{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:18:43Z","timestamp":1789103923381,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"DOI":"10.1007\/s00402-023-04951-6","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T19:01:30Z","timestamp":1688151690000},"page":"6527-6533","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Is malunion of the greater tuberosity after reverse shoulder arthroplasty in patients with complex proximal humerus fracture associated with worse clinical outcomes? A prospective cohort study"],"prefix":"10.1007","volume":"143","author":[{"given":"Janic","family":"Fischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoEllen","family":"Welter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Graber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Christoph","family":"Pape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurenz","family":"Jaberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4529-0932","authenticated-orcid":false,"given":"Florian","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"issue":"4","key":"4951_CR1","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s10195-017-0468-5","volume":"18","author":"RN Kruithof","year":"2017","unstructured":"Kruithof RN, Formijne Jonkers HA, van der Ven DJC, van Olden GDJ, Timmers TK (2017) Functional and quality of life outcome after non-operatively managed proximal humeral fractures. J Orthop Traumatol 18(4):423\u2013430. https:\/\/doi.org\/10.1007\/s10195-017-0468-5","journal-title":"J Orthop Traumatol"},{"issue":"4","key":"4951_CR2","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1302\/0301-620X.89B4.18435","volume":"89","author":"T Bufquin","year":"2007","unstructured":"Bufquin T, Hersan A, Hubert L, Massin P (2007) Reverse shoulder arthroplasty for the treatment of three- and four-part fractures of the proximal humerus in the elderly: a prospective review of 43 cases with a short-term follow-up. J Bone Jt Surg [Br] 89(4):516\u2013520. https:\/\/doi.org\/10.1302\/0301-620X.89B4.18435","journal-title":"J Bone Jt Surg [Br]"},{"issue":"5","key":"4951_CR3","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.otsr.2009.03.018","volume":"95","author":"JF Cazeneuve","year":"2009","unstructured":"Cazeneuve JF, Cristofari DJ (2009) Delta III reverse shoulder arthroplasty: radiological outcome for acute complex fractures of the proximal humerus in elderly patients. Orthop Traumatol Surg Res 95(5):325\u2013329. https:\/\/doi.org\/10.1016\/j.otsr.2009.03.018","journal-title":"Orthop Traumatol Surg Res"},{"issue":"1","key":"4951_CR4","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.otsr.2008.09.002","volume":"95","author":"D Gallinet","year":"2009","unstructured":"Gallinet D, Clappaz P, Garbuio P, Tropet Y, Obert L (2009) Three or four parts complex proximal humerus fractures: hemiarthroplasty versus reverse prosthesis: a comparative study of 40 cases. Orthop Traumatol Surg Res 95(1):48\u201355. https:\/\/doi.org\/10.1016\/j.otsr.2008.09.002","journal-title":"Orthop Traumatol Surg Res"},{"issue":"10","key":"4951_CR5","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1097\/BOT.0b013e31818afe40","volume":"22","author":"M Klein","year":"2008","unstructured":"Klein M, Juschka M, Hinkenjann B, Scherger B, Ostermann PA (2008) Treatment of comminuted fractures of the proximal humerus in elderly patients with the Delta III reverse shoulder prosthesis. J Orthop Trauma 22(10):698\u2013704. https:\/\/doi.org\/10.1097\/BOT.0b013e31818afe40","journal-title":"J Orthop Trauma"},{"issue":"9","key":"4951_CR6","first-page":"458","volume":"40","author":"RD Reitman","year":"2011","unstructured":"Reitman RD, Kerzhner E (2011) Reverse shoulder arthoplasty as treatment for comminuted proximal humeral fractures in elderly patients. Am J Orthop 40(9):458\u2013461","journal-title":"Am J Orthop"},{"issue":"7","key":"4951_CR7","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1007\/s00264-020-04612-y","volume":"44","author":"P Valenti","year":"2020","unstructured":"Valenti P, Zampeli F, Ciais G, Kany J, Katz D (2020) The initial treatment of complex proximal humerus fracture affects the outcome of revision with reverse shoulder arthroplasty. Int Orthop 44(7):1331\u20131340. https:\/\/doi.org\/10.1007\/s00264-020-04612-y","journal-title":"Int Orthop"},{"issue":"4","key":"4951_CR8","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.hcl.2007.08.002","volume":"23","author":"B Wall","year":"2007","unstructured":"Wall B, Walch G (2007) Reverse shoulder arthroplasty for the treatment of proximal humeral fractures. Hand Clin 23(4):425\u2013430. https:\/\/doi.org\/10.1016\/j.hcl.2007.08.002. (v\u2013vi)","journal-title":"Hand Clin"},{"issue":"9","key":"4951_CR9","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1007\/s00264-016-3227-y","volume":"40","author":"DD Savin","year":"2016","unstructured":"Savin DD, Zamfirova I, Iannotti J, Goldberg BA, Youderian AR (2016) Survey study suggests that reverse total shoulder arthroplasty is becoming the treatment of choice for four-part fractures of the humeral head in the elderly. Int Orthop 40(9):1919\u20131925. https:\/\/doi.org\/10.1007\/s00264-016-3227-y","journal-title":"Int Orthop"},{"issue":"1 Suppl S","key":"4951_CR10","doi-asserted-by":"publisher","first-page":"147S","DOI":"10.1016\/j.jse.2004.10.006","volume":"14","author":"P Boileau","year":"2005","unstructured":"Boileau P, Watkinson DJ, Hatzidakis AM, Balg F (2005) Grammont reverse prosthesis: design, rationale, and biomechanics. J Shoulder Elbow Surg 14(1 Suppl S):147S-161S. https:\/\/doi.org\/10.1016\/j.jse.2004.10.006","journal-title":"J Shoulder Elbow Surg"},{"issue":"12","key":"4951_CR11","doi-asserted-by":"publisher","first-page":"3324","DOI":"10.1007\/s11999-011-2055-z","volume":"469","author":"C Lenarz","year":"2011","unstructured":"Lenarz C, Shishani Y, McCrum C, Nowinski RJ, Edwards TB, Gobezie R (2011) Is reverse shoulder arthroplasty appropriate for the treatment of fractures in the older patient? Early observations. Clin Orthop Relat Res 469(12):3324\u20133331. https:\/\/doi.org\/10.1007\/s11999-011-2055-z","journal-title":"Clin Orthop Relat Res"},{"issue":"5","key":"4951_CR12","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1097\/BOT.0b013e3181f22088","volume":"25","author":"JC Levy","year":"2011","unstructured":"Levy JC, Badman B (2011) Reverse shoulder prosthesis for acute four-part fracture: tuberosity fixation using a horseshoe graft. J Orthop Trauma 25(5):318\u2013324. https:\/\/doi.org\/10.1097\/BOT.0b013e3181f22088","journal-title":"J Orthop Trauma"},{"issue":"1","key":"4951_CR13","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jse.2010.08.001","volume":"20","author":"MA Zumstein","year":"2011","unstructured":"Zumstein MA, Pinedo M, Old J, Boileau P (2011) Problems, complications, reoperations, and revisions in reverse total shoulder arthroplasty: a systematic review. J Shoulder Elbow Surg 20(1):146\u2013157. https:\/\/doi.org\/10.1016\/j.jse.2010.08.001","journal-title":"J Shoulder Elbow Surg"},{"issue":"5","key":"4951_CR14","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1067\/mse.2002.124527","volume":"11","author":"P Boileau","year":"2002","unstructured":"Boileau P, Krishnan SG, Tinsi L, Walch G, Coste JS, Mole D (2002) Tuberosity malposition and migration: reasons for poor outcomes after hemiarthroplasty for displaced fractures of the proximal humerus. J Shoulder Elbow Surg 11(5):401\u2013412","journal-title":"J Shoulder Elbow Surg"},{"issue":"3","key":"4951_CR15","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.jse.2018.08.025","volume":"28","author":"P Boileau","year":"2019","unstructured":"Boileau P, Alta TD, Decroocq L, Sirveaux F, Clavert P, Favard L, Chelli M (2019) Reverse shoulder arthroplasty for acute fractures in the elderly: is it worth reattaching the tuberosities? J Shoulder Elbow Surg 28(3):437\u2013444. https:\/\/doi.org\/10.1016\/j.jse.2018.08.025","journal-title":"J Shoulder Elbow Surg"},{"issue":"7","key":"4951_CR16","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1016\/j.jse.2016.11.034","volume":"26","author":"YM Chun","year":"2017","unstructured":"Chun YM, Kim DS, Lee DH, Shin SJ (2017) Reverse shoulder arthroplasty for four-part proximal humerus fracture in elderly patients: can a healed tuberosity improve the functional outcomes? J Shoulder Elbow Surg 26(7):1216\u20131221. https:\/\/doi.org\/10.1016\/j.jse.2016.11.034","journal-title":"J Shoulder Elbow Surg"},{"key":"4951_CR17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s13018-015-0261-1","volume":"10","author":"R Garofalo","year":"2015","unstructured":"Garofalo R, Flanagin B, Castagna A, Lo EY, Krishnan SG (2015) Reverse shoulder arthroplasty for proximal humerus fracture using a dedicated stem: radiological outcomes at a minimum 2 years of follow-up-case series. J Orthop Surg Res 10:129. https:\/\/doi.org\/10.1186\/s13018-015-0261-1","journal-title":"J Orthop Surg Res"},{"issue":"10","key":"4951_CR18","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1016\/j.jse.2016.02.024","volume":"25","author":"F Grubhofer","year":"2016","unstructured":"Grubhofer F, Wieser K, Meyer DC, Catanzaro S, Beeler S, Riede U, Gerber C (2016) Reverse total shoulder arthroplasty for acute head-splitting, 3- and 4-part fractures of the proximal humerus in the elderly. J Shoulder Elbow Surg 25(10):1690\u20131698. https:\/\/doi.org\/10.1016\/j.jse.2016.02.024","journal-title":"J Shoulder Elbow Surg"},{"issue":"7","key":"4951_CR19","doi-asserted-by":"publisher","first-page":"e263","DOI":"10.1097\/BOT.0000000000001465","volume":"33","author":"JO Wright","year":"2019","unstructured":"Wright JO, Ho A, Kalma J, Koueiter D, Esterle J, Marcantonio D, Wiater JM, Wiater B (2019) Uncemented reverse total shoulder arthroplasty as initial treatment for comminuted proximal humerus fractures. J Orthop Trauma 33(7):e263\u2013e269. https:\/\/doi.org\/10.1097\/BOT.0000000000001465","journal-title":"J Orthop Trauma"},{"issue":"1","key":"4951_CR20","doi-asserted-by":"publisher","first-page":"230949901876013","DOI":"10.1177\/2309499018760132","volume":"26","author":"C Torrens","year":"2018","unstructured":"Torrens C, Alentorn-Geli E, Mingo F, Gamba C, Santana F (2018) Reverse shoulder arthroplasty for the treatment of acute complex proximal humeral fractures: influence of greater tuberosity healing on the functional outcomes. J Orthop Surg (Hong Kong) 26(1):2309499018760132. https:\/\/doi.org\/10.1177\/2309499018760132","journal-title":"J Orthop Surg (Hong Kong)"},{"issue":"6","key":"4951_CR21","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.2106\/00004623-197052060-00001","volume":"52","author":"CS Neer 2nd","year":"1970","unstructured":"Neer CS 2nd (1970) Displaced proximal humeral fractures. I. Classification and evaluation. J Bone Jt Surg [Am] 52(6):1077\u20131089","journal-title":"J Bone Jt Surg [Am]"},{"issue":"6","key":"4951_CR22","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.jse.2019.02.015","volume":"28","author":"C Spross","year":"2019","unstructured":"Spross C, Meester J, Mazzucchelli RA, Puskas GJ, Zdravkovic V, Jost B (2019) Evidence-based algorithm to treat patients with proximal humerus fractures\u2014a prospective study with early clinical and overall performance results. J Shoulder Elbow Surg 28(6):1022\u20131032. https:\/\/doi.org\/10.1016\/j.jse.2019.02.015","journal-title":"J Shoulder Elbow Surg"},{"key":"4951_CR23","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1097\/00003086-198701000-00023","volume":"214","author":"CR Constant","year":"1987","unstructured":"Constant CR, Murley AH (1987) A clinical method of functional assessment of the shoulder. Clin Orthop Relat Res 214:160\u2013164","journal-title":"Clin Orthop Relat Res"},{"issue":"1","key":"4951_CR24","doi-asserted-by":"publisher","first-page":"16","DOI":"10.2106\/00004623-200001000-00003","volume":"82","author":"B Fuchs","year":"2000","unstructured":"Fuchs B, Jost B, Gerber C (2000) Posterior-inferior capsular shift for the treatment of recurrent, voluntary posterior subluxation of the shoulder. J Bone Jt Surg [Am] 82(1):16\u201325. https:\/\/doi.org\/10.2106\/00004623-200001000-00003","journal-title":"J Bone Jt Surg [Am]"},{"issue":"6","key":"4951_CR25","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.jse.2007.02.123","volume":"16","author":"MK Gilbart","year":"2007","unstructured":"Gilbart MK, Gerber C (2007) Comparison of the subjective shoulder value and the Constant score. J Shoulder Elbow Surg 16(6):717\u2013721. https:\/\/doi.org\/10.1016\/j.jse.2007.02.123","journal-title":"J Shoulder Elbow Surg"},{"issue":"6","key":"4951_CR26","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.jse.2008.02.010","volume":"17","author":"C Levigne","year":"2008","unstructured":"Levigne C, Boileau P, Favard L, Garaud P, Mole D, Sirveaux F, Walch G (2008) Scapular notching in reverse shoulder arthroplasty. J Shoulder Elbow Surg 17(6):925\u2013935. https:\/\/doi.org\/10.1016\/j.jse.2008.02.010","journal-title":"J Shoulder Elbow Surg"},{"issue":"3","key":"4951_CR27","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1302\/0301-620x.86b3.14024","volume":"86","author":"F Sirveaux","year":"2004","unstructured":"Sirveaux F, Favard L, Oudet D, Huquet D, Walch G, Mole D (2004) Grammont inverted total shoulder arthroplasty in the treatment of glenohumeral osteoarthritis with massive rupture of the cuff. Results of a multicentre study of 80 shoulders. J Bone Jt Surg [Br] 86(3):388\u2013395. https:\/\/doi.org\/10.1302\/0301-620x.86b3.14024","journal-title":"J Bone Jt Surg [Br]"},{"issue":"6","key":"4951_CR28","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1067\/mse.2000.109384","volume":"9","author":"JW Sperling","year":"2000","unstructured":"Sperling JW, Cofield RH, O\u2019Driscoll SW, Torchia ME, Rowland CM (2000) Radiographic assessment of ingrowth total shoulder arthroplasty. J Shoulder Elbow Surg 9(6):507\u2013513. https:\/\/doi.org\/10.1067\/mse.2000.109384","journal-title":"J Shoulder Elbow Surg"},{"issue":"3","key":"4951_CR29","doi-asserted-by":"publisher","first-page":"e78","DOI":"10.1016\/j.jse.2018.09.006","volume":"28","author":"NP Jain","year":"2019","unstructured":"Jain NP, Mannan SS, Dharmarajan R, Rangan A (2019) Tuberosity healing after reverse shoulder arthroplasty for complex proximal humeral fractures in elderly patients-does it improve outcomes? A systematic review and meta-analysis. J Shoulder Elbow Surg 28(3):e78\u2013e91. https:\/\/doi.org\/10.1016\/j.jse.2018.09.006","journal-title":"J Shoulder Elbow Surg"},{"issue":"22","key":"4951_CR30","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.2106\/JBJS.L.01637","volume":"95","author":"DJ Cuff","year":"2013","unstructured":"Cuff DJ, Pupello DR (2013) Comparison of hemiarthroplasty and reverse shoulder arthroplasty for the treatment of proximal humeral fractures in elderly patients. J Bone Jt Surg [Am] 95(22):2050\u20132055. https:\/\/doi.org\/10.2106\/JBJS.L.01637","journal-title":"J Bone Jt Surg [Am]"},{"issue":"1","key":"4951_CR31","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jse.2012.03.011","volume":"22","author":"D Gallinet","year":"2013","unstructured":"Gallinet D, Adam A, Gasse N, Rochet S, Obert L (2013) Improvement in shoulder rotation in complex shoulder fractures treated by reverse shoulder arthroplasty. J Shoulder Elbow Surg 22(1):38\u201344. https:\/\/doi.org\/10.1016\/j.jse.2012.03.011","journal-title":"J Shoulder Elbow Surg"},{"issue":"10","key":"4951_CR32","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1016\/j.jse.2014.06.035","volume":"23","author":"E Sebastia-Forcada","year":"2014","unstructured":"Sebastia-Forcada E, Cebrian-Gomez R, Lizaur-Utrilla A, Gil-Guillen V (2014) Reverse shoulder arthroplasty versus hemiarthroplasty for acute proximal humeral fractures. A blinded, randomized, controlled, prospective study. J Shoulder Elbow Surg 23(10):1419\u20131426. https:\/\/doi.org\/10.1016\/j.jse.2014.06.035","journal-title":"J Shoulder Elbow Surg"},{"issue":"12","key":"4951_CR33","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1007\/s00264-020-04831-3","volume":"44","author":"F Hess","year":"2020","unstructured":"Hess F, Bohnert L, Jaberg L, Welter J, Pape HC, Sireus A (2020) Tuberosity union in patients with proximal humerus fractures treated with reverse shoulder arthroplasty: a technical note and exploratory analysis. Int Orthop 44(12):2711\u20132717. https:\/\/doi.org\/10.1007\/s00264-020-04831-3","journal-title":"Int Orthop"},{"issue":"4","key":"4951_CR34","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1302\/0301-620X.92B4.22450","volume":"92","author":"JF Cazeneuve","year":"2010","unstructured":"Cazeneuve JF, Cristofari DJ (2010) The reverse shoulder prosthesis in the treatment of fractures of the proximal humerus in the elderly. J Bone Jt Surg [Br] 92(4):535\u2013539. https:\/\/doi.org\/10.1302\/0301-620X.92B4.22450","journal-title":"J Bone Jt Surg [Br]"},{"issue":"5","key":"4951_CR35","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1067\/mse.2002.126098","volume":"11","author":"MA Frankle","year":"2002","unstructured":"Frankle MA, Ondrovic LE, Markee BA, Harris ML, Lee WE 3rd (2002) Stability of tuberosity reattachment in proximal humeral hemiarthroplasty. J Shoulder Elbow Surg 11(5):413\u2013420. https:\/\/doi.org\/10.1067\/mse.2002.126098","journal-title":"J Shoulder Elbow Surg"},{"issue":"12","key":"4951_CR36","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.1007\/s11999-011-1919-6","volume":"469","author":"SG Krishnan","year":"2011","unstructured":"Krishnan SG, Reineck JR, Bennion PD, Feher L, Burkhead WZ Jr (2011) Shoulder arthroplasty for fracture: does a fracture-specific stem make a difference? Clin Orthop Relat Res 469(12):3317\u20133323. https:\/\/doi.org\/10.1007\/s11999-011-1919-6","journal-title":"Clin Orthop Relat Res"},{"issue":"10","key":"4951_CR37","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.jse.2014.04.017","volume":"23","author":"F Li","year":"2014","unstructured":"Li F, Zhu Y, Lu Y, Liu X, Wu G, Jiang C (2014) Hemiarthroplasty for the treatment of complex proximal humeral fractures: does a trabecular metal prosthesis make a difference? A prospective, comparative study with a minimum 3-year follow-up. J Shoulder Elbow Surg 23(10):1437\u20131443. https:\/\/doi.org\/10.1016\/j.jse.2014.04.017","journal-title":"J Shoulder Elbow Surg"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-023-04951-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00402-023-04951-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-023-04951-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T14:31:21Z","timestamp":1695997881000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00402-023-04951-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,30]]},"references-count":37,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["4951"],"URL":"https:\/\/doi.org\/10.1007\/s00402-023-04951-6","relation":{},"ISSN":["1434-3916"],"issn-type":[{"value":"1434-3916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,30]]},"assertion":[{"value":"21 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Eastern Switzerland (EKOS 2019-00414).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}