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QoL and joint-specific function were assessed preoperatively and before planned reimplantation using EQ-5D-5\u00a0L, Western Ontario and McMaster University (WOMAC), and Knee Society Score (KSS). Minimum clinically important difference (MCID) thresholds were derived using a distribution-based method. Receiver operating characteristic (ROC) analysis identified baseline predictors of achieving MCID.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All outcome measures improved significantly after spacer implantation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), exceeding MCID thresholds for pain and function. The largest EQ-5D-5\u00a0L domain gain was for pain\/discomfort. Predictive thresholds for achieving MCID were an EQ-5D-5\u00a0L index\u2009\u2264\u20090.44 and WOMAC index\u2009\u2265\u200942.5. Female sex was associated with better preoperative and postoperative WOMAC and KSS scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Metal-on-polyethylene articulating spacers are associated with short-term improvements in pain, mobility, and QoL during the interval between stages of revision for PJI. Patients with poor baseline status may experience the greatest benefit, thereby supporting consideration of avoiding definitive reimplantation (1.5 stage). While these interim results may inform patient selection for leaving the spacer indefinitely, long-term follow-up is required to determine durability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00402-026-06260-0","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:59:13Z","timestamp":1776412753000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional and quality-of-life outcomes after metal-on-polyethylene articulating spacer implantation for periprosthetic knee infection: a retrospective evaluation of a prospectively collected cohort"],"prefix":"10.1007","volume":"146","author":[{"given":"Giovanni","family":"Balato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Festa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Ascione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"De Mauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Di Gennaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Mariconda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"6260_CR1","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1056\/NEJMcp0905029","volume":"361","author":"JL Del Pozo","year":"2009","unstructured":"Del Pozo JL, Patel R (2009) Clinical practice. 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