{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:35:17Z","timestamp":1769164517030,"version":"3.49.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T00:00:00Z","timestamp":1146096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T00:00:00Z","timestamp":1146096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1007\/s00403-006-0659-z","type":"journal-article","created":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T13:19:52Z","timestamp":1146057592000},"page":"64-72","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Recombined DNA vaccines encoding calreticulin linked to HPV6bE7 enhance immune response and inhibit angiogenic activity in B16 melanoma mouse model expressing HPV 6bE7 antigen"],"prefix":"10.1007","volume":"298","author":[{"given":"Ke-Jia","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke-Jian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Fang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,4,27]]},"reference":[{"key":"659_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1084\/jem.182.1.155","volume":"182","author":"AL Angiolillo","year":"1995","unstructured":"Angiolillo AL, Sgadari C, Taub DD et al (1995) Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med 182:155\u2013162","journal-title":"J Exp Med"},{"key":"659_CR2","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1084\/jem.182.3.885","volume":"182","author":"D Arnold","year":"1995","unstructured":"Arnold D, Faath S, Rammensee H et al (1995) Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96. J Exp Med 182:885\u2013889","journal-title":"J Exp Med"},{"key":"659_CR3","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1084\/jem.189.5.797","volume":"189","author":"S Basu","year":"1999","unstructured":"Basu S, Srivastava PK (1999) Calreticulin, a peptide-binding chaperone of the endoplasmic reticulum, elicits tumor- and peptide-specific immunity. J Exp Med 189:797\u2013802","journal-title":"J Exp Med"},{"key":"659_CR4","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S1074-7613(01)00111-X","volume":"14","author":"S Basu","year":"2001","unstructured":"Basu S, Binder RJ, Ramalingam T et al (2001) CD91 is a common receptor for heat shock protein gp96, hsp90, hsp70, and calreticulin. Immunity 14:303\u2013313","journal-title":"Immunity"},{"key":"659_CR5","doi-asserted-by":"publisher","first-page":"S333","DOI":"10.2741\/1003","volume":"8","author":"JM Berry","year":"2003","unstructured":"Berry JM, Palefsky JM (2003) A review of humane papillomavirus vaccines: from basic science to clinical trials. Front Biosci 8:S333\u2013S345","journal-title":"Front Biosci"},{"issue":"12","key":"659_CR6","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/S0161-5890(02)00261-4","volume":"39","author":"M Boubier","year":"2003","unstructured":"Boubier M (2003) Accessory proteins and assembly of human class I MHC molecules: a molecular and structural perspective perspective. Mol Immunol 39(12):697\u2013706","journal-title":"Mol Immunol"},{"key":"659_CR7","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1006\/scbi.1999.0147","volume":"9","author":"F Breitburd","year":"1999","unstructured":"Breitburd F, Coursaget P (1999) Human papillomavirus vaccines. Semin Cancer Biol 9:431\u2013444","journal-title":"Semin Cancer Biol"},{"key":"659_CR8","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1046\/j.0022-202x.2001.00036.x","volume":"6","author":"D Carrasco","year":"2001","unstructured":"Carrasco D, Straten MV, Tyring SK et al (2001) Prophylactic and therapeutic vaccines for genital papillomavirus infection. J Investig Dermatol Symp Proc 6:238\u2013243","journal-title":"J Investig Dermatol Symp Proc"},{"key":"659_CR9","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1084\/jem.191.11.1957","volume":"191","author":"F Castellino","year":"2000","unstructured":"Castellino F et al (2000) Receptor-mediated uptake of antigen\/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways. J Exp Med 191:1957\u20131964","journal-title":"J Exp Med"},{"issue":"4","key":"659_CR10","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/BF00915552","volume":"7","author":"R Cauda","year":"1987","unstructured":"Cauda R, Tyring SK, Grossi CE et al (1987) Patents with condyloma acuminatum exhibit decreased interleukin-2 and interferon gamma production and depressed natural killer activity. J Clin Immunol 7(4):304\u2013311","journal-title":"J Clin Immunol"},{"key":"659_CR11","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1073\/pnas.88.1.110","volume":"88","author":"LP Chen","year":"1991","unstructured":"Chen LP, Thomas EK, Hu SL et al (1991) Human papillomavirus type 16 nucleoprotein E7 is a tumor rejection antigen. Proc Natl Acad Sci 88:110\u2013114","journal-title":"Proc Natl Acad Sci"},{"key":"659_CR12","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1002\/(SICI)1097-0142(19990201)85:3<651::AID-CNCR15>3.0.CO;2-9","volume":"85","author":"WF Cheng","year":"1999","unstructured":"Cheng WF et al (1999) Vascularity index as a novel parameter for the in vivo assessment of angiogenesis in patients with cervical carcinoma. Cancer 85:651\u2013657","journal-title":"Cancer"},{"key":"659_CR13","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1172\/JCI200112346","volume":"108","author":"WF Cheng","year":"2001","unstructured":"Cheng WF, Hung CF, Chai CY et al (2001) Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen. J Clin Invest 108:669\u2013678","journal-title":"J Clin Invest"},{"key":"659_CR14","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1172\/JCI1555","volume":"101","author":"CM Conghlin","year":"1998","unstructured":"Conghlin CM et al (1998) Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis. J Clin Invest 101:1441\u20131452","journal-title":"J Clin Invest"},{"key":"659_CR15","doi-asserted-by":"publisher","first-page":"17011","DOI":"10.1074\/jbc.270.28.17011","volume":"270","author":"EM Conway","year":"1995","unstructured":"Conway EM, Liu L, Nowakowski B et al (1995) Heat shock-sensitive expression of calreticulin. In vitro and in vivo up-regulation. J Biol Chem 270:17011\u201317016","journal-title":"J Biol Chem"},{"key":"659_CR16","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1146\/annurev.immunol.15.1.617","volume":"15","author":"JJ Donnelly","year":"1997","unstructured":"Donnelly JJ, Ulmer JB, Shiver JW et al (1997) DNA vaccines. Annu Rev Immunol 15:617\u2013648","journal-title":"Annu Rev Immunol"},{"key":"659_CR17","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/j.1749-6632.1982.tb25720.x","volume":"401","author":"J Folkman","year":"1982","unstructured":"Folkman J (1982) Angiogenesis: initiation and control. Ann NY Acad Sci 401:212\u2013227","journal-title":"Ann NY Acad Sci"},{"key":"659_CR18","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S0168-1702(02)00195-8","volume":"89","author":"I Frazer","year":"2002","unstructured":"Frazer I (2002) Vaccines for papillomavirus infection. Virus Res 89:271\u2013274","journal-title":"Virus Res"},{"issue":"1","key":"659_CR19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4049\/jimmunol.167.1.147","volume":"167","author":"D Golgher","year":"2001","unstructured":"Golgher D, Korangy F, Gao B et al (2001) An immunodominant MHC class II-restricted tumor antigen is conformation dependent and bind to the endoplasmic reticulum chaperone, calreticulin. J Imnunol 167(1):147\u2013155","journal-title":"J Imnunol"},{"key":"659_CR20","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1128\/jvi.66.4.2125-2134.1992","volume":"66","author":"CL Halbert","year":"1992","unstructured":"Halbert CL, Demers GW, Galloway DA (1992) The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells. J Virol 66:2125\u20132134","journal-title":"J Virol"},{"key":"659_CR21","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S0092-8674(00)80108-7","volume":"86","author":"D. J Hanahan Folkman","year":"1996","unstructured":"Hanahan D. Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:353\u2013364","journal-title":"Cell"},{"key":"659_CR22","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1126\/science.7513904","volume":"264","author":"AY Huang","year":"1994","unstructured":"Huang AY et al (1994) Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 264:961\u2013965","journal-title":"Science"},{"key":"659_CR23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1346-8138.2000.tb02126.x","volume":"27","author":"T Ishiji","year":"2000","unstructured":"Ishiji T (2000) Molecular mechanism of carcinogenesis by human papillomavirus-16. J Dermatol 27:73\u201386","journal-title":"J Dermatol"},{"key":"659_CR24","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1038\/sj.gt.3302252","volume":"11","author":"JW Kim","year":"2004","unstructured":"Kim JW, Hung CF, Juang J et al (2004) Comparison of HPV DNA vaccines employing intracellular targeting strategies. Gene Ther 11:1011\u20131018","journal-title":"Gene Ther"},{"key":"659_CR25","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S0092-8674(00)81884-X","volume":"88","author":"KH Krause","year":"1997","unstructured":"Krause KH, Michaelak M (1997) Calreticulin. Cell 88:439\u2013443","journal-title":"Cell"},{"key":"659_CR26","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1042\/bj2850681","volume":"285","author":"M. Michalak","year":"1992","unstructured":"Michalak M., Milner RE, Burns K et al (1992) Calreticulin. Biochem J 285:681\u2013692","journal-title":"Biochem J"},{"key":"659_CR27","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1042\/0264-6021:3440281","volume":"344","author":"M Michalak","year":"1999","unstructured":"Michalak M, Corbett EF, Mesaeli N et al (1999) Calreticulin: one protein, one gene, many functions. Biochem J 344:281\u2013292","journal-title":"Biochem J"},{"key":"659_CR28","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/BF00925962","volume":"135","author":"PD Nash","year":"1994","unstructured":"Nash PD, Opas M, Michalak M (1994) Calreticulin: not just another calcium-binding protein. Mol Cell Biochem 135:71\u201378","journal-title":"Mol Cell Biochem"},{"key":"659_CR29","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/1074-7613(95)90085-3","volume":"3","author":"DM Pardoll","year":"1995","unstructured":"Pardoll DM, Beckerleg AM (1995) Exposing the immunology of naked DNA vaccines. Immunity 3:165\u2013169","journal-title":"Immunity"},{"key":"659_CR30","first-page":"519","volume":"67","author":"A Passniti","year":"1992","unstructured":"Passniti A et al (1992) A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factors. Lab Invest 67:519\u2013528","journal-title":"Lab Invest"},{"key":"659_CR31","doi-asserted-by":"publisher","first-page":"8468","DOI":"10.1128\/JVI.78.16.8468-8476.2004","volume":"78","author":"S Peng","year":"2004","unstructured":"Peng S, Ji H, Trimble C et al (2004) Development of a DNA vaccine targeting human papillomavirus type 16 oncoprotein E6. J Virol 78:8468\u20138476","journal-title":"J Virol"},{"key":"659_CR32","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1084\/jem.188.12.2349","volume":"188","author":"SE Pike","year":"1998","unstructured":"Pike SE, Yao L, Jones KD et al (1998) Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth. J Exp Med 188:2349\u20132356","journal-title":"J Exp Med"},{"issue":"7","key":"659_CR33","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1182\/blood.V94.7.2461.419a26_2461_2468","volume":"94","author":"SE Pike","year":"1999","unstructured":"Pike SE, Yao L, Setsuda J et al (1999) Calreticulin and calreticulin fragments are endothelial cell inhibitors that suppress tumor growth. Blood 94(7):2461\u20132468","journal-title":"Blood"},{"key":"659_CR34","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1128\/JVI.73.7.5402-5410.1999","volume":"77","author":"AD Santin","year":"1999","unstructured":"Santin AD, Hermonat PL, Ravaggiet A et al (1999) Induction of human papillomavirus-specific CD4+ and CD8+ lymphocytes by E7-pulsed autologous dendritic cells in patients with human papillomavirus type 16-and 18-positive cervical cancer. J virol 77:5402\u20135410","journal-title":"J virol"},{"key":"659_CR35","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1189\/jlb.68.6.793","volume":"68","author":"DJ Shedlock","year":"2000","unstructured":"Shedlock DJ, Weiner DB (2000) DNA vaccination: antigen presentation and the induction of immunity. J Leukoc Biol 68:793\u2013806","journal-title":"J Leukoc Biol"},{"key":"659_CR36","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/BF00188611","volume":"39","author":"PK Srivastava","year":"1994","unstructured":"Srivastava PK, Udono H, Blachere NE et al (1994) Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics 39:93\u201398","journal-title":"Immunogenetics"},{"key":"659_CR37","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S1386-6532(00)00128-1","volume":"19","author":"PL Stern","year":"2000","unstructured":"Stern PL, Brown M, Stacey SN et al (2000) Natural HPV immunity and vaccination strategies. J Clin Virol 19:57\u201366","journal-title":"J Clin Virol"},{"key":"659_CR38","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1126\/science.7545313","volume":"269","author":"R Suto","year":"1995","unstructured":"Suto R, Srivastava PK (1995) A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 269:1585\u20131588","journal-title":"Science"},{"issue":"6","key":"659_CR39","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.4049\/jimmunol.171.6.2970","volume":"171","author":"WK Tae","year":"2003","unstructured":"Tae WK, Chien FH, David B et al (2003) Enhancing DNA vaccine potency by combining a strategy to prolong dendritic cell life with intracellular targeting strategies. J Immunol 171(6):2970\u20132976","journal-title":"J Immunol"},{"key":"659_CR40","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/sj.gt.3301160","volume":"7","author":"TL Wang","year":"1999","unstructured":"Wang TL et al (1999) Intramuscular administration of E7-transfected dendritic cells generates the most potent E7-specific anti-tumor immunity. Gen Ther 7:726\u2013733","journal-title":"Gen Ther"},{"key":"659_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0166-6851(02)00105-6","volume":"123","author":"P Wang","year":"2002","unstructured":"Wang P, Wang Q, Sims PF et al (2002) Rapid positive selection of stable integrants following transfection of plasmodium falciparum. Mol Biochem Parasitol 123:1\u201310","journal-title":"Mol Biochem Parasitol"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-006-0659-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-006-0659-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-006-0659-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-006-0659-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T20:16:49Z","timestamp":1744057009000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-006-0659-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,27]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["659"],"URL":"https:\/\/doi.org\/10.1007\/s00403-006-0659-z","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,27]]},"assertion":[{"value":"2 October 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2006","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2006","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}