{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:30:32Z","timestamp":1793406632857,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T00:00:00Z","timestamp":1454889600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s00403-016-1626-y","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T04:12:55Z","timestamp":1454904775000},"page":"229-237","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Resistin gene polymorphisms are associated with acne and serum lipid levels, providing a potential nexus between lipid metabolism and inflammation"],"prefix":"10.1007","volume":"308","author":[{"given":"Sidra","family":"Younis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Blumenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qamar","family":"Javed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,8]]},"reference":[{"issue":"6","key":"1626_CR1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1590\/S0100-879X2009000600005","volume":"42","author":"KO Abulnaja","year":"2009","unstructured":"Abulnaja KO (2009) Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris. Braz J Med Biol Res 42(6):501\u2013505","journal-title":"Braz J Med Biol Res"},{"key":"1626_CR2","author":"NM Aisha","year":"2015","unstructured":"Aisha NM, Haroon J, Hussain S, Tahir CM, Ikramullah M, Rahim H, Kishwar N, Younis S, Hassan MJ, Javed Q (2015) Association between tumour necrosis-\u03b1 gene polymorphisms and acne vulgaris in a Pakistani population. Clin Exp Dermatol. doi: 10.1111\/ced.12757","journal-title":"Clin Exp Dermatol"},{"issue":"18","key":"1626_CR3","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.clinbiochem.2010.09.010","volume":"43","author":"MK Arora","year":"2010","unstructured":"Arora MK, Seth S, Dayal S (2010) The relationship of lipid profile and menstrual cycle with acne vulgaris. Clin Biochem 43(18):1415\u20131420","journal-title":"Clin Biochem"},{"issue":"2","key":"1626_CR4","first-page":"141","volume":"39","author":"SA Asim","year":"2014","unstructured":"Asim SA, Ali A, Nisa QU, Salam JU, Siddiqui MH (2014) Dermatological manifestations in obese patients presenting in out patient department. Rawal Med J 39(2):141\u2013144","journal-title":"Rawal Med J"},{"issue":"Suppl 1","key":"1626_CR5","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.4103\/2229-5178.144506","volume":"5","author":"OA Bakry","year":"2014","unstructured":"Bakry OA, El Shazly RM, El Farargy SM, Kotb D (2014) Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females. Indian Dermatol Online J 5(Suppl 1):S9\u2013S16","journal-title":"Indian Dermatol Online J"},{"issue":"6","key":"1626_CR6","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1046\/j.1523-1747.2002.19621.x","volume":"119","author":"V Bataille","year":"2002","unstructured":"Bataille V, Snieder H, MacGregor AJ, Sasieni P, Spector TD (2002) The influence of genetics and environmental factors in the pathogenesis of acne: a twin study of acne in women. J Invest Dermatol 119(6):1317\u20131322","journal-title":"J Invest Dermatol"},{"issue":"9","key":"1626_CR7","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s100380170040","volume":"46","author":"H Cao","year":"2001","unstructured":"Cao H, Hegele RA (2001) Single nucleotide polymorphisms of the resistin (RSTN) gene. J Hum Genet 46(9):553\u2013555","journal-title":"J Hum Genet"},{"issue":"3","key":"1626_CR8","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00125-003-1319-x","volume":"47","author":"YM Cho","year":"2004","unstructured":"Cho YM, Youn BS, Chung SS, Kim KW, Lee HK, Yu KY, Park HJ, Shin HD, Park KS (2004) Common genetic polymorphisms in the promoter of resistin gene are major determinants of plasma resistin concentrations in humans. Diabetologia 47(3):559\u2013565","journal-title":"Diabetologia"},{"issue":"4","key":"1626_CR9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/ajcn\/25.4.365","volume":"25","author":"DT Downing","year":"1972","unstructured":"Downing DT, Strauss JS, Pochi PE (1972) Changes in skin surface lipid composition induced by severe caloric restriction in man. Am J Clin Nutr 25(4):365\u2013367","journal-title":"Am J Clin Nutr"},{"issue":"9","key":"1626_CR10","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1038\/jid.2009.47","volume":"129","author":"SZ Ghodsi","year":"2009","unstructured":"Ghodsi SZ, Orawa H, Zouboulis CC (2009) Prevalence, severity, and severity risk factors of acne in high school pupils: a community-based study. J Invest Dermatol 129(9):2136\u20132141","journal-title":"J Invest Dermatol"},{"issue":"6","key":"1626_CR11","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1038\/sj.jid.5700743","volume":"127","author":"WJ Harrison","year":"2007","unstructured":"Harrison WJ, Bull JJ, Seltmann H, Zouboulis CC, Philpott MP (2007) Expression of lipogenic factors galectin-12, resistin, SREBP-1, and SCD in human sebaceous glands and cultured sebocytes. J Invest Dermatol 127(6):1309\u20131317","journal-title":"J Invest Dermatol"},{"issue":"2","key":"1626_CR12","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.febslet.2004.12.010","volume":"579","author":"SW Huang","year":"2005","unstructured":"Huang SW, Seow KM, Ho LT, Chien Y, Chung DY, Chang CL, Lai YH, Hwang JL, Juan CC (2005) Resistin mRNA levels are downregulated by estrogen in vivo and in vitro. FEBS Lett 579(2):449\u2013454","journal-title":"FEBS Lett"},{"issue":"5","key":"1626_CR13","first-page":"526","volume":"18","author":"S Hussain","year":"2015","unstructured":"Hussain S, Faraz A, Iqbal T (2015) The RETN gene rs1862513 polymorphism as a novel predisposing marker for familial acne vulgaris in a Pakistani population. Iran J Basic Med Sci 18(5):526\u2013528","journal-title":"Iran J Basic Med Sci"},{"issue":"2","key":"1626_CR14","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/jcb.24374","volume":"114","author":"SW Kang","year":"2013","unstructured":"Kang SW, Kim MS, Kim HS, Kim Y, Shin D, Park JH, Kang YH (2013) Celastrol attenuates adipokine resistin-associated matrix interaction and migration of vascular smooth muscle cells. J Cell Biochem 114(2):398\u2013408","journal-title":"J Cell Biochem"},{"issue":"2","key":"1626_CR15","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bbrc.2003.07.003","volume":"309","author":"S Kaser","year":"2003","unstructured":"Kaser S, Kaser A, Sandhofer A, Ebenbichler CF, Tilg H, Patsch JR (2003) Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. Biochem Biophys Res Commun 309(2):286\u2013290","journal-title":"Biochem Biophys Res Commun"},{"key":"1626_CR16","author":"D Kov\u00e1cs","year":"2015","unstructured":"Kov\u00e1cs D, Lov\u00e1szi M, P\u00f3liska S, Ol\u00e1h A, B\u00edr\u00f3 T, Veres I, Zouboulis CC, St\u00e5hle M, R\u00fchl R, Remenyik \u00c9, T\u00f6r\u0151csik D (2015) Sebocytes differentially express and secrete adipokines. Exp Dermatol. doi: 10.1111\/exd.12879","journal-title":"Exp Dermatol"},{"issue":"3","key":"1626_CR17","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.cmet.2014.01.013","volume":"19","author":"S Lee","year":"2014","unstructured":"Lee S, Lee HC, Kwon YW, Lee SE, Cho Y, Kim J, Lee S, Kim JY, Lee J, Yang HM et al (2014) Adenylyl cyclase-associated protein 1 is a receptor for human\u00a0resistin\u00a0and mediates inflammatory actions of human monocytes. Cell Metab 19(3):484\u2013497","journal-title":"Cell Metab"},{"issue":"2","key":"1626_CR18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1067\/mjd.2002.120912","volume":"47","author":"HP Lehmann","year":"2002","unstructured":"Lehmann HP, Robinson KA, Andrews JS, Holloway V, Goodman SN (2002) Acne therapy: a methodologic review. J Am Acad Dermatol 47(2):231\u2013240","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"1626_CR19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0014-5793(01)02961-1","volume":"507","author":"C Ling","year":"2001","unstructured":"Ling C, Kindblom J, Wennbo H, Billig H (2001) Increased resistin expression in the adipose tissue of male prolactin transgenic mice and in male mice with elevated androgen levels. FEBS Lett 507(2):147\u2013150","journal-title":"FEBS Lett"},{"issue":"1\u20133","key":"1626_CR20","first-page":"158","volume":"530","author":"SC Lu","year":"2002","unstructured":"Lu SC, Shieh WY, Chen CY, Hsu SC, Chen HL (2002) Lipopolysaccharide increases resistin gene expression in vivo and in vitro. FEBS Lett 530(1\u20133):158\u2013162","journal-title":"FEBS Lett"},{"key":"1626_CR21","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/2031067b0","volume":"203","author":"I Macdonald","year":"1964","unstructured":"Macdonald I (1964) Changes in the fatty acid composition of sebum associated with high carbohydrate diets. Nature 203:1067\u20131068","journal-title":"Nature"},{"issue":"9859","key":"1626_CR22","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","volume":"380","author":"CJ Murray","year":"2012","unstructured":"Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S et al (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990\u20132010: a systematic analysis for the global burden of disease study 2010. Lancet 380(9859):2197\u20132223","journal-title":"Lancet"},{"issue":"5","key":"1626_CR23","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.0022-202X.2005.23705.x","volume":"124","author":"I Nagy","year":"2005","unstructured":"Nagy I, Pivarcsi A, Koreck A, Sz\u00e9ll M, Urb\u00e1n E, Kem\u00e9ny L (2005) Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors. J Invest Dermatol 124(5):931\u2013938","journal-title":"J Invest Dermatol"},{"issue":"1\u20133","key":"1626_CR24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-5793(03)00708-7","volume":"548","author":"R Nogueiras","year":"2003","unstructured":"Nogueiras R, Gallego R, Gualillo O, Caminos JE, Garc\u00eda-Caballero T, Casanueva FF, Di\u00e9guez C (2003) Resistin is expressed in different rat tissues and is regulated in a tissue- and gender-specific manner. FEBS Lett 548(1\u20133):21\u201327","journal-title":"FEBS Lett"},{"issue":"2","key":"1626_CR25","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.bbrc.2005.07.122","volume":"335","author":"H Osawa","year":"2005","unstructured":"Osawa H, Onuma H, Ochi M, Murakami A, Yamauchi J, Takasuka T, Tanabe F, Shimizu I, Kato K, Nishida W et al (2005) Resistin SNP \u2212420 determines its monocyte mRNA and serum levels inducing type 2 diabetes. Biochem Biophys Res Commun 335(2):596\u2013602","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"1626_CR26","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1086\/424761","volume":"75","author":"H Osawa","year":"2004","unstructured":"Osawa H, Yamada K, Onuma H, Murakami A, Ochi M, Kawata H, Nishimiya T, Niiya T, Shimizu I, Nishida W (2004) The G\/G genotype of a resistin single-nucleotide polymorphism at \u2212420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1\/3. Am J Hum Genet 75(4):678\u2013686","journal-title":"Am J Hum Genet"},{"issue":"2","key":"1626_CR27","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0006-291X(02)02841-3","volume":"300","author":"L Patel","year":"2003","unstructured":"Patel L, Buckels AC, Kinghorn IJ, Murdock PR, Holbrook JD, Plumpton C, Macphee CH, Smith SA (2003) Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochem Biophys Res Commun 300(2):472\u2013476","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"1626_CR28","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jaad.2005.07.014","volume":"53","author":"M Placzek","year":"2005","unstructured":"Placzek M, Arnold B, Schmidt H, Gaube S, Keller E, Plewig G, Degitz K (2005) Elevated 17-hydroxyprogesterone serum values in male patients with acne. J Am Acad Dermatol 53(6):955\u2013958","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"1626_CR29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/jid.1969.4","volume":"52","author":"PE Pochi","year":"1969","unstructured":"Pochi PE, Strauss JS (1969) Sebaceous gland response in man to the administration of testosterone, delta-4-androstenedione, and dehydroisoandrosterone. J Invest Dermatol 52(1):32\u201336","journal-title":"J Invest Dermatol"},{"issue":"4","key":"1626_CR30","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1586\/ecp.10.27","volume":"3","author":"LJ Savage","year":"2010","unstructured":"Savage LJ, Layton AM (2010) Treating acne vulgaris: systemic, local and combination therapy. Expert Rev Clin Pharmacol 3(4):563\u2013580","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"9","key":"1626_CR31","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.humimm.2011.05.012","volume":"72","author":"K Szabo","year":"2011","unstructured":"Szabo K, Kemeny L (2011) Studying the genetic predisposing factors in the pathogenesis of acne vulgaris. Hum Immunol 72(9):766\u2013773","journal-title":"Hum Immunol"},{"issue":"10","key":"1626_CR32","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nri1937","volume":"6","author":"H Tilg","year":"2006","unstructured":"Tilg H, Moschen AR (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6(10):772\u2013783","journal-title":"Nat Rev Immunol"},{"issue":"9813","key":"1626_CR33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(11)60321-8","volume":"379","author":"HC Williams","year":"2012","unstructured":"Williams HC, Dellavalle RP, Garner S (2012) Acne vulgaris. Lancet 379(9813):361\u2013372","journal-title":"Lancet"},{"issue":"4","key":"1626_CR34","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00403-014-1519-x","volume":"307","author":"S Younis","year":"2014","unstructured":"Younis S, Javed Q (2014) The interleukin-6 and interleukin-1A gene promoter polymorphism is associated with the pathogenesis of acne vulgaris. Arch Dermatol Res 307(4):365\u2013370","journal-title":"Arch Dermatol Res"},{"issue":"2","key":"1626_CR35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1055\/s-2007-961807","volume":"39","author":"CC Zouboulis","year":"2007","unstructured":"Zouboulis CC, Chen WC, Thornton MJ, Qin K, Rosenfield R (2007) Sexual hormones in human skin. Horm Metab Res 39(2):85\u201395","journal-title":"Horm Metab Res"},{"issue":"5","key":"1626_CR36","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/jdv.12298","volume":"28","author":"CC Zouboulis","year":"2014","unstructured":"Zouboulis CC, Jourdan E, Picardo M (2014) Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions. J Eur Acad Dermatol Venereol 28(5):527\u2013532","journal-title":"J Eur Acad Dermatol Venereol"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-016-1626-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00403-016-1626-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-016-1626-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T06:23:32Z","timestamp":1567578212000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00403-016-1626-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,8]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["1626"],"URL":"https:\/\/doi.org\/10.1007\/s00403-016-1626-y","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,8]]}}}