{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:15:36Z","timestamp":1777468536943,"version":"3.51.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2007,6,19]],"date-time":"2007-06-19T00:00:00Z","timestamp":1182211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2007,8,16]]},"DOI":"10.1007\/s00403-007-0763-8","type":"journal-article","created":{"date-parts":[[2007,6,18]],"date-time":"2007-06-18T06:50:12Z","timestamp":1182149412000},"page":"337-343","source":"Crossref","is-referenced-by-count":17,"title":["Ultrastructural localization of Fras1 in the sublamina densa of embryonic epithelial basement membranes"],"prefix":"10.1007","volume":"299","author":[{"given":"Yannis","family":"Dalezios","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babis","family":"Papasozomenos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petros","family":"Petrou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Chalepakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,6,19]]},"reference":[{"key":"763_CR1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng0195-31","volume":"9","author":"K Andrikopoulos","year":"1995","unstructured":"Andrikopoulos K, Liu X, Keene DR, Jaenisch R, Ramirez F (1995) Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly. Nat Genet 9:31\u201336","journal-title":"Nat Genet"},{"key":"763_CR2","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1093\/hmg\/7.13.2135","volume":"7","author":"P Bonaldo","year":"1998","unstructured":"Bonaldo P, Braghetta P, Zanetti M, Piccolo S, Volpin D, Bressan GM (1998) Collagen VI deficiency induces early onset myopathy in the mouse: an animal model for Bethlem myopathy. Hum Mol Genet 7:2135\u20132140","journal-title":"Hum Mol Genet"},{"key":"763_CR3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0945-053X(98)00007-9","volume":"18","author":"L Bruckner-Tuderman","year":"1999","unstructured":"Bruckner-Tuderman L, Hopfner B, Hammami-Hauasli N (1999) Biology of anchoring fibrils: lessons from dystrophic epidermolysis bullosa. Matrix Biol 18:43\u201354","journal-title":"Matrix Biol"},{"key":"763_CR4","doi-asserted-by":"crossref","first-page":"26110","DOI":"10.1074\/jbc.271.42.26110","volume":"271","author":"MA Burg","year":"1996","unstructured":"Burg MA, Tillet E, Timpl R, Stallcup WB (1996) Binding of the NG2 proteoglycan to type VI collagen and other extracellular matrix molecules. J Biol Chem 271:26110\u201326116","journal-title":"J Biol Chem"},{"key":"763_CR5","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/1523-1747.ep12365129","volume":"101","author":"RE Burgeson","year":"1993","unstructured":"Burgeson RE (1993) Type VII collagen, anchoring fibrils, and epidermolysis bullosa. J Invest Dermatol 101:252\u2013255","journal-title":"J Invest Dermatol"},{"key":"763_CR6","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0955-0674(97)80118-4","volume":"9","author":"RE Burgeson","year":"1997","unstructured":"Burgeson RE, Christiano AM (1997) The dermal\u2013epidermal junction. Curr Opin Cell Biol 9:651\u2013658","journal-title":"Curr Opin Cell Biol"},{"key":"763_CR7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2741\/A196","volume":"15","author":"LS Chan","year":"1997","unstructured":"Chan LS (1997) Human skin basement membrane in health and in autoimmune diseases. Front Biosci 15:343\u2013352","journal-title":"Front Biosci"},{"key":"763_CR8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.modgep.2006.12.001","volume":"7","author":"R Chiotaki","year":"2007","unstructured":"Chiotaki R, Petrou P, Giakoumaki E, Pavlakis E, Sitaru C, Chalepakis G (2007) Spatiotemporal distribution of Fras1\/Frem proteins during mouse embryonic development. Gene Expr Patterns 7:381\u2013388","journal-title":"Gene Expr Patterns"},{"key":"763_CR9","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/cercor\/12.9.961","volume":"12","author":"Y Dalezios","year":"2002","unstructured":"Dalezios Y, Lujan R, Shigemoto R, Roberts JDB, Somogyi P (2002) Enrichment of mGluR7a in the presynaptic active zones of GABAergic and non-GABAergic terminals on interneurons in the rat somatosensory cortex. Cereb Cortex 12:961\u2013974","journal-title":"Cereb Cortex"},{"key":"763_CR10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00019605-199404000-00001","volume":"3","author":"S Darling","year":"1994","unstructured":"Darling S, Gossler A (1994) A mouse model for Fraser syndrome? Clin Dysmorphol 3:91\u201395","journal-title":"Clin Dysmorphol"},{"key":"763_CR11","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1177\/002215540004801001","volume":"48","author":"AC Erickson","year":"2000","unstructured":"Erickson AC, Couchman JR (2000) Still more complexity in mammalian basement membranes. J Histochem Cytochem 48:1291\u20131306","journal-title":"J Histochem Cytochem"},{"key":"763_CR12","doi-asserted-by":"crossref","first-page":"16831","DOI":"10.1074\/jbc.274.24.16831","volume":"274","author":"L Goretzki","year":"1999","unstructured":"Goretzki L, Burg MA, Grako KA, Stallcup WB (1999) High-affinity binding of basic fibroblast growth factor and platelet-derived growth factor-AA to the core protein of the NG2 proteoglycan. J Biol Chem 274:16831\u201316837","journal-title":"J Biol Chem"},{"key":"763_CR13","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1242\/jcs.112.21.3641","volume":"112","author":"S Heinonen","year":"1999","unstructured":"Heinonen S, Mannikko M, Klement JF, Whitaker-Menezes D, Murphy GF, Uitto J (1999) Targeted inactivation of the type VII collagen gene (Col7a1) in mice results in severe blistering phenotype: a model for recessive dystrophic epidermolysis bullosa. J Cell Sci 112:3641\u20133648","journal-title":"J Cell Sci"},{"key":"763_CR14","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/ng1549","volume":"37","author":"S Jadeja","year":"2005","unstructured":"Jadeja S, Smyth I, Pitera JE, Taylor MS, van Haelst M, Bentley E, McGregor L, Hopkins J, Chalepakis G, Philip N, Perez-Aytes A, Watt FM, Darling SM, Jackson I, Woolf AS, Scambler PJ (2005) Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs. Nat Genet 37:520\u2013525","journal-title":"Nat Genet"},{"key":"763_CR15","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1083\/jcb.104.3.611","volume":"104","author":"DR Keene","year":"1987","unstructured":"Keene DR, Sakai LY, Lunstrum GP, Morris NP, Burgeson RE (1987) Type VII collagen forms an extended network of anchoring fibrils. J Cell Biol 104:611\u2013621","journal-title":"J Cell Biol"},{"key":"763_CR16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.yexcr.2005.01.020","volume":"306","author":"D Kiyozumi","year":"2005","unstructured":"Kiyozumi D, Osada A, Sugimoto N, Weber CN, Ono Y, Imai T, Okada A, Sekiguchi K (2005) Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle. Exp Cell Res 306:9\u201323","journal-title":"Exp Cell Res"},{"key":"763_CR17","doi-asserted-by":"crossref","first-page":"11981","DOI":"10.1073\/pnas.0601011103","volume":"103","author":"D Kiyozumi","year":"2006","unstructured":"Kiyozumi D, Sugimoto N, Sekiguchi K (2006) Breakdown of the reciprocal stabilization of QBRICK\/Frem1 Fras1 and Frem2 at the basement membrane provokes Fraser syndrome-like defects. Proc Natl Acad Sci 103:11981\u201311986","journal-title":"Proc Natl Acad Sci"},{"key":"763_CR18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/ng1142","volume":"34","author":"L McGregor","year":"2003","unstructured":"McGregor L, Makela V, Darling SM, Vrontou S, Chalepakis G, Roberts C, Smart N, Rutland P, Prescott N, Hopkins J, Bentley E, Shaw A, Roberts E, Mueller R, Jadeja S, Philip N, Nelson J, Francannet C, Perez-Aytes A, Megarbane A, Kerr B, Wainwright B, Woolf AS, Winter RM, Scambler PJ (2003) Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1\/Fras1 encoding a putative extracellular matrix protein. Nat Genet 34:203\u2013208","journal-title":"Nat Genet"},{"key":"763_CR19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0923-1811(03)00045-8","volume":"31","author":"JR McMillan","year":"2003","unstructured":"McMillan JR, Akiyama M, Shimizu H (2003) Epidermal basement membrane zone components: ultrastructural distribution and molecular interactions. J Dermatol Sci 31:169\u2013177","journal-title":"J Dermatol Sci"},{"key":"763_CR20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s004280050197","volume":"432","author":"R Moll","year":"1998","unstructured":"Moll R, Moll I (1998) Epidermal adhesion molecules and basement membrane components as target structures of autoimmunity. Virchows Arch 432:487\u2013504","journal-title":"Virchows Arch"},{"key":"763_CR21","doi-asserted-by":"crossref","first-page":"10350","DOI":"10.1074\/jbc.M412368200","volume":"280","author":"P Petrou","year":"2005","unstructured":"Petrou P, Pavlakis E, Dalezios Y, Galanopoulos VK, Chalepakis G (2005) Basement membrane distortions impair lung lobation and capillary organization in the mouse model for Fraser syndrome. J Biol Chem 280:10350\u201310356","journal-title":"J Biol Chem"},{"key":"763_CR22","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.yexcr.2006.12.008","volume":"313","author":"P Petrou","year":"2007","unstructured":"Petrou P, Chiotaki R, Dalezios Y, Chalepakis G (2007) Overlapping and divergent localization of Frem1 and Fras1 and its functional implications during mouse embryonic development. Exp Cell Res 313:910\u2013920","journal-title":"Exp Cell Res"},{"key":"763_CR23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s100249900098","volume":"2","author":"NK Relan","year":"1999","unstructured":"Relan NK, Schuger L (1999) Basement membranes in development. Pediatr Dev Pathol 2:103\u2013118","journal-title":"Pediatr Dev Pathol"},{"key":"763_CR24","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1083\/jcb.103.4.1577","volume":"103","author":"LY Sakai","year":"1986","unstructured":"Sakai LY, Keene DR, Morris NP, Burgeson RE (1986) Type VII collagen is a major structural component of anchoring fibrils. J Cell Biol 103:1577\u20131586","journal-title":"J Cell Biol"},{"key":"763_CR25","first-page":"753","volume":"76","author":"H Shimizu","year":"1997","unstructured":"Shimizu H, Ishiko A, Masunaga T, Kurihara Y, Sato M, Bruckner-Tuderman L, Nishikawa T (1997) Most anchoring fibrils in human skin originate and terminate in the lamina densa. Lab Invest 76:753\u2013763","journal-title":"Lab Invest"},{"key":"763_CR26","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/jmg.39.9.623","volume":"39","author":"AM Slavotinek","year":"2002","unstructured":"Slavotinek AM, Tifft CJ (2002) Fraser syndrome and cryptophthalmos: Review of the diagnostic criteria and evidence for phenotypic modules in complex malformation syndromes. J Med Genet 39:623\u2013633","journal-title":"J Med Genet"},{"key":"763_CR27","doi-asserted-by":"crossref","first-page":"13560","DOI":"10.1073\/pnas.0402760101","volume":"101","author":"I Smyth","year":"2004","unstructured":"Smyth I, Du X, Taylor MS, Justice MJ, Beutler B, Jackson IJ (2004) The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. Proc Natl Acad Sci 101:13560\u201313565","journal-title":"Proc Natl Acad Sci"},{"key":"763_CR28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/hmg\/ddi262","volume":"2","author":"I Smyth","year":"2005","unstructured":"Smyth I, Scambler PJ (2005) The genetics of Fraser syndrome and the blebs mouse mutants. Hum Mol Genet 2:269\u2013274","journal-title":"Hum Mol Genet"},{"key":"763_CR29","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ng1292","volume":"36","author":"K Takamiya","year":"2004","unstructured":"Takamiya K, Kostourou V, Adams S, Jadeja S, Chalepakis G, Scambler PJ, Huganir RL, Adams RH (2004) A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1. Nat Genet 36:172\u2013177","journal-title":"Nat Genet"},{"key":"763_CR30","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/jcb.10268","volume":"86","author":"E Tillet","year":"2002","unstructured":"Tillet E, Gential B, Garrone R, Stallcup WB (2002) NG2 proteoglycan mediates beta1 integrin-independent cell adhesion and spreading on collagen VI. J Cell Biochem 86:726\u2013736","journal-title":"J Cell Biochem"},{"key":"763_CR31","doi-asserted-by":"crossref","first-page":"11746","DOI":"10.1073\/pnas.0505404102","volume":"102","author":"JR Timmer","year":"2005","unstructured":"Timmer JR, Mak TW, Manova K, Anderson KV, Niswander L (2005) Tissue morphogenesis and vascular stability require the Frem2 protein product of the mouse myelencephalic blebs gene. Proc Natl Acad Sci 102:11746\u201311750","journal-title":"Proc Natl Acad Sci"},{"key":"763_CR32","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1432-1033.1989.tb14673.x","volume":"180","author":"R Timpl","year":"1989","unstructured":"Timpl R (1989) Structure and biological activity of basement membrane proteins. Eur J Biochem 180:487\u2013502","journal-title":"Eur J Biochem"},{"key":"763_CR33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/ng1168","volume":"34","author":"S Vrontou","year":"2003","unstructured":"Vrontou S, Petrou P, Meyer BI, Galanopoulos VK, Imai K, Yanagi M, Chowdhury K, Scambler PJ, Chalepakis G (2003) Fras1 deficiency results in cryptophthalmos, renal agenesis and bleb phenotype in mice. Nat Genet 34:209\u2013214","journal-title":"Nat Genet"},{"key":"763_CR34","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1399-0004.1990.tb03539.x","volume":"37","author":"RM Winter","year":"1990","unstructured":"Winter RM (1990) Fraser syndrome and mouse \u2018bleb\u2019 mutants. Clin Genet 37:494\u2013495","journal-title":"Clin Genet"},{"key":"763_CR35","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.matbio.2003.10.006","volume":"22","author":"PD Yurchenco","year":"2004","unstructured":"Yurchenco PD, Amenta PS, Patton BL (2004) Basement membrane assembly stability and activities observed through a developmental lens. Matrix Biol 22:521\u2013538","journal-title":"Matrix Biol"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-007-0763-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00403-007-0763-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-007-0763-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,15]],"date-time":"2021-08-15T02:37:45Z","timestamp":1628995065000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00403-007-0763-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,19]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,8,16]]}},"alternative-id":["763"],"URL":"https:\/\/doi.org\/10.1007\/s00403-007-0763-8","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,19]]}}}