{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:18:05Z","timestamp":1784225885927,"version":"3.55.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81401351"],"award-info":[{"award-number":["No.81401351"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health and Family Planning Commission of Jilin Province","award":["2012Z079"],"award-info":[{"award-number":["2012Z079"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s00403-016-1690-3","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T16:29:12Z","timestamp":1475166552000},"page":"703-710","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Enhanced Th1 and Th17 responses in peripheral blood in active non-segmental vitiligo"],"prefix":"10.1007","volume":"308","author":[{"given":"Yu","family":"Zhen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxia","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,29]]},"reference":[{"key":"1690_CR1","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/ijd.12160","volume":"53","author":"M Abdallah","year":"2014","unstructured":"Abdallah M, Lotfi R, Othman W, Galal R (2014) Assessment of tissue FoxP3+, CD4+\u00a0and CD8+\u00a0T-cells in active and stable nonsegmental vitiligo. Int J Dermatol 53:940\u2013946","journal-title":"Int J Dermatol"},{"key":"1690_CR2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1046\/j.1523-1747.2000.00045.x","volume":"115","author":"T Alanko","year":"2000","unstructured":"Alanko T, Saksela O (2000) Transforming growth factor beta1 induces apoptosis in normal melanocytes but not in nevus cells grown in type I collagen gel. J Invest Dermatol 115:286\u2013291","journal-title":"J Invest Dermatol"},{"key":"1690_CR3","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jaad.2008.09.048","volume":"60","author":"PY Basak","year":"2009","unstructured":"Basak PY, Adiloglu AK, Ceyhan AM, Tas T, Akkaya VB (2009) The role of helper and regulatory T cells in the pathogenesis of vitiligo. J Am Acad Dermatol 60:256\u2013260","journal-title":"J Am Acad Dermatol"},{"key":"1690_CR4","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1365-2230.2010.03972.x","volume":"36","author":"DA Bassiouny","year":"2011","unstructured":"Bassiouny DA, Shaker O (2011) Role of interleukin-17 in the pathogenesis of vitiligo. Clin Exp Dermatol 36:292\u2013297","journal-title":"Clin Exp Dermatol"},{"key":"1690_CR5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1755-148X.2011.00920.x","volume":"25","author":"M Ben Ahmed","year":"2012","unstructured":"Ben Ahmed M, Zaraa I, Rekik R, Elbeldi-Ferchiou A, Kourda N, Belhadj Hmida N, Abdeladhim M, Karoui O, Ben Osman A, Mokni M, Louzir H (2012) Functional defects of peripheral regulatory T lymphocytes in patients with progressive vitiligo. Pigment Cell Melanoma Res 25:99\u2013109","journal-title":"Pigment Cell Melanoma Res"},{"key":"1690_CR6","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/jid.2012.331","volume":"133","author":"H Choi","year":"2013","unstructured":"Choi H, Choi H, Han J, Jin SH, Park JY, Shin DW, Lee TR, Kim K, Lee AY, Noh M (2013) IL-4 inhibits the melanogenesis of normal human melanocytes through the JAK2-STAT6 signaling pathway. J Invest Dermatol 133:528\u2013536","journal-title":"J Invest Dermatol"},{"key":"1690_CR7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cyto.2009.12.003","volume":"50","author":"LJ Edwards","year":"2010","unstructured":"Edwards LJ, Robins RA, Constantinescu CS (2010) Th17\/Th1 phenotype in demyelinating disease. Cytokine 50:19\u201323","journal-title":"Cytokine"},{"key":"1690_CR8","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1684\/ejd.2013.2023","volume":"23","author":"MA Elela","year":"2013","unstructured":"Elela MA, Hegazy RA, Fawzy MM, Rashed LA, Rasheed H (2013) Interleukin 17, interleukin 22 and FoxP3 expression in tissue and serum of non-segmental vitiligo: a case\u2013controlled study on eighty-four patients. Eur J Dermatol 23:350\u2013355","journal-title":"Eur J Dermatol"},{"key":"1690_CR9","first-page":"15","volume":"19","author":"F Fitch","year":"1988","unstructured":"Fitch F, Gajewski T, Nau G, Schell S, Otten G (1988) Nakahara memorial lecture. Regulation of T lymphocyte responses: interactions among receptors. Princess Takamatsu Symp 19:15\u201327","journal-title":"Princess Takamatsu Symp"},{"key":"1690_CR10","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3389\/fimmu.2014.00630","volume":"5","author":"J Geginat","year":"2014","unstructured":"Geginat J, Paroni M, Maglie S, Alfen JS, Kastirr I, Gruarin P, De Simone M, Pagani M, Abrignani S (2014) Plasticity of human CD4 T cell subsets. Front Immunol 5:630","journal-title":"Front Immunol"},{"key":"1690_CR11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jaad.2003.12.031","volume":"51","author":"PE Grimes","year":"2004","unstructured":"Grimes PE, Morris R, Avaniss-Aghajani E, Soriano T, Meraz M, Metzger A (2004) Topical tacrolimus therapy for vitiligo: therapeutic responses and skin messenger RNA expression of proinflammatory cytokines. J Am Acad Dermatol 51:52\u201361","journal-title":"J Am Acad Dermatol"},{"key":"1690_CR12","doi-asserted-by":"crossref","first-page":"7061","DOI":"10.1073\/pnas.1415675112","volume":"112","author":"SN Harbour","year":"2015","unstructured":"Harbour SN, Maynard CL, Zindl CL, Schoeb TR, Weaver CT (2015) Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis. Proc Natl Acad Sci USA 112:7061\u20137066","journal-title":"Proc Natl Acad Sci USA"},{"key":"1690_CR13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1365-2133.2012.11000.x","volume":"167","author":"M Imran","year":"2012","unstructured":"Imran M, Laddha NC, Dwivedi M, Mansuri MS, Singh J, Rani R, Gokhale RS, Sharma VK, Marfatia YS, Begum R (2012) Interleukin-4 genetic variants correlate with its transcript and protein levels in patients with vitiligo. Br J Dermatol 167:314\u2013323","journal-title":"Br J Dermatol"},{"key":"1690_CR14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.smim.2007.10.011","volume":"19","author":"II Ivanov","year":"2007","unstructured":"Ivanov II, Zhou L, Littman DR (2007) Transcriptional regulation of Th17 cell differentiation. Semin Immunol 19:409\u2013417","journal-title":"Semin Immunol"},{"key":"1690_CR15","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1002\/art.23655","volume":"58","author":"C Jandus","year":"2008","unstructured":"Jandus C, Bioley G, Rivals JP, Dudler J, Speiser D, Romero P (2008) Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum 58:2307\u20132317","journal-title":"Arthritis Rheum"},{"key":"1690_CR16","doi-asserted-by":"crossref","first-page":"e003","DOI":"10.1621\/nrs.07003","volume":"7","author":"AM Jetten","year":"2009","unstructured":"Jetten AM (2009) Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal 7:e003","journal-title":"Nucl Recept Signal"},{"key":"1690_CR17","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jaad.2011.07.018","volume":"66","author":"R Khan","year":"2012","unstructured":"Khan R, Gupta S, Sharma A (2012) Circulatory levels of T-cell cytokines (interleukin [IL]-2, IL-4, IL-17, and transforming growth factor-beta) in patients with vitiligo. J Am Acad Dermatol 66:510\u2013511","journal-title":"J Am Acad Dermatol"},{"key":"1690_CR18","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1146\/annurev.immunol.26.021607.090344","volume":"26","author":"C King","year":"2008","unstructured":"King C, Tangye SG, Mackay CR (2008) T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol 26:741\u2013766","journal-title":"Annu Rev Immunol"},{"key":"1690_CR19","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1755-148X.2010.00688.x","volume":"23","author":"J Klarquist","year":"2010","unstructured":"Klarquist J, Denman CJ, Hernandez C, Wainwright DA, Strickland FM, Overbeck A, Mehrotra S, Nishimura MI, Le Poole IC (2010) Reduced skin homing by functional Treg in vitiligo. Pigment Cell Melanoma Res 23:276\u2013286","journal-title":"Pigment Cell Melanoma Res"},{"key":"1690_CR20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1755-148X.2011.00945.x","volume":"25","author":"Y Kotobuki","year":"2012","unstructured":"Kotobuki Y, Tanemura A, Yang L, Itoi S, Wataya-Kaneda M, Murota H, Fujimoto M, Serada S, Naka T, Katayama I (2012) Dysregulation of melanocyte function by Th17-related cytokines: significance of Th17 cell infiltration in autoimmune vitiligo vulgaris. Pigment Cell Melanoma Res 25:219\u2013230","journal-title":"Pigment Cell Melanoma Res"},{"key":"1690_CR21","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.4049\/jimmunol.181.7.4733","volume":"181","author":"I Kryczek","year":"2008","unstructured":"Kryczek I, Bruce AT, Gudjonsson JE, Johnston A, Aphale A, Vatan L, Szeliga W, Wang Y, Liu Y, Welling TH, Elder JT, Zou W (2008) Induction of IL-17+\u00a0T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol 181:4733\u20134741","journal-title":"J Immunol"},{"key":"1690_CR22","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cyto.2014.06.013","volume":"69","author":"J Labikova","year":"2014","unstructured":"Labikova J, Vcelakova J, Ulmannova T, Petruzelkova L, Kolouskova S, Stechova K (2014) The cytokine production of peripheral blood mononuclear cells reflects the autoantibody profile of patients suffering from type 1 diabetes. Cytokine 69:189\u2013195","journal-title":"Cytokine"},{"key":"1690_CR23","doi-asserted-by":"crossref","first-page":"e37513","DOI":"10.1371\/journal.pone.0037513","volume":"7","author":"Y Lili","year":"2012","unstructured":"Lili Y, Yi W, Ji Y, Yue S, Weimin S, Ming L (2012) Global activation of CD8+ cytotoxic T lymphocytes correlates with an impairment in regulatory T cells in patients with generalized vitiligo. PLoS One 7:e37513","journal-title":"PLoS One"},{"key":"1690_CR24","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1684\/ejd.2014.2436","volume":"24","author":"M Lin","year":"2014","unstructured":"Lin M, Zhang BX, Shen N, Dong XJ, Zhang C, Qi XY, Zhu J, Li YZ, Man MQ, Tu CX (2014) Regulatory T cells from active non-segmental vitiligo exhibit lower suppressive ability on CD8+CLA+T cells. Eur J Dermatol EJD 24:676\u2013682","journal-title":"Eur J Dermatol EJD"},{"key":"1690_CR25","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.jaci.2013.08.039","volume":"132","author":"M Lopez-Bravo","year":"2013","unstructured":"Lopez-Bravo M, Minguito de la Escalera M, Dominguez PM, Gonzalez-Cintado L, del Fresno C, Martin P, Martinez del Hoyo G, Ardavin C (2013) IL-4 blocks TH1-polarizing\/inflammatory cytokine gene expression during monocyte-derived dendritic cell differentiation through histone hypoacetylation. J Allergy Clin Immunol 132:1409\u20131419","journal-title":"J Allergy Clin Immunol"},{"key":"1690_CR26","doi-asserted-by":"crossref","first-page":"e329","DOI":"10.1371\/journal.pbio.0050329","volume":"5","author":"PY Mantel","year":"2007","unstructured":"Mantel PY, Kuipers H, Boyman O, Rhyner C, Ouaked N, Ruckert B, Karagiannidis C, Lambrecht BN, Hendriks RW, Crameri R, Akdis CA, Blaser K, Schmidt-Weber CB (2007) GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells. PLoS Biol 5:e329","journal-title":"PLoS Biol"},{"key":"1690_CR27","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/phpp.12104","volume":"30","author":"NH Moftah","year":"2014","unstructured":"Moftah NH, El-Barbary RA, Ismail MA, Ali NA (2014) Effect of narrow band-ultraviolet B on CD4(+) CD25(high) FoxP3(+) T-lymphocytes in the peripheral blood of vitiligo patients. Photodermatol Photoimmunol Photomed 30:254\u2013261","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"1690_CR28","first-page":"562","volume":"79","author":"A Noble","year":"1993","unstructured":"Noble A, Staynov DZ, Kemeny DM (1993) Generation of rat Th2-like cells in vitro is interleukin-4-dependent and inhibited by interferon-gamma. Immunology 79:562\u2013567","journal-title":"Immunology"},{"key":"1690_CR29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/ced.12661","volume":"40","author":"A Nouri-Koupaee","year":"2015","unstructured":"Nouri-Koupaee A, Mansouri P, Jahanbini H, Sanati MH, Jadali Z (2015) Differential expression of mRNA for T-bet and GATA-3 transcription factors in peripheral blood mononuclear cells of patients with vitiligo. Clin Exp Dermatol 40:735\u2013740","journal-title":"Clin Exp Dermatol"},{"key":"1690_CR30","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1046\/j.1365-3083.1998.00435.x","volume":"48","author":"SR Paludan","year":"1998","unstructured":"Paludan SR (1998) Interleukin-4 and interferon-gamma: the quintessence of a mutual antagonistic relationship. Scand J Immunol 48:459\u2013468","journal-title":"Scand J Immunol"},{"key":"1690_CR31","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.4049\/jimmunol.181.5.3137","volume":"181","author":"S Radhakrishnan","year":"2008","unstructured":"Radhakrishnan S, Cabrera R, Schenk EL, Nava-Parada P, Bell MP, Van Keulen VP, Marler RJ, Felts SJ, Pease LR (2008) Reprogrammed FoxP3+\u00a0T regulatory cells become IL-17+\u00a0antigen-specific autoimmune effectors in vitro and in vivo. J Immunol 181:3137\u20133147","journal-title":"J Immunol"},{"key":"1690_CR32","first-page":"575","volume":"54","author":"U Rodeck","year":"1994","unstructured":"Rodeck U, Bossler A, Graeven U, Fox FE, Nowell PC, Knabbe C, Kari C (1994) Transforming growth factor beta production and responsiveness in normal human melanocytes and melanoma cells. Cancer Res 54:575\u2013581","journal-title":"Cancer Res"},{"key":"1690_CR33","doi-asserted-by":"crossref","first-page":"6102","DOI":"10.1182\/blood-2008-12-195354","volume":"113","author":"MD Sharma","year":"2009","unstructured":"Sharma MD, Hou DY, Liu Y, Koni PA, Metz R, Chandler P, Mellor AL, He Y, Munn DH (2009) Indoleamine 2,3-dioxygenase controls conversion of Foxp3+\u00a0Tregs to TH17-like cells in tumor-draining lymph nodes. Blood 113:6102\u20136111","journal-title":"Blood"},{"key":"1690_CR34","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00403-011-1154-8","volume":"303","author":"CX Tu","year":"2011","unstructured":"Tu CX, Jin WW, Lin M, Wang ZH, Man MQ (2011) Levels of TGF-beta(1) in serum and culture supernatants of CD4(+)CD25 (+) T cells from patients with non-segmental vitiligo. Arch Dermatol Res 303:685\u2013689","journal-title":"Arch Dermatol Res"},{"key":"1690_CR35","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/ijd.12392","volume":"54","author":"M Vaccaro","year":"2015","unstructured":"Vaccaro M, Cannavo SP, Imbesi S, Cristani M, Barbuzza O, Tigano V, Gangemi S (2015) Increased serum levels of interleukin-23 circulating in patients with non-segmental generalized vitiligo. Int J Dermatol 54:672\u2013674","journal-title":"Int J Dermatol"},{"key":"1690_CR36","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1755-148X.2010.00703.x","volume":"23","author":"NA Geel van","year":"2010","unstructured":"van Geel NA, Mollet IG, De Schepper S, Tjin EP, Vermaelen K, Clark RA, Kupper TS, Luiten RM, Lambert J (2010) First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. Pigment Cell Melanoma Res 23:375\u2013384","journal-title":"Pigment Cell Melanoma Res"},{"key":"1690_CR37","doi-asserted-by":"crossref","first-page":"e18907","DOI":"10.1371\/journal.pone.0018907","volume":"6","author":"CQ Wang","year":"2011","unstructured":"Wang CQ, Cruz-Inigo AE, Fuentes-Duculan J, Moussai D, Gulati N, Sullivan-Whalen M, Gilleaudeau P, Cohen JA, Krueger JG (2011) Th17 cells and activated dendritic cells are increased in vitiligo lesions. PLoS One 6:e18907","journal-title":"PLoS One"},{"key":"1690_CR38","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2016.3304","author":"Z Wang","year":"2016","unstructured":"Wang Z, Wang Z, Wang J, Diao Y, Qian X, Zhu N (2016) T-bet-expressing B cells are positively associated with Crohn\u2019s disease activity and support Th1 inflammation. DNA Cell Biol. doi: 10.1089\/dna.2016.3304","journal-title":"DNA Cell Biol"},{"key":"1690_CR39","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/01.LAB.0000069521.42488.1B","volume":"83","author":"A Wankowicz-Kalinska","year":"2003","unstructured":"Wankowicz-Kalinska A, van den Wijngaard RM, Tigges BJ, Westerhof W, Ogg GS, Cerundolo V, Storkus WJ, Das PK (2003) Immunopolarization of CD4+\u00a0and CD8+\u00a0T cells to Type-1-like is associated with melanocyte loss in human vitiligo. Lab Invest 83:683\u2013695","journal-title":"Lab Invest"},{"key":"1690_CR40","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/intimm\/dxh050","volume":"16","author":"O Wurtz","year":"2004","unstructured":"Wurtz O, Bajenoff M, Guerder S (2004) IL-4-mediated inhibition of IFN-gamma production by CD4+\u00a0T cells proceeds by several developmentally regulated mechanisms. Int Immunol 16:501\u2013508","journal-title":"Int Immunol"},{"key":"1690_CR41","doi-asserted-by":"crossref","first-page":"664","DOI":"10.2340\/00015555-2080","volume":"95","author":"L Yang","year":"2015","unstructured":"Yang L, Wei Y, Sun Y, Shi W, Yang J, Zhu L, Li M (2015) Interferon-gamma inhibits melanogenesis and induces apoptosis in melanocytes: a pivotal role of CD8+\u00a0Cytotoxic T lymphocytes in vitiligo. Acta Dermato-Venereol 95:664\u2013670","journal-title":"Acta Dermato-Venereol"},{"key":"1690_CR42","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1684\/ejd.2013.2011","volume":"23","author":"BX Zhang","year":"2013","unstructured":"Zhang BX, Lin M, Qi XY, Zhang RX, Wei ZD, Zhu J, Man MQ, Tu CX (2013) Characterization of circulating CD8+\u00a0T cells expressing skin homing and cytotoxic molecules in active non-segmental vitiligo. Eur J Dermatol EJD 23:331\u2013338","journal-title":"Eur J Dermatol EJD"},{"key":"1690_CR43","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1755-148X.2012.01019.x","volume":"25","author":"L Zhou","year":"2012","unstructured":"Zhou L, Li K, Shi YL, Hamzavi I, Gao TW, Henderson M, Huggins RH, Agbai O, Mahmoud B, Mi X, Lim HW, Mi QS (2012) Systemic analyses of immunophenotypes of peripheral T cells in non-segmental vitiligo: implication of defective natural killer T cells. Pigment Cell Melanoma Res 25:602\u2013611","journal-title":"Pigment Cell Melanoma Res"},{"key":"1690_CR44","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/pcmr.12355","volume":"28","author":"L Zhou","year":"2015","unstructured":"Zhou L, Shi YL, Li K, Hamzavi I, Gao TW, Huggins RH, Lim HW, Mi QS (2015) Increased circulating Th17 cells and elevated serum levels of TGF-beta and IL-21 are correlated with human non-segmental vitiligo development. Pigment Cell Melanoma Res 28:324\u2013329","journal-title":"Pigment Cell Melanoma Res"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-016-1690-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00403-016-1690-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-016-1690-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T09:28:32Z","timestamp":1601112512000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00403-016-1690-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,29]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["1690"],"URL":"https:\/\/doi.org\/10.1007\/s00403-016-1690-3","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,29]]}}}