{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:21:29Z","timestamp":1767169289938,"version":"3.48.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Orthop Trauma Surg"],"DOI":"10.1007\/s00402-025-05834-8","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T22:44:54Z","timestamp":1743374694000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thromboprophylaxis in patients admitted to inpatient rehabilitation and skilled nursing facilities post total joint arthroplasty"],"prefix":"10.1007","volume":"145","author":[{"given":"Tiffany D.","family":"Ho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Keshishian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep S.","family":"Bains","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle N.","family":"Swartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Katanbaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy A.","family":"Dubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald E.","family":"Delanois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6659-0945","authenticated-orcid":false,"given":"Nirav K.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"5834_CR1","unstructured":"O B (2011) Prevalence and economic burden of venous thromboembolism after total hip arthroplasty or total knee arthroplasty. Am J Manag Care 17"},{"key":"5834_CR2","doi-asserted-by":"publisher","first-page":"e2345883","DOI":"10.1001\/jamanetworkopen.2023.45883","volume":"6","author":"SJ Simon","year":"2023","unstructured":"Simon SJ, Patell R, Zwicker JI et al (2023) Venous thromboembolism in total hip and total knee arthroplasty. JAMA Netw Open 6:e2345883. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.45883","journal-title":"JAMA Netw Open"},{"key":"5834_CR3","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.arth.2009.06.021","volume":"25","author":"KJ Bozic","year":"2010","unstructured":"Bozic KJ, Vail TP, Pekow PS et al (2010) Does aspirin have a role in venous thromboembolism prophylaxis in total knee arthroplasty patients? J Arthroplasty 25:1053\u20131060. https:\/\/doi.org\/10.1016\/j.arth.2009.06.021","journal-title":"J Arthroplasty"},{"key":"5834_CR4","doi-asserted-by":"publisher","first-page":"589","DOI":"10.2106\/JBJS.18.00335","volume":"101","author":"TL Tan","year":"2019","unstructured":"Tan TL, Foltz C, Huang R et al (2019) Potent anticoagulation does not reduce venous thromboembolism in High-Risk patients. JBJS 101:589. https:\/\/doi.org\/10.2106\/JBJS.18.00335","journal-title":"JBJS"},{"key":"5834_CR5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.arth.2009.06.002","volume":"24","author":"GA Brown","year":"2009","unstructured":"Brown GA (2009) Venous thromboembolism prophylaxis after major orthopaedic surgery: A pooled analysis of randomized controlled trials. J Arthroplasty 24:77\u201383. https:\/\/doi.org\/10.1016\/j.arth.2009.06.002","journal-title":"J Arthroplasty"},{"key":"5834_CR6","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1054\/arth.2001.21499","volume":"16","author":"KR Brookenthal","year":"2001","unstructured":"Brookenthal KR, Freedman KB, Lotke PA et al (2001) A meta-analysis of thromboembolic prophylaxis in total knee arthroplasty. J Arthroplasty 16:293\u2013300. https:\/\/doi.org\/10.1054\/arth.2001.21499","journal-title":"J Arthroplasty"},{"key":"5834_CR7","doi-asserted-by":"publisher","first-page":"929","DOI":"10.2106\/00004623-200007000-00004","volume":"82\u2013A","author":"KB Freedman","year":"2000","unstructured":"Freedman KB, Brookenthal KR, Fitzgerald RH et al (2000) A meta-analysis of thromboembolic prophylaxis following elective total hip arthroplasty. J Bone Joint Surg Am 82\u2013A:929\u2013938. https:\/\/doi.org\/10.2106\/00004623-200007000-00004","journal-title":"J Bone Joint Surg Am"},{"key":"5834_CR8","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1001\/jamainternmed.2019.6108","volume":"180","author":"GS Matharu","year":"2020","unstructured":"Matharu GS, Kunutsor SK, Judge A et al (2020) Clinical effectiveness and safety of aspirin for venous thromboembolism prophylaxis after total hip and knee replacement. JAMA Intern Med 180:376\u2013384. https:\/\/doi.org\/10.1001\/jamainternmed.2019.6108","journal-title":"JAMA Intern Med"},{"key":"5834_CR9","doi-asserted-by":"publisher","first-page":"S113","DOI":"10.1016\/j.arth.2017.01.039","volume":"32","author":"AS McLawhorn","year":"2017","unstructured":"McLawhorn AS, Fu MC, Schairer WW et al (2017) Continued inpatient care after primary total knee arthroplasty increases 30-Day Post-Discharge complications: A propensity Score-Adjusted analysis. J Arthroplasty 32:S113\u2013S118. https:\/\/doi.org\/10.1016\/j.arth.2017.01.039","journal-title":"J Arthroplasty"},{"key":"5834_CR10","doi-asserted-by":"publisher","unstructured":"Fu MC, Samuel AM, Sculco PK et al (2017) Discharge to inpatient facilities after total hip arthroplasty is associated with increased postdischarge morbidity. J Arthroplasty 32. https:\/\/doi.org\/10.1016\/j.arth.2017.03.044. S144-S149.e1","DOI":"10.1016\/j.arth.2017.03.044"},{"key":"5834_CR11","doi-asserted-by":"publisher","first-page":"e483","DOI":"10.1016\/j.wneu.2018.06.221","volume":"118","author":"N Crouser","year":"2018","unstructured":"Crouser N, Malik AT, Jain N et al (2018) Discharge to inpatient care facility after vertebroplasty\/kyphoplasty: incidence, risk factors, and postdischarge outcomes. World Neurosurg 118:e483\u2013e488. https:\/\/doi.org\/10.1016\/j.wneu.2018.06.221","journal-title":"World Neurosurg"},{"key":"5834_CR12","doi-asserted-by":"publisher","unstructured":"G W, B D, P G et al (2008) Prevention of venous thromboembolism: American college of chest physicians Evidence-Based clinical practice guidelines (8th Edition). Chest 133. https:\/\/doi.org\/10.1378\/chest.08-0656","DOI":"10.1378\/chest.08-0656"},{"key":"5834_CR13","doi-asserted-by":"publisher","unstructured":"Sz G, L V, M DR (1999) Acute pulmonary embolism: clinical outcomes in the international cooperative pulmonary embolism registry (ICOPER). https:\/\/doi.org\/10.1016\/s0140-6736(98)07534-5. Lancet Lond Engl 353:","DOI":"10.1016\/s0140-6736(98)07534-5"},{"key":"5834_CR14","doi-asserted-by":"publisher","unstructured":"Tc DK, Dc P M (2012) Thromboembolic prophylaxis in total joint arthroplasty. https:\/\/doi.org\/10.1155\/2012\/837896. Thrombosis 2012:","DOI":"10.1155\/2012\/837896"},{"key":"5834_CR15","doi-asserted-by":"publisher","first-page":"c95","DOI":"10.1136\/bmj.c95","volume":"340","author":"J Hill","year":"2010","unstructured":"Hill J, Treasure T, National Clinical Guideline Centre for Acute and Chronic Conditions (2010) Reducing the risk of venous thromboembolism in patients admitted to hospital: summary of NICE guidance. BMJ 340:c95. https:\/\/doi.org\/10.1136\/bmj.c95","journal-title":"BMJ"},{"key":"5834_CR16","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1177\/1120700020920814","volume":"32","author":"AT Malik","year":"2022","unstructured":"Malik AT, Jain N, Frantz TL et al (2022) Discharge to inpatient care facilities following hip fracture surgery: incidence, risk factors, and 30-day post-discharge outcomes. HIP Int 32:131\u2013139. https:\/\/doi.org\/10.1177\/1120700020920814","journal-title":"HIP Int"},{"key":"5834_CR17","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jss.2018.03.022","volume":"229","author":"H Cheng","year":"2018","unstructured":"Cheng H, Clymer JW, Chen BP-H et al (2018) Prolonged operative duration is associated with complications: a systematic review and meta-analysis. J Surg Res 229:134\u2013144. https:\/\/doi.org\/10.1016\/j.jss.2018.03.022","journal-title":"J Surg Res"},{"key":"5834_CR18","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1097\/SAP.0b013e31825f4e5a","volume":"69","author":"BT Phillips","year":"2012","unstructured":"Phillips BT, Wang ED, Rodman AJ et al (2012) Anesthesia duration as a marker for surgical complications in office-based plastic surgery. Ann Plast Surg 69:408\u2013411. https:\/\/doi.org\/10.1097\/SAP.0b013e31825f4e5a","journal-title":"Ann Plast Surg"},{"key":"5834_CR19","doi-asserted-by":"publisher","first-page":"e57881","DOI":"10.1371\/journal.pone.0057881","volume":"8","author":"WAC Mutch","year":"2013","unstructured":"Mutch WAC, Patel SR, Shahidi AM et al (2013) Cerebral oxygen saturation: graded response to carbon dioxide with isoxia and graded response to oxygen with isocapnia. PLoS ONE 8:e57881. https:\/\/doi.org\/10.1371\/journal.pone.0057881","journal-title":"PLoS ONE"},{"key":"5834_CR20","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1177\/0269215514558641","volume":"29","author":"ML Guerra","year":"2015","unstructured":"Guerra ML, Singh PJ, Taylor NF (2015) Early mobilization of patients who have had a hip or knee joint replacement reduces length of stay in hospital: a systematic review. Clin Rehabil 29:844\u2013854. https:\/\/doi.org\/10.1177\/0269215514558641","journal-title":"Clin Rehabil"},{"key":"5834_CR21","doi-asserted-by":"publisher","unstructured":"Sidhu VS, Kelly T-L, Pratt N et al (2021) CRISTAL (a cluster-randomised, crossover, non-inferiority trial of aspirin compared to low molecular weight heparin for venous thromboembolism prophylaxis in hip or knee arthroplasty, a registry nested study): statistical analysis plan. Trials 22. https:\/\/doi.org\/10.1186\/s13063-021-05486-0","DOI":"10.1186\/s13063-021-05486-0"},{"key":"5834_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.arth.2011.03.032","volume":"27","author":"Intermountain Joint Replacement Center Writing Committee","year":"2012","unstructured":"Intermountain Joint Replacement Center Writing Committee (2012) A prospective comparison of warfarin to aspirin for thromboprophylaxis in total hip and total knee arthroplasty. J Arthroplasty 27:1\u20139e2. https:\/\/doi.org\/10.1016\/j.arth.2011.03.032","journal-title":"J Arthroplasty"},{"key":"5834_CR23","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1007\/s11999-017-5394-6","volume":"475","author":"A Bala","year":"2017","unstructured":"Bala A, Huddleston JI, Goodman SB et al (2017) Venous thromboembolism prophylaxis after TKA: aspirin, Warfarin, Enoxaparin, or factor Xa inhibitors?? Clin Orthop 475:2205\u20132213. https:\/\/doi.org\/10.1007\/s11999-017-5394-6","journal-title":"Clin Orthop"},{"key":"5834_CR24","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.arth.2016.02.074","volume":"31","author":"RC Huang","year":"2016","unstructured":"Huang RC, Parvizi J, Hozack WJ et al (2016) Aspirin is as effective as and safer than warfarin for patients at higher risk of venous thromboembolism undergoing total joint arthroplasty. J Arthroplasty 31:83\u201386. https:\/\/doi.org\/10.1016\/j.arth.2016.02.074","journal-title":"J Arthroplasty"},{"key":"5834_CR25","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1097\/MBC.0000000000000121","volume":"25","author":"Y Zou","year":"2014","unstructured":"Zou Y, Tian S, Wang Y, Sun K (2014) Administering aspirin, Rivaroxaban and low-molecular-weight heparin to prevent deep venous thrombosis after total knee arthroplasty. Blood Coagul Fibrinolysis Int J Haemost Thromb 25:660\u2013664. https:\/\/doi.org\/10.1097\/MBC.0000000000000121","journal-title":"Blood Coagul Fibrinolysis Int J Haemost Thromb"},{"key":"5834_CR26","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.arth.2012.06.001","volume":"28","author":"CJ McDougall","year":"2013","unstructured":"McDougall CJ, Gray HS, Simpson PM et al (2013) Complications related to therapeutic anticoagulation in total hip arthroplasty. J Arthroplasty 28:187\u2013192. https:\/\/doi.org\/10.1016\/j.arth.2012.06.001","journal-title":"J Arthroplasty"},{"key":"5834_CR27","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1093\/eurheartj\/ehw550","volume":"38","author":"M Koupenova","year":"2017","unstructured":"Koupenova M, Kehrel BE, Corkrey HA, Freedman JE (2017) Thrombosis and platelets: an update. Eur Heart J 38:785\u2013791. https:\/\/doi.org\/10.1093\/eurheartj\/ehw550","journal-title":"Eur Heart J"},{"key":"5834_CR28","unstructured":"Artery Thrombosis - an overview| ScienceDirect Topics. https:\/\/www-sciencedirect-com.proxy.library.vcu.edu\/topics\/medicine-and-dentistry\/artery-thrombosis. Accessed 17 Oct 2024"},{"key":"5834_CR29","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1172\/JCI60229","volume":"122","author":"N Mackman","year":"2012","unstructured":"Mackman N (2012) New insights into the mechanisms of venous thrombosis. J Clin Invest 122:2331. https:\/\/doi.org\/10.1172\/JCI60229","journal-title":"J Clin Invest"},{"key":"5834_CR30","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1161\/ATVBAHA.120.315754","volume":"41","author":"G Alkarithi","year":"2021","unstructured":"Alkarithi G, Duval C, Shi Y et al (2021) Thrombus structural composition in cardiovascular disease. Arterioscler Thromb Vasc Biol 41:2370. https:\/\/doi.org\/10.1161\/ATVBAHA.120.315754","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"5834_CR31","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1056\/NEJM199405053301808","volume":"330","author":"C Patrono","year":"1994","unstructured":"Patrono C (1994) Aspirin as an antiplatelet drug. N Engl J Med 330:1287\u20131294. https:\/\/doi.org\/10.1056\/NEJM199405053301808","journal-title":"N Engl J Med"},{"key":"5834_CR32","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1182\/hematology.2020000150","volume":"2020","author":"R Diep","year":"2020","unstructured":"Diep R, Garcia D (2020) Does aspirin prevent venous thromboembolism? Hematol Am Soc Hematol Educ Program 2020:634. https:\/\/doi.org\/10.1182\/hematology.2020000150","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"5834_CR33","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.blre.2014.09.003","volume":"29","author":"JC Chapin","year":"2014","unstructured":"Chapin JC, Hajjar KA (2014) Fibrinolysis and the control of blood coagulation. Blood Rev 29:17. https:\/\/doi.org\/10.1016\/j.blre.2014.09.003","journal-title":"Blood Rev"},{"key":"5834_CR34","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/s12933-021-01372-w","volume":"20","author":"AH Bryk-Wi\u0105zania","year":"2021","unstructured":"Bryk-Wi\u0105zania AH, Undas A (2021) Hypofibrinolysis in type 2 diabetes and its clinical implications: from mechanisms to Pharmacological modulation. Cardiovasc Diabetol 20:191. https:\/\/doi.org\/10.1186\/s12933-021-01372-w","journal-title":"Cardiovasc Diabetol"},{"key":"5834_CR35","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1111\/jth.15701","volume":"20","author":"T Frischmuth","year":"2022","unstructured":"Frischmuth T, Hindberg K, Aukrust P et al (2022) Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism. J Thromb Haemost JTH 20:1618\u20131626. https:\/\/doi.org\/10.1111\/jth.15701","journal-title":"J Thromb Haemost JTH"},{"key":"5834_CR36","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1055\/s-0038-1676954","volume":"119","author":"S Bos","year":"2019","unstructured":"Bos S, van den Boom B, Kamphuisen PW et al (2019) Haemostatic profiles are similar across all aetiologies of cirrhosis. Thromb Haemost 119:246\u2013253. https:\/\/doi.org\/10.1055\/s-0038-1676954","journal-title":"Thromb Haemost"},{"key":"5834_CR37","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1111\/liv.15183","volume":"42","author":"A Zanetto","year":"2022","unstructured":"Zanetto A, Campello E, Pelizzaro F et al (2022) Haemostatic alterations in patients with cirrhosis and hepatocellular carcinoma: laboratory evidence and clinical implications. Liver Int Off J Int Assoc Study Liver 42:1229\u20131240. https:\/\/doi.org\/10.1111\/liv.15183","journal-title":"Liver Int Off J Int Assoc Study Liver"},{"key":"5834_CR38","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1055\/s-0041-1725096","volume":"47","author":"JB Larsen","year":"2021","unstructured":"Larsen JB, Hvas A-M (2021) Fibrinolytic alterations in sepsis: biomarkers and future treatment targets. Semin Thromb Hemost 47:589\u2013600. https:\/\/doi.org\/10.1055\/s-0041-1725096","journal-title":"Semin Thromb Hemost"},{"key":"5834_CR39","doi-asserted-by":"publisher","first-page":"4375","DOI":"10.1182\/blood-2005-07-2636","volume":"107","author":"G Cesarman-Maus","year":"2006","unstructured":"Cesarman-Maus G, R\u00edos-Luna NP, Deora AB et al (2006) Autoantibodies against the fibrinolytic receptor, Annexin 2, in antiphospholipid syndrome. Blood 107:4375\u20134382. https:\/\/doi.org\/10.1182\/blood-2005-07-2636","journal-title":"Blood"},{"key":"5834_CR40","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s11926-009-0075-4","volume":"12","author":"KA Krone","year":"2010","unstructured":"Krone KA, Allen KL, McCrae KR (2010) Impaired fibrinolysis in the antiphospholipid syndrome. Curr Rheumatol Rep 12:53\u201357. https:\/\/doi.org\/10.1007\/s11926-009-0075-4","journal-title":"Curr Rheumatol Rep"},{"key":"5834_CR41","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.thromres.2014.05.041","volume":"134","author":"P Mazur","year":"2014","unstructured":"Mazur P, Soko\u0142owski G, Hubalewska-Dydejczyk A et al (2014) Prothrombotic alterations in plasma fibrin clot properties in thyroid disorders and their post-treatment modifications. Thromb Res 134:510\u2013517. https:\/\/doi.org\/10.1016\/j.thromres.2014.05.041","journal-title":"Thromb Res"}],"container-title":["Archives of Orthopaedic and Trauma Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-025-05834-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00402-025-05834-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00402-025-05834-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:16:46Z","timestamp":1767169006000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00402-025-05834-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5834"],"URL":"https:\/\/doi.org\/10.1007\/s00402-025-05834-8","relation":{},"ISSN":["1434-3916"],"issn-type":[{"type":"electronic","value":"1434-3916"}],"subject":[],"published":{"date-parts":[[2025,3,28]]},"assertion":[{"value":"10 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This is a retrospective study using de-identified data. No ethics approval is required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individuals included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"214"}}