{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T19:09:30Z","timestamp":1776452970913,"version":"3.51.2"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsmedizin Rostock"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Given the significant therapeutic gap for osteoporosis, this study aims to investigate the most common osteoporosis-related fracture. The analysis will also consider patients\u2019 serum vitamin D levels and the indications for basic osteoporosis diagnostic tests and osteoporosis therapy prior to fracture.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>This prospective clinical trial included patients with distal radius fractures who underwent surgery at our hospital between 1 April 2021 and 7 April 2022. Blood samples were taken from all participants and existing risk factors for osteoporosis were recorded. In addition, the indication for a guideline-based osteoporosis diagnosis was assessed and the risk of another future fracture with FRAX<jats:sup>\u00ae<\/jats:sup> was calculated. This information was used to decide whether there was an indication for specific osteoporosis therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A diagnosis gap of 53% and a treatment gap of 84% were identified among the 102 patients investigated. The patients\u2019 ages ranged from 46 to 91\u00a0years, with an average vitamin D level of 57\u00a0nmol\/l, which was below the recommended level of 75\u00a0nmol\/l. It was noted on a monthly basis that the vitamin D level (without substitution) never exceeded the recommended value of 75\u00a0nmol\/l in any month. Three-quarters of patients had indications for a baseline osteoporosis diagnosis, yet less than 50% received one. According to FRAX<jats:sup>\u00ae<\/jats:sup> data, 57% of patients had indications for specific osteoporosis treatment before experiencing the fracture.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Even without a previous distal radius fracture, many patients are in need of osteoporosis diagnosis or treatment. Our research suggests that patients with distal radius fractures should have their vitamin D levels checked via a blood test and be evaluated for osteoporosis. As endogenous vitamin D levels are often inadequate, year-round vitamin D supplementation should be considered for the prevention of osteomalacia and as a basis for the treatment of osteoporosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>German clinical trial register ID<\/jats:title>\n                <jats:p>DRKS00028085.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00402-024-05199-4","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T13:02:48Z","timestamp":1706878968000},"page":"1281-1287","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pre-existing osteoporosis and serum vitamin D levels in patients with distal radius fractures: are we missing something?"],"prefix":"10.1007","volume":"144","clinical-trial-number":[{"clinical-trial-number":"drks00028085","registry":"10.18810\/drks"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0584-343X","authenticated-orcid":false,"given":"Steffi S. I.","family":"Falk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meike","family":"Richter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"B\u00f6hme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Mittlmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"5199_CR1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.15.00793","author":"CM Court-Brown","year":"2016","unstructured":"Court-Brown CM, McQueen MM (2016) Global forum: fractures in the elderly. J Bone Jt Surg Am. https:\/\/doi.org\/10.2106\/JBJS.15.00793","journal-title":"J Bone Jt Surg Am"},{"key":"5199_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-017-1596-z","author":"D Jerrhag","year":"2017","unstructured":"Jerrhag D, Englund M, Karlsson MK, Rosengren BE (2017) Epidemiology and time trends of distal forearm fractures in adults\u2014a study of 11.2 million person-years in Sweden. BMC Musculoskelet Disord. https:\/\/doi.org\/10.1186\/s12891-017-1596-z","journal-title":"BMC Musculoskelet Disord"},{"key":"5199_CR3","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040917","author":"P Haentjens","year":"2004","unstructured":"Haentjens P, Johnell O, Kanis JA, Bouillon R, Cooper C, Lamraski G, Vanderschueren D, Kaufman JM, Boonen S, Network on Male Osteoporosis in Europe NEMO (2004) Evidence from data searches and life-table analyses for gender-related differences in absolute risk of hip fracture after Colles\u2019 or spine fracture: Colles\u2019 fracture as an early and sensitive marker of skeletal fragility in white men. J Bone Miner Res. https:\/\/doi.org\/10.1359\/JBMR.040917","journal-title":"J Bone Miner Res"},{"key":"5199_CR4","doi-asserted-by":"publisher","DOI":"10.1097\/ta.0b013e31824bb325","author":"CW Chen","year":"2013","unstructured":"Chen CW, Huang TL, Su LT, Kuo YC, Wu SC, Li CY, Chen KB, Sung FC (2013) Incidence of subsequent hip fractures is significantly increased within the first month after distal radius fracture in patients older than 60 years. J Trauma Acute Care Surg. https:\/\/doi.org\/10.1097\/ta.0b013e31824bb325","journal-title":"J Trauma Acute Care Surg"},{"key":"5199_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-020-00871-9","author":"JA Kanis","year":"2021","unstructured":"Kanis JA, Norton N, Harvey NC, Jacobson T, Johansson H, Lorentzon M, McCloskey EV, Willers C, Borgstr\u00f6m F (2021) SCOPE 2021: a new scorecard for osteoporosis in Europe. Arch Osteoporos. https:\/\/doi.org\/10.1007\/s11657-020-00871-9","journal-title":"Arch Osteoporos"},{"key":"5199_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s00112-018-0502-6","author":"T Reinehr","year":"2018","unstructured":"Reinehr T, Schnabel D, Wabitsch M, Pozzalla B-D, B\u00fchrer C, Heidtmann B, Jochum F, Kauth T, K\u00f6rner A, Mihatsch W (2018) Vitamin-D-Supplementierung jenseits des zweiten Lebensjahres. Monatsschrift Kinderheilkunde. https:\/\/doi.org\/10.1007\/s00112-018-0502-6","journal-title":"Monatsschrift Kinderheilkunde"},{"key":"5199_CR7","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1673537","author":"F Thomasius","year":"2018","unstructured":"Thomasius F, Baum E, Bernecker P, B\u00f6cker W, Brabant T, Clarenz P, Demary W, Dimai HP, Engelbrecht M, Engelke K (2018) DVO Leitlinie 2017 zur Prophylaxe, Diagnostik und Therapie der Osteoporose bei postmenopausalen Frauen und M\u00e4nnern. Osteologie. https:\/\/doi.org\/10.1055\/s-0038-1673537","journal-title":"Osteologie"},{"key":"5199_CR8","unstructured":"UV-Expositionsrechner f\u00fcr den Vitamin D Status. https:\/\/fastrt.nilu.no\/VitD_quartMEDandMED_v2.html. Accessed 16 Nov 2023"},{"key":"5199_CR9","unstructured":"Faktenblatt Vitamin D und Sonnenstrahlung. https:\/\/www.bag.admin.ch\/dam\/bag\/de\/dokumente\/str\/nis\/uv\/faktenblatt_vitaminD.pdf.download.pdf\/Faktenblatt. Vitamin D D.pdf. accessed 21 Nov 2023"},{"key":"5199_CR10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5893.643","author":"RB Payne","year":"1973","unstructured":"Payne RB, Little AJ, Williams RB, Milner JR (1973) Interpretation of serum calcium in patients with abnormal serum proteins. Br Med J. https:\/\/doi.org\/10.1136\/bmj.4.5893.643","journal-title":"Br Med J"},{"key":"5199_CR11","unstructured":"FRAX. https:\/\/www.sheffield.ac.uk\/FRAX\/tool.aspx?lang=de. Accessed 07 Jan 2023"},{"key":"5199_CR12","doi-asserted-by":"publisher","DOI":"10.4158\/GL-2020-0524","author":"PM Camacho","year":"2020","unstructured":"Camacho PM, Petak SM, Binkley N, Diab DL, Eldeiry LS, Farooki A, Harris ST, Hurley DL, Kelly J, Lewiecki EM, Pessah-Pollack R, McClung M, Wimalawansa SJ, Watts NB (2020) American Association Of Clinical Endocrinologists\/American College of endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis\u20142020 update executive summary. Endocr Pract. https:\/\/doi.org\/10.4158\/GL-2020-0524","journal-title":"Endocr Pract"},{"key":"5199_CR13","first-page":"164","volume-title":"Ern\u00e4hrungsmedizin: Nach dem Curriculum Ern\u00e4hrungsmedizin der Bundes\u00e4rztekammer","author":"HK Biesalski","year":"2017","unstructured":"Biesalski HK (2017) Vitamine. In: Biesalski HK, Bischoff SC, Pirlich M, Weimann A (eds) Ern\u00e4hrungsmedizin: Nach dem Curriculum Ern\u00e4hrungsmedizin der Bundes\u00e4rztekammer, 5th edn. Georg Thieme Verlag, Stuttgart, pp 164\u2013205","edition":"5"},{"key":"5199_CR14","unstructured":"Stellungnahme der Gemeinsamen Expertenkommission BVL \/BfArM zur Bewertung von Vitamin-D-haltigen Produkten (Revision 1.1). https:\/\/www.bvl.bund.de\/SharedDocs\/Downloads\/01_Lebensmittel\/expertenkommission\/Zweite_Stellungnahme_VitaminD_Revision1.1.html. Accessed 30 Mar 2023"},{"key":"5199_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042105","author":"G Rinonapoli","year":"2021","unstructured":"Rinonapoli G, Ruggiero C, Meccariello L, Bisaccia M, Ceccarini P, Caraffa A (2021) Osteoporosis in men: a review of an underestimated bone condition. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22042105","journal-title":"Int J Mol Sci"},{"key":"5199_CR16","doi-asserted-by":"publisher","DOI":"10.1177\/1557988313478826","author":"SY Lim","year":"2013","unstructured":"Lim SY, Lim JH, Nguyen D, Okamura R, Amiri HM, Calmes M, Nugent K (2013) Screening for osteoporosis in men aged 70 years and older in a primary care setting in the United States. Am J Mens Health. https:\/\/doi.org\/10.1177\/1557988313478826","journal-title":"Am J Mens Health"},{"key":"5199_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/medicina54020025","author":"A Bleizgys","year":"2018","unstructured":"Bleizgys A, Kurovskij J (2018) Vitamin D levels of out-patients in Lithuania: deficiency and hypervitaminosis. Medicina (Kaunas). https:\/\/doi.org\/10.3390\/medicina54020025","journal-title":"Medicina (Kaunas)"},{"key":"5199_CR18","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.21749","author":"MA Chinoy","year":"2022","unstructured":"Chinoy MA, Hussain K, Javed S (2022) Serum vitamin D levels in patients with distal radius fractures presenting to a tertiary care hospital. Cureus. https:\/\/doi.org\/10.7759\/cureus.21749","journal-title":"Cureus"},{"key":"5199_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2011.10.020","author":"WY Jang","year":"2012","unstructured":"Jang WY, Chung MS, Baek GH, Song CH, Cho HE, Gong HS (2012) Vitamin D levels in post-menopausal Korean women with a distal radius fracture. Injury. https:\/\/doi.org\/10.1016\/j.injury.2011.10.020","journal-title":"Injury"},{"key":"5199_CR20","doi-asserted-by":"publisher","DOI":"10.5114\/pm.2014.46471","author":"A Stolarczyk","year":"2014","unstructured":"Stolarczyk A, Horvath A, Szczechura M, Kami\u0144ska M, Dziechciarz P (2014) High prevalence of vitamin D insufficiency in community-dwelling postmenopausal Polish women. Prz Menopauzalny. https:\/\/doi.org\/10.5114\/pm.2014.46471","journal-title":"Prz Menopauzalny"},{"key":"5199_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-014-0061-1","author":"MH Gannag\u00e9-Yared","year":"2014","unstructured":"Gannag\u00e9-Yared MH, Helou E, Zaraket V, Abi Akl S, Antonios L, Moussalli ML, Wakim S (2014) Serum 25 hydroxyvitamin D in employees of a Middle Eastern University Hospital. J Endocrinol Invest. https:\/\/doi.org\/10.1007\/s40618-014-0061-1","journal-title":"J Endocrinol Invest"},{"key":"5199_CR22","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980017002804","author":"M Cabral","year":"2018","unstructured":"Cabral M, Ara\u00fajo J, Lopes C, Barros H, Guimar\u00e3es JT, Severo M, Ramos E (2018) Relationship between dietary vitamin D and serum 25-hydroxyvitamin D levels in Portuguese adolescents. Public Health Nutr. https:\/\/doi.org\/10.1017\/S1368980017002804","journal-title":"Public Health Nutr"},{"key":"5199_CR23","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.916326","author":"X Yan","year":"2019","unstructured":"Yan X, Zhang N, Cheng S, Wang Z, Qin Y (2019) Gender differences in vitamin D status in China. Med Sci Monit. https:\/\/doi.org\/10.12659\/MSM.916326","journal-title":"Med Sci Monit"},{"key":"5199_CR24","doi-asserted-by":"publisher","DOI":"10.1024\/1661-8157\/a003007","author":"I H\u00e4rdi","year":"2018","unstructured":"H\u00e4rdi I, Reinhard S, Conzelmann M, Kressig RW, Bridenbaugh SA (2018) Vitamin D level in employees of a Swiss University Geriatric Hospital. Praxis (Bern 1994). https:\/\/doi.org\/10.1024\/1661-8157\/a003007","journal-title":"Praxis (Bern 1994)"},{"key":"5199_CR25","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.O.00313","author":"TD Rozental","year":"2015","unstructured":"Rozental TD, Herder LM, Walley KC, Zurakowski D, Coyle K, Bouxsein ML, Wolf JM (2015) 25-hydroxyvitamin-D and bone turnover marker levels in patients with distal radial fracture. J Bone Jt Surg Am. https:\/\/doi.org\/10.2106\/JBJS.O.00313","journal-title":"J Bone Jt Surg Am"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-024-05199-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00402-024-05199-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-024-05199-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T02:13:12Z","timestamp":1708999992000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00402-024-05199-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,2]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["5199"],"URL":"https:\/\/doi.org\/10.1007\/s00402-024-05199-4","relation":{},"ISSN":["1434-3916"],"issn-type":[{"value":"1434-3916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,2]]},"assertion":[{"value":"25 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Steffi S. I. Falk, Sina B\u00f6hme, Meike Richter, Josephine Schr\u00f6der declare that they have no relevant financial or non-financial interests to disclose. Thomas Mittlmeier Funding: BMBF, 2017\u20132020. Travel expenses, speaker fees: Johnson & Johnson DePuy Synthes (surgical technique courses), AO Germany seminars (surgical courses), BDC courses fracture care, Aesculap Academy. Co-owner patent: FH Orthopedics, Mulhouse.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This research was conducted in accordance with the principles of the Helsinki Declaration and its subsequent amendments or comparable ethical standards. Our study protocol has been approved by the local ethics committee (A2021-0043).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients signed an informed consent before inclusion.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"This study is a prospective study.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}