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In this cohort study, we retrospectively analyzed clinical and radiological outcome measures as well as complications.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The median (range) age was 47 (17\u201363) years, height 1.68 (1.56\u20131.98) m, body mass 80 (49\u2013105) kg, and body mass index (BMI) 27.4 (18.6\u201337.0) kg\/m<jats:sup>2<\/jats:sup>. The clinical follow-up was 21 (7\u201381) months, the need for total or unicompartmental knee arthroplasty (TKA\/UKA) and hardware removal was followed up for 59 (7\u2013108) months postoperatively. Preoperatively, hip-knee-ankle angle (HKA, negative values denote varus) was 7.0 (2.0\u201313.0)\u00b0, mechanical lateral distal femoral angle (mLDFA) was 83.7 (79.9\u201388.2)\u00b0, and mechanical proximal tibial angle (MPTA) was 89.0 (86.6\u201394.5)\u00b0. Postoperatively, HKA was \u22121.3 (\u22129.0\u20131.2)\u00b0 and mLDFA was 90.8 (87.3\u201397.3)\u00b0. The incidence of minor and major complications was 25% and 14%, the incidence of delayed and nonunion was 18% and 4%, respectively. At the last follow-up, 18% of the patients had pain at rest, 25% during activities of daily living, and 39% during physical activity, and\u00a071% were satisfied with the outcome. 7% of the cases received a TKA\/UKA, 71% received a hardware removal.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>DFO is a reasonable treatment for lateral osteoarthritis in younger patients to avoid disease progression and the need for an UKA\/TKA. However, there is a long rehabilitation time, a considerable risk for complications, and a high need for hardware removal. While many patients experienced symptoms at the long-term follow-up, most were satisfied with the outcome. Appropriate patient information is essential.<\/jats:p>\n                <jats:p><jats:bold>Level of evidence<\/jats:bold> Level IV, Case Series.<\/jats:p>\n                <jats:p><jats:bold>Trial registration number<\/jats:bold> NCT04382118, clinicaltrials.gov, May 11, 2020.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00402-023-04923-w","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T04:01:29Z","timestamp":1686024089000},"page":"6147-6157","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Distal femoral osteotomy for the valgus knee: indications, complications, clinical and radiological outcome"],"prefix":"10.1007","volume":"143","clinical-trial-number":[{"clinical-trial-number":"nct04382118","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-7902","authenticated-orcid":false,"given":"Petros","family":"Ismailidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julika","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"N\u00fcesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"M\u00fcndermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Pagenstert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Egloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"issue":"2","key":"4923_CR1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1177\/15563316211051295","volume":"18","author":"H Abdel Khalik","year":"2022","unstructured":"Abdel Khalik H, Lameire DL, Rubinger L, Ekhtiari S, Khanna V, Ayeni OR (2022) Return to sport and work following distal femoral varus osteotomy: a systematic review. 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