{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:07:52Z","timestamp":1787162872632,"version":"build-2736575974"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007653","name":"Universit\u00e4tsklinikum Jena","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007653","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Osteoporotic vertebral fractures are a major healthcare problem. Vertebral cement augmentation (VCA) is frequently used as a minimally invasive surgical approach to manage symptomatic fractures. However, there is a potential risk of adjacent segment fracture (ASF), which may require second surgery. The addition of transcutaneous screw-fixation with cement augmentation superior and inferior to the fracture [Hybrid transcutaneous screw fixation (HTSF)] might represent an alternative treatment option to reduce the incidence of ASF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We retrospectively compared surgery time, hospital stay, intraoperative complication rate and the occurrence of ASF with the need for a surgical treatment in a cohort of 165 consecutive patients receiving either VCA or HTSF in our academic neurosurgical department from 2012 to 2020. The median follow-up was 52.3\u00a0weeks in the VCA-group and 51.9 in the HTSF-group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, 93 patients underwent VCA, and 72 had HTSF. Of all patients, 113 were females (64 VCA; 49 HTSF) and 52 were males (29 VCA; 23 HTSF). The median age was 77\u00a0years in both groups. Median surgery time was 32\u00a0min in the VCA-group and 81\u00a0min in the HTSF-group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). No surgery-related complications occurred in the VCA-group with two in the HTSF-group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.19). ASF was significantly higher in the VCA-group compared to HTSF (24 [26%] vs. 8 [11%] patients;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.02). The proportion of patients requiring additional surgery due to ASF was higher in the VCA-group (13 vs. 6%), but this difference was not statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.18). Median hospital stay was 9\u00a0days in the VCA-group and 11.5\u00a0days in the HTSF-group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on this single-center cohort study, HTSF appears to be a safe and effective option for the treatment of osteoporotic vertebral compression fractures. Surgical time and duration of hospital stay were longer in the HTSF-group, but the rate of ASF was significantly reduced with this approach. Further studies are required to ascertain whether HTSF results in superior long-term outcomes or improved quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00402-022-04434-0","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:02:33Z","timestamp":1649635353000},"page":"2333-2339","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Occurrence of adjacent segment fractures after surgical treatment of an osteoporotic vertebral fracture: a retrospective comparison between two different treatment methods"],"prefix":"10.1007","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1825-3877","authenticated-orcid":false,"given":"Nazeer","family":"Aboud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Eckardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel A.","family":"Kamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Senft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falko","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"4434_CR1","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1002\/art.1780360603","volume":"36","author":"DJ Cook","year":"1993","unstructured":"Cook DJ, Guyatt GH, Adachi JD, Clifton J, Griffith LE, Epstein RS, Juniper EF (1993) Quality of life issues in women with vertebral fractures due to osteoporosis. Arthritis Rheum 36:750\u2013756. https:\/\/doi.org\/10.1002\/art.1780360603","journal-title":"Arthritis Rheum"},{"key":"4434_CR2","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1359\/jbmr.2002.17.4.716","volume":"17","author":"D Felsenberg","year":"2002","unstructured":"European Prospective Osteoporosis Study G, Felsenberg D, Silman AJ, Lunt M, Armbrecht G, Ismail AA, Finn JD, Cockerill WC, Banzer D, Benevolenskaya LI, Bhalla A, Bruges Armas J, Cannata JB, Cooper C, Dequeker J, Eastell R, Felsch B, Gowin W, Havelka S, Hoszowski K, Jajic I, Janott J, Johnell O, Kanis JA, Kragl G, Lopes Vaz A, Lorenc R, Lyritis G, Masaryk P, Matthis C, Miazgowski T, Parisi G, Pols HA, Poor G, Raspe HH, Reid DM, Reisinger W, Schedit-Nave C, Stepan JJ, Todd CJ, Weber K, Woolf AD, Yershova OB, Reeve J, O\u2019Neill TW (2002) Incidence of vertebral fracture in europe: results from the European Prospective Osteoporosis Study (EPOS). J Bone Miner Res 17:716\u2013724. https:\/\/doi.org\/10.1359\/jbmr.2002.17.4.716","journal-title":"J Bone Miner Res"},{"key":"4434_CR3","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1007\/s00586-006-0158-0","volume":"15","author":"AM Briggs","year":"2006","unstructured":"Briggs AM, Wrigley TV, van Dieen JH, Phillips B, Lo SK, Greig AM, Bennell KL (2006) The effect of osteoporotic vertebral fracture on predicted spinal loads in vivo. Eur Spine J 15:1785\u20131795. https:\/\/doi.org\/10.1007\/s00586-006-0158-0","journal-title":"Eur Spine J"},{"key":"4434_CR4","doi-asserted-by":"publisher","first-page":"185S","DOI":"10.1016\/8756-3282(95)00500-5","volume":"18","author":"DT Gold","year":"1996","unstructured":"Gold DT (1996) The clinical impact of vertebral fractures: quality of life in women with osteoporosis. Bone 18:185S-189S. https:\/\/doi.org\/10.1016\/8756-3282(95)00500-5","journal-title":"Bone"},{"key":"4434_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-021-04184-5","author":"F Buenger","year":"2021","unstructured":"Buenger F, Sakr Y, Eckardt N, Senft C, Schwarz F (2021) Correlation of quantitative computed tomography derived bone density values with Hounsfield units of a contrast medium computed tomography in 98 thoraco-lumbar vertebral bodies. Arch Orthop Trauma Surg. https:\/\/doi.org\/10.1007\/s00402-021-04184-5","journal-title":"Arch Orthop Trauma Surg"},{"key":"4434_CR6","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s00508-012-0167-4","volume":"124","author":"I Movrin","year":"2012","unstructured":"Movrin I (2012) Adjacent level fracture after osteoporotic vertebral compression fracture: a nonrandomized prospective study comparing balloon kyphoplasty with conservative therapy. Wien Klin Wochenschr 124:304\u2013311. https:\/\/doi.org\/10.1007\/s00508-012-0167-4","journal-title":"Wien Klin Wochenschr"},{"key":"4434_CR7","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1007\/s00402-010-1106-3","volume":"130","author":"I Movrin","year":"2010","unstructured":"Movrin I, Vengust R, Komadina R (2010) Adjacent vertebral fractures after percutaneous vertebral augmentation of osteoporotic vertebral compression fracture: a comparison of balloon kyphoplasty and vertebroplasty. Arch Orthop Trauma Surg 130:1157\u20131166. https:\/\/doi.org\/10.1007\/s00402-010-1106-3","journal-title":"Arch Orthop Trauma Surg"},{"key":"4434_CR8","first-page":"147","volume":"48","author":"S Takata","year":"2001","unstructured":"Takata S, Yasui N (2001) Disuse osteoporosis. J Med Invest 48:147\u2013156","journal-title":"J Med Invest"},{"key":"4434_CR9","first-page":"166","volume":"33","author":"P Galibert","year":"1987","unstructured":"Galibert P, Deramond H, Rosat P, Le Gars D (1987) Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. Neurochirurgie 33:166\u2013168","journal-title":"Neurochirurgie"},{"key":"4434_CR10","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1055\/s-2008-1080150","volume":"1","author":"H Deramond","year":"1997","unstructured":"Deramond H, Depriester C, Toussaint P, Galibert P (1997) Percutaneous vertebroplasty. Semin Musculoskelet Radiol 1:285\u2013296. https:\/\/doi.org\/10.1055\/s-2008-1080150","journal-title":"Semin Musculoskelet Radiol"},{"key":"4434_CR11","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1097\/00007632-200203010-00005","volume":"27","author":"N Aebli","year":"2002","unstructured":"Aebli N, Krebs J, Davis G, Walton M, Williams MJ, Theis JC (2002) Fat embolism and acute hypotension during vertebroplasty: an experimental study in sheep. Spine (Phila Pa 1976) 27:460\u2013466. https:\/\/doi.org\/10.1097\/00007632-200203010-00005","journal-title":"Spine (Phila Pa 1976)"},{"key":"4434_CR12","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1148\/radiol.2261011911","volume":"226","author":"AA Uppin","year":"2003","unstructured":"Uppin AA, Hirsch JA, Centenera LV, Pfiefer BA, Pazianos AG, Choi IS (2003) Occurrence of new vertebral body fracture after percutaneous vertebroplasty in patients with osteoporosis. Radiology 226:119\u2013124. https:\/\/doi.org\/10.1148\/radiol.2261011911","journal-title":"Radiology"},{"key":"4434_CR13","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1097\/00007632-200107150-00002","volume":"26","author":"SR Garfin","year":"2001","unstructured":"Garfin SR, Yuan HA, Reiley MA (2001) New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures. Spine (Phila Pa 1976) 26:1511\u20131515. https:\/\/doi.org\/10.1097\/00007632-200107150-00002","journal-title":"Spine (Phila Pa 1976)"},{"key":"4434_CR14","doi-asserted-by":"publisher","first-page":"210","DOI":"10.31616\/asj.2018.0224","volume":"13","author":"BS Ko","year":"2019","unstructured":"Ko BS, Cho KJ, Park JW (2019) Early adjacent vertebral fractures after balloon kyphoplasty for osteoporotic vertebral compression fractures. Asian Spine J 13:210\u2013215. https:\/\/doi.org\/10.31616\/asj.2018.0224","journal-title":"Asian Spine J"},{"key":"4434_CR15","doi-asserted-by":"publisher","first-page":"E73","DOI":"10.1097\/01.brs.0000152162.64015.fb","volume":"30","author":"JJ Verlaan","year":"2005","unstructured":"Verlaan JJ, Dhert WJ, Verbout AJ, Oner FC (2005) Balloon vertebroplasty in combination with pedicle screw instrumentation: a novel technique to treat thoracic and lumbar burst fractures. Spine (Phila Pa 1976) 30:E73\u2013E79. https:\/\/doi.org\/10.1097\/01.brs.0000152162.64015.fb","journal-title":"Spine (Phila Pa 1976)"},{"key":"4434_CR16","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s00586-010-1444-4","volume":"19","author":"S Fuentes","year":"2010","unstructured":"Fuentes S, Blondel B, Metellus P, Gaudart J, Adetchessi T, Dufour H (2010) Percutaneous kyphoplasty and pedicle screw fixation for the management of thoraco-lumbar burst fractures. Eur Spine J 19:1281\u20131287. https:\/\/doi.org\/10.1007\/s00586-010-1444-4","journal-title":"Eur Spine J"},{"key":"4434_CR17","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1259\/bjr\/10254271","volume":"76","author":"WC Peh","year":"2003","unstructured":"Peh WC, Gilula LA (2003) Percutaneous vertebroplasty: indications, contraindications, and technique. Br J Radiol 76:69\u201375. https:\/\/doi.org\/10.1259\/bjr\/10254271","journal-title":"Br J Radiol"},{"key":"4434_CR18","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00402-013-1886-3","volume":"134","author":"X Yi","year":"2014","unstructured":"Yi X, Lu H, Tian F, Wang Y, Li C, Liu H, Liu X, Li H (2014) Recompression in new levels after percutaneous vertebroplasty and kyphoplasty compared with conservative treatment. Arch Orthop Trauma Surg 134:21\u201330. https:\/\/doi.org\/10.1007\/s00402-013-1886-3","journal-title":"Arch Orthop Trauma Surg"},{"key":"4434_CR19","doi-asserted-by":"publisher","first-page":"46S","DOI":"10.1177\/2192568217717972","volume":"8","author":"Schnake KJ, Blattert TR, Hahn P, Franck A, Hartmann F, Ullrich B, Verheyden A, Mork S, Zimmermann V, Gonschorek O, Muller M, Katscher S, Saman AE, Pajenda G, Morrison R, Schinkel C, Piltz S, Partenheimer A, Muller CW, Gercek E, Scherer M, Bouzraki N, Kandziora F, Spine Section of the German Society for O, Trauma","year":"2018","unstructured":"Schnake KJ, Blattert TR, Hahn P, Franck A, Hartmann F, Ullrich B, Verheyden A, Mork S, Zimmermann V, Gonschorek O, Muller M, Katscher S, Saman AE, Pajenda G, Morrison R, Schinkel C, Piltz S, Partenheimer A, Muller CW, Gercek E, Scherer M, Bouzraki N, Kandziora F, Spine Section of the German Society for O, Trauma (2018) Classification of osteoporotic thoracolumbar spine fractures: recommendations of the spine section of the German Society for Orthopaedics and Trauma (DGOU). Global Spine J 8:46S-49S. https:\/\/doi.org\/10.1177\/2192568217717972","journal-title":"Global Spine J"},{"key":"4434_CR20","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s00198-008-0745-5","volume":"20","author":"AS Mudano","year":"2009","unstructured":"Mudano AS, Bian J, Cope JU, Curtis JR, Gross TP, Allison JJ, Kim Y, Briggs D, Melton ME, Xi J, Saag KG (2009) Vertebroplasty and kyphoplasty are associated with an increased risk of secondary vertebral compression fractures: a population-based cohort study. Osteoporos Int 20:819\u2013826. https:\/\/doi.org\/10.1007\/s00198-008-0745-5","journal-title":"Osteoporos Int"},{"key":"4434_CR21","doi-asserted-by":"publisher","first-page":"E99","DOI":"10.1097\/BSD.0000000000000734","volume":"32","author":"W Yang","year":"2019","unstructured":"Yang W, Yang J, Liang M (2019) Percutaneous vertebroplasty does not increase the incidence of new fractures in adjacent and nonadjacent vertebral bodies. Clin Spine Surg 32:E99\u2013E106. https:\/\/doi.org\/10.1097\/BSD.0000000000000734","journal-title":"Clin Spine Surg"},{"key":"4434_CR22","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s00270-019-02205-w","volume":"42","author":"CE Firanescu","year":"2019","unstructured":"Firanescu CE, De Vries J, Lodder P, Schoemaker MC, Smeets AJ, Donga E, Juttmann JR, Klazen CAH, Elgersma OEH, Jansen FH, Van Der Horst I, Blonk M, Venmans A, Lohle PNM (2019) Percutaneous vertebroplasty is no risk factor for new vertebral fractures and protects against further height loss (VERTOS IV). Cardiovasc Intervent Radiol 42:991\u20131000. https:\/\/doi.org\/10.1007\/s00270-019-02205-w","journal-title":"Cardiovasc Intervent Radiol"},{"key":"4434_CR23","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1097\/01.brs.0000142469.41565.2a","volume":"29","author":"D Fribourg","year":"2004","unstructured":"Fribourg D, Tang C, Sra P, Delamarter R, Bae H (2004) Incidence of subsequent vertebral fracture after kyphoplasty. Spine (Phila Pa 1976) 29:2270\u20132276. https:\/\/doi.org\/10.1097\/01.brs.0000142469.41565.2a (discussion 2277)","journal-title":"Spine (Phila Pa 1976)"},{"key":"4434_CR24","doi-asserted-by":"publisher","first-page":"565","DOI":"10.14444\/5069","volume":"12","author":"F Schwarz","year":"2018","unstructured":"Schwarz F, Burckhart M, McLean AL, Kalff R, Waschke A (2018) Risk factors for adjacent fractures after cement-augmented thoracolumbar pedicle screw instrumentation. Int J Spine Surg 12:565\u2013570. https:\/\/doi.org\/10.14444\/5069","journal-title":"Int J Spine Surg"},{"key":"4434_CR25","doi-asserted-by":"publisher","first-page":"S45","DOI":"10.1097\/01.BRS.0000076898.37566.32","volume":"28","author":"FM Phillips","year":"2003","unstructured":"Phillips FM (2003) Minimally invasive treatments of osteoporotic vertebral compression fractures. Spine (Phila Pa 1976) 28:S45-53. https:\/\/doi.org\/10.1097\/01.BRS.0000076898.37566.32","journal-title":"Spine (Phila Pa 1976)"},{"key":"4434_CR26","first-page":"559","volume":"52","author":"FM Phillips","year":"2003","unstructured":"Phillips FM, Pfeifer BA, Lieberman IH, Kerr EJ 3rd, Choi IS, Pazianos AG (2003) Minimally invasive treatments of osteoporotic vertebral compression fractures: vertebroplasty and kyphoplasty. Instr Course Lect 52:559\u2013567","journal-title":"Instr Course Lect"},{"key":"4434_CR27","doi-asserted-by":"publisher","first-page":"180","DOI":"10.4184\/asj.2011.5.3.180","volume":"5","author":"MH Kim","year":"2011","unstructured":"Kim MH, Lee AS, Min SH, Yoon SH (2011) Risk factors of new compression fractures in adjacent vertebrae after percutaneous vertebroplasty. Asian Spine J 5:180\u2013187. https:\/\/doi.org\/10.4184\/asj.2011.5.3.180","journal-title":"Asian Spine J"},{"key":"4434_CR28","doi-asserted-by":"publisher","first-page":"E150","DOI":"10.1097\/BSD.0b013e31827412a5","volume":"26","author":"Z Zhang","year":"2013","unstructured":"Zhang Z, Fan J, Ding Q, Wu M, Yin G (2013) Risk factors for new osteoporotic vertebral compression fractures after vertebroplasty: a systematic review and meta-analysis. J Spinal Disord Tech 26:E150\u2013E157. https:\/\/doi.org\/10.1097\/BSD.0b013e31827412a5","journal-title":"J Spinal Disord Tech"},{"key":"4434_CR29","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.2147\/CIA.S312623","volume":"16","author":"ZL Zhang","year":"2021","unstructured":"Zhang ZL, Yang JS, Hao DJ, Liu TJ, Jing QM (2021) Risk factors for new vertebral fracture after percutaneous vertebroplasty for osteoporotic vertebral compression fractures. Clin Interv Aging 16:1193\u20131200. https:\/\/doi.org\/10.2147\/CIA.S312623","journal-title":"Clin Interv Aging"},{"key":"4434_CR30","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/ans.13428","volume":"86","author":"J Cao","year":"2016","unstructured":"Cao J, Kong L, Meng F, Zhang Y, Shen Y (2016) Risk factors for new vertebral compression fractures after vertebroplasty: a meta-analysis. ANZ J Surg 86:549\u2013554. https:\/\/doi.org\/10.1111\/ans.13428","journal-title":"ANZ J Surg"},{"key":"4434_CR31","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1007\/s00586-015-3786-4","volume":"24","author":"HL Ren","year":"2015","unstructured":"Ren HL, Jiang JM, Chen JT, Wang JX (2015) Risk factors of new symptomatic vertebral compression fractures in osteoporotic patients undergone percutaneous vertebroplasty. Eur Spine J 24:750\u2013758. https:\/\/doi.org\/10.1007\/s00586-015-3786-4","journal-title":"Eur Spine J"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-022-04434-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00402-022-04434-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-022-04434-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T08:05:14Z","timestamp":1681718714000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00402-022-04434-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,11]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["4434"],"URL":"https:\/\/doi.org\/10.1007\/s00402-022-04434-0","relation":{},"ISSN":["1434-3916"],"issn-type":[{"value":"1434-3916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,11]]},"assertion":[{"value":"5 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the local ethic committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not necessary.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}