{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:08:40Z","timestamp":1777648120233,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s00403-014-1493-3","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T13:37:19Z","timestamp":1409060239000},"page":"915-920","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Characterization and profiling of immunomodulatory genes in resident mesenchymal stem cells reflect the Th1-Th17\/Th2 imbalance of psoriasis"],"prefix":"10.1007","volume":"306","author":[{"given":"A.","family":"Campanati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Orciani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Consales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Lazzarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ganzetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Di Benedetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Di Primio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Offidani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,8,27]]},"reference":[{"key":"1493_CR1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3899\/jrheum.120256","volume":"89","author":"F Atzeni","year":"2012","unstructured":"Atzeni F, Ventura D, Batticciotto A, Boccassini L, Sarzi-Puttini P (2012) Interleukin 6 blockade: tocilizumab in psoriatic arthritis. J Rheumatol Suppl 89:97\u201399","journal-title":"J Rheumatol Suppl"},{"issue":"Suppl 1","key":"1493_CR2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2165\/1153424-S0-000000000-00000","volume":"11","author":"A Campanati","year":"2010","unstructured":"Campanati A, Giuliodori K, Ganzetti G, Liberati G, Offidani AM (2010) A patient with psoriasis and vitiligo treated with etanercept. Am J Clin Dermatol 11(Suppl 1):46\u201348","journal-title":"Am J Clin Dermatol"},{"key":"1493_CR3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1365-2133.2012.10900.x","volume":"167","author":"A Campanati","year":"2012","unstructured":"Campanati A, Orciani M, Gorbi S, Regoli F, Di Primio R, Offidani A (2012) Effect of biologic therapies targeting tumour necrosis factor-\u03b1 on cutaneous mesenchymal stem cells in psoriasis. Br J Dermatol 167:68\u201376","journal-title":"Br J Dermatol"},{"key":"1493_CR4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2340\/00015555-1373","volume":"93","author":"A Campanati","year":"2013","unstructured":"Campanati A, Gesuita R, Giannoni M, Piraccini F, Sandroni L, Martina E, Conocchiari L, Bendia E, Di Sario A, Offidani A (2013) Role of small intestinal bacterial overgrowth and Helicobacter pylori infection in chronic spontaneous urticaria: a prospective analysis. Acta Derm Venereol 93:161\u2013164","journal-title":"Acta Derm Venereol"},{"key":"1493_CR5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00535-013-0769-2","volume":"48","author":"A Campanati","year":"2013","unstructured":"Campanati A, Ganzetti G, Di Sario A, Benedetti A, Offidani A (2013) Insulin resistance, serum insulin and HOMA-R. J Gastroenterol 48:673","journal-title":"J Gastroenterol"},{"key":"1493_CR6","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00535-012-0678-9","volume":"48","author":"A Campanati","year":"2013","unstructured":"Campanati A, Ganzetti G, Di Sario A, Damiani A, Sandroni L, Rosa L, Benedetti A, Offidani A (2013) The effect of etanercept on hepatic fibrosis risk in patients with non-alcoholic fatty liver disease, metabolic syndrome, and psoriasis. J Gastroenterol 48:839\u2013846","journal-title":"J Gastroenterol"},{"key":"1493_CR7","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1177\/1721727X1301100218","volume":"11","author":"A Campanati","year":"2013","unstructured":"Campanati A, Moroncini G, Ganzetti G, Pozniak KN, Goteri G, Giuliano A, Martina E, Liberati G, Ricotti F, Gabrielli A, Offidani A (2013) Adalimumab modulates angiogenesis in psoriatic skin. Eur J Inflamm 11:489\u2013498","journal-title":"Eur J Inflamm"},{"key":"1493_CR8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ad.2012.08.003","volume":"105","author":"JM Carrascosa","year":"2014","unstructured":"Carrascosa JM, Rocamora V, Fernandez-Torres RM, Jimenez-Puya R, Moreno JC, Coll-Puigserver N, Fonseca E (2014) Obesity and psoriasis: inflammatory nature of obesity, relationship between psoriasis and obesity, and therapeutic implications. Actas Dermosifiliogr 105:31\u201344","journal-title":"Actas Dermosifiliogr"},{"key":"1493_CR9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00403-007-0764-7","volume":"299","author":"M Groot de","year":"2007","unstructured":"de Groot M, Teunissen MB, Ortonne JP, Lambert JR, Naeyaert JM, Picavet DI, Arreaza MG, Simon JS, Kraan M, Bos JD, de Rie MA (2007) Expression of the chemokine receptor CCR5 in psoriasis and results of a randomized placebo controlled trial with a CCR5 inhibitor. Arch Dermatol Res 299:305\u2013313","journal-title":"Arch Dermatol Res"},{"key":"1493_CR10","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1517\/14712598.2013.848194","volume":"13","author":"C Simone De","year":"2013","unstructured":"De Simone C, Amerio P, Amoruso G, Bardazzi F, Campanati A, Conti A, Gisondi P, Gualdi G, Guarneri C, Leoni L, Loconsole F, Mazzotta A, Musumeci ML, Piaserico S, Potenza C, Prestinari F (2013) Immunogenicity of anti-TNF\u03b1 therapy in psoriasis: a clinical issue? Expert Opin Biol Ther 13:1673\u20131682","journal-title":"Expert Opin Biol Ther"},{"key":"1493_CR11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop Dj, Horwitz E (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315\u2013317","journal-title":"Cytotherapy"},{"key":"1493_CR12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2340\/00015555-1545","volume":"93","author":"AK Ekman","year":"2013","unstructured":"Ekman AK, Sigurdardottir G, Carlstr\u00f6m M, Kartul N, Jenmalm MC, Enerb\u00e4ck C (2013) Systemically elevated Th1-, Th2- and Th17-associated chemokines in psoriasis vulgaris before and after ultraviolet B treatment. Acta Derm Venereol 93:527\u2013531","journal-title":"Acta Derm Venereol"},{"key":"1493_CR13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/sji.12114","volume":"78","author":"JH Eysteinsd\u00f3ttir","year":"2013","unstructured":"Eysteinsd\u00f3ttir JH, Sigurgeirsson B, \u00d3lafsson JH, Fridriksson T, Agnarsson BA, Dav\u00ed\u00f0sson S, Valdimarsson H, L\u00fa\u00f0v\u00edksson BR (2013) The role of Th17\/Tc17 peripheral blood T cells in psoriasis and their positive therapeutic response. Scand J Immunol 78:529\u2013537","journal-title":"Scand J Immunol"},{"key":"1493_CR14","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.crohns.2012.05.023","volume":"6","author":"G Ganzetti","year":"2012","unstructured":"Ganzetti G, Campanati A, Offidani A (2012) Alopecia areata: a possible extraintestinal manifestation of Crohn\u2019s disease. J Crohns Colitis 6:962\u2013963","journal-title":"J Crohns Colitis"},{"key":"1493_CR15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1468-3083.2011.04372.x","volume":"27","author":"S Garcia-Rodriguez","year":"2013","unstructured":"Garcia-Rodriguez S, Arias-Santiago S, Perandr\u00e9s-L\u00f3pez R, Castellote L, Zumaquero E, Navarro P, Buend\u00eda-Eisman A, Ruiz JC, Orgaz-Molina J, Sancho J, Zubiaur M (2013) Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis. J Eur Acad Dermatol Venereol 27:242\u2013250","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1493_CR16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4081\/1208","volume":"52","author":"A Gigante","year":"2008","unstructured":"Gigante A, Manzotti S, Bevilacqua C, Orciani M, Di Primio R, Mattioli-Belmonte M (2008) Adult mesenchymal stem cells for bone and cartilage engineering: effect of scaffold materials. Eur J Histochem 52:169\u2013174","journal-title":"Eur J Histochem"},{"key":"1493_CR17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1089\/scd.2010.0040","volume":"20","author":"S Halfon","year":"2011","unstructured":"Halfon S, Abramov N, Grinblat B, Ginis I (2011) Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging. Stem Cells Dev 20:53\u201366","journal-title":"Stem Cells Dev"},{"key":"1493_CR18","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/jid.2009.65","volume":"129","author":"EG Harper","year":"2009","unstructured":"Harper EG, Guo C, Rizzo H, Lillis JV, Kurtz SE, Skorcheva I, Purdy D, Fitch E, Iordanov M, Blauvelt A (2009) Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J Invest Dermatol 129:2175\u20132183","journal-title":"J Invest Dermatol"},{"key":"1493_CR19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-2133.2012.10899.x","volume":"167","author":"Z He","year":"2012","unstructured":"He Z, Jin L, Liu ZF, Hu L, Dang EL, Feng ZZ, Li QJ, Wang G (2012) Elevated serum levels of interleukin 21 are associated with disease severity in patients with psoriasis. Serum IL-21 levels in patients with psoriasis are elevated and positively correlate with PASI scores. Br J Dermatol 167:191\u2013193","journal-title":"Br J Dermatol"},{"key":"1493_CR20","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-2613.2009.00669.x","volume":"90","author":"R Heidenreich","year":"2009","unstructured":"Heidenreich R, R\u00f6cken M, Ghoreschi K (2009) Angiogenesis drives psoriasis pathogenesis. Int J Exp Pathol 90:232\u2013248","journal-title":"Int J Exp Pathol"},{"key":"1493_CR21","author":"R Hou","year":"2014","unstructured":"Hou R, Yan H, Niu X, Chang W, An P, Wang C, Yang Y, Yan X, Li J, Liu R, Li X, Zhang K (2014) Gene expression profile of dermal mesenchymal stem cells from patients with psoriasis. J Eur Acad Dermatol Venereol. doi: 10.1111\/jdv.12420","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1493_CR22","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1093\/rheumatology\/kes432","volume":"52","author":"M Hughes","year":"2013","unstructured":"Hughes M, Chinoy H (2013) Successful use of tocilizumab in a patient with psoriatic arthritis. Rheumatology (Oxford) 52:1728\u20131729","journal-title":"Rheumatology (Oxford)"},{"key":"1493_CR23","first-page":"865","volume":"20","author":"D Kempuraj","year":"2010","unstructured":"Kempuraj D, Conti P, Vasiadi M, Alysandratos KD, Tagen M, Kalogeromitros D, Kourelis T, Gregoriou S, Makris M, Stavrianeas NG, Theoharides TC (2010) IL-32 is increased along with tryptase in lesional psoriatic skin and is up-regulated by substance P in human mast cells. Eur J Dermatol 20:865\u2013867","journal-title":"Eur J Dermatol"},{"key":"1493_CR24","doi-asserted-by":"crossref","first-page":"ii30","DOI":"10.1136\/ard.2004.031120","volume":"64","author":"J Krueger","year":"2005","unstructured":"Krueger J, Bowcock A (2005) Psoriasis pathophysiology: current concepts of pathogenesis. Ann Rheum Dis 64:ii30\u2013ii36","journal-title":"Ann Rheum Dis"},{"key":"1493_CR25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00441-013-1725-4","volume":"355","author":"R Lazzarini","year":"2014","unstructured":"Lazzarini R, Olivieri F, Ferretti C, Mattioli-Belmonte M, Di Primio R, Orciani M (2014) mRNAs and miRNAs profiling of mesenchymal stem cells derived from amniotic fluid and skin: the double face of the coin. Cell Tissue Res 355:121\u2013130","journal-title":"Cell Tissue Res"},{"key":"1493_CR26","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1155\/2013\/856056","volume":"35","author":"A Michalak-Stoma","year":"2013","unstructured":"Michalak-Stoma A, Bartosi\u0144ska J, Kowal M, Juszkiewicz-Borowiec M, Gerkowicz A, Chodorowska G (2013) Serum levels of selected Th17 and Th22 cytokines in psoriatic patients. Dis Markers 35:625\u2013631","journal-title":"Dis Markers"},{"key":"1493_CR27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1684\/ecn.2011.0294","volume":"22","author":"A Michalak-Stoma","year":"2011","unstructured":"Michalak-Stoma A, Pietrzak A, Szepietowski JC, Zalewska-Janowska A, Paszkowski T, Chodorowska G (2011) Cytokine network in psoriasis revisited. Eur Cytokine Netw 22:160\u2013168","journal-title":"Eur Cytokine Netw"},{"key":"1493_CR28","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/039463200802100312","volume":"21","author":"M Orciani","year":"2008","unstructured":"Orciani M, Emanuelli M, Martino C, Pugnaloni A, Tranquilli AL, Di Primio R (2008) Potential role of culture mediums for successful isolation and neuronal differentiation of amniotic fluid stem cells. Int J Immunopathol Pharmacol 21:595\u2013602","journal-title":"Int J Immunopathol Pharmacol"},{"key":"1493_CR29","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000270383","volume":"23","author":"M Orciani","year":"2010","unstructured":"Orciani M, Mariggi\u00f2 MA, Morabito C, Di Benedetto G, Di Primio R (2010) Functional characterization of calcium-signaling pathways of human skin-derived mesenchymal stem cells. Skin Pharmacol Physiol 23:124\u2013132","journal-title":"Skin Pharmacol Physiol"},{"key":"1493_CR30","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.freeradbiomed.2010.06.007","volume":"49","author":"M Orciani","year":"2010","unstructured":"Orciani M, Gorbi S, Benedetti M, Di Benedetto G, Mattioli-Belmonte M, Regoli F, Di Primio R (2010) Oxidative stress defense in human-skin-derived mesenchymal stem cells versus human keratinocytes: Different mechanisms of protection and cell selection. Free Radic Biol Med 49:830\u2013838","journal-title":"Free Radic Biol Med"},{"key":"1493_CR31","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1365-2133.2011.10438.x","volume":"165","author":"M Orciani","year":"2011","unstructured":"Orciani M, Campanati A, Salvolini E, Lucarini G, Di Benedetto G, Offidani A, Di Primio R (2011) The mesenchymal stem cell profile in psoriasis. Br J Dermatol 165:585\u2013592","journal-title":"Br J Dermatol"},{"key":"1493_CR32","first-page":"211","volume":"27","author":"M Orciani","year":"2013","unstructured":"Orciani M, Svegliati S, Gorbi S, Spadoni T, Lazzarini R, Regoli F, Di Primio R, Gabrielli A (2013) Alterations of ROS pathways in scleroderma begin at stem cell level. J Biol Regul Homeost Agents 27:211\u2013224","journal-title":"J Biol Regul Homeost Agents"},{"key":"1493_CR33","author":"L Puig","year":"2013","unstructured":"Puig L, L\u00f3pez A, Vilarrasa E, Garc\u00eda I (2013) Efficacy of biologics in the treatment of moderate-to-severe plaque psoriasis: a systematic review and meta-analysis of randomized controlled trials with different time points. J Eur Acad Dermatol Venereol. doi: 10.1111\/jdv.12238","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1493_CR34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12016-012-8307-1","volume":"44","author":"SP Raychaudhuri","year":"2013","unstructured":"Raychaudhuri SP (2013) Role of IL-17 in psoriasis and psoriatic arthritis. Clin Rev Allergy Immunol 44:183\u2013193","journal-title":"Clin Rev Allergy Immunol"},{"key":"1493_CR35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00403-009-1018-7","volume":"302","author":"E Salvolini","year":"2010","unstructured":"Salvolini E, Lucarini G, Zizzi A, Orciani M, Di Benedetto G, Di Primio R (2010) Human skin-derived mesenchymal stem cells as a source of VEGF and nitric oxide. Arch Dermatol Res 302:367\u2013374","journal-title":"Arch Dermatol Res"},{"key":"1493_CR36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2362.2010.02370.x","volume":"41","author":"E Salvolini","year":"2011","unstructured":"Salvolini E, Orciani M, Lucarini G, Vignini A, Tranquilli AL, Di Primio R (2011) VEGF and nitric oxide synthase immunoexpression in Down\u2019s syndrome amniotic fluid stem cells. Eur J Clin Invest 41:23\u201329","journal-title":"Eur J Clin Invest"},{"key":"1493_CR37","doi-asserted-by":"crossref","first-page":"e34594","DOI":"10.1371\/journal.pone.0034594","volume":"7","author":"WR Swindell","year":"2012","unstructured":"Swindell WR, Xing X, Stuart PE, Chen CS, Aphale A, Nair RP, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE (2012) Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis. PLoS ONE 7:e34594","journal-title":"PLoS ONE"},{"key":"1493_CR38","author":"JM Reek van den","year":"2014","unstructured":"van den Reek JM, van L\u00fcmig PP, Otero ME, Zweegers J, van de Kerkhof PC, Ossenkoppele PM, Njoo MD, Mommers JM, Koetsier MI, Arnold WP, Sybrandy-Fleuren BA, Kuijpers AL, Andriessen MP, Seyger MM, Kievit W, de Jong EM (2014) Satisfaction with medication is high for biologics in psoriasis. Results from the BioCAPTURE network. Br J Dermatol. doi: 10.1111\/bjd.12862","journal-title":"Br J Dermatol"},{"key":"1493_CR39","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/j.1529-8019.2010.01306.x","volume":"23","author":"U Wollina","year":"2010","unstructured":"Wollina U, Unger L, Heinig B, Kittner T (2010) Psoriatic arthritis. Dermatol Ther 23:1231\u20131236","journal-title":"Dermatol Ther"},{"key":"1493_CR40","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1001\/jamadermatol.2013.5015","volume":"149","author":"H Yeung","year":"2013","unstructured":"Yeung H, Takeshita J, Mehta NN, Kimmel SE, Ogdie A, Margolis DJ, Shin DB, Attor R, Troxel AB, Gelfand JM (2013) Psoriasis severity and the prevalence of major medical comorbidity: a population-based study. JAMA Dermatol 149:1173\u20131179","journal-title":"JAMA Dermatol"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-014-1493-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00403-014-1493-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-014-1493-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T18:36:49Z","timestamp":1598207809000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00403-014-1493-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,27]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1493"],"URL":"https:\/\/doi.org\/10.1007\/s00403-014-1493-3","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,27]]}}}