{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:37:08Z","timestamp":1761676628586},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T00:00:00Z","timestamp":1525305600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s00403-018-1835-7","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T08:06:27Z","timestamp":1525334787000},"page":"463-473","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ex vivo nonlinear microscopy imaging of Ehlers\u2013Danlos syndrome-affected skin"],"prefix":"10.1007","volume":"310","author":[{"given":"Norbert","family":"Kiss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f3ra","family":"Haluszka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kende","family":"L\u0151rincz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enik\u0151","family":"Kuroli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"H\u00e1rsing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarolta","family":"K\u00e1rp\u00e1ti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"Fekete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00f3bert","family":"Szip\u0151cs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Wikonk\u00e1l","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rta","family":"Medvecz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,3]]},"reference":[{"key":"1835_CR1","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/ajmg.1320290316","volume":"29","author":"P Beighton","year":"1988","unstructured":"Beighton P, de Paepe A, Danks D, Finidori G, Gedde-Dahl T, Goodman R, Hall JG, Hollister DW, Horton W, McKusick VA et al (1988) International nosology of heritable disorders of connective tissue, Berlin, 1986. Am J Med Genet 29:581\u2013594. \n                    https:\/\/doi.org\/10.1002\/ajmg.1320290316","journal-title":"Am J Med Genet"},{"key":"1835_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O","volume":"77","author":"P Beighton","year":"1998","unstructured":"Beighton P, De Paepe A, Steinmann B, Tsipouras P, Wenstrup RJ (1998) Ehlers-Danlos syndromes: revised nosology, Villefranche, 1997. Ehlers-Danlos National Foundation (USA) and Ehlers-Danlos Support Group (UK). Am J Med Genet 77:31\u201337","journal-title":"Am J Med Genet"},{"key":"1835_CR3","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1007\/s00296-010-1778-6","volume":"32","author":"M Carlesimo","year":"2012","unstructured":"Carlesimo M, Cortesi G, Gamba A, Narcisi A, Turturro F, Raffa S, Torrisi MR, Camplone G (2012) Ehlers-Danlos syndrome: case report and an electron microscopy study. Rheumat Int 32:1507\u20131510. \n                    https:\/\/doi.org\/10.1007\/s00296-010-1778-6","journal-title":"Rheumat Int"},{"key":"1835_CR4","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/ajmg.c.31539","volume":"175","author":"M Castori","year":"2017","unstructured":"Castori M, Tinkle B, Levy H, Grahame R, Malfait F, Hakim A (2017) A framework for the classification of joint hypermobility and related conditions. Am J Med Genet Part C Semin Med Genet 175:148\u2013157. \n                    https:\/\/doi.org\/10.1002\/ajmg.c.31539","journal-title":"Am J Med Genet Part C Semin Med Genet"},{"key":"1835_CR5","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/nprot.2012.009","volume":"7","author":"X Chen","year":"2012","unstructured":"Chen X, Nadiarynkh O, Plotnikov S, Campagnola PJ (2012) Second harmonic generation microscopy for quantitative analysis of collagen fibrillar structure. Nat Protoc 7:654\u2013669. \n                    https:\/\/doi.org\/10.1038\/nprot.2012.009","journal-title":"Nat Protoc"},{"key":"1835_CR6","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1007\/s10620-014-3165-8","volume":"59","author":"R Cicchi","year":"2014","unstructured":"Cicchi R (2014) The new digital pathology: just say NLO. Dig Dis Sci 59:1347\u20131348. \n                    https:\/\/doi.org\/10.1007\/s10620-014-3165-8","journal-title":"Dig Dis Sci"},{"key":"1835_CR7","doi-asserted-by":"publisher","first-page":"903589","DOI":"10.1155\/2014\/903589","volume":"2014","author":"R Cicchi","year":"2014","unstructured":"Cicchi R, Kapsokalyvas D, Pavone FS (2014) Clinical nonlinear laser imaging of human skin: a review. Biomed Res Int 2014:903589. \n                    https:\/\/doi.org\/10.1155\/2014\/903589","journal-title":"Biomed Res Int"},{"key":"1835_CR8","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.jsb.2014.07.003","volume":"187","author":"JZ Cui","year":"2014","unstructured":"Cui JZ, Tehrani AY, Jett KA, Bernatchez P, van Breemen C, Esfandiarei M (2014) Quantification of aortic and cutaneous elastin and collagen morphology in Marfan syndrome by multiphoton microscopy. J Struct Biol 187:242\u2013253. \n                    https:\/\/doi.org\/10.1016\/j.jsb.2014.07.003","journal-title":"J Struct Biol"},{"key":"1835_CR9","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1002\/ajmg.10373","volume":"109","author":"C Giunta","year":"2002","unstructured":"Giunta C, Nuytinck L, Raghunath M, Hausser I, De Paepe A, Steinmann B (2002) Homozygous Gly530Ser substitution in COL5A1 causes mild classical Ehlers-Danlos syndrome. Am J Med Genet 109:284\u2013290. \n                    https:\/\/doi.org\/10.1002\/ajmg.10373","journal-title":"Am J Med Genet"},{"key":"1835_CR10","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/(SICI)1096-8628(20000103)90:1<72::AID-AJMG13>3.0.CO;2-C","volume":"90","author":"C Giunta","year":"2000","unstructured":"Giunta C, Steinmann B (2000) Compound heterozygosity for a disease-causing G1489E [corrected] and disease-modifying G530S substitution in COL5A1 of a patient with the classical type of Ehlers-Danlos syndrome: an explanation of intrafamilial variability? Am J Med Genet 90:72\u201379","journal-title":"Am J Med Genet"},{"key":"1835_CR11","doi-asserted-by":"publisher","first-page":"4480","DOI":"10.1364\/BOE.7.004480","volume":"7","author":"D Haluszka","year":"2016","unstructured":"Haluszka D, Lorincz K, Kiss N, Szipocs R, Kuroli E, Gyongyosi N, Wikonkal NM (2016) Diet-induced obesity skin changes monitored by in vivo SHG and ex vivo CARS microscopy. Biomed Opt Express 7:4480\u20134489. \n                    https:\/\/doi.org\/10.1364\/BOE.7.004480","journal-title":"Biomed Opt Express"},{"key":"1835_CR12","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/jemt.22545","volume":"78","author":"D Haluszka","year":"2015","unstructured":"Haluszka D, Lorincz K, Molnar G, Tamas G, Kolonics A, Szipocs R, Karpati S, Wikonkal NM (2015) In vivo second-harmonic generation and ex vivo coherent anti-stokes raman scattering microscopy to study the effect of obesity to fibroblast cell function using an Yb-fiber laser-based CARS extension unit. Microsc Res Tech 78:823\u2013830. \n                    https:\/\/doi.org\/10.1002\/jemt.22545","journal-title":"Microsc Res Tech"},{"key":"1835_CR13","doi-asserted-by":"publisher","unstructured":"Hermanns-L\u00ea T, Reginster M-A, Pi\u00e9rard-Franchimont C, Pi\u00e9rard GE (2012) Ehlers\u2013Danlos syndrome. In: Stirling JW, Curry A, Eyden B (eds) Diagnostic electron microscopy\u2014a practical guide to interpretation and technique. Wiley, pp\u00a0309\u2013321. \n                    https:\/\/doi.org\/10.1002\/9781118452813.ch12","DOI":"10.1002\/9781118452813.ch12"},{"key":"1835_CR14","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1046\/j.1365-4362.2001.01197.x","volume":"40","author":"S Iurassich","year":"2001","unstructured":"Iurassich S, Rocco D, Aurilia A (2001) Type III Ehlers-Danlos syndrome: correlations among clinical signs, ultrasound, and histologic findings in a study of 35 cases. Int J Dermatol 40:175\u2013178","journal-title":"Int J Dermatol"},{"key":"1835_CR15","doi-asserted-by":"publisher","first-page":"4504","DOI":"10.1529\/biophysj.107.114405","volume":"94","author":"R Lacomb","year":"2008","unstructured":"Lacomb R, Nadiarnykh O, Campagnola PJ (2008) Quantitative second harmonic generation imaging of the diseased state osteogenesis imperfecta: experiment and simulation. Biophys J 94:4504\u20134514. \n                    https:\/\/doi.org\/10.1529\/biophysj.107.114405","journal-title":"Biophys J"},{"key":"1835_CR16","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s00403-017-1715-6","volume":"309","author":"K Lorincz","year":"2017","unstructured":"Lorincz K, Haluszka D, Kiss N, Gyongyosi N, Banvolgyi A, Szipocs R, Wikonkal NM (2017) Voluntary exercise improves murine dermal connective tissue status in high-fat diet-induced obesity. Arch Dermatol Res 309:209\u2013215. \n                    https:\/\/doi.org\/10.1007\/s00403-017-1715-6","journal-title":"Arch Dermatol Res"},{"key":"1835_CR17","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/humu.20107","volume":"25","author":"F Malfait","year":"2005","unstructured":"Malfait F, Coucke P, Symoens S, Loeys B, Nuytinck L, De Paepe A (2005) The molecular basis of classic Ehlers-Danlos syndrome: a comprehensive study of biochemical and molecular findings in 48 unrelated patients. Hum Mutat 25:28\u201337. \n                    https:\/\/doi.org\/10.1002\/humu.20107","journal-title":"Hum Mutat"},{"key":"1835_CR18","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/ajmg.c.31552","volume":"175","author":"F Malfait","year":"2017","unstructured":"Malfait F, Francomano C, Byers P, Belmont J, Berglund B, Black J, Bloom L, Bowen JM, Brady AF, Burrows NP, Castori M, Cohen H, Colombi M, Demirdas S, De Backer J, De Paepe A, Fournel-Gigleux S, Frank M, Ghali N, Giunta C, Grahame R, Hakim A, Jeunemaitre X, Johnson D, Juul-Kristensen B, Kapferer-Seebacher I, Kazkaz H, Kosho T, Lavallee ME, Levy H, Mendoza-Londono R, Pepin M, Pope FM, Reinstein E, Robert L, Rohrbach M, Sanders L, Sobey GJ, Van Damme T, Vandersteen A, van Mourik C, Voermans N, Wheeldon N, Zschocke J, Tinkle B (2017) The 2017 international classification of the Ehlers-Danlos syndromes. Am J Med Genet Part C Semin Med Genet 175:8\u201326. \n                    https:\/\/doi.org\/10.1002\/ajmg.c.31552","journal-title":"Am J Med Genet Part C Semin Med Genet"},{"key":"1835_CR19","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1111\/j.1469-7580.2009.01149.x","volume":"215","author":"J Mansfield","year":"2009","unstructured":"Mansfield J, Yu J, Attenburrow D, Moger J, Tirlapur U, Urban J, Cui Z, Winlove P (2009) The elastin network: its relationship with collagen and cells in articular cartilage as visualized by multiphoton microscopy. J Anat 215:682\u2013691. \n                    https:\/\/doi.org\/10.1111\/j.1469-7580.2009.01149.x","journal-title":"J Anat"},{"key":"1835_CR20","doi-asserted-by":"publisher","unstructured":"Mayer K, Kennerknecht I, Steinmann B (2013) Clinical utility gene card for: Ehlers\u2013Danlos syndrome types I\u2013VII and variants\u2014update 2012. Eur J Hum Genet 21. \n                    https:\/\/doi.org\/10.1038\/ejhg.2012.162","DOI":"10.1038\/ejhg.2012.162"},{"key":"1835_CR21","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1002\/humu.21000","volume":"30","author":"AL Mitchell","year":"2009","unstructured":"Mitchell AL, Schwarze U, Jennings JF, Byers PH (2009) Molecular mechanisms of classical Ehlers-Danlos syndrome (EDS). Hum Mutat 30:995\u20131002. \n                    https:\/\/doi.org\/10.1002\/humu.21000","journal-title":"Hum Mutat"},{"key":"1835_CR22","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.jdermsci.2013.06.016","volume":"72","author":"T Murata","year":"2013","unstructured":"Murata T, Honda T, Miyachi Y, Kabashima K (2013) Morphological character of pseudoxanthoma elasticum observed by multiphoton microscopy. J Dermatol Sci 72:199\u2013201. \n                    https:\/\/doi.org\/10.1016\/j.jdermsci.2013.06.016","journal-title":"J Dermatol Sci"},{"key":"1835_CR23","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1365-2141.2008.06994.x","volume":"141","author":"LA Parapia","year":"2008","unstructured":"Parapia LA, Jackson C (2008) Ehlers-Danlos syndrome\u2014a historical review. Br J Haematol 141:32\u201335. \n                    https:\/\/doi.org\/10.1111\/j.1365-2141.2008.06994.x","journal-title":"Br J Haematol"},{"key":"1835_CR24","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/j.1365-4362.1983.tb02142.x","volume":"22","author":"GE Pierard","year":"1983","unstructured":"Pierard GE, Pierard-Franchimont C, Lapiere CM (1983) Histopathological aid at the diagnosis of the Ehlers-Danlos syndrome, gravis and mitis types. Int J Dermatol 22:300\u2013304","journal-title":"Int J Dermatol"},{"key":"1835_CR25","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1073\/pnas.72.4.1314","volume":"72","author":"FM Pope","year":"1975","unstructured":"Pope FM, Martin GR, Lichtenstein JR, Penttinen R, Gerson B, Rowe DW, McKusick VA (1975) Patients with Ehlers-Danlos syndrome type IV lack type III collagen. Proc Natl Acad Sci USA 72:1314\u20131316","journal-title":"Proc Natl Acad Sci USA"},{"key":"1835_CR26","doi-asserted-by":"publisher","unstructured":"Ranjit S, Dvornikov A, Stakic M, Hong SH, Levi M, Evans RM, Gratton E (2015) Imaging fibrosis and separating collagens using second harmonic generation and phasor approach to fluorescence lifetime imaging. Sci Rep 5. \n                    https:\/\/doi.org\/10.1038\/srep13378","DOI":"10.1038\/srep13378"},{"key":"1835_CR27","doi-asserted-by":"publisher","unstructured":"Ricard-Blum S (2011) The Collagen family. Cold Spring Harb Perspect Biol 3. \n                    https:\/\/doi.org\/10.1101\/cshperspect.a004978","DOI":"10.1101\/cshperspect.a004978"},{"key":"1835_CR28","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1146\/annurev.biochem.77.032207.120833","volume":"78","author":"MD Shoulders","year":"2009","unstructured":"Shoulders MD, Raines RT (2009) Collagen structure and stability. Annu Rev Biochem 78:929\u2013958. \n                    https:\/\/doi.org\/10.1146\/annurev.biochem.77.032207.120833","journal-title":"Annu Rev Biochem"},{"key":"1835_CR29","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1001\/archderm.1979.04010010012004","volume":"115","author":"VI Sulica","year":"1979","unstructured":"Sulica VI, Cooper PH, Pope FM, Hambrick GW Jr, Gerson BM, McKusick VA (1979) Cutaneous histologic features in Ehlers-Danlos syndrome: study of 21 patients. Arch Dermatol 115:40\u201342","journal-title":"Arch Dermatol"},{"key":"1835_CR30","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1002\/humu.22137","volume":"33","author":"S Symoens","year":"2012","unstructured":"Symoens S, Syx D, Malfait F, Callewaert B, De Backer J, Vanakker O, Coucke P, De Paepe A (2012) Comprehensive molecular analysis demonstrates type V collagen mutations in over 90% of patients with classic EDS and allows to refine diagnostic criteria. Hum Mutat 33:1485\u20131493. \n                    https:\/\/doi.org\/10.1002\/humu.22137","journal-title":"Hum Mutat"},{"key":"1835_CR31","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/ajmg.c.31538","volume":"175","author":"B Tinkle","year":"2017","unstructured":"Tinkle B, Castori M, Berglund B, Cohen H, Grahame R, Kazkaz H, Levy H (2017) Hypermobile Ehlers-Danlos syndrome (a.k.a. Ehlers-Danlos syndrome Type III and Ehlers-Danlos syndrome hypermobility type): clinical description and natural history. Am J Med Genet Part C Semin Med Genet 175:48\u201369. \n                    https:\/\/doi.org\/10.1002\/ajmg.c.31538","journal-title":"Am J Med Genet Part C Semin Med Genet"},{"key":"1835_CR32","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/srt.12390","volume":"24","author":"SY Tzeng","year":"2018","unstructured":"Tzeng SY, Kuo TY, Hu SB, Chen YW, Lin YL, Chu KY, Tseng SH (2018) Skin collagen can be accurately quantified through noninvasive optical method: validation on a swine study. Skin Res Technol 24:59\u201364. \n                    https:\/\/doi.org\/10.1111\/srt.12390","journal-title":"Skin Res Technol"},{"key":"1835_CR33","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1089\/ten.tec.2014.0578","volume":"21","author":"Y Wang","year":"2015","unstructured":"Wang Y, Xu R, He W, Yao Z, Li H, Zhou J, Tan J, Yang S, Zhan R, Luo G, Wu J (2015) Three-Dimensional histological structures of the human dermis. Tissue Eng Part C Methods 21:932\u2013944. \n                    https:\/\/doi.org\/10.1089\/ten.TEC.2014.0578","journal-title":"Tissue Eng Part C Methods"},{"key":"1835_CR34","doi-asserted-by":"publisher","first-page":"698","DOI":"10.3346\/jkms.2007.22.4.698","volume":"22","author":"JH Yang","year":"2007","unstructured":"Yang JH, Lee ST, Kim JA, Kim SH, Jang SY, Ki CS, Kim DK (2007) Genetic analysis of three Korean patients with clinical features of Ehlers-Danlos syndrome type IV. J Korean Med Sci 22:698\u2013705. \n                    https:\/\/doi.org\/10.3346\/jkms.2007.22.4.698","journal-title":"J Korean Med Sci"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00403-018-1835-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-018-1835-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-018-1835-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T23:11:54Z","timestamp":1556838714000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00403-018-1835-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,3]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["1835"],"URL":"https:\/\/doi.org\/10.1007\/s00403-018-1835-7","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,3]]},"assertion":[{"value":"15 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}