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Mehling and R.F. Pronk declared no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article. J. van Schoonhoven has a speaker`s contract with the KLS Martin, Tuttlingen, Germany. The clinical study is part of the doctoral thesis of R.F. Pronk. All authors were in varying proportions but equally involved. In the conception of the trial, in acquisition, analysis and interpretation of the data In drafting the work or revising it critically for its intellectual content. All authors were involved in final approval of the draft and gave their informed consent. All authors agree to be accountable for all aspects of the work and ensure that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"An ethical approval was submitted before starting this study and is available.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}