{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:03:18Z","timestamp":1761102198654},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s00403-016-1656-5","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T20:37:11Z","timestamp":1464122231000},"page":"429-436","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immunohistochemical study of toll-like receptors 2, 4, and 9 expressions in pemphigus and bullous pemphigoid lesions"],"prefix":"10.1007","volume":"308","author":[{"given":"Xiu-Kun","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Fan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"1656_CR1","doi-asserted-by":"crossref","first-page":"e22945","DOI":"10.4161\/onci.22945","volume":"2","author":"A Ahmed","year":"2013","unstructured":"Ahmed A, Redmond HP, Wang JH (2013) Links between Toll-like receptor 4 and breast cancer. Oncoimmunology 2:e22945","journal-title":"Oncoimmunology"},{"issue":"3 Pt 2","key":"1656_CR2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/jid.2011.390","volume":"132","author":"M Amagai","year":"2012","unstructured":"Amagai M, Stanley JR (2012) Desmoglein as a target in skin disease and beyond. J Invest Dermatol 132(3 Pt 2):776\u2013784","journal-title":"J Invest Dermatol"},{"key":"1656_CR3","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1111\/j.1600-0625.2011.01378.x","volume":"20","author":"M Arakawa","year":"2011","unstructured":"Arakawa M, Dainichi T, Ishii N et al (2011) Lesional Th17 cells and regulatory T cells in bullous pemphigoid. Exp Dermatol 20:1022\u20131024","journal-title":"Exp Dermatol"},{"key":"1656_CR4","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1046\/j.1365-2133.2003.05287.x","volume":"148","author":"BS Baker","year":"2003","unstructured":"Baker BS, Ovigne JM, Powles AV, Corcoran S, Fry L (2003) Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis. Br J Dermatol 148:670\u2013679","journal-title":"Br J Dermatol"},{"key":"1656_CR5","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.2217\/imt.14.96","volume":"6","author":"KJ Bednar","year":"2014","unstructured":"Bednar KJ, Ridgway WM (2014) Targeting innate immunity for treatment of type 1 diabetes. Immunotherapy 6:1239\u20131242","journal-title":"Immunotherapy"},{"key":"1656_CR6","first-page":"497","volume":"17","author":"E Begon","year":"2007","unstructured":"Begon E, Michel L, Flageul B et al (2007) Expression, subcellular localization and cytokinic modulation of Toll-like receptors (TLRs) in normal human keratinocytes: TLR2 up-regulation in psoriatic skin. Eur J Dermatol 17:497\u2013506","journal-title":"Eur J Dermatol"},{"key":"1656_CR7","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s11926-014-0474-z","volume":"17","author":"S Bhattacharyya","year":"2015","unstructured":"Bhattacharyya S, Varga J (2015) Emerging roles of innate immune signaling and toll-like receptors in fibrosis and systemic sclerosis. Curr Rheumatol Rep 17:474","journal-title":"Curr Rheumatol Rep"},{"key":"1656_CR8","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.4049\/jimmunol.1300789","volume":"191","author":"EB Brandt","year":"2013","unstructured":"Brandt EB, Gibson AM, Bass S, Rydyznski C, Khurana Hershey GK (2013) Exacerbation of allergen-induced eczema in TLR4- and TRIF-deficient mice. J Immunol 191:3519\u20133525","journal-title":"J Immunol"},{"key":"1656_CR9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1600-0714.1999.tb02026.x","volume":"28","author":"P Chaiyarit","year":"1999","unstructured":"Chaiyarit P, Kafrawy AH, Miles DA, Zunt SL, Van dis ML, Gregory RL (1999) Oral lichen planus: an immunohistochemical study of heat shock proteins (HSPs) and cytokeratins(CKs) and a unifying hypothesis of pathogenesis. J Oral Pathol Med 28:210\u2013215","journal-title":"J Oral Pathol Med"},{"key":"1656_CR10","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/jid.2012.267","volume":"133","author":"L Chen","year":"2013","unstructured":"Chen L, Guo S, Ranzer MJ, DiPietro LA (2013) Toll-like receptor 4 has an essential role in early skin wound healing. J Invest Dermatol 133:258\u2013267","journal-title":"J Invest Dermatol"},{"key":"1656_CR11","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1038\/jid.2015.32","volume":"135","author":"TL Cheng","year":"2015","unstructured":"Cheng TL, Lai CH, Chen PK et al (2015) Thrombomodulin promotes diabetic wound healing by regulating toll-like receptor 4 expression. J Invest Dermatol 135:1668\u20131675","journal-title":"J Invest Dermatol"},{"key":"1656_CR12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.5858\/2003-127-178-IIRRIN","volume":"127","author":"JL Curry","year":"2003","unstructured":"Curry JL, Qin JZ, Bonish B et al (2003) Innate immune-related receptors in normal and psoriatic skin. Arch Pathol Lab Med 127:178\u2013186","journal-title":"Arch Pathol Lab Med"},{"key":"1656_CR13","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.3892\/etm.2015.2258","volume":"9","author":"Y Fan","year":"2015","unstructured":"Fan Y, Liu B (2015) Expression of Toll-like receptors in the mucosa of patients with ulcerative colitis. Exp Ther Med 9:1455\u20131459","journal-title":"Exp Ther Med"},{"key":"1656_CR14","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.4049\/jimmunol.151.10.5742","volume":"151","author":"GJ Giudice","year":"1993","unstructured":"Giudice GJ, Emery DJ, Zelickson BD, Anhalt GJ, Liu Z, Diaz LA (1993) Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain. J Immunol 151:5742\u20135750","journal-title":"J Immunol"},{"key":"1656_CR15","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.4049\/jimmunol.1402583","volume":"194","author":"E Harberts","year":"2015","unstructured":"Harberts E, Zhou H, Fishelevich R, Liu J, Gaspari AA (2015) Ultraviolet radiation signaling through TLR4\/MyD88 constrains DNA repair and plays a role in cutaneous immunosuppression. J Immunol 194:3127\u20133135","journal-title":"J Immunol"},{"key":"1656_CR16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ni1303","volume":"7","author":"T Kawai","year":"2006","unstructured":"Kawai T, Akira S (2006) Innate immune recognition of viral infection. Nat Immunol 7:131\u2013137","journal-title":"Nat Immunol"},{"key":"1656_CR17","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","volume":"11","author":"T Kawai","year":"2010","unstructured":"Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11:373\u2013384","journal-title":"Nat Immunol"},{"key":"1656_CR18","doi-asserted-by":"crossref","first-page":"e47713","DOI":"10.1371\/journal.pone.0047713","volume":"7","author":"KA Kim","year":"2012","unstructured":"Kim KA, Gu W, Lee IA, Joh EH, Kim DH (2012) High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway. PLoS ONE 7:e47713","journal-title":"PLoS ONE"},{"key":"1656_CR19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/sj.jid.5700530","volume":"127","author":"MC Lebre","year":"2006","unstructured":"Lebre MC, van der Aar AM, van Baarsen L et al (2006) Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J Invest Dermatol 127:331\u2013341","journal-title":"J Invest Dermatol"},{"key":"1656_CR20","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s12016-013-8402-y","volume":"47","author":"Y Liu","year":"2014","unstructured":"Liu Y, Yin H, Zhao M, Lu Q (2014) TLR2 and TLR4 in autoimmune diseases: a comprehensive review. Clin Rev Allergy Immunol 47:136\u2013147","journal-title":"Clin Rev Allergy Immunol"},{"key":"1656_CR21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jaut.2008.08.009","volume":"31","author":"Z Liu","year":"2008","unstructured":"Liu Z, Sui W, Zhao M et al (2008) Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model. J Autoimmun 31:331\u2013338","journal-title":"J Autoimmun"},{"key":"1656_CR22","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nri1957","volume":"6","author":"A Marshak-Rothstein","year":"2006","unstructured":"Marshak-Rothstein A (2006) Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol 6:823\u2013835","journal-title":"Nat Rev Immunol"},{"key":"1656_CR23","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1172\/JCI23025","volume":"115","author":"TK Means","year":"2005","unstructured":"Means TK, Latz E, Hayashi F, Murali MR, Golenbock DT, Luster AD (2005) Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest 115:407\u2013417","journal-title":"J Clin Invest"},{"key":"1656_CR24","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1111\/j.1523-1747.2003.12630.x","volume":"121","author":"M Mempel","year":"2003","unstructured":"Mempel M, Voelcker V, Kollisch G et al (2003) Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet activating factor receptor dependent. J Invest Dermatol 121:1389\u20131396","journal-title":"J Invest Dermatol"},{"key":"1656_CR25","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nri3095","volume":"11","author":"KH Mills","year":"2011","unstructured":"Mills KH (2011) TLR-dependent T cell activation in autoimmunity. Nat Rev Immunol 11:807\u2013822","journal-title":"Nat Rev Immunol"},{"key":"1656_CR26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/jid.2011.259","volume":"132","author":"S Morizane","year":"2012","unstructured":"Morizane S, Yamasaki K, M\u00fchleisen B et al (2012) Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligands. J Invest Dermatol 132:135\u2013143","journal-title":"J Invest Dermatol"},{"key":"1656_CR27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nri3446","volume":"13","author":"LA O\u2019Neill","year":"2013","unstructured":"O\u2019Neill LA, Golenbock D, Bowie AG (2013) The history of Toll-like receptors\u2014redefining innate immunity. Nat Rev Immunol 13:453\u2013460","journal-title":"Nat Rev Immunol"},{"key":"1656_CR28","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/exd.12383","volume":"23","author":"R Panzer","year":"2014","unstructured":"Panzer R, Blobel C, F\u00f6lster-Holst R, Proksch E (2014) TLR2 and TLR4 expression in atopic dermatitis, contact dermatitis and psoriasis. Exp Dermatol 23:364\u2013366","journal-title":"Exp Dermatol"},{"key":"1656_CR29","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/intimm\/dxg068","volume":"15","author":"A Pivarcsi","year":"2003","unstructured":"Pivarcsi A, Bodai L, Rethi B (2003) Expression and function of Toll-like receptors 2 and 4 in human keratinocytes. Int Immunol 15:721\u2013730","journal-title":"Int Immunol"},{"key":"1656_CR30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00403-012-1267-8","volume":"305","author":"SA Salem","year":"2013","unstructured":"Salem SA, Abu-Zeid RM, Nada OH (2013) Immunohistochemical study of Toll-like receptors 1 and 2 expression in cutaneous lichen planus lesions. Arch Dermatol Res 305:125\u2013131","journal-title":"Arch Dermatol Res"},{"key":"1656_CR31","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1365-2230.2010.03918.x","volume":"36","author":"DF Sebaratnam","year":"2011","unstructured":"Sebaratnam DF, Martin LK, Rubin AI et al (2011) Reversible relapse of pemphigus foliaceus triggered by topical imiquimod suggests that Toll-like receptor 7 inhibitors may be useful treatments for pemphigus. Clin Exp Dermatol 36:91\u201393","journal-title":"Clin Exp Dermatol"},{"key":"1656_CR32","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-5945-13-10","volume":"13","author":"JL Selway","year":"2013","unstructured":"Selway JL, Kurczab T, Kealey T, Langlands K (2013) Toll-like receptor 2 activation and comedogenesis: implications for the pathogenesis of acne. BMC Dermatol 13:10","journal-title":"BMC Dermatol"},{"key":"1656_CR33","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1600-0560.2007.00756.x","volume":"34","author":"NR Seung","year":"2007","unstructured":"Seung NR, Park EJ, Kim CW et al (2007) Comparison of expression of heat-shock protein 60, Toll-like receptors 2 and 4, and T-cell receptor gammadelta in plaque and guttate psoriasis. J Cutan Pathol 34:903\u2013911","journal-title":"J Cutan Pathol"},{"key":"1656_CR34","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1046\/j.1523-1747.2002.01847.x","volume":"119","author":"PI Song","year":"2002","unstructured":"Song PI, Park YM, Abraham T et al (2002) Human keratinocytes express functional CD14 and toll-like receptor 4. J Invest Dermatol 119:424\u2013432","journal-title":"J Invest Dermatol"},{"key":"1656_CR35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jdermsci.2013.10.009","volume":"73","author":"H Suga","year":"2014","unstructured":"Suga H, Sugaya M, Fujita H et al (2014) TLR4, rather than TLR2, regulates wound healing through TGF-\u03b2 and CCL5 expression. J Dermatol Sci 73:117\u2013124","journal-title":"J Dermatol Sci"},{"key":"1656_CR36","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/exd.12011","volume":"21","author":"H Ujiie","year":"2012","unstructured":"Ujiie H, Shimizu H (2012) Evidence for pathogenicity of autoreactive T cells in autoimmune bullous diseases shown by animal disease models. Exp Dermatol 21:901\u2013905","journal-title":"Exp Dermatol"},{"key":"1656_CR37","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/jcp.22454","volume":"226","author":"J Wang","year":"2011","unstructured":"Wang J, Hori K, Ding J et al (2011) Toll-like receptors expressed by dermal fibroblasts contribute to hypertrophic scarring. J Cell Physiol 226:1265\u20131273","journal-title":"J Cell Physiol"},{"key":"1656_CR38","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1172\/JCI31008","volume":"117","author":"H Wu","year":"2007","unstructured":"Wu H, Chen G, Wyburn KR et al (2007) TLR4 activation mediates kidney ischemia\/reperfusion injury. J Clin Invest 117:2847\u20132859","journal-title":"J Clin Invest"},{"key":"1656_CR39","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/jid.2010.351","volume":"131","author":"K Yamasaki","year":"2011","unstructured":"Yamasaki K, Kanada K, Macleod DT et al (2011) TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol 131:688\u2013697","journal-title":"J Invest Dermatol"},{"key":"1656_CR40","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1038\/ncomms6256","volume":"5","author":"LX Yu","year":"2014","unstructured":"Yu LX, Yan L, Yang W et al (2014) Platelets promote tumour metastasis via interaction between TLR4 and tumour cell-released high-mobility group box1 protein. Nat Commun 5:5256","journal-title":"Nat Commun"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-016-1656-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00403-016-1656-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-016-1656-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T16:04:20Z","timestamp":1692374660000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00403-016-1656-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,24]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["1656"],"URL":"https:\/\/doi.org\/10.1007\/s00403-016-1656-5","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,24]]}}}