{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:21:43Z","timestamp":1786980103449,"version":"build-2736575974"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T00:00:00Z","timestamp":1426723200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s00403-015-1558-y","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T15:42:53Z","timestamp":1426693373000},"page":"569-581","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Topical glucocorticoid or pimecrolimus treatment suppresses thymic stromal lymphopoietin-related allergic inflammatory mechanism in an oxazolone-induced atopic dermatitis murine model"],"prefix":"10.1007","volume":"307","author":[{"given":"Na Young","family":"Yoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min young","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hye","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eung Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,3,19]]},"reference":[{"key":"1558_CR1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/sj.jid.5701099","volume":"128","author":"KM Aberg","year":"2008","unstructured":"Aberg KM, Man MQ, Gallo RL, Ganz T, Crumrine D, Brown BE, Choi EH, Kim DK, Schroder JM, Feingold KR, Elias PM (2008) Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol 128:917\u2013925","journal-title":"J Invest Dermatol"},{"key":"1558_CR2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1084\/jem.20062211","volume":"204","author":"Z Allakhverdi","year":"2007","unstructured":"Allakhverdi Z, Comeau MR, Jessup HK, Yoon BR, Brewer A, Chartier S, Paquette N, Ziegler SF, Sarfati M, Delespesse G (2007) Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J Exp Med 204:253\u2013258","journal-title":"J Exp Med"},{"key":"1558_CR3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S1382-6689(97)10045-X","volume":"4","author":"RL Bergmann","year":"1997","unstructured":"Bergmann RL, Wahn U, Bergmann KE (1997) The allergy march: from food to pollen. Environ Toxicol Pharmacol 4:79\u201383","journal-title":"Environ Toxicol Pharmacol"},{"key":"1558_CR4","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20082242","volume":"206","author":"A Briot","year":"2009","unstructured":"Briot A, Deraison C, Lacroix M, Bonnart C, Robin A, Besson C, Dubus P, Hovnanian A (2009) Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome. J Exp Med 206:1135\u20131147","journal-title":"J Exp Med"},{"key":"1558_CR5","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1038\/jid.2010.233","volume":"130","author":"A Briot","year":"2010","unstructured":"Briot A, Lacroix M, Robin A, Steinhoff M, Deraison C, Hovnanian A (2010) Par2 inactivation inhibits early production of TSLP, but not cutaneous inflammation, in Netherton syndrome adult mouse model. J Invest Dermatol 130:2736\u20132742","journal-title":"J Invest Dermatol"},{"key":"1558_CR6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/18223","volume":"398","author":"TM Cocks","year":"1999","unstructured":"Cocks TM, Fong B, Chow JM, Anderson GP, Frauman AG, Goldie RG, Henry PJ, Carr MJ, Hamilton J, Moffatt JD (1999) A protective role for protease activated receptors in the airways. Nature 398:156\u2013160","journal-title":"Nature"},{"key":"1558_CR7","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/jid.2009.133","volume":"129","author":"MJ Cork","year":"2009","unstructured":"Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane ME, Moustafa M, Guy RH, Macgowan AL, Tazi-Ahnini R, Ward SJ (2009) Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol 129:1892\u20131908","journal-title":"J Invest Dermatol"},{"key":"1558_CR8","doi-asserted-by":"crossref","first-page":"e1000067","DOI":"10.1371\/journal.pbio.1000067","volume":"7","author":"S Demehri","year":"2009","unstructured":"Demehri S, Morimoto M, Holtzman MJ, Kopan R (2009) Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol 7:e1000067","journal-title":"PLoS Biol"},{"key":"1558_CR9","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1371\/journal.pbio.0060123","volume":"6","author":"S Demehri","year":"2008","unstructured":"Demehri S, Liu Z, Lee J et al (2008) Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol 6:e123","journal-title":"PLoS Biol"},{"key":"1558_CR10","doi-asserted-by":"crossref","first-page":"e9258","DOI":"10.1371\/journal.pone.0009258","volume":"5","author":"A Dumortier","year":"2010","unstructured":"Dumortier A, Durham AD (2010) Di Piazza M (2010) Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One 5:e9258","journal-title":"PLoS One"},{"key":"1558_CR11","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jaci.2007.01.003","volume":"119","author":"S Ebner","year":"2007","unstructured":"Ebner S, Nguyen VA, Forstner M, Wang YH, Wolfram D, Liu YJ, Romani N (2007) Thymic stromal lymphopoietin converts human epidermal Langerhans cells into antigen-presenting cells that induce proallergic T cells. J Allergy Clin Immunol 119:982\u2013990","journal-title":"J Allergy Clin Immunol"},{"key":"1558_CR12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jdermsci.2009.02.002","volume":"54","author":"MM El-Batawy","year":"2009","unstructured":"El-Batawy MM, Bosseila MA, Mashaly HM, Hafez VS (2009) Topical calcineurin inhibitors in atopic dermatitis: a systematic review and meta-analysis. J Dermatol Sci 54:76\u201387","journal-title":"J Dermatol Sci"},{"key":"1558_CR13","first-page":"533","volume":"13","author":"Z Fehervari","year":"2012","unstructured":"Fehervari Z (2012) TSLP underlies the atopic march. Nat Immunol 13:533","journal-title":"Nat Immunol"},{"key":"1558_CR14","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1084\/jem.20112258","volume":"209","author":"CW Franzke","year":"2012","unstructured":"Franzke CW, Cobzaru C, Triantafyllopoulou A et al (2012) Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation. J Exp Med 209:1105\u20131119","journal-title":"J Exp Med"},{"key":"1558_CR15","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/mi.2012.14","volume":"5","author":"H Han","year":"2012","unstructured":"Han H, Xu W, Headley MB, Jessup HK, Lee KS, Omori M, Comeau MR, Marshak-Rothstein A, Ziegler SF (2012) Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma. Mucosal Immunol 5:342\u2013351","journal-title":"Mucosal Immunol"},{"key":"1558_CR16","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1038\/jid.2011.144","volume":"131","author":"Y Hatano","year":"2011","unstructured":"Hatano Y, Elias PM, Crumrine D, Feingold KR, Katagiri K, Fujiwara S (2011) Efficacy of combined peroxisome proliferator-activated receptor-alpha ligand and glucocorticoid therapy in a murine model of atopic dermatitis. J Invest Dermatol 131:1845\u20131852","journal-title":"J Invest Dermatol"},{"key":"1558_CR17","doi-asserted-by":"crossref","first-page":"11875","DOI":"10.1073\/pnas.0801532105","volume":"105","author":"R He","year":"2008","unstructured":"He R, Oyoshi MK, Garibyan L, Kumar L, Ziegler SF, Geha RS (2008) TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. Proc Natl Acad Sci USA 105:11875\u201311880","journal-title":"Proc Natl Acad Sci USA"},{"key":"1558_CR18","first-page":"607","volume":"58","author":"D Jenerowicz","year":"2005","unstructured":"Jenerowicz D, Czarnecka-Operacz M, Silny W (2005) Corticosteroid phobia in patients with atopic dermatitis. Wiad Lek 58:607\u2013615","journal-title":"Wiad Lek"},{"key":"1558_CR19","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/jid.2010.344","volume":"131","author":"YJ Jung","year":"2011","unstructured":"Jung YJ, Jung M, Kim M, Hong SP, Choi EH (2011) IL-1alpha stimulation restores epidermal permeability and antimicrobial barriers compromised by topical tacrolimus. J Invest Dermatol 131:698\u2013705","journal-title":"J Invest Dermatol"},{"key":"1558_CR20","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.4049\/jimmunol.0900904","volume":"183","author":"H Kouzaki","year":"2009","unstructured":"Kouzaki H, O\u2019Grady SM, Lawrence CB, Kita H (2009) Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2. J Immunol 183:1427\u20131434","journal-title":"J Immunol"},{"key":"1558_CR21","doi-asserted-by":"crossref","first-page":"e457","DOI":"10.1111\/j.1399-3038.2009.00919.x","volume":"21","author":"EB Lee","year":"2010","unstructured":"Lee EB, Kim KW, Hong JY, Jee HM, Sohn MH, Kim KE (2010) Increased serum thymic stromal lymphopoietin in children with atopic dermatitis. Pediatr Allergy Immunol 21:e457\u2013e460","journal-title":"Pediatr Allergy Immunol"},{"key":"1558_CR22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.5021\/ad.2012.24.2.181","volume":"24","author":"HJ Lee","year":"2012","unstructured":"Lee HJ, Jung M, Kim JH, Yoon NY, Choi EH (2012) The effect of adipose-derived stem cell-cultured media on oxazolone treated atopic dermatitis-like murine model. Ann Dermatol 24:181\u2013188","journal-title":"Ann Dermatol"},{"key":"1558_CR23","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/j.1398-9995.2009.02032.x","volume":"64","author":"TA Le","year":"2009","unstructured":"Le TA, Takai T, Kinoshita H, Suto H, Ikeda S, Okumura K, Ogawa H (2009) Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids. Allergy 64:1231\u20131232","journal-title":"Allergy"},{"key":"1558_CR24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000301576","volume":"153","author":"TA Le","year":"2010","unstructured":"Le TA, Takai T, Vu AT, Kinoshita H, Ikeda S, Ogawa H, Okumura K (2010) Glucocorticoids inhibit double-stranded RNA-induced thymic stromal lymphopoietin release from keratinocytes in an atopic cytokine milieu more effectively than tacrolimus. Int Arch Allergy Immunol 153:27\u201334","journal-title":"Int Arch Allergy Immunol"},{"key":"1558_CR25","doi-asserted-by":"crossref","first-page":"11736","DOI":"10.1073\/pnas.0604575103","volume":"103","author":"M Li","year":"2006","unstructured":"Li M, Hener P, Zhang Z, Kato S, Metzger D, Chambon P (2006) Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci USA 103:11736\u201311741","journal-title":"Proc Natl Acad Sci USA"},{"key":"1558_CR26","doi-asserted-by":"crossref","first-page":"e15842","DOI":"10.1371\/journal.pone.0015842","volume":"6","author":"HY Lin","year":"2011","unstructured":"Lin HY, Kao CH, Lin KM, Kaartinen V, Yang LT (2011) Notch signaling regulates late-stage epidermal differentiation and maintains postnatal hair cycle homeostasis. PLoS One 6:e15842","journal-title":"PLoS One"},{"key":"1558_CR27","first-page":"816","volume":"12","author":"H Liu","year":"2010","unstructured":"Liu H, Pan JH, Lou WL, He JG (2010) Effects of inhaled budesonide on the bronchial-pulmonary pathology and expression of thymic stromal lymphopoietin in lung tissues in asthmatic rats. Zhongguo Dang Dai Er Ke Za Zhi 12:816\u2013819","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"1558_CR28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1084\/jem.20051745","volume":"203","author":"YJ Liu","year":"2006","unstructured":"Liu YJ (2006) Thymic stromal lymphopoietin: master switch for allergic inflammation. J Exp Med 203:269\u2013273","journal-title":"J Exp Med"},{"key":"1558_CR29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.jid.5701011","volume":"128","author":"MQ Man","year":"2008","unstructured":"Man MQ, Hatano Y, Lee SH, Man M, Chang S, Feingold KR, Leung DY, Holleran W, Uchida Y, Elias PM (2008) Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges. J Invest Dermatol 128:79\u201386","journal-title":"J Invest Dermatol"},{"key":"1558_CR30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1523-1747.2003.12331.x","volume":"121","author":"JG Meingassner","year":"2003","unstructured":"Meingassner JG, Fahrngruber H, Bavandi A (2003) Pimecrolimus inhibits the elicitation phase but does not suppress the sensitization phase in murine contact hypersensitivity, in contrast to tacrolimus and cyclosporine A. J Invest Dermatol 121:77\u201380","journal-title":"J Invest Dermatol"},{"key":"1558_CR31","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/exd.12460","volume":"23","author":"BC Melnik","year":"2014","unstructured":"Melnik BC (2014) Does therapeutic intervention in atopic dermatitis normalize epidermal Notch deficiency? Exp Dermatol 23:696\u2013700","journal-title":"Exp Dermatol"},{"key":"1558_CR32","doi-asserted-by":"crossref","unstructured":"Melnik BC (2014) The potential role of impaired Notch signalling in atopic dermatitis. Acta Derm Venereol May [Epub ahead of print]","DOI":"10.2340\/00015555-1898"},{"key":"1558_CR33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.immuni.2012.01.005","volume":"36","author":"A Murthy","year":"2012","unstructured":"Murthy A, Shao YW, Narala S et al (2012) Notch activation by the metalloproteinase ADAM17 regulates myeloproliferation and atopic barrier immunity by suppressing epithelial cytokine synthesis. Immunity 36:105\u2013119","journal-title":"Immunity"},{"key":"1558_CR34","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1056\/NEJMoa021481","volume":"347","author":"PY Ong","year":"2002","unstructured":"Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, Gallo RL, Leung DY (2002) Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 347:1151\u20131160","journal-title":"N Engl J Med"},{"key":"1558_CR35","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3109\/s10165-007-0620-9","volume":"17","author":"T Ozawa","year":"2007","unstructured":"Ozawa T, Koyama K, Ando T, Ohnuma Y, Hatsushika K, Ohba T, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A (2007) Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors\/nuclear factor-kappaB pathway and interferon-gamma\/dexamethasone. Mod Rheumatol 17:459\u2013463","journal-title":"Mod Rheumatol"},{"key":"1558_CR36","first-page":"127","volume":"127","author":"R Palatsi","year":"2011","unstructured":"Palatsi R, Hagg P (2011) The immune response against microbial infections in the skin\u2013weak in atopic dermatitis and strong in psoriasis. Duodecim 127:127\u2013134","journal-title":"Duodecim"},{"key":"1558_CR37","first-page":"279425","volume":"2011","author":"A Patrizi","year":"2011","unstructured":"Patrizi A, Pileri A, Bellini F, Raone B, Neri I, Ricci G (2011) Atopic dermatitis and the atopic march: what is new? J Allergy (Cairo) 2011:279425","journal-title":"J Allergy (Cairo)"},{"key":"1558_CR38","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrm910","volume":"3","author":"V Soumelis","year":"2002","unstructured":"Soumelis V, Reche PA, Kanzler H, Yuan W, Edward G, Homey B, Gilliet M, Ho S, Antonenko S, Lauerma A, Smith K, Gorman D, Zurawski S, Abrams J, Menon S, McClanahan T, de Waal-Malefyt RdR, Bazan F, Kastelein RA, Liu YJ (2002) Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 3:673\u2013680","journal-title":"Nat Immunol"},{"key":"1558_CR39","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1016\/j.jaci.2003.09.033","volume":"112","author":"JM Spergel","year":"2003","unstructured":"Spergel JM, Paller AS (2003) Atopic dermatitis and the atopic march. J Allergy Clin Immunol 112:S118\u2013S127","journal-title":"J Allergy Clin Immunol"},{"key":"1558_CR40","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1242\/dev.055210","volume":"138","author":"S Weber","year":"2011","unstructured":"Weber S, Niessen MT, Prox J et al (2011) The disintegrin\/metalloproteinase Adam10 is essential for epidermal integrity and notch-mediated signaling. Development 138:495\u2013505","journal-title":"Development"},{"key":"1558_CR41","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1172\/JCI115884","volume":"90","author":"LC Wood","year":"1992","unstructured":"Wood LC, Jackson SM, Elias PM, Grunfeld C, Feingold KR (1992) Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice. J Clin Invest 90:482\u2013487","journal-title":"J Clin Invest"},{"key":"1558_CR42","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/eji.201142123","volume":"42","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Zhou X, Zhou B (2012) DC-derived TSLP promotes Th2 polarization in LPS-primed allergic airway inflammation. Eur J Immunol 42:1735\u20131743","journal-title":"Eur J Immunol"},{"key":"1558_CR43","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ni.1852","volume":"11","author":"SF Ziegler","year":"2010","unstructured":"Ziegler SF, Artis D (2010) Sensing the outside world: TSLP regulates barrier immunity. Nat Immunol 11:289\u2013293","journal-title":"Nat Immunol"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-015-1558-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00403-015-1558-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-015-1558-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T23:47:36Z","timestamp":1566431256000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00403-015-1558-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,19]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["1558"],"URL":"https:\/\/doi.org\/10.1007\/s00403-015-1558-y","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,19]]}}}