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This study evaluated short- and long-term complications following TSA in patients with a history of mastectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort analysis was performed using the TriNetX Research Network, including patients who underwent primary TSA. Individuals with a history of mastectomy were identified using procedural and diagnostic coding, and those with contralateral mastectomy and TSA were excluded. Propensity score matching 1:1 was performed to balance demographics and comorbidities. Ninety-day and two-year outcomes were compared between matched cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After matching, 1,865 patients with prior mastectomy were compared with 1,865 controls. Patients with a history of mastectomy had a significantly higher incidence of postoperative lymphedema (3.48% vs. 0.67%; RR 5.15;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001). They also demonstrated increased risk of venous thromboembolism (4.56% vs. 3.11%; RR 1.47;\n                      <jats:italic>P<\/jats:italic>\n                      = .018). Overall postoperative infection rates were higher in the mastectomy cohort (3.96% vs. 2.70%; RR 1.47;\n                      <jats:italic>P<\/jats:italic>\n                      = .0378), including higher rates of cellulitis (2.81% vs. 1.72%; RR 1.63;\n                      <jats:italic>P<\/jats:italic>\n                      = .031). No significant differences were observed for 2-year outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with a history of mastectomy undergoing TSA are at increased risk of perioperative postoperative lymphedema, thromboembolic events, and cellulitis. These findings highlight the importance of heightened perioperative surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00402-026-06215-5","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:33:19Z","timestamp":1770888799000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of prior mastectomy on outcomes following total shoulder arthroplasty"],"prefix":"10.1007","volume":"146","author":[{"given":"Akin","family":"Adio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarishi","family":"Parmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Boufadel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafiz F.","family":"Kassam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam Z.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Horneff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Abboud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"6215_CR1","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jseint.2022.04.011","volume":"6","author":"B Altintas","year":"2022","unstructured":"Altintas B, Horan MP, Dornan GJ et al (2022) The recovery curve of anatomic total shoulder arthroplasty for primary glenohumeral osteoarthritis: midterm results at a minimum of 5 years. 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