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Outcome was evaluated by pre- and postinterventional pain (Numeric Rating Scale - NRS), patient reported outcome (subjective knee value (SKV), Oxford Knee Score (OKS)) at latest follow-up (2.9 months\u2009\u00b1\u20091) as well as quantitative artificial intelligence assisted analysis of bone marrow edema (BME) in Magnetic Resonance Imaging (MRI) before and after 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Radiologically, there was a 71% reduction in edema (pre-intervention: 37.0\u00a0cm\u00b3\u00b137.7, post-intervention: 10.8\u00a0cm\u00b3 \u00b1 14.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Overall satisfaction was 2.0\u2009\u00b1\u20091.3, SKV was 83.3%\u00b116.6 and NRS at follow-up was 1.3\u2009\u00b1\u20091.8. OKS reached 33.6\u2009\u00b1\u200912.0. No major complications were observed. Rare side effects were dizziness which required premature termination of Ilomedin therapy on day 3.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Iloprost treatment seems a safe and promising therapeutic option also in SONK with excellent subjective outcome and reduction of BME of 70% within 3 months after Iloprost infusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00402-025-06057-7","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:15:10Z","timestamp":1760080510000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Iloprost therapy achieves good clinical and radiological short and mid-term outcomes in patients with idiopathic aseptic osteonecrosis of the knee joint also in ARCO level II"],"prefix":"10.1007","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8263-4354","authenticated-orcid":false,"given":"Stephanie","family":"Kirschbaum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0993-581X","authenticated-orcid":false,"given":"Carsten","family":"Perka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0280-1819","authenticated-orcid":false,"given":"Moses","family":"El-Kayali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7489-245X","authenticated-orcid":false,"given":"Clemens","family":"Gwinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2003-8351","authenticated-orcid":false,"given":"Thula Cannon","family":"Walter-Rittel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Soujon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8270-0462","authenticated-orcid":false,"given":"Stefanie","family":"Donner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"issue":"6","key":"6057_CR1","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1007\/s00296-012-2584-0","volume":"33","author":"C Baier","year":"2013","unstructured":"Baier C, Schaumburger J, Gotz J, Heers G, Schmidt T, Grifka J et al (2013) Bisphosphonates or Prostacyclin in the treatment of bone-marrow oedema syndrome of the knee and foot. 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