{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:09:25Z","timestamp":1779124165117,"version":"3.51.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,2,23]],"date-time":"2019-02-23T00:00:00Z","timestamp":1550880000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Federal Ministry of Science and Technology"},{"DOI":"10.13039\/501100003185","name":"Fraunhofer-Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003185","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rector?s scholarship from the University of Erciyes"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s00403-019-01889-x","type":"journal-article","created":{"date-parts":[[2019,2,23]],"date-time":"2019-02-23T01:45:47Z","timestamp":1550886347000},"page":"325-330","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Nestin+ progenitor cells isolated from adult human sweat gland stroma promote reepithelialisation and may\u00a0stimulate angiogenesis in wounded human skin ex vivo"],"prefix":"10.1007","volume":"311","author":[{"given":"Tian","family":"Liao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janin","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Sternstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"Yay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Emilia","family":"Matthie\u00dfen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Schumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Siemers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charli","family":"Kruse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer E.","family":"Hundt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewan A.","family":"Langan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Tiede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Paus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,2,23]]},"reference":[{"key":"1889_CR1","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/exd.13359","volume":"26","author":"NA Agabalyan","year":"2017","unstructured":"Agabalyan NA, Rosin NL, Rahmani W, Biernaskie J (2017) Hair follicle dermal stem cells and skin-derived precursor cells: exciting tools for endogenous and exogenous therapies. Exp Dermatol 26:505\u2013509. \n                    https:\/\/doi.org\/10.1111\/exd.13359","journal-title":"Exp Dermatol"},{"key":"1889_CR2","doi-asserted-by":"publisher","first-page":"17734","DOI":"10.1073\/pnas.0508440102","volume":"102","author":"Y Amoh","year":"2005","unstructured":"Amoh Y, Li L, Campillo R, Kawahara K, Katsuoka K, Penman S, Hoffman RM (2005) Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves. Proc Natl Acad Sci USA 102:17734\u201317738. \n                    https:\/\/doi.org\/10.1073\/pnas.0508440102","journal-title":"Proc Natl Acad Sci USA"},{"key":"1889_CR3","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.4161\/cc.7.12.6056","volume":"7","author":"Y Amoh","year":"2008","unstructured":"Amoh Y, Li L, Katsuoka K, Hoffman RM (2008) Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function. Cell Cycle 7:1865\u20131869. \n                    https:\/\/doi.org\/10.4161\/cc.7.12.6056","journal-title":"Cell Cycle"},{"key":"1889_CR4","doi-asserted-by":"publisher","first-page":"5530","DOI":"10.1073\/pnas.0501263102","volume":"102","author":"Y Amoh","year":"2005","unstructured":"Amoh Y, Li L, Katsuoka K, Penman S, Hoffman RM (2005) Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons. Proc Natl Acad Sci USA 102:5530\u20135534. \n                    https:\/\/doi.org\/10.1073\/pnas.0501263102","journal-title":"Proc Natl Acad Sci USA"},{"key":"1889_CR5","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1038\/jid.2012.31","volume":"132","author":"S Danner","year":"2012","unstructured":"Danner S, Kremer M, Petschnik AE, Nagel S, Zhang Z, Hopfner U, Reckhenrich AK, Weber C, Schenck TL, Becker T, Kruse C, Machens HG, Egana JT (2012) The use of human sweat gland-derived stem cells for enhancing vascularization during dermal regeneration. J Invest Dermatol 132:1707\u20131716. \n                    https:\/\/doi.org\/10.1038\/jid.2012.31","journal-title":"J Invest Dermatol"},{"key":"1889_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/exd.13281","volume":"26","author":"SA Eming","year":"2017","unstructured":"Eming SA, Tomic-Canic M (2017) Updates in wound healing: Mechanisms and translation. Exp Dermatol 26:97\u201398. \n                    https:\/\/doi.org\/10.1111\/exd.13281","journal-title":"Exp Dermatol"},{"key":"1889_CR7","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1111\/wrr.12600","volume":"25","author":"GD Glinos","year":"2017","unstructured":"Glinos GD, Verne SH, Aldahan AS, Liang L, Nouri K, Elliot S, Glassberg M, Cabrera DeBuc D, Koru-Sengul T, Tomic-Canic M, Pastar I (2017) Optical coherence tomography for assessment of epithelialization in a human ex vivo wound model. Wound Repair Regen 25:1017\u20131026. \n                    https:\/\/doi.org\/10.1111\/wrr.12600","journal-title":"Wound Repair Regen"},{"key":"1889_CR8","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s13287-015-0209-8","volume":"6","author":"N Kalinina","year":"2015","unstructured":"Kalinina N, Kharlampieva D, Loguinova M, Butenko I, Pobeguts O, Efimenko A, Ageeva L, Sharonov G, Ischenko D, Alekseev D, Grigorieva O, Sysoeva V, Rubina K, Lazarev V, Govorun V (2015) Characterization of secretomes provides evidence for adipose-derived mesenchymal stromal cells subtypes. Stem Cell Res Ther 6:221. \n                    https:\/\/doi.org\/10.1186\/s13287-015-0209-8","journal-title":"Stem Cell Res Ther"},{"key":"1889_CR9","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1111\/j.1600-0625.2006.00471.x","volume":"15","author":"C Kruse","year":"2006","unstructured":"Kruse C, Bodo E, Petschnik AE, Danner S, Tiede S, Paus R (2006) Towards the development of a pragmatic technique for isolating and differentiating nestin-positive cells from human scalp skin into neuronal and glial cell populations: generating neurons from human skin? Exp Dermatol 15:794\u2013800. \n                    https:\/\/doi.org\/10.1111\/j.1600-0625.2006.00471.x","journal-title":"Exp Dermatol"},{"key":"1889_CR10","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/j.1600-0625.2009.00942.x","volume":"18","author":"K Lau","year":"2009","unstructured":"Lau K, Paus R, Tiede S, Day P, Bayat A (2009) Exploring the role of stem cells in cutaneous wound healing. Exp Dermatol 18:921\u2013933. \n                    https:\/\/doi.org\/10.1111\/j.1600-0625.2009.00942.x","journal-title":"Exp Dermatol"},{"key":"1889_CR11","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/j.1600-0625.2006.00510.x","volume":"16","author":"Z Lu","year":"2007","unstructured":"Lu Z, Hasse S, Bodo E, Rose C, Funk W, Paus R (2007) Towards the development of a simplified long-term organ culture method for human scalp skin and its appendages under serum-free conditions. Exp Dermatol 16:37\u201344. \n                    https:\/\/doi.org\/10.1111\/j.1600-0625.2006.00510.x","journal-title":"Exp Dermatol"},{"key":"1889_CR12","doi-asserted-by":"publisher","first-page":"e73596","DOI":"10.1371\/journal.pone.0073596","volume":"8","author":"NT Meier","year":"2013","unstructured":"Meier NT, Haslam IS, Pattwell DM, Zhang GY, Emelianov V, Paredes R, Debus S, Augustin M, Funk W, Amaya E, Kloepper JE, Hardman MJ, Paus R (2013) Thyrotropin-releasing hormone (TRH) promotes wound re-epithelialisation in frog and human skin. PLoS One 8:e73596. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0073596","journal-title":"PLoS One"},{"key":"1889_CR13","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1046\/j.1523-1747.1998.00265.x","volume":"111","author":"I Moll","year":"1998","unstructured":"Moll I, Houdek P, Schmidt H, Moll R (1998) Characterization of epidermal wound healing in a human skin organ culture model: acceleration by transplanted keratinocytes. J Invest Dermatol 111:251\u2013258. \n                    https:\/\/doi.org\/10.1046\/j.1523-1747.1998.00265.x","journal-title":"J Invest Dermatol"},{"key":"1889_CR14","doi-asserted-by":"publisher","first-page":"e78365","DOI":"10.1371\/journal.pone.0078365","volume":"8","author":"S Nagel","year":"2013","unstructured":"Nagel S, Rohr F, Weber C, Kier J, Siemers F, Kruse C, Danner S, Brandenburger M, Matthiessen AE (2013) Multipotent nestin-positive stem cells reside in the stroma of human eccrine and apocrine sweat glands and can be propagated robustly in vitro. PLoS One 8:e78365. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0078365","journal-title":"PLoS One"},{"key":"1889_CR15","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/j.1365-2133.2009.09512.x","volume":"162","author":"AE Petschnik","year":"2010","unstructured":"Petschnik AE, Klatte JE, Evers LH, Kruse C, Paus R, Danner S (2010) Phenotypic indications that human sweat glands are a rich source of nestin-positive stem cell populations. Br J Dermatol 162:380\u2013383. \n                    https:\/\/doi.org\/10.1111\/j.1365-2133.2009.09512.x","journal-title":"Br J Dermatol"},{"key":"1889_CR16","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/exd.13099","volume":"26","author":"S Sotomayor","year":"2017","unstructured":"Sotomayor S, Pascual G, Blanc-Guillemaud V, Mesa-Ciller C, Garcia-Honduvilla N, Cifuentes A, Bujan J (2017) Effects of a novel NADPH oxidase inhibitor (S42909) on wound healing in an experimental ischemic excisional skin model. Exp Dermatol 26:148\u2013155. \n                    https:\/\/doi.org\/10.1111\/exd.13099","journal-title":"Exp Dermatol"},{"key":"1889_CR17","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/978-1-62703-505-7_14","volume":"1037","author":"O Stojadinovic","year":"2013","unstructured":"Stojadinovic O, Tomic-Canic M (2013) Human ex vivo wound healing model. Methods Mol Biol 1037:255\u2013264. \n                    https:\/\/doi.org\/10.1007\/978-1-62703-505-7_14","journal-title":"Methods Mol Biol"},{"key":"1889_CR18","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1038\/jid.2009.148","volume":"129","author":"S Tiede","year":"2009","unstructured":"Tiede S, Kloepper J, Ernst N (2009) Nestin in human skin: exclusive expression in intramesenchymal skin compartments and regultaion by leptin. Journal of Investigative Dermatolog 129:2711\u20132720","journal-title":"Journal of Investigative Dermatolog"},{"key":"1889_CR19","doi-asserted-by":"publisher","first-page":"535","DOI":"10.2174\/1574888X12666170829161058","volume":"12","author":"CH Won","year":"2017","unstructured":"Won CH, Park GH, Wu X, Tran TN, Park KY, Park BS, Kim DY, Kwon O, Kim KH (2017) The basic mechanism of hair growth stimulation by adipose-derived stem cells and their secretory factors. Curr Stem Cell Res Ther 12:535\u2013543. \n                    https:\/\/doi.org\/10.2174\/1574888X12666170829161058","journal-title":"Curr Stem Cell Res Ther"},{"key":"1889_CR20","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1042\/CS20140735","volume":"129","author":"M Wu","year":"2015","unstructured":"Wu M, Ji S, Xiao S, Kong Z, Fang H, Zhang Y, Ji K, Zheng Y, Liu H, Xia Z (2015) JAM-A promotes wound healing by enhancing both homing and secretory activities of mesenchymal stem cells. Clin Sci (Lond) 129:575\u2013588. \n                    https:\/\/doi.org\/10.1042\/CS20140735","journal-title":"Clin Sci (Lond)"},{"key":"1889_CR21","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/labinvest.2011.184","volume":"92","author":"W Xu","year":"2012","unstructured":"Xu W, Jong Hong S, Jia S, Zhao Y, Galiano RD, Mustoe TA (2012) Application of a partial-thickness human ex vivo skin culture model in cutaneous wound healing study. Lab Invest 92:584\u2013599. \n                    https:\/\/doi.org\/10.1038\/labinvest.2011.184","journal-title":"Lab Invest"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00403-019-01889-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-019-01889-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-019-01889-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T20:14:59Z","timestamp":1582402499000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00403-019-01889-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,23]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["1889"],"URL":"https:\/\/doi.org\/10.1007\/s00403-019-01889-x","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,23]]},"assertion":[{"value":"26 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors state no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Patients provides informed consent and ethical approval was obtained from the University of Luebeck Ethics Committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}