{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:27:01Z","timestamp":1780504021790,"version":"3.54.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2009,12,31]],"date-time":"2009-12-31T00:00:00Z","timestamp":1262217600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1007\/s00403-009-1019-6","type":"journal-article","created":{"date-parts":[[2009,12,30]],"date-time":"2009-12-30T05:11:39Z","timestamp":1262149899000},"page":"429-433","source":"Crossref","is-referenced-by-count":38,"title":["Effect of dihydrotestosterone on the upregulation of inflammatory cytokines in cultured sebocytes"],"prefix":"10.1007","volume":"302","author":[{"given":"Weon Ju","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Dae","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Geun","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Jong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Kyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Chul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,12,31]]},"reference":[{"key":"1019_CR1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/1523-1747.ep12616181","volume":"99","author":"H Akamatsu","year":"1992","unstructured":"Akamatsu H, Zouboulis CC, Orfanos CE (1992) Control of human sebocyte proliferation in vitro by testosterone and 5-\u03b1-dihydrotestosterone is dependent on the localization of the sebaceous glands. J Invest Dermatol 99:509\u2013511","journal-title":"J Invest Dermatol"},{"key":"1019_CR2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1677\/joe.0.1330467","volume":"133","author":"R Choudhry","year":"1992","unstructured":"Choudhry R, Hodgins MB, Van der Kwast TH, Brinkmann AO, Boersma WJ (1992) Localization of androgen receptors in human skin by immunohistochemistry: implications for the hormonal regulation of hair growth, sebaceous glands and sweat glands. J Endocrinol 133:467\u2013475","journal-title":"J Endocrinol"},{"key":"1019_CR3","volume-title":"Acne","author":"WJ Cunliffe","year":"1989","unstructured":"Cunliffe WJ (1989) Acne. Martin Dunitz, London"},{"key":"1019_CR4","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/BF02505281","volume":"288","author":"T Fujie","year":"1996","unstructured":"Fujie T, Shikiji T, Uchida N, Urano Y, Nagae H, Arase S (1996) Culture of cells derived from the human sebaceous glands under serum-free conditions without a biological feeder layer or specific matrices. Arch Dermatol Res 288:703\u2013708","journal-title":"Arch Dermatol Res"},{"key":"1019_CR5","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/jcbfm.2008.115","volume":"28","author":"RJ Gonzales","year":"2009","unstructured":"Gonzales RJ, Duckles SP, Krause DN (2009) Dihydrotestosterone stimulates cerebrovascular inflammation through NF\u03baB, modulating contractile function. J Cereb Blood Flow Metab 28:244\u2013253","journal-title":"J Cereb Blood Flow Metab"},{"key":"1019_CR6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/1523-1747.ep12329907","volume":"106","author":"R Guy","year":"1996","unstructured":"Guy R, Green MR, Kealey T (1996) Modeling acne in vitro. J Invest Dermatol 106:176\u2013182","journal-title":"J Invest Dermatol"},{"key":"1019_CR7","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1084\/jem.172.6.1609","volume":"172","author":"A K\u00f6ch","year":"1990","unstructured":"K\u00f6ch A, Schwarz T, Kirnbauer R, Urbanski A, Perry P, Ansel JC et al (1990) Human keratinocytes are a source for tumor necrosis factor \u03b1: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J Exp Med 172:1609\u20131614","journal-title":"J Exp Med"},{"key":"1019_CR8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00403-008-0854-1","volume":"300","author":"WJ Lee","year":"2008","unstructured":"Lee WJ, Jung HD, Lee HJ, Kim BS, Lee SJ, Kim DW (2008) Influence of substance-P on cultured sebocytes. Arch Dermatol Res 300:311\u2013316","journal-title":"Arch Dermatol Res"},{"key":"1019_CR9","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/1523-1747.ep12874944","volume":"95","author":"TA Luger","year":"1990","unstructured":"Luger TA, Schwarz T (1990) Evidence for an epidermal cytokine network. J Invest Dermatol 95:1005\u20131011","journal-title":"J Invest Dermatol"},{"key":"1019_CR10","first-page":"59","volume":"3","author":"MG Mercurio","year":"2000","unstructured":"Mercurio MG, Gogstetter DS (2000) Androgen physiology and the cutaneous pilosebaceous unit. J Gend Specif Med 3:59\u201364","journal-title":"J Gend Specif Med"},{"key":"1019_CR11","first-page":"687","volume-title":"Fitzpatrick\u2019s dermatology in general medicine","author":"AM Nelson","year":"2008","unstructured":"Nelson AM, Thiboutot DM (2008) Biology of sebaceous glands. In: Wolff K et al (eds) Fitzpatrick\u2019s dermatology in general medicine, 7th edn. McGraw-Hill, New York, pp 687\u2013690","edition":"7"},{"key":"1019_CR12","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/1523-1747.ep12471723","volume":"96","author":"M Partridge","year":"1991","unstructured":"Partridge M, Chantry D, Turner M, Feldmann M (1991) Production of IL-1 and and IL-6 by human keratinocytes and squamous cell carcinoma cell lines. J Invest Dermatol 96:771\u2013776","journal-title":"J Invest Dermatol"},{"key":"1019_CR13","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/1523-1747.ep12261252","volume":"56","author":"G Sansone","year":"1971","unstructured":"Sansone G, Reiser RM (1971) Differential rates of conversion of testosterone to dihydrotestosterone in acne and in normal human skin\u2014a possible pathogenic factor in acne. J Invest Dermatol 56:366\u2013372","journal-title":"J Invest Dermatol"},{"key":"1019_CR14","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/0022-202X(89)90193-0","volume":"93","author":"KH Singer","year":"1989","unstructured":"Singer KH, Tuck DT, Sampson HA, Hall RP (1989) Epidermal keratinocytes express the adhesion molecule intercellular adhesion molecule-1 in inflammatory dermatoses. J Invest Dermatol 93:746\u2013750","journal-title":"J Invest Dermatol"},{"key":"1019_CR15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/jid.1962.94","volume":"39","author":"JS Strauss","year":"1962","unstructured":"Strauss JS, Kligman AM, Pochi PE (1962) The effect of androgens and estrogens on human sebaceous glands. J Invest Dermatol 39:139\u2013155","journal-title":"J Invest Dermatol"},{"key":"1019_CR16","first-page":"4","volume":"76","author":"GF Webster","year":"2005","unstructured":"Webster GF (2005) The pathophysiology of acne. Cutis 76:4\u20137","journal-title":"Cutis"},{"key":"1019_CR17","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0031-3955(16)38158-5","volume":"38","author":"MH Winston","year":"1991","unstructured":"Winston MH, Shalita AR (1991) Acne vulgaris. Pathogenesis and treatment. Pediatr Clin North Am 38:889\u2013903","journal-title":"Pediatr Clin North Am"},{"key":"1019_CR18","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.clindermatol.2004.03.004","volume":"22","author":"CC Zouboulis","year":"2004","unstructured":"Zouboulis CC (2004) Acne and sebaceous gland function. Clin Dermatol 22:360\u2013366","journal-title":"Clin Dermatol"},{"key":"1019_CR19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1055\/s-2007-961807","volume":"39","author":"CC Zouboulis","year":"2007","unstructured":"Zouboulis CC, Chen WC, Thornton MJ, Qin K, Rosenfield R (2007) Sexual hormones in human skin. Horm Metab Res 39:85\u201395","journal-title":"Horm Metab Res"},{"key":"1019_CR20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000017861","volume":"196","author":"CC Zouboulis","year":"1998","unstructured":"Zouboulis CC, Xia L, Akamatsu H, Seltmann H, Fritsch M, Hornemann S et al (1998) The human sebocyte culture model provides new insights into development and management of seborrhea and acne. Dermatology 196:21\u201331","journal-title":"Dermatology"},{"key":"1019_CR21","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000210927","volume":"4","author":"CC Zouboulis","year":"1991","unstructured":"Zouboulis CC, Xia L, Detmar M, Bogdanoff B, Giannakopoulos G, Gollnick H et al (1991) Culture of human sebocytes and markers of sebocytic differentiation in vitro. Skin Pharmacol 4:74\u201383","journal-title":"Skin Pharmacol"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-009-1019-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00403-009-1019-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-009-1019-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T13:37:42Z","timestamp":1559050662000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00403-009-1019-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,31]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["1019"],"URL":"https:\/\/doi.org\/10.1007\/s00403-009-1019-6","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,31]]}}}