.org\/10.1007\/s00402-014-2012-x","journal-title":"Arch Orthop Trauma Surg"},{"issue":"3","key":"4071_CR32","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/s00330-017-5069-4","volume":"28","author":"A Chopra","year":"2018","unstructured":"Chopra A, Grainger AJ, Dube B et al (2018) Comparative reliability and diagnostic performance of conventional 3T magnetic resonance imaging and 1.5T magnetic resonance arthrography for the evaluation of internal derangement of the hip. Eur Radiol 28(3):963\u2013971. https:\/\/doi.org\/10.1007\/s00330-017-5069-4","journal-title":"Eur Radiol"},{"issue":"3","key":"4071_CR33","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00402-011-1370-x","volume":"132","author":"JJ Halma","year":"2012","unstructured":"Halma JJ, Eshuis R, Krebbers YMJ et al (2012) Interdisciplinary inter-observer agreement and accuracy of MR imaging of the shoulder with arthroscopic correlation. Arch Orthop Trauma Surg 132(3):311\u2013320. https:\/\/doi.org\/10.1007\/s00402-011-1370-x","journal-title":"Arch Orthop Trauma Surg"},{"issue":"2","key":"4071_CR34","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1148\/radiol.12111397","volume":"263","author":"TJ Dietrich","year":"2012","unstructured":"Dietrich TJ, Suter A, Pfirrmann CWA et al (2012) Supraacetabular fossa (pseudodefect of acetabular cartilage): frequency at MR arthrography and comparison of findings at MR arthrography and arthroscopy. Radiology 263(2):484\u2013491. https:\/\/doi.org\/10.1148\/radiol.12111397","journal-title":"Radiology"},{"issue":"3","key":"4071_CR35","doi-asserted-by":"publisher","first-page":"W394","DOI":"10.2214\/AJR.12.9860","volume":"201","author":"MS Nguyen","year":"2013","unstructured":"Nguyen MS, Kheyfits V, Giordano BD et al (2013) Hip anatomic variants that may mimic abnormalities at MRI: labral variants. Am J Roentgenol 201(3):W394-400. https:\/\/doi.org\/10.2214\/AJR.12.9860","journal-title":"Am J Roentgenol"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-021-04071-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00402-021-04071-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-021-04071-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T13:09:06Z","timestamp":1655903346000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00402-021-04071-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,19]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["4071"],"URL":"https:\/\/doi.org\/10.1007\/s00402-021-04071-z","relation":{},"ISSN":["1434-3916"],"issn-type":[{"type":"electronic","value":"1434-3916"}],"subject":[],"published":{"date-parts":[[2021,7,19]]},"assertion":[{"value":"21 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by IRB\/Ethikkommission Landes\u00e4rztekammer Baden-W\u00fcrttemberg, Germany.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}