{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:29:36Z","timestamp":1793388576968,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T00:00:00Z","timestamp":1484092800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"DST-INSPIRE Faculty Project","award":["IFA11-LSBM-61"],"award-info":[{"award-number":["IFA11-LSBM-61"]}]},{"name":"INSPIRES fellowship","award":["IF140212"],"award-info":[{"award-number":["IF140212"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s00403-016-1713-0","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T08:19:55Z","timestamp":1484122795000},"page":"123-132","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Senescence in the lesional fibroblasts of non-segmental vitiligo patients"],"prefix":"10.1007","volume":"309","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-3959","authenticated-orcid":false,"given":"Seema","family":"Rani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niharika","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay Lakshmi","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davinder","family":"Parsad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,11]]},"reference":[{"key":"1713_CR1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0092-8674(01)00365-8","volume":"105","author":"AM Arias","year":"2001","unstructured":"Arias AM (2001) Epithelial mesenchymal interactions in cancer and development. Cell 105:425\u2013431","journal-title":"Cell"},{"key":"1713_CR2","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1073\/pnas.85.14.5112","volume":"85","author":"K Bayreuther","year":"1988","unstructured":"Bayreuther K, Rodemann HP, Hommel R, Dittmann K, Albiez M, Francz PI (1988) Human skin fibroblasts in vitro differentiate along a terminal cell lineage. Proc Natl Acad Sci USA 85:5112\u20135116","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"1713_CR3","doi-asserted-by":"crossref","first-page":"e59782","DOI":"10.1371\/journal.pone.0059782","volume":"8","author":"B Bellei","year":"2013","unstructured":"Bellei B, Pitisci A, Ottaviani M, Ludovici M, Cota C et al (2013) Vitiligo: a possible model of degenerative diseases. PLoS One 8(3):e59782","journal-title":"PLoS One"},{"key":"1713_CR4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s40257-013-0039-3","volume":"14","author":"CR Camara-Lemarroy","year":"2013","unstructured":"Camara-Lemarroy CR, Salas-Alanis JC (2013) The role of tumor necrosis factor-\u03b1 in the pathogenesis of vitiligo. Am J Clin Dermatol 14:343","journal-title":"Am J Clin Dermatol"},{"issue":"2","key":"1713_CR5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1101\/gad.1050003","volume":"17","author":"L Cao","year":"2003","unstructured":"Cao L, Li W, Kim S, Brodie SG, Deng CX (2003) Senescence, aging and malignant transformation mediated by p53 in mice lacking the Brca1 full length isoform. Genes Dev 17(2):201\u2013213","journal-title":"Genes Dev"},{"issue":"1","key":"1713_CR6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/pros.10204","volume":"55","author":"P Castro","year":"2003","unstructured":"Castro P, Giri D, Lamb D, Ittmann M (2003) Cellular senescence in the pathogenesis of benign prostatic hyperplasia. Prostate 55(1):30\u201338","journal-title":"Prostate"},{"key":"1713_CR7","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1371\/journal.pbio.0020007","volume":"2","author":"HY Chang","year":"2004","unstructured":"Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K et al (2004) Gene expression signature of fibroblast serum response predicts human cancer progression: Similarities between tumors and wounds. PLoS Biol 2:E7","journal-title":"PLoS Biol"},{"key":"1713_CR8","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1242\/jcs.064774","volume":"123","author":"W Choi","year":"2010","unstructured":"Choi W, Wolber R, Gerwat W, Mann T, Batzer J, Smuda C et al (2010) The fibroblast-derived paracrine factor neuregulin-1 has a novel role in regulating the constitutive color and melanocyte function in human skin. J Cell Sci 123:3102\u20133111","journal-title":"J Cell Sci"},{"key":"1713_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-2395-3-1","volume":"3","author":"CM Clara","year":"2014","unstructured":"Clara CM, Graeme H, Joao F P (2014) Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence? Longev Healthspan 3:1","journal-title":"Longev Healthspan"},{"issue":"7051","key":"1713_CR10","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/436642a","volume":"436","author":"M Collado","year":"2005","unstructured":"Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M et al (2005) Tumour biology: senescence in premalignant tumours. Nat 436(7051):642.","journal-title":"Nat"},{"key":"1713_CR11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1034\/j.1600-0749.2003.00087.x","volume":"16","author":"ML Dell\u2019Anna","year":"2003","unstructured":"Dell\u2019Anna ML, Urbanelli S, Mastrofrancesco A, Camera E, Iacovelli P, Leone G et al (2003) Alterations of mitochondria in peripheral blood monoculear cells of vitiligo patients. Pigment Cell Res 16:553\u2013559","journal-title":"Pigment Cell Res"},{"issue":"4","key":"1713_CR12","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1128\/MCB.20.4.1436-1447.2000","volume":"20","author":"MA Dickson","year":"2000","unstructured":"Dickson MA, Hahn WC, Ino Y, Ronfard V, Wu JY, Weinberg RA et al (2000) Human keratinocytes that express hTERT and also bypass a p16INK4a-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol 20(4):1436\u20131447","journal-title":"Mol Cell Biol"},{"key":"1713_CR13","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1034\/j.1600-0749.2003.00070.x","volume":"16","author":"Y Gauthier","year":"2003","unstructured":"Gauthier Y, Cario Andre M, Taieb A (2003) A critical appraisal of vitiligo etiologic theories. Is melanocyte loss a melanocytorrhagy? Pigment Cell Res 16:322\u2013332","journal-title":"Pigment Cell Res"},{"key":"1713_CR14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mrfmmm.2004.07.005","volume":"556","author":"L Giovannelli","year":"2004","unstructured":"Giovannelli L, Bellandi S, Pitozzi V, Fabbri P, Dolara P, Moretti S (2004) Increased oxidative DNA damage in mononuclear leukocytes in vitiligo. Mutat Res 556:101\u2013106","journal-title":"Mutat Res"},{"key":"1713_CR15","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/34848","volume":"391","author":"A Glinka","year":"1998","unstructured":"Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C (1998). Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nat 391:357\u2013362","journal-title":"Nat"},{"key":"1713_CR16","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1006\/excr.1999.4393","volume":"248","author":"M Helenius","year":"1999","unstructured":"Helenius M, Makelainen L, Salminen A (1999) Attenuation of NF-kappaB signaling response to UVB light during cellular senescence. Exp Cell Res 248:194\u2013202","journal-title":"Exp Cell Res"},{"key":"1713_CR17","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1042\/bj3301235","volume":"330","author":"G Imokawa","year":"1998","unstructured":"Imokawa G, Yada Y, Morisaki N, Kimura M (1998) Biological characterization of human fibroblast-derived mitogenic factors for human melanocytes. J Biochem 330:1235\u20131239","journal-title":"J Biochem"},{"key":"1713_CR18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-59745-361-5_3","volume":"371","author":"K Itahana","year":"2007","unstructured":"Itahana K, Campisi J, Dimri GP (2007) Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. Methods Mol Biol 371:21\u201331","journal-title":"Methods Mol Biol"},{"key":"1713_CR19","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1006\/excr.2000.4943","volume":"258","author":"MK Kang","year":"2000","unstructured":"Kang MK, Bibb C, Baluda MA, Rey O, Park NH (2000) In vitro replication and differentiation of normal human oral keratinocytes. Exp Cell Res 258:288\u2013297","journal-title":"Exp Cell Res"},{"key":"1713_CR20","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/path.1538","volume":"202","author":"R Kitamura","year":"2004","unstructured":"Kitamura R, Tsukamoto K, Harada K, Shimizu A, Shimada S, Kobayashi T et al (2004) Mechanisms underlying the dysfunction of melanocytes in vitiligo epidermis: role of SCF\/KIT protein interactions and the downstream effector, MITF-M. J Pathol 202:463\u2013475","journal-title":"J Pathol"},{"issue":"3","key":"1713_CR21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4161\/cc.10.3.14707","volume":"10","author":"M Kosar","year":"2011","unstructured":"Kosar M, Bartkova J, Hubackova S, Hodny Z, Lukas J, Bartek J (2011) Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type and insult-dependent manner, and follow expression of p16ink4a. Cell Cycle 10(3):457\u2013468","journal-title":"Cell Cycle"},{"key":"1713_CR22","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI22475","volume":"114","author":"J Krishnamurthy","year":"2004","unstructured":"Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L et al (2004) Ink4a\/Arf expression is a biomarker of aging. J Clin Invest 114:1299\u20131307","journal-title":"J Clin Invest"},{"key":"1713_CR23","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.0022-202X.2005.23667.x","volume":"124","author":"AY Lee","year":"2005","unstructured":"Lee AY, Kim NH, Choi WI, Youm YH (2005) Less keratinocyte-derived factors related to more keratinocyte apoptosis in depigmented than normally pigmented suction-blistered epidermis may cause passive melanocyte death in vitiligo. J Invest Dermatol 124:976\u2013983","journal-title":"J Invest Dermatol"},{"key":"1713_CR24","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/j.1365-2133.2004.06136.x","volume":"151","author":"AY Lee","year":"2004","unstructured":"Lee AY, Youm YH, Kim NH, Yang H, Choi WI (2004) Keratinocytes in the depigmented epidermis of vitiligo are more vulnerable to trauma (suction) than keratinocytes in the normally pigmented epidermis, resulting in their apoptosis. Br J Dermatol 151:995\u20131003","journal-title":"Br J Dermatol"},{"issue":"3","key":"1713_CR25","first-page":"561","volume":"13","author":"O Loughran","year":"1996","unstructured":"Loughran O, Malliri A, Owens D, Gallimore PH, Stanley MA, Ozanne B et al (1996) Association of CDKN2A\/p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia. Oncogene 13(3):561\u2013568","journal-title":"Oncogene"},{"key":"1713_CR26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0006-291X(92)92375-8","volume":"188","author":"K Matsumoto","year":"1992","unstructured":"Matsumoto K, Okazaki H, Nakamura T (1992) Up-regulation of hepatocyte growth factor gene expression by interleukin-1 in human skin fibroblasts. Biochem Biophys Res Commun 188:235\u2013243","journal-title":"Biochem Biophys Res Commun"},{"key":"1713_CR27","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1523-1755.2004.00438.x","volume":"65","author":"A Melk","year":"2004","unstructured":"Melk A, Schmidt BM, Takeuchi O, Sawitzki B, Rayner DC, Halloran PF (2004) Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney. Kidney Int 65:510\u2013520","journal-title":"Kidney Int"},{"issue":"3","key":"1713_CR28","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1034\/j.1600-0749.2001.140303.x","volume":"14","author":"FL Meyskens Jr","year":"2001","unstructured":"Meyskens FL Jr, Farmer P, Fruehauf JP (2001) Redox regulation in human melanocytes and melanoma. Pigment Cell Res 14(3):148\u2013154","journal-title":"Pigment Cell Res"},{"key":"1713_CR29","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1038\/sj.jid.5700938","volume":"127","author":"M Mildner","year":"2007","unstructured":"Mildner M, Mlitz V, Gruber F, Wojta J, Tschachler E (2007) Hepatocyte growth factor establishes autocrine and paracrine feedback loops for the protection of skin cells after UV irradiation. J Invest Dermatol 127:2637\u20132644","journal-title":"J Invest Dermatol"},{"key":"1713_CR30","first-page":"849","volume":"24","author":"S Moretti","year":"2009","unstructured":"Moretti S, Fabbri P, Baroni G, Berti S, Bani D, Berti E et al (2009) Keratinocyte dysfunction in vitiligo epidermis: cytokine microenvironment and correlation to keratinocyte apoptosis. Histol Histopathol 24:849\u2013857","journal-title":"Histol Histopathol"},{"key":"1713_CR31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1034\/j.1600-0749.2002.1o049.x","volume":"15","author":"S Moretti","year":"2002","unstructured":"Moretti S, Spallanzani A, Amato L, Hautmann G, Gallerani I, Fabiani M et al (2002) New insight into the pathogenesis of vitiligo: Imbalance of epidermal cytokines at sites of lesions. Pigment Cell Res 15:87\u201392","journal-title":"Pigment Cell Res"},{"key":"1713_CR32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jdermsci.2012.01.010","volume":"66","author":"SH Oh","year":"2012","unstructured":"Oh SH, Kim JY, Kim MR, Do JE, Shin JY, Hann SK (2012) DKK1 is highly expressed in the dermis of vitiligo lesion: is there association between DKK1 and vitiligo? J Dermatol Sci 66:163\u2013165","journal-title":"J Dermatol Sci"},{"key":"1713_CR33","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1242\/dev.128.20.3949","volume":"128","author":"C Paratore","year":"2001","unstructured":"Paratore C, Goerich DE, Suter U, Wegner M, Sommer L (2001) Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling. Development 128:3949\u20133961","journal-title":"Development"},{"key":"1713_CR34","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1111\/jcmm.12411","volume":"18","author":"V Purpura","year":"2014","unstructured":"Purpura V, Persechino F, Belleudi F, Scrofani C, Raffa S, Persechino S et al (2014) Decreased expression of KGF\/FGF7 and its receptor in pathological hypopigmentation. J Cell Mol Med 18:2553\u20132557","journal-title":"J Cell Mol Med"},{"issue":"19","key":"1713_CR35","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1128\/MCB.22.14.5157-5172.2002","volume":"22","author":"JG Rheinwald","year":"2002","unstructured":"Rheinwald JG, Hahn WC, Ramsey MR, Wu JY, Guo Z, Tsao H et al (2002) A two-stage, p16INK4A- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol 22(19):5157\u20135172","journal-title":"Mol Cell Biol"},{"key":"1713_CR36","doi-asserted-by":"crossref","first-page":"6950","DOI":"10.1158\/0008-5472.CAN-04-0677","volume":"64","author":"N Sato","year":"2004","unstructured":"Sato N, Maehara N, Goggins M (2004) Gene expression profiling of tumor-stromal interactions between pancreatic cancer cells and stromal fibroblasts. Cancer Res 64:6950\u20136956","journal-title":"Cancer Res"},{"key":"1713_CR37","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/sj.jidsp.5640189","volume":"4","author":"KU Schallreuter","year":"1999","unstructured":"Schallreuter KU, Moore J, Wood JM, Beazley WD, Gaze DC et al (1999) In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase. J Invetsig Dermatol Symp Proc 4:91\u201396","journal-title":"J Invetsig Dermatol Symp Proc"},{"issue":"2","key":"1713_CR38","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0921-8777(00)00049-5","volume":"461","author":"I Schulz","year":"2000","unstructured":"Schulz I, Mahler HC, Boiteux S, Epe B (2000) Oxidative DNA base damage induced by singlet oxygen and photosensitization: Recognition by repair endonucleases and mutagenicity. Mutation res 461(2):145\u2013156","journal-title":"Mutation res"},{"key":"1713_CR39","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0092-8674(00)81079-X","volume":"85","author":"M Serrano","year":"1996","unstructured":"Serrano M, Lee H, Chin L, Cordon-Cardo C, Beacg D, DePinho RA (1996) Role of the Ink4a locus in tumor suppression and cell mortality. Cell 85:27\u201337","journal-title":"Cell"},{"key":"1713_CR40","first-page":"273","volume":"5","author":"M Singh","year":"2016","unstructured":"Singh M, Mansuri MS, Parasrampuria MA, Begum R (2016) Interleukin 1-\u03b1: A modulator of melanocyte homeostasis in vitiligo. Biochem Anal Biochem 5:273","journal-title":"Biochem Anal Biochem"},{"issue":"9","key":"1713_CR41","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1101\/gad.1176104","volume":"18","author":"LQ Sun","year":"2004","unstructured":"Sun LQ, Lee DW, Zhang Q, Xiao W, Raabe EH, Meeker A et al (2004) Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene. Genes Dev 18(9):1035\u20131046","journal-title":"Genes Dev"},{"key":"1713_CR42","first-page":"65","volume-title":"New research on cell aging","author":"O Susuma","year":"2007","unstructured":"Susuma O (2007) Abnormal mitosis and aberrant nuclear morphology in senescent human fibroblasts. In: Garvey RB (eds) New research on cell aging. Nova Science Publishers, New York, pp\u00a065\u201381"},{"key":"1713_CR43","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-3-540-69361-1_2","volume-title":"Vitiligo","author":"A Ta\u00efeb","year":"2010","unstructured":"Ta\u00efeb A, Picardo M (2010) Epidemiology, definitions and classification. In: Picardo Mauro (ed) Vitiligo, springer, Berlin, pp\u00a013\u201324"},{"key":"1713_CR44","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1242\/jcs.064774","volume":"123","author":"C Wonseon","year":"2010","unstructured":"Wonseon C, Rainer W, Wolfram G, Tobias M, Jan B, Christoph S et al (2010) The fibroblast-derived paracrine factor neuregulin-1 has a novel role in regulating the constitutive color and melanocyte function in human skin. J Cell Sci 123:3102\u20133111","journal-title":"J Cell Sci"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-016-1713-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00403-016-1713-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-016-1713-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T07:23:33Z","timestamp":1658388213000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00403-016-1713-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,11]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["1713"],"URL":"https:\/\/doi.org\/10.1007\/s00403-016-1713-0","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,11]]}}}