{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:36:54Z","timestamp":1740141414703,"version":"3.37.3"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Children\u2019s Hospital Orthopaedic Surgery Foundation"},{"name":"Boston Children\u2019s Hospital Faculty Council"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"DOI":"10.1007\/s00402-023-04795-0","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T14:02:48Z","timestamp":1677679368000},"page":"5457-5466","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of joint loading on the development of capital femoral epiphysis morphology"],"prefix":"10.1007","volume":"143","author":[{"given":"Charles","family":"Mitchell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koroush","family":"Emami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Emami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayan","family":"Hosseinzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Shore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo N.","family":"Novais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7742-5769","authenticated-orcid":false,"given":"Ata M.","family":"Kiapour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"issue":"Suppl 2","key":"4795_CR1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.2106\/JBJS.K.00040","volume":"93","author":"MB Millis","year":"2011","unstructured":"Millis MB, Novais EN (2011) In situ fixation for slipped capital femoral epiphysis: perspectives in 2011. J Bone Joint Surg Am 93(Suppl 2):46\u201351","journal-title":"J Bone Joint Surg Am"},{"issue":"12","key":"4795_CR2","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1302\/0301-620X.89B12.19637","volume":"89","author":"CR Fraitzl","year":"2007","unstructured":"Fraitzl CR et al (2007) Radiological evidence of femoroacetabular impingement in mild slipped capital femoral epiphysis: a mean follow-up of 14.4 years after pinning in situ. J Bone Joint Surg Br 89(12):1592\u20131596","journal-title":"J Bone Joint Surg Br"},{"issue":"3","key":"4795_CR3","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/01.bpo.0000217718.10728.70","volume":"26","author":"CL Lehmann","year":"2006","unstructured":"Lehmann CL et al (2006) The epidemiology of slipped capital femoral epiphysis: an update. J Pediatr Orthop 26(3):286\u2013290","journal-title":"J Pediatr Orthop"},{"issue":"12","key":"4795_CR4","first-page":"1055","volume":"61","author":"C Zhang","year":"2015","unstructured":"Zhang C et al (2015) Femoroacetabular impingement and osteoarthritis of the hip. Can Fam Physician 61(12):1055\u20131060","journal-title":"Can Fam Physician"},{"issue":"1","key":"4795_CR5","doi-asserted-by":"publisher","first-page":"82","DOI":"10.2106\/JBJS.K.01219","volume":"95","author":"A Bedi","year":"2013","unstructured":"Bedi A, Kelly BT (2013) Femoroacetabular impingement. J Bone Joint Surg Am 95(1):82\u201392","journal-title":"J Bone Joint Surg Am"},{"issue":"5","key":"4795_CR6","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/BPO.0b013e31817e240d","volume":"28","author":"EC Benson","year":"2008","unstructured":"Benson EC et al (2008) A new look at the incidence of slipped capital femoral epiphysis in new Mexico. J Pediatr Orthop 28(5):529\u2013533","journal-title":"J Pediatr Orthop"},{"issue":"1","key":"4795_CR7","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1302\/0301-620X.90B1.19502","volume":"90","author":"AW Murray","year":"2008","unstructured":"Murray AW, Wilson NI (2008) Changing incidence of slipped capital femoral epiphysis: a relationship with obesity? J Bone Joint Surg Br 90(1):92\u201394","journal-title":"J Bone Joint Surg Br"},{"key":"4795_CR8","doi-asserted-by":"crossref","unstructured":"Beck, M., et al., Hip morphology influences the pattern of damage to the acetabular cartilage: femoroacetabular impingement as a cause of early osteoarthritis of the hip. 2005. p. 1012\u20138.","DOI":"10.1302\/0301-620X.87B7.15203"},{"issue":"12","key":"4795_CR9","doi-asserted-by":"publisher","first-page":"3432","DOI":"10.1007\/s11999-012-2452-y","volume":"470","author":"EN Novais","year":"2012","unstructured":"Novais EN, Millis MB (2012) Slipped capital femoral epiphysis: prevalence, pathogenesis, and natural history. Clin Orthop Relat Res 470(12):3432\u20133438","journal-title":"Clin Orthop Relat Res"},{"issue":"1","key":"4795_CR10","doi-asserted-by":"publisher","first-page":"66","DOI":"10.2106\/JBJS.17.00377","volume":"100","author":"EN Novais","year":"2018","unstructured":"Novais EN et al (2018) Body mass index affects proximal femoral but not acetabular morphology in adolescents without hip pathology. J Bone Joint Surg Am 100(1):66\u201374","journal-title":"J Bone Joint Surg Am"},{"issue":"5","key":"4795_CR11","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1177\/0363546512438381","volume":"40","author":"R Agricola","year":"2012","unstructured":"Agricola R et al (2012) The development of Cam-type deformity in adolescent and young male soccer players. Am J Sports Med 40(5):1099\u20131106","journal-title":"Am J Sports Med"},{"issue":"6","key":"4795_CR12","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1097\/01.bpo.0000184651.34475.8e","volume":"25","author":"EM Manoff","year":"2005","unstructured":"Manoff EM, Banffy MB, Winell JJ (2005) Relationship between Body Mass Index and slipped capital femoral epiphysis. J Pediatr Orthop 25(6):744\u2013746","journal-title":"J Pediatr Orthop"},{"issue":"4","key":"4795_CR13","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1007\/s11999-012-2740-6","volume":"471","author":"KA Siebenrock","year":"2013","unstructured":"Siebenrock KA et al (2013) Growth plate alteration precedes cam-type deformity in elite basketball players. Clin Orthop Relat Res 471(4):1084\u20131091","journal-title":"Clin Orthop Relat Res"},{"issue":"10","key":"4795_CR14","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.1177\/0363546513497564","volume":"41","author":"KA Siebenrock","year":"2013","unstructured":"Siebenrock KA et al (2013) Prevalence of cam-type deformity and hip pain in elite ice hockey players before and after the end of growth. Am J Sports Med 41(10):2308\u20132313","journal-title":"Am J Sports Med"},{"issue":"6","key":"4795_CR15","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1302\/0301-620X.96B6.33000","volume":"96-B","author":"J Murgier","year":"2014","unstructured":"Murgier J et al (2014) The frequency of sequelae of slipped upper femoral epiphysis in cam-type femoroacetabular impingement. Bone Joint J 96-B(6):724\u2013729","journal-title":"Bone Joint J"},{"issue":"7","key":"4795_CR16","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1007\/s11999-013-2818-9","volume":"471","author":"K Ziebarth","year":"2013","unstructured":"Ziebarth K et al (2013) Slipped capital femoral epiphysis: relevant pathophysiological findings with open surgery. Clin Orthop Relat Res 471(7):2156\u20132162","journal-title":"Clin Orthop Relat Res"},{"issue":"10","key":"4795_CR17","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.2106\/00004623-199710000-00005","volume":"79","author":"DA Goodman","year":"1997","unstructured":"Goodman DA et al (1997) Subclinical slipped capital femoral epiphysis. Relationship to osteoarthrosis of the hip. J Bone Joint Surg Am 79(10):1489\u20131497","journal-title":"J Bone Joint Surg Am"},{"issue":"12","key":"4795_CR18","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1016\/j.joca.2014.09.011","volume":"22","author":"P Roels","year":"2014","unstructured":"Roels P et al (2014) Mechanical factors explain development of cam-type deformity. Osteoarthritis Cartilage 22(12):2074\u20132082","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"4795_CR19","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1007\/s11999-014-4068-x","volume":"473","author":"CE Albers","year":"2015","unstructured":"Albers CE et al (2015) Twelve percent of hips with a primary cam deformity exhibit a slip-like morphology resembling sequelae of slipped capital femoral epiphysis. Clin Orthop Relat Res 473(4):1212\u20131223","journal-title":"Clin Orthop Relat Res"},{"issue":"6","key":"4795_CR20","doi-asserted-by":"publisher","first-page":"e341","DOI":"10.2106\/JBJS.L.00474","volume":"95","author":"RW Liu","year":"2013","unstructured":"Liu RW et al (2013) An anatomic study of the epiphyseal tubercle and its importance in the pathogenesis of slipped capital femoral epiphysis. J Bone Joint Surg Am 95(6):e341\u2013e348","journal-title":"J Bone Joint Surg Am"},{"issue":"10","key":"4795_CR21","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1302\/0301-620X.89B10.19563","volume":"89","author":"K Tayton","year":"2007","unstructured":"Tayton K (2007) Does the upper femoral epiphysis slip or rotate? J Bone Joint Surg Br 89(10):1402\u20131406","journal-title":"J Bone Joint Surg Br"},{"issue":"4","key":"4795_CR22","doi-asserted-by":"publisher","first-page":"416","DOI":"10.3109\/17453670903153550","volume":"80","author":"K Tayton","year":"2009","unstructured":"Tayton K (2009) The epiphyseal tubercle in adolescent hips. Acta Orthop 80(4):416\u2013419","journal-title":"Acta Orthop"},{"issue":"1","key":"4795_CR23","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40634-014-0004-y","volume":"1","author":"PS Jonasson","year":"2014","unstructured":"Jonasson PS et al (2014) Strength of the porcine proximal femoral epiphyseal plate: the effect of different loading directions and the role of the perichondrial fibrocartilaginous complex and epiphyseal tubercle - an experimental biomechanical study. J Exp Orthop 1(1):4","journal-title":"J Exp Orthop"},{"issue":"4","key":"4795_CR24","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1177\/0363546514524364","volume":"42","author":"R Agricola","year":"2014","unstructured":"Agricola R et al (2014) A cam deformity is gradually acquired during skeletal maturation in adolescent and young male soccer players: a prospective study with minimum 2-year follow-up. Am J Sports Med 42(4):798\u2013806","journal-title":"Am J Sports Med"},{"issue":"9","key":"4795_CR25","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1136\/bjsports-2017-097626","volume":"52","author":"A Palmer","year":"2018","unstructured":"Palmer A et al (2018) Physical activity during adolescence and the development of cam morphology: a cross-sectional cohort study of 210 individuals. Br J Sports Med 52(9):601\u2013610","journal-title":"Br J Sports Med"},{"issue":"3","key":"4795_CR26","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1302\/1863-2548.14.200010","volume":"14","author":"S Hosseinzadeh","year":"2020","unstructured":"Hosseinzadeh S et al (2020) The metaphyseal fossa surrounding the epiphyseal tubercle is larger in hips with moderate and severe slipped capital femoral epiphysis than normal hips. J Child Orthop 14(3):184\u2013189","journal-title":"J Child Orthop"},{"issue":"6","key":"4795_CR27","doi-asserted-by":"publisher","first-page":"232596711878157","DOI":"10.1177\/2325967118781579","volume":"6","author":"EN Novais","year":"2018","unstructured":"Novais EN et al (2018) Age- and sex-specific morphologic variations of capital femoral epiphysis growth in children and adolescents without hip disorders. Orthop J Sports Med 6(6):2325967118781579","journal-title":"Orthop J Sports Med"},{"key":"4795_CR28","doi-asserted-by":"crossref","unstructured":"Hosseinzadeh, S., et al., Age- and sex-specific morphologic changes in the metaphyseal fossa adjacent to epiphyseal tubercle in children and adolescents without hip disorders. J Orthop Res, 2020.","DOI":"10.1002\/jor.24638"},{"issue":"2","key":"4795_CR29","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1302\/1863-2548.12.170193","volume":"12","author":"EN Novais","year":"2018","unstructured":"Novais EN et al (2018) Age- and gender-specific variations of the epiphyseal tilt and epiphyseal angle in adolescents without hip pathology. J Child Orthop 12(2):152\u2013159","journal-title":"J Child Orthop"},{"issue":"2","key":"4795_CR30","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/00004694-199703000-00002","volume":"17","author":"HT Kim","year":"1997","unstructured":"Kim HT, Wenger DR (1997) Location of acetabular deficiency and associated hip dislocation in neuromuscular hip dysplasia: three-dimensional computed tomographic analysis. J Pediatric Orthop 17(2):143\u2013151","journal-title":"J Pediatric Orthop"},{"issue":"11","key":"4795_CR31","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1002\/jor.22698","volume":"32","author":"L Bosmans","year":"2014","unstructured":"Bosmans L et al (2014) Hip contact force in presence of aberrant bone geometry during normal and pathological gait. J Orthop Res 32(11):1406\u20131415","journal-title":"J Orthop Res"},{"issue":"3","key":"4795_CR32","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1097\/01202412-199707000-00010","volume":"6","author":"R Brunner","year":"1997","unstructured":"Brunner R, Picard C, Robb J (1997) Morphology of the acetabulum in hip dislocations caused by cerebral palsy. J Pediatr Orthopaed B 6(3):207\u2013211","journal-title":"J Pediatr Orthopaed B"},{"issue":"8","key":"4795_CR33","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1097\/BPO.0b013e3181c0e957","volume":"29","author":"S Gose","year":"2009","unstructured":"Gose S et al (2009) Morphometric analysis of acetabular dysplasia in cerebral palsy: three-dimensional CT study. J Pediatr Orthopaed 29(8):896\u2013902","journal-title":"J Pediatr Orthopaed"},{"issue":"2","key":"4795_CR34","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1302\/0301-620X.88B2.16274","volume":"88-B","author":"CY Chung","year":"2006","unstructured":"Chung CY et al (2006) Morphometric analysis of acetabular dysplasia in cerebral palsy. J Bone Jt Surg Br 88-B(2):243\u2013247","journal-title":"J Bone Jt Surg Br"},{"issue":"1","key":"4795_CR35","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s12938-018-0610-5","volume":"17","author":"T Inai","year":"2018","unstructured":"Inai T et al (2018) Effect of hip joint angle at seat-off on hip joint contact force during sit-to-stand movement: a computer simulation study. Biomed Eng Online 17(1):177","journal-title":"Biomed Eng Online"},{"issue":"1","key":"4795_CR36","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1097\/PEP.0b013e3180302111","volume":"19","author":"TW Pin","year":"2007","unstructured":"Pin TW (2007) Effectiveness of static weight-bearing exercises in children with cerebral palsy. Pediatr Phys Ther 19(1):62\u201373","journal-title":"Pediatr Phys Ther"},{"issue":"7","key":"4795_CR37","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/j.1469-8749.2008.03021.x","volume":"50","author":"HH Kecskemethy","year":"2008","unstructured":"Kecskemethy HH et al (2008) Quantifying weight bearing while in passive standers and a comparison of standers. Dev Med Child Neurol 50(7):520\u2013523","journal-title":"Dev Med Child Neurol"},{"key":"4795_CR38","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.apergo.2017.04.008","volume":"63","author":"J Van Houcke","year":"2017","unstructured":"Van Houcke J et al (2017) Computer-based estimation of the hip joint reaction force and hip flexion angle in three different sitting configurations. Appl Ergon 63:99\u2013105","journal-title":"Appl Ergon"},{"key":"4795_CR39","doi-asserted-by":"crossref","unstructured":"Kiapour AM et al (2019) Relative contribution of epiphyseal tubercle and peripheral cupping to capital femoral epiphysis stability during daily activities. J Orthop Res","DOI":"10.1002\/jor.24278"},{"key":"4795_CR40","doi-asserted-by":"crossref","unstructured":"Novais EN et al (2019) Smaller epiphyseal tubercle and larger peripheral cupping in slipped capital femoral epiphysis compared with healthy hips: A 3-Dimensional Computed Tomography Study. J Bone Joint Surg Am","DOI":"10.2106\/JBJS.19.00291"},{"issue":"1437","key":"4795_CR41","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1098\/rstb.2003.1346","volume":"358","author":"DR Carter","year":"2003","unstructured":"Carter DR, Wong M (2003) Modelling cartilage mechanobiology. Philos Trans R Soc Lond B Biol Sci 358(1437):1461\u20131471","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"5","key":"4795_CR42","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1002\/jor.1100170505","volume":"17","author":"SS Stevens","year":"1999","unstructured":"Stevens SS, Beaupre GS, Carter DR (1999) Computer model of endochondral growth and ossification in long bones: biological and mechanobiological influences. J Orthop Res 17(5):646\u2013653","journal-title":"J Orthop Res"},{"issue":"2","key":"4795_CR43","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/tera.1420450215","volume":"45","author":"JI Rodriguez","year":"1992","unstructured":"Rodriguez JI et al (1992) Morphological changes in long bone development in fetal akinesia deformation sequence: an experimental study in curarized rat fetuses. Teratology 45(2):213\u2013221","journal-title":"Teratology"},{"issue":"3","key":"4795_CR44","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1469-7580.2007.00698.x","volume":"210","author":"C Gomez","year":"2007","unstructured":"Gomez C et al (2007) Absence of mechanical loading in utero influences bone mass and architecture but not innervation in Myod-Myf5-deficient mice. J Anat 210(3):259\u2013271","journal-title":"J Anat"},{"issue":"15","key":"4795_CR45","doi-asserted-by":"publisher","first-page":"3247","DOI":"10.1242\/dev.063768","volume":"138","author":"A Sharir","year":"2011","unstructured":"Sharir A et al (2011) Muscle force regulates bone shaping for optimal load-bearing capacity during embryogenesis. Development 138(15):3247\u20133259","journal-title":"Development"},{"key":"4795_CR46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.11604\/pamj.2018.31.89.6832","volume":"31","author":"Y Nhamoucha","year":"2018","unstructured":"Nhamoucha Y et al (2018) Slipped capital femoral epiphysis in a patient with cerebral palsy due to seizure. Pan Afr Med J 31:89","journal-title":"Pan Afr Med J"},{"issue":"5","key":"4795_CR47","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1097\/BPB.0b013e32833af50a","volume":"19","author":"G Kardashian","year":"2010","unstructured":"Kardashian G, Strongwater AM (2010) Slipped capital femoral epiphysis in a cerebral palsy patient: a case report. J Pediatr Orthop B 19(5):428\u2013430","journal-title":"J Pediatr Orthop B"},{"key":"4795_CR48","doi-asserted-by":"crossref","unstructured":"Perry DC et al (2018) Childhood obesity and slipped capital femoral epiphysis. Pediatrics 142(5)","DOI":"10.1542\/peds.2018-1067"},{"issue":"2","key":"4795_CR49","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s12178-019-09547-5","volume":"12","author":"JD Wylie","year":"2019","unstructured":"Wylie JD, Novais EN (2019) Evolving understanding of and treatment approaches to slipped capital femoral epiphysis. Curr Rev Musculoskelet Med 12(2):213\u2013219","journal-title":"Curr Rev Musculoskelet Med"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-023-04795-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00402-023-04795-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-023-04795-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T03:28:24Z","timestamp":1692934104000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00402-023-04795-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["4795"],"URL":"https:\/\/doi.org\/10.1007\/s00402-023-04795-0","relation":{},"ISSN":["1434-3916"],"issn-type":[{"type":"electronic","value":"1434-3916"}],"subject":[],"published":{"date-parts":[[2023,3,1]]},"assertion":[{"value":"20 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Review Board of Boston Children\u2019s Hospital (IRB-P00015233).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This a retrospective study and consent was not required as approved by the IRB.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"This a retrospective study and consent was not required as approved by the IRB.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}