{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:49:30Z","timestamp":1781279370299,"version":"3.54.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"DOI":"10.1007\/s00402-024-05363-w","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T12:01:41Z","timestamp":1716465701000},"page":"3969-3976","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Treatment of anterior knee pain due to chondromalacia patellae with platelet-rich plasma and hyaluronic acid in young and middle-aged adults, a cohort study"],"prefix":"10.1007","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0108-5750","authenticated-orcid":false,"given":"Marko","family":"Ostojic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan Tarek","family":"Hakam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Lovrekovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai","family":"Ramadanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Prill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"issue":"4","key":"5363_CR1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0749-8063(88)80037-9","volume":"4","author":"AC Merchant","year":"1988","unstructured":"Merchant AC (1988) Classification of patellofemoral disorders. Arthroscopy 4(4):235\u2013240","journal-title":"Arthroscopy"},{"issue":"7","key":"5363_CR2","doi-asserted-by":"publisher","first-page":"3919","DOI":"10.1007\/s00402-022-04663-3","volume":"143","author":"S Barroso Rosa","year":"2023","unstructured":"Barroso Rosa S, Grant A, McEwen P (2023) Patient-reported outcome measures for patellofemoral disorders: a systematic review. Arch Orthop Trauma Surg 143(7):3919\u20133927","journal-title":"Arch Orthop Trauma Surg"},{"issue":"2","key":"5363_CR3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/00042752-200104000-00007","volume":"11","author":"K Crossley","year":"2001","unstructured":"Crossley K, Bennell K, Green S, McConnell J (2001) A systematic review of physical interventions for patellofemoral pain syndrome. Clin J Sport Med 11(2):103\u2013110","journal-title":"Clin J Sport Med"},{"issue":"3","key":"5363_CR4","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1177\/1941738112441915","volume":"4","author":"JL Frye","year":"2012","unstructured":"Frye JL, Ramey LN, Hart JM (2012) The effects of exercise on decreasing pain and increasing function in patients with patellofemoral pain syndrome: a systematic review. Sports Health 4(3):205\u2013210","journal-title":"Sports Health"},{"issue":"12","key":"5363_CR5","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1007\/s00402-020-03543-y","volume":"140","author":"T K\u00f6lle","year":"2020","unstructured":"K\u00f6lle T, Alt W, Wagner D (2020) Effects of a 12-week home exercise therapy program on pain and neuromuscular activity in patients with patellofemoral pain syndrome. Arch Orthop Trauma Surg 140(12):1985\u20131992","journal-title":"Arch Orthop Trauma Surg"},{"issue":"23","key":"5363_CR6","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1136\/bjsports-2016-096329","volume":"51","author":"L Giles","year":"2017","unstructured":"Giles L, Webster KE, McClelland J, Cook JL (2017) Quadriceps strengthening with and without blood flow restriction in the treatment of patellofemoral pain: a double-blind randomised trial. Br J Sports Med 51(23):1688\u20131694","journal-title":"Br J Sports Med"},{"issue":"7","key":"5363_CR7","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1007\/s00402-016-2464-2","volume":"136","author":"W Petersen","year":"2016","unstructured":"Petersen W, Ellermann A, Rembitzki IV, Scheffler S, Herbort M, Br\u00fcggemann GP et al (2016) Evaluating the potential synergistic benefit of a realignment brace on patients receiving exercise therapy for patellofemoral pain syndrome: a randomized clinical trial. Arch Orthop Trauma Surg 136(7):975\u2013982","journal-title":"Arch Orthop Trauma Surg"},{"issue":"4","key":"5363_CR8","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s12178-020-09646-8","volume":"13","author":"D Sisk","year":"2020","unstructured":"Sisk D, Fredericson M (2020) Taping, Bracing, and Injection Treatment for Patellofemoral Pain and Patellar Tendinopathy. Curr Rev Musculoskelet Med 13(4):537\u2013544","journal-title":"Curr Rev Musculoskelet Med"},{"issue":"1","key":"5363_CR9","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1186\/s13287-021-02478-4","volume":"12","author":"W Zheng","year":"2021","unstructured":"Zheng W, Li H, Hu K, Li L, Bei M (2021) Chondromalacia patellae: current options and emerging cell therapies. Stem Cell Res Ther 12(1):412","journal-title":"Stem Cell Res Ther"},{"issue":"7","key":"5363_CR10","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1016\/j.arthro.2021.02.045","volume":"37","author":"D Zhao","year":"2021","unstructured":"Zhao D, Pan JK, Yang WY, Han YH, Zeng LF, Liang GH et al (2021) Intra-articular injections of Platelet-Rich Plasma, adipose mesenchymal stem cells, and bone marrow mesenchymal stem cells Associated with Better outcomes Than Hyaluronic acid and saline in knee osteoarthritis: a systematic review and network Meta-analysis. Arthroscopy 37(7):2298\u2013314e10","journal-title":"Arthroscopy"},{"key":"5363_CR11","unstructured":"De Girolamo L, Laver L, ESSKA Orthobiologic Initiative (ORBIT) (2022) : Consensus Process on Blood Derived Products. https:\/\/wwwesskaorg\/news\/593282\/ESSKA-Orthobiologic-Initiative-ORBIT-Consensus-Process-on-Blood-Derived-Products-htm2022"},{"key":"5363_CR12","doi-asserted-by":"crossref","unstructured":"Laver L, Filardo G, Sanchez M, Magalon J, Tischer T, Abat F et al (2024) The use of injectable orthobiologics for knee osteoarthritis: a European ESSKA-ORBIT consensus. Part 1-Blood-derived products (platelet-rich plasma). Knee Surg Sports Traumatol Arthrosc","DOI":"10.1002\/ksa.12077"},{"key":"5363_CR13","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1186\/s12891-015-0775-z","volume":"16","author":"RD Altman","year":"2015","unstructured":"Altman RD, Manjoo A, Fierlinger A, Niazi F, Nicholls M (2015) The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review. BMC Musculoskelet Disord 16:321","journal-title":"BMC Musculoskelet Disord"},{"issue":"3","key":"5363_CR14","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00167-017-4464-3","volume":"26","author":"MA Tompkins","year":"2018","unstructured":"Tompkins MA, Rohr SR, Agel J, Arendt EA (2018) Anatomic patellar instability risk factors in primary lateral patellar dislocations do not predict injury patterns: an MRI-based study. Knee Surg Sports Traumatol Arthrosc 26(3):677\u2013684","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"5","key":"5363_CR15","doi-asserted-by":"publisher","first-page":"100658","DOI":"10.1016\/j.bj.2023.100658","volume":"46","author":"CC Wu","year":"2023","unstructured":"Wu CC (2023) Patellar malalignment: a common disorder associated with knee pain. Biomedical J 46(5):100658","journal-title":"Biomedical J"},{"issue":"8","key":"5363_CR16","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1007\/s11547-021-01372-6","volume":"126","author":"F Cobianchi Bellisari","year":"2021","unstructured":"Cobianchi Bellisari F, De Marino L, Arrigoni F, Mariani S, Bruno F, Palumbo P et al (2021) T2-mapping MRI evaluation of patellofemoral cartilage in patients submitted to intra-articular platelet-rich plasma (PRP) injections. Radiol Med 126(8):1085\u20131094","journal-title":"Radiol Med"},{"issue":"8","key":"5363_CR17","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1007\/s00167-023-07442-8","volume":"31","author":"R Prill","year":"2023","unstructured":"Prill R, Kr\u00f3likowska A, de Girolamo L, Becker R, Karlsson J (2023) Checklists, risk of bias tools, and reporting guidelines for research in orthopedics, sports medicine, and rehabilitation. Knee Surg Sports Traumatol Arthrosc 31(8):3029\u20133033","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"1086","key":"5363_CR18","doi-asserted-by":"publisher","first-page":"20170456","DOI":"10.1259\/bjr.20170456","volume":"91","author":"A Gulati","year":"2018","unstructured":"Gulati A, McElrath C, Wadhwa V, Shah JP, Chhabra A (2018) Current clinical, radiological and treatment perspectives of patellofemoral pain syndrome. Br J Radiol 91(1086):20170456","journal-title":"Br J Radiol"},{"issue":"10","key":"5363_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00402-021-03878-0","volume":"142","author":"SA Hamawandi","year":"2022","unstructured":"Hamawandi SA, Amin HI, Al-Humairi AK (2022) Open versus arthroscopic release for lateral patellar compression syndrome: a randomized-controlled trial. Arch Orthop Trauma Surg 142(10):1\u20137","journal-title":"Arch Orthop Trauma Surg"},{"issue":"2","key":"5363_CR20","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0749-8063(05)80366-4","volume":"9","author":"UM Kujala","year":"1993","unstructured":"Kujala UM, Jaakkola LH, Koskinen SK, Taimela S, Hurme M, Nelimarkka O (1993) Scoring of patellofemoral disorders. Arthroscopy 9(2):159\u2013163","journal-title":"Arthroscopy"},{"issue":"1suppl","key":"5363_CR21","doi-asserted-by":"publisher","first-page":"364s","DOI":"10.1177\/1947603520931170","volume":"13","author":"G Filardo","year":"2021","unstructured":"Filardo G, Previtali D, Napoli F, Candrian C, Zaffagnini S, Grassi A (2021) PRP injections for the treatment of knee osteoarthritis: a Meta-analysis of Randomized controlled trials. Cartilage 13(1suppl):364s\u201375s","journal-title":"Cartilage"},{"issue":"6","key":"5363_CR22","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1002\/art.34453","volume":"64","author":"RF Loeser","year":"2012","unstructured":"Loeser RF, Goldring SR, Scanzello CR, Goldring MB (2012) Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum 64(6):1697\u20131707","journal-title":"Arthritis Rheum"},{"issue":"6","key":"5363_CR23","doi-asserted-by":"publisher","first-page":"232596711985419","DOI":"10.1177\/2325967119854192","volume":"7","author":"JM Hart","year":"2019","unstructured":"Hart JM, Kuenze C, Norte G, Bodkin S, Patrie J, Denny C et al (2019) Prospective, randomized, double-blind evaluation of the efficacy of a single-dose Hyaluronic Acid for the treatment of Patellofemoral Chondromalacia. Orthop J Sports Med 7(6):2325967119854192","journal-title":"Orthop J Sports Med"},{"issue":"5","key":"5363_CR24","doi-asserted-by":"publisher","first-page":"e64569","DOI":"10.1371\/journal.pone.0064569","volume":"8","author":"J Pak","year":"2013","unstructured":"Pak J, Lee JH, Lee SH (2013) A novel biological approach to treat chondromalacia patellae. PLoS ONE 8(5):e64569","journal-title":"PLoS ONE"},{"issue":"11","key":"5363_CR25","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1016\/j.arthro.2015.03.041","volume":"31","author":"KA Campbell","year":"2015","unstructured":"Campbell KA, Saltzman BM, Mascarenhas R, Khair MM, Verma NN, Bach BR Jr. et al (2015) Does intra-articular platelet-rich plasma injection provide clinically Superior outcomes compared with other therapies in the treatment of knee osteoarthritis? A systematic review of overlapping Meta-analyses. Arthroscopy 31(11):2213\u20132221","journal-title":"Arthroscopy"},{"issue":"9","key":"5363_CR26","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1007\/s00167-013-2743-1","volume":"23","author":"G Filardo","year":"2015","unstructured":"Filardo G, Kon E, Roffi A, Di Matteo B, Merli ML, Marcacci M (2015) Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration. Knee Surg Sports Traumatol Arthrosc 23(9):2459\u20132474","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"2","key":"5363_CR27","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00264-020-04801-9","volume":"45","author":"R Gilat","year":"2021","unstructured":"Gilat R, Haunschild ED, Knapik DM, Evuarherhe A Jr., Parvaresh KC, Cole BJ (2021) Hyaluronic acid and platelet-rich plasma for the management of knee osteoarthritis. Int Orthop 45(2):345\u2013354","journal-title":"Int Orthop"},{"issue":"5","key":"5363_CR28","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1517\/14712598.2014.889677","volume":"14","author":"I Andia","year":"2014","unstructured":"Andia I, Abate M (2014) Knee osteoarthritis: hyaluronic acid, platelet-rich plasma or both in association? Expert Opin Biol Ther 14(5):635\u2013649","journal-title":"Expert Opin Biol Ther"},{"issue":"1","key":"5363_CR29","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1186\/s13018-019-1352-1","volume":"14","author":"M-I Lee","year":"2019","unstructured":"Lee M-I, Kim J-H, Kwak H-H, Woo H-M, Han J-H, Yayon A et al (2019) A placebo-controlled study comparing the efficacy of intra-articular injections of hyaluronic acid and a novel hyaluronic acid-platelet-rich plasma conjugate in a canine model of osteoarthritis. J Orthop Surg Res 14(1):314","journal-title":"J Orthop Surg Res"},{"issue":"2","key":"5363_CR30","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/ar623","volume":"5","author":"LW Moreland","year":"2003","unstructured":"Moreland LW (2003) Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action. Arthritis Res Ther 5(2):54","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"5363_CR31","doi-asserted-by":"publisher","first-page":"226","DOI":"10.2174\/1573397113666170710115558","volume":"14","author":"T Conrozier","year":"2018","unstructured":"Conrozier T (2018) Is the addition of a polyol to Hyaluronic Acid a significant advance in the treatment of Osteoarthritis? Curr Rheumatol Reviews 14(3):226\u2013230","journal-title":"Curr Rheumatol Reviews"},{"issue":"3","key":"5363_CR32","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.arthro.2015.08.005","volume":"32","author":"CJ Meheux","year":"2016","unstructured":"Meheux CJ, McCulloch PC, Lintner DM, Varner KE, Harris JD (2016) Efficacy of intra-articular platelet-rich plasma injections in knee osteoarthritis: a systematic review. Arthroscopy 32(3):495\u2013505","journal-title":"Arthroscopy"},{"issue":"8","key":"5363_CR33","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1002\/jor.24322","volume":"37","author":"C O\u2019Donnell","year":"2019","unstructured":"O\u2019Donnell C, Migliore E, Grandi FC, Koltsov J, Lingampalli N, Cisar C et al (2019) Platelet-Rich plasma (PRP) from older males with knee osteoarthritis depresses chondrocyte metabolism and upregulates inflammation. J Orthop Res 37(8):1760\u20131770","journal-title":"J Orthop Res"},{"issue":"1","key":"5363_CR34","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/1529-0131(200201)46:1<100::AID-ART10037>3.0.CO;2-V","volume":"46","author":"JD Bradley","year":"2002","unstructured":"Bradley JD, Heilman DK, Katz BP, Gsell P, Wallick JE, Brandt KD (2002) Tidal irrigation as treatment for knee osteoarthritis: a sham-controlled, randomized, double-blinded evaluation. Arthritis Rheum 46(1):100\u2013108","journal-title":"Arthritis Rheum"},{"issue":"2","key":"5363_CR35","doi-asserted-by":"publisher","first-page":"190","DOI":"10.4085\/1062-6050-43.2.190","volume":"43","author":"ST Doberstein","year":"2008","unstructured":"Doberstein ST, Romeyn RL, Reineke DM (2008) The diagnostic value of the Clarke sign in assessing chondromalacia patella. J Athl Train 43(2):190\u2013196","journal-title":"J Athl Train"},{"issue":"4","key":"5363_CR36","doi-asserted-by":"publisher","first-page":"927","DOI":"10.2106\/JBJS.H.01527","volume":"92","author":"HK Pihlajam\u00e4ki","year":"2010","unstructured":"Pihlajam\u00e4ki HK, Kuikka PI, Lepp\u00e4nen VV, Kiuru MJ, Mattila VM (2010) Reliability of clinical findings and magnetic resonance imaging for the diagnosis of chondromalacia patellae. J Bone Joint Surg Am 92(4):927\u2013934","journal-title":"J Bone Joint Surg Am"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-024-05363-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00402-024-05363-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-024-05363-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T13:06:59Z","timestamp":1731589619000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00402-024-05363-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,23]]},"references-count":36,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["5363"],"URL":"https:\/\/doi.org\/10.1007\/s00402-024-05363-w","relation":{},"ISSN":["1434-3916"],"issn-type":[{"value":"1434-3916","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,23]]},"assertion":[{"value":"8 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Bioethics Committee of the University Hospital Mostar, Bosnia and Herzegovina approved the study which was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments (2008) or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participants included in the study read and signed the informed consent where they also gave a consent to have their data published for scientific publishing purposes.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All authors declare they have no conflict of interest concerning this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}