{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:00:09Z","timestamp":1777438809689,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,1,22]],"date-time":"2010-01-22T00:00:00Z","timestamp":1264118400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1007\/s00403-010-1028-5","type":"journal-article","created":{"date-parts":[[2010,1,21]],"date-time":"2010-01-21T03:44:27Z","timestamp":1264045467000},"page":"461-468","source":"Crossref","is-referenced-by-count":5,"title":["Cutaneous PGP 9.5 distribution patterns in hidradenitis suppurativa"],"prefix":"10.1007","volume":"302","author":[{"given":"Karin","family":"Sartorius","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Emtestam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Lapins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olle","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,1,22]]},"reference":[{"key":"1028_CR1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1365-2230.1995.tb01354.x","volume":"20","author":"MS Al\u2019Abadie","year":"1995","unstructured":"Al\u2019Abadie MS, Senior HJ, Bleehen SS, Gawkrodger DJ (1995) Neuropeptides and general neuronal marker in psoriasis\u2014an immunohistochemical study. Clin Exp Dermatol 20:384\u2013389","journal-title":"Clin Exp Dermatol"},{"key":"1028_CR2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000104863","volume":"13","author":"P Arck","year":"2006","unstructured":"Arck P, Paus R (2006) From the brain\u2013skin connection: the neuroendocrine-immune misalliance of stress and itch. Neuroimmunomodulation 13:347\u2013356","journal-title":"Neuroimmunomodulation"},{"key":"1028_CR3","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1038\/sj.jid.5700104","volume":"126","author":"PC Arck","year":"2006","unstructured":"Arck PC, Slominski A, Theoharides TC, Peters EM, Paus R (2006) Neuroimmunology of stress: skin takes center stage. J Invest Dermatol 126:1697\u20131704","journal-title":"J Invest Dermatol"},{"key":"1028_CR4","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1365-4632.2008.03723.x","volume":"47","author":"K Aroni","year":"2008","unstructured":"Aroni K, Grapsa A, Lazaris AC, Kavantzas N, Kordosis T, Patsouris ES (2008) Tissue estimation of protein gene product 9.5 (PGP 9.5) expression and apoptosis in vitiligo. Int J Dermatol 47:911\u2013917","journal-title":"Int J Dermatol"},{"key":"1028_CR5","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1365-2133.1996.tb03880.x","volume":"135","author":"J Boer","year":"1996","unstructured":"Boer J, Weltevreden EF (1996) Hidradenitis suppurativa or acne inversa. A clinicopathological study of early lesions. Br J Dermatol 135:721\u2013725","journal-title":"Br J Dermatol"},{"key":"1028_CR6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0002-9378(11)91446-X","volume":"167","author":"JW Bogers","year":"1992","unstructured":"Bogers JW, Minderhoud-Bassie W, Huikeshoven FJ (1992) A case of hidradenitis suppurativa treated with gonadotropin-releasing hormone agonist and by total abdominal hysterectomy with bilateral salpingo-oophorectomy. Am J Obstet Gynecol 167:517\u2013518","journal-title":"Am J Obstet Gynecol"},{"key":"1028_CR7","first-page":"543","volume":"34","author":"C Camisa","year":"1989","unstructured":"Camisa C, Sexton C, Friedman C (1989) Treatment of hidradenitis suppurativa with combination hypothalamic-pituitary-ovarian and adrenal suppression. A case report. J Reprod Med 34:543\u2013546","journal-title":"J Reprod Med"},{"key":"1028_CR8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jaad.2009.02.013","volume":"61","author":"F Canoui-Poitrine","year":"2009","unstructured":"Canoui-Poitrine F, Revuz JE, Wolkenstein P, Viallette C, Gabison G, Pouget F, Poli F, Faye O, Bastuji-Garin S (2009) Clinical characteristics of a series of 302 French patients with hidradenitis suppurativa, with an analysis of factors associated with disease severity. J Am Acad Dermatol 61:51\u201357","journal-title":"J Am Acad Dermatol"},{"key":"1028_CR9","doi-asserted-by":"crossref","unstructured":"Day IN, Thompson RJ (2009) UCHL1 (PGP 9.5): neuronal biomarker and ubiquitin system protein. Prog Neurobiol (Epub ahead of print)","DOI":"10.1016\/j.pneurobio.2009.10.020"},{"key":"1028_CR10","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1080\/08923970601067136","volume":"28","author":"H El-Nour","year":"2006","unstructured":"El-Nour H, Lundeberg L, Al-Tawil R, Granlund A, Lonne-Rahm SB, Nordlind K (2006) Upregulation of the axonal growth and the expression of substance P and its NK1 receptor in human allergic contact dermatitis. Immunopharmacol Immunotoxicol 28:621\u2013631","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"1028_CR11","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1111\/j.1468-3083.2009.03287.x","volume":"23","author":"H El-Nour","year":"2009","unstructured":"El-Nour H, Santos A, Nordin M, Jonsson P, Svensson M, Nordlind K, Berg M (2009) Neuronal changes in psoriasis exacerbation. J Eur Acad Dermatol Venereol 23:1240\u20131245","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1028_CR12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s004030000132","volume":"292","author":"E Hagforsen","year":"2000","unstructured":"Hagforsen E, Nordlind K, Michaelsson G (2000) Skin nerve fibres and their contacts with mast cells in patients with palmoplantar pustulosis. Arch Dermatol Res 292:269\u2013274","journal-title":"Arch Dermatol Res"},{"key":"1028_CR13","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S0190-9622(96)90277-7","volume":"34","author":"GB Jemec","year":"1996","unstructured":"Jemec GB, Hansen U (1996) Histology of hidradenitis suppurativa. J Am Acad Dermatol 34:994\u2013999","journal-title":"J Am Acad Dermatol"},{"key":"1028_CR14","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1365-2230.1996.tb00145.x","volume":"21","author":"GB Jemec","year":"1996","unstructured":"Jemec GB, Heidenheim M, Nielsen NH (1996) Hidradenitis suppurativa\u2014characteristics and consequences. Clin Exp Dermatol 21:419\u2013423","journal-title":"Clin Exp Dermatol"},{"key":"1028_CR15","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/BF00371926","volume":"283","author":"O Johansson","year":"1991","unstructured":"Johansson O, Han SW, Enhamre A (1991) Altered cutaneous innervation in psoriatic skin as revealed by PGP 9.5 immunohistochemistry. Arch Dermatol Res 283:519\u2013523","journal-title":"Arch Dermatol Res"},{"key":"1028_CR16","first-page":"43","volume":"4","author":"O Johansson","year":"1999","unstructured":"Johansson O, Wang L, Hilliges M, Liang Y (1999) Intraepidermal nerves in human skin: PGP 9.5 immunohistochemistry with special reference to the nerve density in skin from different body regions. J Peripher Nerv Syst 4:43\u201352","journal-title":"J Peripher Nerv Syst"},{"key":"1028_CR17","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/sj.jid.5701144","volume":"128","author":"CE Kleyn","year":"2008","unstructured":"Kleyn CE, Schneider L, Saraceno R, Mantovani C, Richards HL, Fortune DG, Cumberbatch M, Dearman RJ, Terenghi G, Kimber I, Griffiths CEM (2008) The effects of acute social stress on epidermal Langerhans\u2019 cell frequency and expression of cutaneous neuropeptides. J Invest Dermatol 128:1273\u20131279","journal-title":"J Invest Dermatol"},{"key":"1028_CR18","doi-asserted-by":"crossref","unstructured":"Laffert MV, Helmbold P, Wohlrab J, Fiedler E, Stadie V, Marsch WC (2009) Hidradenitis suppurativa (acne inversa): early inflammatory events at terminal follicles and at interfollicular epidermis*. Exp Dermatol (Epub ahead of print)","DOI":"10.1111\/j.1600-0625.2009.00915.x"},{"key":"1028_CR19","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0166-2236(96)10058-8","volume":"19","author":"R Levi-Montalcini","year":"1996","unstructured":"Levi-Montalcini R, Skaper SD, Dal Toso R, Petrelli L, Leon A (1996) Nerve growth factor: from neurotrophin to neurokine. Trends Neurosci 19:514\u2013520","journal-title":"Trends Neurosci"},{"key":"1028_CR20","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/BF00157874","volume":"25","author":"A Ljungberg","year":"1993","unstructured":"Ljungberg A, Johansson O (1993) Methodological aspects on immunohistochemistry in dermatology with special reference to neuronal markers. Histochem J 25:735\u2013745","journal-title":"Histochem J"},{"key":"1028_CR21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0923-1811(02)00103-2","volume":"30","author":"TA Luger","year":"2002","unstructured":"Luger TA (2002) Neuromediators\u2014a crucial component of the skin immune system. J Dermatol Sci 30:87\u201393","journal-title":"J Dermatol Sci"},{"key":"1028_CR22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1468-3083.1998.tb00736.x","volume":"10","author":"TA Luger","year":"1998","unstructured":"Luger TA, Lotti T (1998) Neuropeptides: role in inflammatory skin diseases. J Eur Acad Dermatol Venereol 10:207\u2013211","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1028_CR23","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00403-009-0962-6","volume":"301","author":"A Mastoraki","year":"2009","unstructured":"Mastoraki A, Ioannidis E, Patsouris E, Safioleas M, Aroni K (2009) PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas. Arch Dermatol Res 301:653\u2013658","journal-title":"Arch Dermatol Res"},{"key":"1028_CR24","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1046\/j.1523-1747.1998.00330.x","volume":"111","author":"JE Olerud","year":"1998","unstructured":"Olerud JE, Chiu DS, Usui ML, Gibran NS, Ansel JC (1998) Protein gene product 9.5 is expressed by fibroblasts in human cutaneous wounds. J Invest Dermatol 111:565\u2013572","journal-title":"J Invest Dermatol"},{"key":"1028_CR25","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/art.10303","volume":"46","author":"R Omdal","year":"2002","unstructured":"Omdal R, Mellgren SI, Goransson L, Skjesol A, Lindal S, Koldingsnes W, Husby G (2002) Small nerve fiber involvement in systemic lupus erythematosus: a controlled study. Arthritis Rheum 46:1228\u20131232","journal-title":"Arthritis Rheum"},{"key":"1028_CR26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.it.2005.10.002","volume":"27","author":"R Paus","year":"2006","unstructured":"Paus R, Theoharides TC, Arck PC (2006) Neuroimmunoendocrine circuitry of the \u2018brain\u2013skin connection\u2019. Trends Immunol 27:32\u201339","journal-title":"Trends Immunol"},{"key":"1028_CR27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000056237","volume":"70","author":"A Picardi","year":"2001","unstructured":"Picardi A, Abeni D (2001) Stressful life events and skin diseases: disentangling evidence from myth. Psychother Psychosom 70:118\u2013136","journal-title":"Psychother Psychosom"},{"key":"1028_CR28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000247232","volume":"187","author":"C Pincelli","year":"1993","unstructured":"Pincelli C, Fantini F, Giannetti A (1993) Neuropeptides and skin inflammation. Dermatology 187:153\u2013158","journal-title":"Dermatology"},{"key":"1028_CR29","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1089\/met.2005.3.113","volume":"3","author":"GL Pittenger","year":"2005","unstructured":"Pittenger GL, Mehrabyan A, Simmons K, Rice A, Dublin C, Barlow P, Vinik AI (2005) Small fiber neuropathy is associated with the metabolic syndrome. Metab Syndr Relat Disord 3:113\u2013121","journal-title":"Metab Syndr Relat Disord"},{"key":"1028_CR30","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.2337\/diacare.27.8.1974","volume":"27","author":"GL Pittenger","year":"2004","unstructured":"Pittenger GL, Ray M, Burcus NI, McNulty P, Basta B, Vinik AI (2004) Intraepidermal nerve fibers are indicators of small-fiber neuropathy in both diabetic and nondiabetic patients. Diabetes Care 27:1974\u20131979","journal-title":"Diabetes Care"},{"key":"1028_CR31","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1468-3083.2009.03356.x","volume":"23","author":"J Revuz","year":"2009","unstructured":"Revuz J (2009) Hidradenitis suppurativa. J Eur Acad Dermatol Venereol 23:985\u2013998","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1028_CR32","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jaad.2008.06.020","volume":"59","author":"JE Revuz","year":"2008","unstructured":"Revuz JE, Canoui-Poitrine F, Wolkenstein P, Viallette C, Gabison G, Pouget F, Poli F, Faye O, Roujeau JC, Bonnelye G, Grob JJ, Bastuji-Garin S (2008) Prevalence and factors associated with hidradenitis suppurativa: results from two case\u2013control studies. J Am Acad Dermatol 59:596\u2013601","journal-title":"J Am Acad Dermatol"},{"key":"1028_CR33","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1365-2133.2009.09198.x","volume":"161","author":"K Sartorius","year":"2009","unstructured":"Sartorius K, Emtestam L, Jemec GB, Lapins J (2009) Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity. Br J Dermatol 161:831\u2013839","journal-title":"Br J Dermatol"},{"key":"1028_CR34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000087012","volume":"211","author":"A Slominski","year":"2005","unstructured":"Slominski A (2005) Neuroendocrine system of the skin. Dermatology 211:199\u2013208","journal-title":"Dermatology"},{"key":"1028_CR35","first-page":"457","volume":"21","author":"A Slominski","year":"2000","unstructured":"Slominski A, Wortsman J (2000) Neuroendocrinology of the skin. Endocr Rev 21:457\u2013487","journal-title":"Endocr Rev"},{"key":"1028_CR36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s004030050167","volume":"289","author":"H Sugiura","year":"1997","unstructured":"Sugiura H, Omoto M, Hirota Y, Danno K, Uehara M (1997) Density and fine structure of peripheral nerves in various skin lesions of atopic dermatitis. Arch Dermatol Res 289:125\u2013131","journal-title":"Arch Dermatol Res"},{"key":"1028_CR37","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/0006-8993(83)90241-X","volume":"278","author":"RJ Thompson","year":"1983","unstructured":"Thompson RJ, Doran JF, Jackson P, Dhillon AP, Rode J (1983) PGP 9.5\u2014a new marker for vertebrate neurons and neuroendocrine cells. Brain Res 278:224\u2013228","journal-title":"Brain Res"},{"key":"1028_CR38","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/j.1464-5491.2009.02823.x","volume":"26","author":"NO Thomsen","year":"2009","unstructured":"Thomsen NO, Englund E, Thrainsdottir S, Rosen I, Dahlin LB (2009) Intraepidermal nerve fibre density at wrist level in diabetic and non-diabetic patients. Diabet Med 26:1120\u20131126","journal-title":"Diabet Med"},{"key":"1028_CR39","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0091-6749(92)90134-N","volume":"90","author":"D Tobin","year":"1992","unstructured":"Tobin D, Nabarro G, Baart de la Faille H, van Vloten WA, van der Putte SC, Schuurman HJ (1992) Increased number of immunoreactive nerve fibers in atopic dermatitis. J Allergy Clin Immunol 90:613\u2013622","journal-title":"J Allergy Clin Immunol"},{"key":"1028_CR40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00329435","volume":"261","author":"L Wang","year":"1990","unstructured":"Wang L, Hilliges M, Jernberg T, Wiegleb-Edstrom D, Johansson O (1990) Protein gene product 9.5-immunoreactive nerve fibres and cells in human skin. Cell Tissue Res 261:25\u201333","journal-title":"Cell Tissue Res"},{"key":"1028_CR41","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1046\/j.1468-3083.2000.00087.x","volume":"14","author":"JM der Werth von","year":"2000","unstructured":"von der Werth JM, Williams HC (2000) The natural history of hidradenitis suppurativa. J Eur Acad Dermatol Venereol 14:389\u2013392","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1028_CR42","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.clindermatol.2004.03.004","volume":"22","author":"CC Zouboulis","year":"2004","unstructured":"Zouboulis CC (2004) Acne and sebaceous gland function. Clin Dermatol 22:360\u2013366","journal-title":"Clin Dermatol"},{"issue":"Suppl 4","key":"1028_CR43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1600-0625.2004.00254.x","volume":"13","author":"CC Zouboulis","year":"2004","unstructured":"Zouboulis CC, Bohm M (2004) Neuroendocrine regulation of sebocytes\u2014a pathogenetic link between stress and acne. Exp Dermatol 13(Suppl 4):31\u201335","journal-title":"Exp Dermatol"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-010-1028-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00403-010-1028-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-010-1028-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T17:37:42Z","timestamp":1559065062000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00403-010-1028-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,22]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["1028"],"URL":"https:\/\/doi.org\/10.1007\/s00403-010-1028-5","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,22]]}}}