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Most frequently spacers (Sp) with or without antibiotics are implanted in a two-stage procedure even though not always indicated due to unknown pathogen, femoral and acetabular defects or muscular insufficiency.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>\u00a0A retrospective analysis of a prospectively collected database was conducted, analyzing\u00a0the treatment of 44\u00a0consecutive cases\u00a0with chronic PJI undergoing two-stage revision using a Girdlestone situation (GS) in the interim period between\u00a001\/2015 and 12\/2018. Diagnostics included intraoperative microbiological cultures, histological analysis, sonication of the\u00a0initial\u00a0implant, analysis of hip aspiration,\u00a0as well as laboratory diagnostics and\u00a0blood cultures. We analyzed the general and age-group-specific success rate of treatment using GS. Furthermore, we compared our data with the current literature on spacer implantation regarding common complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In total, 21 female and 23 male patients at a mean age of 59.3\u2009\u00b1\u20099.6\u00a0years were included. Age groups were divided into young, mid-age, and elderly. In most patients, microbiology revealed Staphylococcus epidermidis in 39.1% of cases, following <jats:italic>Staphylococcus lugdunensis<\/jats:italic> and <jats:italic>Staphylococcus aureus<\/jats:italic> in 10.9% after THA explantation. For histology, Krenn and Morawietz type 2 (infectious type) was diagnosed in 40.9%, type 3 (infectious and abrade-induced type) in 25.0%. With GS, the total cure rate was 84.1% compared to 90.1% (range 61\u2013100%) using Sp as described in the literature. Among age-groups, cure rate varied between 77.8 and 100%. Other complications, which only occurred in the mid-age and elderly group, included the necessity of transfusion in 31.1%, and in total, one periprosthetic fracture was identified (2.3%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>GS shows an acceptable cure rate at a minimum of 2\u00a0years when compared to the cure rate reported in the literature for Sp without major complications. For patients with increased risks for treatment failure using spacer, GS seems to be an alternative for chronic PJI when looking at the success rate of treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Level of evidence<\/jats:title>\n                <jats:p>III, Retrospective trial.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00402-022-04463-9","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T18:07:58Z","timestamp":1652119678000},"page":"2199-2207","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cure rate of infections is not an argument for spacer in two-stage revision arthroplasty of the hip"],"prefix":"10.1007","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8555-7304","authenticated-orcid":false,"given":"Dominik","family":"Adl Amini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia H.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Perka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik C.","family":"B\u00e4cker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"4463_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60457-7","author":"ID Learmonth","year":"2007","unstructured":"Learmonth ID, Young C, Rorabeck C, Bs B (2007) The operation of the century\u202f: total hip replacement. 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