{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:32:35Z","timestamp":1762540355422},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T00:00:00Z","timestamp":1101254400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1007\/s00403-004-0521-0","type":"journal-article","created":{"date-parts":[[2004,11,23]],"date-time":"2004-11-23T14:07:03Z","timestamp":1101218823000},"page":"286-295","source":"Crossref","is-referenced-by-count":28,"title":["Keratinocyte and dermal vascular endothelial cell capacities remain unimpaired in the margin of chronic venous ulcer"],"prefix":"10.1007","volume":"296","author":[{"given":"Hanna","family":"Galkowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldemar L.","family":"Olszewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urszula","family":"Wojewodzka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,11,24]]},"reference":[{"key":"CR6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0140-6736(82)90325-7","volume":"2","author":"NL Browse","year":"1982","unstructured":"Browse NL, Burnand KG (1982) The causes of chronic venous ulceration. Lancet 2:243?245","journal-title":"Lancet"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1136\/bmj.296.6638.1726","volume":"296","author":"PD Coleridge-Smith","year":"1988","unstructured":"Coleridge-Smith PD, Thomas P, Scurr JH, Dormandy JA (1988) Causes of venous ulceration: a new hypothesis. Br Med J 296:1726?1727","journal-title":"Br Med J"},{"key":"CR19","first-page":"1085","volume":"141","author":"SE Herrick","year":"1992","unstructured":"Herrick SE, Sloan P, McGurk M, Ferguson MWJ (1992) Sequential changes in histological pattern and extracellular matrix deposition during the healing of chronic venous ulcers. Am J Pathol 141:1085?1095","journal-title":"Am J Pathol"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/0140-6736(93)91085-Z","volume":"341","author":"V Falanga","year":"1993","unstructured":"Falanga V, Eaglstein W (1993) The ?trap? hypothesis of venous ulceration. Lancet 341:1006?1007","journal-title":"Lancet"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.276.5309.75","volume":"276","author":"P Martin","year":"1997","unstructured":"Martin P (1997) Wound healing?aiming for perfect skin regeneration. Science 276:75?81","journal-title":"Science"},{"key":"CR44","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1346-8138.2001.tb00025.x","volume":"28","author":"Y Yamaguchi","year":"2001","unstructured":"Yamaguchi Y, Yoshikawa K (2001) Cutaneous wound healing: an update. J Dermatol 28:521?534","journal-title":"J Dermatol"},{"key":"CR8","first-page":"865","volume-title":"Inflammation: basic principles and clinical correlates","author":"S Chettibi","year":"1999","unstructured":"Chettibi S, Ferguson MWJ (1999) Wound repair: an overview. In: Gallin JI, Snyderman R (eds) Inflammation: basic principles and clinical correlates, 3rd edn. Lippincott Williams & Wilkins, Philadelphia, pp 865?881","edition":"3"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","volume":"83","author":"S Werner","year":"2002","unstructured":"Werner S, Grose R (2002) Regulation of wound healing by growth factors and cytokines. Physiol Rev 83:835?870","journal-title":"Physiol Rev"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1067\/msy.2003.223","volume":"134","author":"H Galkowska","year":"2003","unstructured":"Galkowska H, Olszewski WL, Wojewodzka U, Mijal J, Filipiuk E (2003) Expression of apoptosis- and cell cycle-related protein in epidermis of venous leg and diabetic foot ulcers. Surgery 134:213?220","journal-title":"Surgery"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/00000658-199406000-00012","volume":"219","author":"DM Cooper","year":"1994","unstructured":"Cooper DM, Yu EZ, Hennesey P (1994) Determination of endogenous cytokines in chronic wounds. Ann Surg 219:688?692","journal-title":"Ann Surg"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2337\/diacare.18.1.64","volume":"18","author":"JL Richard","year":"1995","unstructured":"Richard JL, Parer-Richard C, Daures JP (1995) Effect of topical basic fibroblast growth factor on the healing of chronic diabetic neuropathic ulcer of the foot: a pilot, randomized, double-blind, placebo-controlled study. Diabetes Care 18:64?69","journal-title":"Diabetes Care"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/00000658-199210000-00002","volume":"216","author":"M Robson","year":"1992","unstructured":"Robson M, Phillips L, Lowrence W (1992) The safety and effect of topically applied recombinant basic fibroblast factor on the healing of chronic pressure sores. Ann Surg 216:401?408","journal-title":"Ann Surg"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1046\/j.1524-475X.2003.11502.x","volume":"11","author":"YW Tian","year":"2003","unstructured":"Tian YW, Stacey MC (2003) Cytokines and growth factors in keratinocytes and sweat glands in chronic venous leg ulcers. An immunohistochemical study. Wound Repair Regen 11:316?325","journal-title":"Wound Repair Regen"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1600-0625.1995.tb00058.x","volume":"4","author":"IR Harris","year":"1995","unstructured":"Harris IR, Yee KC, Walters CE, et al (1995) Cytokine and protease levels in healing and non-healing chronic venous leg ulcers. Exp Dermatol 4:342?349","journal-title":"Exp Dermatol"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1524-475x.2000.00013.x","volume":"8","author":"NJ Trengove","year":"2000","unstructured":"Trengove NJ, Bielefeld-Ohmann H, Stacey MC (2000) Mitogenic activity and cytokine levels in non-healing and healing chronic leg ulcers. Wound Repair Regen 8:13?25","journal-title":"Wound Repair Regen"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1172\/JCI118169","volume":"96","author":"GF Pierce","year":"1995","unstructured":"Pierce GF, Trapley JE, Tseng J, Bready J, Chang D, Kenney WC (1995) Detection of platelet derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinated PDGF-BB and absence of PDGF in chronic nonhealing wounds. J Clin Invest 96:1336?1350","journal-title":"J Clin Invest"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0738-081X(95)93817-8","volume":"13","author":"IA McKay","year":"1995","unstructured":"McKay IA, Leigh IM (1995) Altered keratinocyte growth and differentiation in psoriasis. Clin Dermatol 13:105?108","journal-title":"Clin Dermatol"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1046\/j.1524-475x.2000.00216.x","volume":"8","author":"JA Iocono","year":"2000","unstructured":"Iocono JA, Colleran KR, Remick DG, Gillespie BW, Ehrlich HP, Garner WL (2000) Interleukin-8 levels and activity in delayed-healing human thermal wounds. Wound Repair Regen 8:216?225","journal-title":"Wound Repair Regen"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/oxfordjournals.bmb.a072331","volume":"45","author":"AW Burgess","year":"1989","unstructured":"Burgess AW (1989) Epidermal growth factor and transforming growth factor alpha. Br Med Bull 45:401?424","journal-title":"Br Med Bull"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/0092-8674(87)90179-6","volume":"50","author":"Y Barrandon","year":"1987","unstructured":"Barrandon Y, Green H (1987) Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor alpha and epidermal growth factor. Cell 50:1131?1137","journal-title":"Cell"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1056\/NEJM198907133210203","volume":"321","author":"GL Brown","year":"1989","unstructured":"Brown GL, Nanney LB, Griffin J, et al (1989) Enhancement of wound healing by topical treatment with epidermal growth factor. N Engl J Med 321:76?79","journal-title":"N Engl J Med"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1357-2725(96)00120-3","volume":"29","author":"S O?Kane","year":"1997","unstructured":"O?Kane S, Ferguson MWJ (1997) Transforming growth factor ?s and wound healing. Int J Biochem Cell Biol 29:63?78","journal-title":"Int J Biochem Cell Biol"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1046\/j.0022-202x.2001.01501.x","volume":"117","author":"AJ Cowin","year":"2001","unstructured":"Cowin AJ, Hatzirodos N, Holding CA, et al (2001) Effect of healing on the expression of TGF?s and their receptors in chronic venous leg ulcers. J Invest Dermatol 117:1282?1289","journal-title":"J Invest Dermatol"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1699-0463.1995.tb01109.x","volume":"103","author":"K Rosner","year":"1995","unstructured":"Rosner K, Ross C, Karlsmark T, Petersen AA, Gottrup F, Vejlsgaard GL (1995) Immunohistochemical characterization of the cutaneous cellular infiltrate in different areas of chronic leg ulcers. APMIS 103:293?299","journal-title":"APMIS"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1182\/blood.V92.11.4150","volume":"92","author":"D Gabrilovich","year":"1998","unstructured":"Gabrilovich D, Ishida T, Oyama T, et al (1998) Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 92:4150?4166","journal-title":"Blood"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nm1096-1096","volume":"2","author":"D Gabrilovich","year":"1996","unstructured":"Gabrilovich D, Chen HL, Girgis KR, et al (1996) Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med 2:1096?1103","journal-title":"Nat Med"},{"key":"CR1","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1182\/blood.V87.8.3336.bloodjournal8783336","volume":"87","author":"B Barleon","year":"1996","unstructured":"Barleon B, Sozzani S, Zhou D, Weich HA, Mantovani A, Marme D (1996) Migration of human monocytes to vascular endothelial growth factor (VEGF) is mediated via VEGF receptor (flt1). Blood 87:3336?3343","journal-title":"Blood"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/archsurg.134.12.1325","volume":"134","author":"M McCourt","year":"1999","unstructured":"McCourt M, Wang JH, Sookhai S, Redmond HP (1999) Proinflammatory mediators stimulate neutrophil-directed angiogenesis. Arch Surg 134:1325?1331","journal-title":"Arch Surg"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1046\/j.1523-1747.2000.00036.x","volume":"115","author":"G Lauer","year":"2000","unstructured":"Lauer G, Sollberg S, Cole M, et al (2000) Expression and proteolysis of vascular endothelial growth factor is increased in chronic wounds. J Invest Dermatol 115:12?18","journal-title":"J Invest Dermatol"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s004030050307","volume":"290","author":"M Peschen","year":"1998","unstructured":"Peschen M, Grenz H, Brand-Seberi B, et al (1998) Increased expression of platelet-derived growth factor receptor alpha and beta and vascular endothelial growth factor in the skin of patients with chronic venous insufficiency. Arch Dermatol Res 290:291?297","journal-title":"Arch Dermatol Res"},{"key":"CR4","first-page":"111","volume":"11","author":"K Breuhahn","year":"2000","unstructured":"Breuhahn K, Mann A, Muller G, et al (2000) Epidermal overexpression of granulocyte-macrophage colony stimulating factor induces both keratinocyte proliferation and apoptosis. Cell Growth Differ 11:111?121","journal-title":"Cell Growth Differ"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0140-6736(94)91819-8","volume":"344","author":"R Marquesde Costa","year":"1994","unstructured":"Marques de Costa R, Aniceto C, Jezus FM, Mendes M (1994) Quick healing of leg ulcers after molgramostim. Lancet 344:481?482","journal-title":"Lancet"},{"key":"CR37","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1067\/msy.2000.104166","volume":"127","author":"FH Siddiqui","year":"2000","unstructured":"Siddiqui FH, Biundo JJ, Moore C, Ermitano ML, Ortigas AP, DeFrancesch F (2000) Recombinant granulocyte macrophage colony stimulating factor (rhu-GMCSF) in the treatment of extensive leg ulcers: a case report. Surgery 127:589?592","journal-title":"Surgery"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1046\/j.1365-2133.1998.02074.x","volume":"138","author":"I Ure","year":"1998","unstructured":"Ure I, Partsch B, Wolff K, Petzelbauer P (1998) Granulocyte\/macrophage colony stimulating factor increases wound-fluid interleukin 8 in normal subjects but does not accelerate wound healing. Br J Dermatol 138:277?282","journal-title":"Br J Dermatol"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1097\/00000658-200211000-00020","volume":"236","author":"LN Jorgensen","year":"2002","unstructured":"Jorgensen LN, Agren M, Madsen SM, et al (2002) Dose-dependent impairment of collagen deposition by topical granulocyte-macrophage colony stimulating factor in human experimental wounds. Ann Surg 236:684?692","journal-title":"Ann Surg"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1006\/jsre.1998.5410","volume":"79","author":"YQ Li","year":"1998","unstructured":"Li YQ, Doyle JW, Roth TP, Dunn RM, Lawrence WT (1998) IL10 and GMCSF expression and the presence of antigen presenting cells in chronic venous ulcers. J Surg Res 79:128?135","journal-title":"J Surg Res"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1046\/j.1523-1747.1998.00381.x","volume":"111","author":"MAM Loots","year":"1998","unstructured":"Loots MAM, Lamme EN, Zeegelaar J, Mekkes JR, Bos JD, Middelkoop E (1998) Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds. J Invest Dermatol 111:850?857","journal-title":"J Invest Dermatol"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1046\/j.1365-2133.1997.18041895.x","volume":"137","author":"K Moore","year":"1997","unstructured":"Moore K, Ruge F, Harding KG (1997) T lymphocytes and the lack of activated macrophages in wound margin biopsies from chronic leg ulcers. Br J Dermatol 137:188?194","journal-title":"Br J Dermatol"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1046\/j.1524-475X.2003.11617.x","volume":"11","author":"RF Diegelmann","year":"2003","unstructured":"Diegelmann RF (2003) Excessive neutrophils characterize chronic pressure ulcers. Wound Repair Regen 11:490?495","journal-title":"Wound Repair Regen"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1046\/j.1365-2133.2000.03591.x","volume":"143","author":"DE Boyce","year":"2000","unstructured":"Boyce DE, Jones WD, Ruge F, Harding KG, Moore K (2000) The role of lymphocytes in dermal wound healing. Br J Dermatol 143:59?65","journal-title":"Br J Dermatol"},{"key":"CR41","first-page":"213","volume":"22","author":"JCJM Veraart","year":"1993","unstructured":"Veraart JCJM, Verhaegh MEJM, Neumann HAM, Hulsmans RFHJ, Arends JW (1993) Adhesion molecule expression in venous leg ulcers. Vasa 22:213?218","journal-title":"Vasa"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/000155501317140034","volume":"81","author":"K Rosner","year":"2001","unstructured":"Rosner K, Ross C, Karlsmark T, Skovgaard GL (2001) Role of LFA-1\/ICAM1, CLA\/E-selectin and VLA-4\/VCAM1 pathways in recruiting leukocytes to the various regions of the chronic leg ulcer. Acta Derm Venereol 81:334?339","journal-title":"Acta Derm Venereol"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0190-9622(96)90432-6","volume":"34","author":"A Weyl","year":"1996","unstructured":"Weyl A, Vanscheidt W, Weiss JM, Peschen M, Schoepf E, Simon J (1996) Expression of the adhesion molecules ICAM-1, VCAM-1, and E-selectin and their ligands VLA-4 and LFA-1 in chronic venous leg ulcers. J Am Acad Dermatol 34:418?423","journal-title":"J Am Acad Dermatol"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1046\/j.1524-475x.2001.00050.x","volume":"9","author":"JV Edwards","year":"2001","unstructured":"Edwards JV, Yager DR, Cohen IK, et al (2001) Modified cotton gauze dressings that selectively absorb neutrophil elastase activity in solution. Wound Repair Regen 9:50?58","journal-title":"Wound Repair Regen"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-004-0521-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00403-004-0521-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-004-0521-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T07:33:20Z","timestamp":1585985600000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00403-004-0521-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,24]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["521"],"URL":"https:\/\/doi.org\/10.1007\/s00403-004-0521-0","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,24]]}}}