{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:10:51Z","timestamp":1788361851354,"version":"build-2803163510"},"reference-count":130,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s00403-019-01968-z","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T03:40:36Z","timestamp":1566790836000},"page":"5-23","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Promising plant-derived secondary metabolites for treatment of acne vulgaris: a mechanistic review"],"prefix":"10.1007","volume":"312","author":[{"given":"Samaneh","family":"Soleymani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hosein","family":"Farzaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Zargaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Niknam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8637-4350","authenticated-orcid":false,"given":"Roja","family":"Rahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,26]]},"reference":[{"issue":"4","key":"1968_CR1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.2042-7158.2010.01241.x","volume":"63","author":"YH Song","year":"2011","unstructured":"Song YH, Cai H, Gu N et al (2011) Icariin attenuates cardiac remodelling through down-regulating myocardial apoptosis and matrix metalloproteinase activity in rats with congestive heart failure. J Pharm Pharmacol 63(4):541\u2013549","journal-title":"J Pharm Pharmacol"},{"issue":"4","key":"1968_CR2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1248\/cpb.c12-01043","volume":"61","author":"CH Liu","year":"2013","unstructured":"Liu CH, Huang HY (2013) In vitro anti-propionibacterium activity by curcumin containing vesicle system. Chem Pharm Bull (Tokyo) 61(4):419\u2013425","journal-title":"Chem Pharm Bull (Tokyo)"},{"issue":"2","key":"1968_CR3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.0906-6705.2005.0285a.x","volume":"14","author":"C Zouboulis","year":"2005","unstructured":"Zouboulis C, Eady A, Philpott M et al (2005) What is the pathogenesis of acne? Exp Dermatol 14(2):143","journal-title":"Exp Dermatol"},{"issue":"4","key":"1968_CR4","first-page":"407","volume":"19","author":"T-Q Wu","year":"2007","unstructured":"Wu T-Q, Mei S-Q, Zhang J-X et al (2007) Prevalence and risk factors of facial acne vulgaris among Chinese adolescents. Int J Adolesc Med Health 19(4):407\u2013412","journal-title":"Int J Adolesc Med Health"},{"issue":"2","key":"1968_CR5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1089\/jwh.2010.2722","volume":"21","author":"AC Perkins","year":"2012","unstructured":"Perkins AC, Maglione J, Hillebrand GG, Miyamoto K, Kimball AB (2012) Acne vulgaris in women: prevalence across the life span. J Womens Health 21(2):223\u2013230","journal-title":"J Womens Health"},{"issue":"5","key":"1968_CR6","first-page":"945-973.e33","volume":"74","author":"Andrea L. Zaenglein","year":"2016","unstructured":"Zaenglein AL, Pathy AL, Schlosser BJ et al (2016) Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol 74(5):945\u201373.e33","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"3","key":"1968_CR7","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/bjd.12149","volume":"168","author":"K Bhate","year":"2013","unstructured":"Bhate K, Williams H (2013) Epidemiology of acne vulgaris. Br J Dermatol 168(3):474\u2013485","journal-title":"Br J Dermatol"},{"issue":"3","key":"1968_CR8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2165\/00128071-200607030-00005","volume":"7","author":"SR Rapp","year":"2006","unstructured":"Rapp SR, Feldman SR, Graham G et al (2006) The acne quality of life index (Acne-QOLI). Am J Clin Dermatol 7(3):185\u2013192","journal-title":"Am J Clin Dermatol"},{"issue":"6","key":"1968_CR9","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3923\/rjmp.2011.650.669","volume":"5","author":"S Kapoor","year":"2011","unstructured":"Kapoor S, Saraf S (2011) Topical herbal therapies an alternative and complementary choice to combat acne. Res J Med Plant 5(6):650\u2013659","journal-title":"Res J Med Plant"},{"issue":"1","key":"1968_CR10","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/s12906-016-1387-3","volume":"16","author":"I Tahir","year":"2016","unstructured":"Tahir I, Khan MR, Shah NA, Aftab M (2016) Evaluation of phytochemicals, antioxidant activity and amelioration of pulmonary fibrosis with Phyllanthus emblica leaves. BMC Complement Altern Med 16(1):406","journal-title":"BMC Complement Altern Med"},{"issue":"9813","key":"1968_CR11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(11)60321-8","volume":"379","author":"HC Williams","year":"2012","unstructured":"Williams HC, Dellavalle RP, Garner S (2012) Acne vulgaris. Lancet 379(9813):361\u2013372","journal-title":"Lancet"},{"issue":"27","key":"1968_CR12","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.2174\/1381612822666160601100823","volume":"22","author":"Mohammad Hosein Farzaei","year":"2016","unstructured":"Hosein Farzaei M, Bahramsoltani R, Rahimi (2016) Phytochemicals as adjunctive with conventional anticancer therapies. Curr Pharm Des 22(27):4201\u20134218","journal-title":"Current Pharmaceutical Design"},{"issue":"7","key":"1968_CR13","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00403-014-1474-6","volume":"306","author":"Roodabeh Bahramsoltani","year":"2014","unstructured":"Bahramsoltani R, Farzaei MH, Rahimi (2014) Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review. Arch Dermatol Res 306(7):601\u2013617","journal-title":"Archives of Dermatological Research"},{"issue":"8","key":"1968_CR14","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.fitote.2012.03.026","volume":"83","author":"H Azimi","year":"2012","unstructured":"Azimi H, Fallah-Tafti M, Khakshur AA, Abdollahi M (2012) A review of phytotherapy of acne vulgaris: perspective of new pharmacological treatments. Fitoterapia 83(8):1306\u20131317","journal-title":"Fitoterapia"},{"issue":"5","key":"1968_CR15","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1346-8138.2000.tb02174.x","volume":"27","author":"S Nishijima","year":"2000","unstructured":"Nishijima S, Kurokawa I, Katoh N, Watanabe K (2000) The bacteriology of acne vulgaris and antimicrobial susceptibility of Propionibacterium acnes and Staphylococcus epidermidis isolated from acne lesions. J Dermatol 27(5):318\u2013323","journal-title":"J Dermatol"},{"issue":"15","key":"1968_CR16","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.2165\/00003495-200363150-00005","volume":"63","author":"H Gollnick","year":"2003","unstructured":"Gollnick H (2003) Current concepts of the pathogenesis of acne. Drugs 63(15):1579\u20131596","journal-title":"Drugs"},{"issue":"3","key":"1968_CR17","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000095058","volume":"213","author":"R Ganceviciene","year":"2006","unstructured":"Ganceviciene R, Fimmel S, Glass E, Zouboulis CC (2006) Psoriasin and follicular hyperkeratinization in acne comedones. Dermatology 213(3):270\u2013272","journal-title":"Dermatology"},{"issue":"4","key":"1968_CR18","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1610-0387.2007.06274.x","volume":"5","author":"K Degitz","year":"2007","unstructured":"Degitz K, Placzek M, Borelli C, Plewig G (2007) Pathophysiology of acne. J Dtsch Dermatol Ges 5(4):316\u2013323","journal-title":"J Dtsch Dermatol Ges"},{"key":"1968_CR19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.imu.2017.10.005","volume":"13","author":"J Vora","year":"2017","unstructured":"Vora J, Srivastava A, Modi H (2017) Antibacterial and antioxidant strategies for acne treatment through plant extracts. Inf Med Unlock 13:128\u2013132","journal-title":"Inf Med Unlock"},{"issue":"3","key":"1968_CR20","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.4049\/jimmunol.169.3.1535","volume":"169","author":"J Kim","year":"2002","unstructured":"Kim J, Ochoa M-T, Krutzik SR et al (2002) Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol 169(3):1535\u20131541","journal-title":"J Immunol"},{"issue":"1","key":"1968_CR21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1046\/j.1523-1747.2003.12321.x","volume":"121","author":"AH Jeremy","year":"2003","unstructured":"Jeremy AH, Holland DB, Roberts SG, Thomson KF, Cunliffe WJ (2003) Inflammatory events are involved in acne lesion initiation. J Invest Dermatol 121(1):20\u201327","journal-title":"J Invest Dermatol"},{"issue":"9","key":"1968_CR22","first-page":"27","volume":"6","author":"EA Tanghetti","year":"2013","unstructured":"Tanghetti EA (2013) The role of inflammation in the pathology of acne. J Clin Aesthet Dermatol 6(9):27","journal-title":"J Clin Aesthet Dermatol"},{"issue":"2","key":"1968_CR23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1523-1747.1998.00264.x","volume":"111","author":"MM Downie","year":"1998","unstructured":"Downie MM, Kealey T (1998) Lipogenesis in the human sebaceous gland: glycogen and glycerophosphate are substrates for the synthesis of sebum lipids. J Invest Dermatol 111(2):199\u2013205","journal-title":"J Invest Dermatol"},{"issue":"1","key":"1968_CR24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-5945-13-2","volume":"13","author":"AJ McNairn","year":"2013","unstructured":"McNairn AJ, Doucet Y, Demaude J et al (2013) TGF\u03b2 signaling regulates lipogenesis in human sebaceous glands cells. BMC Dermatol 13(1):2","journal-title":"BMC Dermatol"},{"key":"1968_CR25","volume-title":"Acne: diagnosis and management","author":"CC Lyon","year":"2001","unstructured":"Lyon CC (2001) Acne: diagnosis and management. SAGE Publications Sage UK, London"},{"issue":"6","key":"1968_CR26","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1155\/MI.2005.380","volume":"2005","author":"O Arican","year":"2005","unstructured":"Arican O, Kurutas EB, Sasmaz S (2005) Oxidative stress in patients with acne vulgaris. Mediators Inflamm 2005(6):380\u2013384","journal-title":"Mediators Inflamm"},{"issue":"6","key":"1968_CR27","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1021\/jf052649z","volume":"54","author":"H-A Jung","year":"2006","unstructured":"Jung H-A, Su B-N, Keller WJ, Mehta RG, Kinghorn AD (2006) Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). J Agric Food Chem 54(6):2077\u20132082","journal-title":"J Agric Food Chem"},{"issue":"2","key":"1968_CR28","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1208\/s12249-013-0057-8","volume":"15","author":"R Asasutjarit","year":"2014","unstructured":"Asasutjarit R, Larpmahawong P, Fuongfuchat A, Sareedenchai V, Veeranondha S (2014) Physicochemical properties and anti-Propionibacterium acnes activity of film-forming solutions containing alpha-mangostin-rich extract. AAPS Pharm Sci Tech 15(2):306\u2013316","journal-title":"AAPS Pharm Sci Tech"},{"issue":"1","key":"1968_CR29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10753-018-0876-6","volume":"42","author":"W Zou","year":"2019","unstructured":"Zou W, Yin P, Shi Y et al (2019) A novel biological role of \u03b1-Mangostin via TAK1-NF-\u03baB pathway against inflammatory. Inflammation 42(1):103\u2013112","journal-title":"Inflammation"},{"issue":"11","key":"1968_CR30","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1002\/jcp.25348","volume":"231","author":"S Franceschelli","year":"2016","unstructured":"Franceschelli S, Pesce M, Ferrone A et al (2016) A novel biological role of alpha-mangostin in modulating inflammatory response through the activation of SIRT-1 signaling pathway. J Cell Physiol 231(11):2439\u20132451","journal-title":"J Cell Physiol"},{"key":"1968_CR31","first-page":"1018","volume":"6","author":"Y Fang","year":"2016","unstructured":"Fang Y, Su T, Qiu X et al (2016) Protective effect of alpha-mangostin against oxidative stress induced-retinal cell death. Sci Rep 6:1018\u20131038","journal-title":"Sci Rep"},{"issue":"5","key":"1968_CR32","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1179\/147683012X13327575416400","volume":"15","author":"B Marquez-Valadez","year":"2012","unstructured":"Marquez-Valadez B, Maldonado PD, Galvan-Arzate S et al (2012) Alpha-mangostin induces changes in glutathione levels associated with glutathione peroxidase activity in rat brain synaptosomes. Nutr Neurosci 15(5):13\u201319","journal-title":"Nutr Neurosci"},{"issue":"1","key":"1968_CR33","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.fshw.2012.08.001","volume":"1","author":"X Kou","year":"2012","unstructured":"Kou X, Chen N (2012) Pharmacological potential of ampelopsin in Rattan tea. Food Sci Hum Wellness 1(1):14\u201318","journal-title":"Food Sci Hum Wellness"},{"issue":"1","key":"1968_CR34","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.intimp.2011.12.001","volume":"12","author":"S Qi","year":"2012","unstructured":"Qi S, Xin Y, Guo Y et al (2012) Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K\/Akt\/NF-\u03baB signaling pathways. Int Immunopharmacol 12(1):278\u2013287","journal-title":"Int Immunopharmacol"},{"key":"1968_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.intimp.2016.12.018","volume":"44","author":"L Weng","year":"2017","unstructured":"Weng L, Zhang H, Li X et al (2017) Ampelopsin attenuates lipopolysaccharide-induced inflammatory response through the inhibition of the NF-\u03baB and JAK2\/STAT3 signaling pathways in microglia. Int Immunopharmacol 44:1\u20138","journal-title":"Int Immunopharmacol"},{"issue":"9","key":"1968_CR36","doi-asserted-by":"crossref","first-page":"e108314","DOI":"10.1371\/journal.pone.0108314","volume":"9","author":"X Hou","year":"2014","unstructured":"Hou X, Zhang J, Ahmad H et al (2014) Evaluation of antioxidant activities of ampelopsin and its protective effect in lipopolysaccharide-induced oxidative stress piglets. PLoS ONE 9(9):e108314","journal-title":"PLoS ONE"},{"issue":"3","key":"1968_CR37","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2174\/1389201016666150118131704","volume":"16","author":"MH Farzaei","year":"2015","unstructured":"Farzaei MH, Rahimi R, Abdollahi M (2015) The role of dietary polyphenols in the management of inflammatory bowel disease. Curr Pharm Biotechnol 16(3):196\u2013210","journal-title":"Curr Pharm Biotechnol"},{"issue":"10","key":"1968_CR38","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/exd.13319","volume":"26","author":"KE Lee","year":"2017","unstructured":"Lee KE, Youm JK, Lee WJ, Kang S, Kim YJ (2017) Polyphenol-rich apple extract inhibits dexamethasone-induced sebaceous lipids production by regulating SREBP1 expression. Exp Dermatol 26(10):958\u2013960","journal-title":"Exp Dermatol"},{"issue":"1","key":"1968_CR39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0308-8146(99)00167-3","volume":"68","author":"Y Lu","year":"2000","unstructured":"Lu Y, Foo LY (2000) Antioxidant and radical scavenging activities of polyphenols from apple pomace. Food Chem 68(1):81\u201385","journal-title":"Food Chem"},{"issue":"6","key":"1968_CR40","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1189\/jlb.0311168","volume":"90","author":"JA Skyberg","year":"2011","unstructured":"Skyberg JA, Robison A, Golden S et al (2011) Apple polyphenols require T cells to ameliorate dextran sulfate sodium-induced colitis and dampen proinflammatory cytokine expression. J Leukoc Biol 90(6):1043\u20131054","journal-title":"J Leukoc Biol"},{"issue":"8","key":"1968_CR41","doi-asserted-by":"crossref","first-page":"7085","DOI":"10.3390\/nu7085324","volume":"7","author":"ZR Xu","year":"2015","unstructured":"Xu ZR, Li JY, Dong XW et al (2015) Apple polyphenols decrease atherosclerosis and hepatic steatosis in ApoE\u2212\/\u2212 mice through the ROS\/MAPK\/NF-kappaB pathway. Nutrients 7(8):7085\u20137105","journal-title":"Nutrients"},{"issue":"8","key":"1968_CR42","doi-asserted-by":"crossref","first-page":"e0182357","DOI":"10.1371\/journal.pone.0182357","volume":"12","author":"IC Etti","year":"2017","unstructured":"Etti IC, Abdullah R, Kadir A et al (2017) The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells. PLoS ONE 12(8):e0182357","journal-title":"PLoS ONE"},{"key":"1968_CR43","unstructured":"Nayak M, Nagarajan A, Majeed M, Nagabhushanam K, Choudhury AK (2017) In vitro anti-acne activity of phytoactives from the stem bark of Artocarpus hirsutus Lam. and characterisation of pyranocycloartobiloxanthone A as a mixture of two anomers. Nat Prod Res 2017:1\u20135"},{"issue":"1","key":"1968_CR44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0006-2952(91)90018-Z","volume":"41","author":"GR Reddy","year":"1991","unstructured":"Reddy GR, Ueda N, Hada T et al (1991) A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor. Biochem Pharmacol 41(1):115\u2013118","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"1968_CR45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.18632\/oncotarget.13921","volume":"8","author":"CG Li","year":"2017","unstructured":"Li CG, Yan L, Jing YY et al (2017) Berberine augments ATP-induced inflammasome activation in macrophages by enhancing AMPK signaling. Oncotarget 8(1):95\u2013109","journal-title":"Oncotarget"},{"key":"1968_CR46","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3389\/fphar.2014.00230","volume":"5","author":"C Spatuzza","year":"2014","unstructured":"Spatuzza C, Postiglione L, Covelli B et al (2014) Effects of berberine and red yeast on proinflammatory cytokines IL-6 and TNF-alpha in peripheral blood mononuclear cells (PBMCs) of human subjects. Front pharmacol 5:230","journal-title":"Front pharmacol"},{"key":"1968_CR47","doi-asserted-by":"crossref","unstructured":"Zhang H, Shan Y, Wu Y et al (2017) Berberine suppresses LPS-induced inflammation through modulating Sirt1\/NF-kappaB signaling pathway in RAW264.7 cells. Int Immunopharmacol 52:93\u2013100","DOI":"10.1016\/j.intimp.2017.08.032"},{"issue":"1","key":"1968_CR48","doi-asserted-by":"crossref","first-page":"11340","DOI":"10.1038\/s41598-017-11860-3","volume":"7","author":"Y Sun","year":"2017","unstructured":"Sun Y, Yuan X, Zhang F et al (2017) Berberine ameliorates fatty acid-induced oxidative stress in human hepatoma cells. Sci Rep 7(1):11340","journal-title":"Sci Rep"},{"issue":"5","key":"1968_CR49","first-page":"594","volume":"20","author":"HR Sadeghnia","year":"2017","unstructured":"Sadeghnia HR, Kolangikhah M, Asadpour E, Forouzanfar F, Hosseinzadeh H (2017) Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells. Iran J Basic Med Sci 20(5):594\u2013603","journal-title":"Iran J Basic Med Sci"},{"issue":"4","key":"1968_CR50","doi-asserted-by":"crossref","first-page":"607","DOI":"10.4103\/1008-682X.169997","volume":"18","author":"Y Tian","year":"2016","unstructured":"Tian Y, Zhao L, Wang Y et al (2016) Berberine inhibits androgen synthesis by interaction with aldo-keto reductase 1C3 in 22Rv1 prostate cancer cells. Asian J Androl 18(4):607\u2013612","journal-title":"Asian J Androl"},{"issue":"1","key":"1968_CR51","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000211087","volume":"6","author":"T Seki","year":"1993","unstructured":"Seki T, Morohashi M (1993) Effect of some alkaloids, flavonoids and triterpenoids, contents of Japanese\u2013Chinese traditional herbal medicines, on the lipogenesis of sebaceous glands. Skin Pharmacol Physiol 6(1):56\u201360","journal-title":"Skin Pharmacol Physiol"},{"issue":"7","key":"1968_CR52","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3390\/nu10070855","volume":"10","author":"Mohammad Farzaei","year":"2018","unstructured":"Farzaei MH, Zobeiri M, Parvizi F et al (2018) Curcumin in liver diseases: a systematic review of the cellular mechanisms of oxidative stress and clinical perspective. Nutrients 10:7","journal-title":"Nutrients"},{"issue":"4","key":"1968_CR53","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12029-017-9997-7","volume":"48","author":"A Haghi","year":"2017","unstructured":"Haghi A, Azimi H, Rahimi R (2017) A comprehensive review on pharmacotherapeutics of three phytochemicals, curcumin, quercetin, and Allicin, in the treatment of gastric cancer. J Gastrointest Cancer 48(4):314\u2013320","journal-title":"J Gastrointest Cancer"},{"issue":"9","key":"1968_CR54","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1248\/cpb.c12-00220","volume":"60","author":"CH Liu","year":"2012","unstructured":"Liu CH, Huang HY (2012) Antimicrobial activity of curcumin-loaded myristic acid microemulsions against Staphylococcus epidermidis. Chem Pharm Bull 60(9):1118\u20131124","journal-title":"Chem Pharm Bull"},{"key":"1968_CR55","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.intimp.2017.11.009","volume":"54","author":"J Dai","year":"2018","unstructured":"Dai J, Gu L, Su Y et al (2018) Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2\/4, p38\/JNK MAPK and NF-kappaB pathways. Int Immunopharmacol 54:177\u2013187","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"1968_CR56","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/jdi.12767","volume":"9","author":"Z Zhang","year":"2018","unstructured":"Zhang Z, Li K (2018) Curcumin attenuates high glucose-induced inflammatory injury through the reactive oxygen species-phosphoinositide 3-kinase\/protein kinase B-nuclear factor-kappaB signaling pathway in rat thoracic aorta endothelial cells. J Diabetes Investig 9(4):731\u2013740","journal-title":"J Diabetes Investig"},{"key":"1968_CR57","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.12659\/MSM.909557","volume":"24","author":"S Yu","year":"2018","unstructured":"Yu S, Wang M, Guo X, Qin R (2018) Curcumin attenuates inflammation in a severe acute pancreatitis animal model by regulating TRAF1\/ASK1 signaling. Med Sci Monit 24:2280\u20132286","journal-title":"Med Sci Monit"},{"issue":"4","key":"1968_CR58","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/08927014.2016.1148141","volume":"32","author":"C Sivasankar","year":"2016","unstructured":"Sivasankar C, Maruthupandiyan S, Balamurugan K et al (2016) A combination of ellagic acid and tetracycline inhibits biofilm formation and the associated virulence of Propionibacterium acnes in vitro and in vivo. Biofouling 32(4):397\u2013410","journal-title":"Biofouling"},{"issue":"2","key":"1968_CR59","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1742-7843.2010.00565.x","volume":"107","author":"S Umesalma","year":"2010","unstructured":"Umesalma S, Sudhandiran G (2010) Differential inhibitory effects of the polyphenol ellagic acid on inflammatory mediators NF-\u03baB, iNOS, COX-2, TNF-\u03b1, and IL-6 in 1, 2-dimethylhydrazine-induced rat colon carcinogenesis. Basic Clin Pharmacol Toxicol 107(2):650\u2013655","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"1968_CR60","doi-asserted-by":"crossref","unstructured":"Rios JL, Giner RM, Marin M, Recio MC (2018) A pharmacological update of ellagic acid. Planta Med","DOI":"10.1055\/a-0633-9492"},{"issue":"3","key":"1968_CR61","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1159\/000485448","volume":"44","author":"A Rozentsvit","year":"2017","unstructured":"Rozentsvit A, Vinokur K, Samuel S, Li Y, Gerdes AM, Carrillo-Sepulveda MA (2017) Ellagic acid reduces high glucose-induced vascular oxidative stress through ERK1\/2\/NOX4 signaling pathway. Cell Physiol Biochem 44(3):1174\u20131187","journal-title":"Cell Physiol Biochem"},{"key":"1968_CR62","unstructured":"Ural MS, Yonar ME, Mise Yonar S (2015) Protective effect of ellagic acid on oxidative stress and antioxidant status in Cyprinus carpio during malathion exposure. Cell Mol Biol (Noisy-le-grand) 61(5):58\u201363"},{"issue":"3","key":"1968_CR63","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10072-011-0775-1","volume":"33","author":"E Uzar","year":"2012","unstructured":"Uzar E, Alp H, Cevik MU et al (2012) Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats. Neurol Sci 33(3):567\u2013574","journal-title":"Neurol Sci"},{"issue":"10","key":"1968_CR64","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s40263-017-0466-4","volume":"31","author":"MH Farzaei","year":"2017","unstructured":"Farzaei MH, Shahpiri Z, Bahramsoltani R et al (2017) Efficacy and tolerability of phytomedicines in multiple sclerosis patients: a review. CNS Drugs 31(10):867\u2013889","journal-title":"CNS Drugs"},{"issue":"2","key":"1968_CR65","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/jid.2012.292","volume":"133","author":"Ji Young Yoon","year":"2013","unstructured":"Yoon JY, Kwon HH, Min SU, Thiboutot DM, Suh DH (2013) Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes. J Invest Dermatol 133(2):429\u2013440","journal-title":"Journal of Investigative Dermatology"},{"key":"1968_CR66","doi-asserted-by":"crossref","unstructured":"Koseki J, Matsumoto T, Matsubara Y et al (2015) Inhibition of Rat 5alpha-reductase activity and testosterone-induced sebum synthesis in hamster sebocytes by an extract of quercus acutissima cortex. Evid Based Complement Alternat Med. 2015:853846","DOI":"10.1155\/2015\/853846"},{"issue":"2","key":"1968_CR67","first-page":"818","volume":"41","author":"N Yang","year":"2018","unstructured":"Yang N, Zhang H, Cai X, Shang Y (2018) Epigallocatechin-3-gallate inhibits inflammation and epithelialmesenchymal transition through the PI3K\/AKT pathway via upregulation of PTEN in asthma. Int J Mol Med 41(2):818\u2013828","journal-title":"Int J Mol Med"},{"key":"1968_CR68","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.chemosphere.2016.10.037","volume":"168","author":"J Shi","year":"2017","unstructured":"Shi J, Deng H, Pan H, Xu Y, Zhang M (2017) Epigallocatechin-3-gallate attenuates microcystin-LR induced oxidative stress and inflammation in human umbilical vein endothelial cells. Chemosphere 168:25\u201331","journal-title":"Chemosphere"},{"issue":"6","key":"1968_CR69","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1007\/s10753-017-0656-8","volume":"40","author":"M Guo","year":"2017","unstructured":"Guo M, An F, Wei X, Hong M, Lu Y (2017) Comparative effects of schisandrin A, B, and C on acne-related inflammation. Inflammation 40(6):2163\u20132172","journal-title":"Inflammation"},{"issue":"2","key":"1968_CR70","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10086-013-1388-5","volume":"60","author":"I Batubara","year":"2014","unstructured":"Batubara I, Kuspradini H, Muddathir AM, Mitsunaga T (2014) Intsia palembanica wood extracts and its isolated compounds as Propionibacterium acnes lipase inhibitor. J Wood Sci 60(2):169\u2013174","journal-title":"J Wood Sci"},{"issue":"11","key":"1968_CR71","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1089\/jmf.2014.3411","volume":"18","author":"Ji Eun Moon","year":"2015","unstructured":"Moon JE, Shin J-H, Kwon O, Kim JY, Jomf J (2015) A standardized extract of rhus verniciflua stokes protects wistar rats against lipopolysaccharide-induced acute inflammation. J Med Food 18(11):1223\u20131230","journal-title":"Journal of Medicinal Food"},{"issue":"3","key":"1968_CR72","first-page":"225","volume":"22","author":"N Kahkeshani","year":"2019","unstructured":"Kahkeshani N, Farzaei F, Fotouhi M et al (2019) Pharmacological effects of gallic acid in health and disease: a mechanistic review. Iran J Basic Med Sci 22(3):225\u2013237","journal-title":"Iran J Basic Med Sci"},{"issue":"6","key":"1968_CR73","first-page":"555","volume":"18","author":"WH Lin","year":"2015","unstructured":"Lin WH, Kuo HH, Ho LH, Tseng ML, Siao AC, Hung CT et al (2015) Gardenia jasminoides extracts and gallic acid inhibit lipopolysaccharide-induced inflammation by suppression of JNK2\/1 signaling pathways in BV-2 cells. Iran J Basic Med Sci 18(6):555\u2013562","journal-title":"Iran J Basic Med Sci"},{"key":"1968_CR74","doi-asserted-by":"crossref","first-page":"827","DOI":"10.12659\/MSM.908550","volume":"24","author":"G Wei","year":"2018","unstructured":"Wei G, Wu Y, Gao Q et al (2018) Gallic acid attenuates postoperative intra-abdominal adhesion by inhibiting inflammatory reaction in a rat model. Med Sci Monit 24:827\u2013838","journal-title":"Med Sci Monit"},{"issue":"4","key":"1968_CR75","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3109\/19390211.2015.1103827","volume":"13","author":"AA Oyagbemi","year":"2016","unstructured":"Oyagbemi AA, Omobowale TO, Saba AB et al (2016) Gallic acid ameliorates cyclophosphamide-induced neurotoxicity in Wistar rats through free radical scavenging activity and improvement in antioxidant defense system. J Diet Suppl 13(4):402\u2013419","journal-title":"J Diet Suppl"},{"key":"1968_CR76","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.etap.2016.08.019","volume":"48","author":"HM Mohamed","year":"2016","unstructured":"Mohamed HM, Abd El-Twab SM (2016) Gallic acid attenuates chromium-induced thyroid dysfunction by modulating antioxidant status and inflammatory cytokines. Environ Toxicol Pharmacol 48:225\u2013236","journal-title":"Environ Toxicol Pharmacol"},{"issue":"1","key":"1968_CR77","doi-asserted-by":"crossref","first-page":"E15","DOI":"10.3390\/molecules21010015","volume":"21","author":"PJ Tsai","year":"2015","unstructured":"Tsai PJ, Huang WC, Hsieh MC et al (2015) Flavones isolated from scutellariae radix suppress propionibacterium acnes-induced cytokine production in vitro and in vivo. Molecules 21(1):E15","journal-title":"Molecules"},{"issue":"6","key":"1968_CR78","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/(SICI)1099-1573(199909)13:6<479::AID-PTR484>3.0.CO;2-M","volume":"13","author":"BO Lim","year":"1999","unstructured":"Lim BO, Yu BP, Kim SC, Park DK (1999) The antioxidative effect of ganhuangenin against lipid peroxidation. Phytother Res 13(6):479\u2013483","journal-title":"Phytother Res"},{"issue":"4","key":"1968_CR79","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.phymed.2008.12.006","volume":"16","author":"H Nian","year":"2009","unstructured":"Nian H, Ma M-H, Nian S-S, Xu L-L (2009) Antiosteoporotic activity of icariin in ovariectomized rats. Phytomedicine 16(4):320\u2013326","journal-title":"Phytomedicine"},{"issue":"1\u20133","key":"1968_CR80","first-page":"146","volume":"642","author":"CQ Xu","year":"2010","unstructured":"Xu CQ, Liu BJ, Wu JF et al (2010) Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K\/Akt and NF-kappaB signaling pathway. Eur J Pharmacol 642(1\u20133):146\u2013153","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"1968_CR81","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.intimp.2015.10.023","volume":"29","author":"L Kong","year":"2015","unstructured":"Kong L, Liu J, Wang J, Luo Q, Zhang H, Liu B et al (2015) Icariin inhibits TNF-alpha\/IFN-gamma induced inflammatory response via inhibition of the substance P and p38-MAPK signaling pathway in human keratinocytes. Int Immunopharmacol 29(2):401\u2013407","journal-title":"Int Immunopharmacol"},{"key":"1968_CR82","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.biopha.2016.08.016","volume":"83","author":"YH Song","year":"2016","unstructured":"Song YH, Cai H, Zhao ZM et al (2016) Icariin attenuated oxidative stress induced-cardiac apoptosis by mitochondria protection and ERK activation. Biomed Pharmacother 83:1089\u20131094","journal-title":"Biomed Pharmacother"},{"issue":"1\u20132","key":"1968_CR83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrfmmm.2010.12.017","volume":"708","author":"WW Li","year":"2011","unstructured":"Li WW, Gao XM, Wang XM, Guo H, Zhang BL (2011) Icariin inhibits hydrogen peroxide-induced toxicity through inhibition of phosphorylation of JNK\/p38 MAPK and p53 activity. Mutat Res 708(1\u20132):1\u201310","journal-title":"Mutat Res"},{"key":"1968_CR84","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1572-5995(01)80009-0","volume":"25","author":"C Demetzos","year":"2001","unstructured":"Demetzos C, Dimas KS (2001) Labdane-type diterpenes: chemistry and biological activity. Stud Nat Prod Chem 25:235\u2013292","journal-title":"Stud Nat Prod Chem"},{"issue":"2","key":"1968_CR85","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.taap.2007.12.006","volume":"228","author":"N Gir\u00f3n","year":"2008","unstructured":"Gir\u00f3n N, Trav\u00e9s PG, Rodr\u00edguez B et al (2008) Supression of inflammatory responses by labdane-type diterpenoids. Toxicol Appl Pharmacol 228(2):179\u2013189","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"1968_CR86","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1248\/cpb.60.246","volume":"60","author":"P Van Kiem","year":"2012","unstructured":"Van Kiem P, Anh HLT, Nhiem NX et al (2012) Labdane-type diterpenoids from the rhizomes of Hedychium coronarium inhibit lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Chem Pharm Bull (Tokyo) 60(2):246\u2013250","journal-title":"Chem Pharm Bull (Tokyo)"},{"issue":"1","key":"1968_CR87","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1475-2867-13-108","volume":"13","author":"F Liu","year":"2013","unstructured":"Liu F, He Y, Liang Y et al (2013) PI3-kinase inhibition synergistically promoted the anti-tumor effect of lupeol in Hepatocellular carcinoma. Cancer Cell Int 13(1):108","journal-title":"Cancer Cell Int"},{"issue":"6","key":"1968_CR88","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1038\/jid.2015.29","volume":"135","author":"HH Kwon","year":"2015","unstructured":"Kwon HH, Yoon JY, Park SY, Min S, Kim YI, Park JY et al (2015) Activity-guided purification identifies lupeol, a pentacyclic triterpene, as a therapeutic agent targeting multiple pathogenic factors of acne. Invest Dermatol 135(6):1491\u20131500","journal-title":"Invest Dermatol"},{"key":"1968_CR89","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.intimp.2015.11.031","volume":"30","author":"Y Zhu","year":"2016","unstructured":"Zhu Y, Li X, Chen J, Chen T, Shi Z, Lei M et al (2016) The pentacyclic triterpene Lupeol switches M1 macrophages to M2 and ameliorates experimental inflammatory bowel disease. Int Immunopharmacol 30:74\u201384","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"1968_CR90","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1745-7262.2008.00313.x","volume":"10","author":"S Prasad","year":"2008","unstructured":"Prasad S, Kalra N, Singh M, Shukla Y (2008) Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice. Asian J Androl 10(2):313\u2013318","journal-title":"Asian J Androl"},{"issue":"2","key":"1968_CR91","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/nu8020090","volume":"8","author":"DK Semwal","year":"2016","unstructured":"Semwal DK, Semwal RB, Combrinck S, Viljoen A (2016) Myricetin: a dietary molecule with diverse biological activities. Nutrients 8(2):90","journal-title":"Nutrients"},{"issue":"19","key":"1968_CR92","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.4155\/fmc-2018-0172","volume":"10","author":"Wei Hou","year":"2018","unstructured":"Hou W, Hu S, Su Z et al (2018) Myricetin attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models. Future Med Chem 10(19):2253\u20132264","journal-title":"Future Medicinal Chemistry"},{"key":"1968_CR93","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ejphar.2016.05.025","volume":"784","author":"H da Lee","year":"2016","unstructured":"da Lee H, Lee CS (2016) Flavonoid myricetin inhibits TNF-alpha-stimulated production of inflammatory mediators by suppressing the Akt, mTOR and NF-kappaB pathways in human keratinocytes. Eur J Pharmacol 784:164\u2013172","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"1968_CR94","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1080\/09168451.2016.1171697","volume":"80","author":"Byoung Ok Cho","year":"2016","unstructured":"Cho BO, Yin HH, Park SH et al (2016) Anti-inflammatory activity of myricetin from Diospyros lotus through suppression of NF-kappaB and STAT1 activation and Nrf2-mediated HO-1 induction in lipopolysaccharide-stimulated RAW264.7 macrophages. Biosci Biotechnol Biochem 80(8):1520\u20131530","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"issue":"11","key":"1968_CR95","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.3390\/ijms11114348","volume":"11","author":"KA Kang","year":"2010","unstructured":"Kang KA, Wang ZH, Zhang R et al (2010) Myricetin protects cells against oxidative stress-induced apoptosis via regulation of PI3K\/Akt and MAPK signaling pathways. Int J Mol Sci 11(11):4348\u20134360","journal-title":"Int J Mol Sci"},{"issue":"6","key":"1968_CR96","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1179\/1351000211Y.0000000015","volume":"16","author":"V Chobot","year":"2011","unstructured":"Chobot V, Hadacek F (2011) Exploration of pro-oxidant and antioxidant activities of the flavonoid myricetin. Redox Rep 16(6):242\u2013247","journal-title":"Redox Rep"},{"issue":"7","key":"1968_CR97","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.pnpbp.2011.06.002","volume":"35","author":"M Pereira","year":"2011","unstructured":"Pereira M, Siba I, Chioca L et al (2011) Myricitrin, a nitric oxide and protein kinase C inhibitor, exerts antipsychotic-like effects in animal models. Prog Neuropsychopharmacol Biol Psychiatry 35(7):1636\u20131644","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"1968_CR98","first-page":"9738745","volume":"2017","author":"S Qi","year":"2017","unstructured":"Qi S, Feng Z, Li Q, Qi Z, Zhang Y (2017) Myricitrin modulates NADPH oxidase-dependent ROS production to inhibit endotoxin-mediated inflammation by blocking the JAK\/STAT1 and NOX2\/p47(phox) pathways. Oxid Med Cell Longev 2017:9738745","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"1968_CR99","first-page":"7381","volume":"17","author":"J Gao","year":"2018","unstructured":"Gao J, Chen S, Qiu Z et al (2018) Myricitrin ameliorates ethanol-induced steatosis in mouse AML12 liver cells by activating AMPK, and reducing oxidative stress and expression of inflammatory cytokines. Mol Med Rep 17(5):7381\u20137387","journal-title":"Mol Med Rep"},{"key":"1968_CR100","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cbi.2015.01.030","volume":"230","author":"R Domitrovic","year":"2015","unstructured":"Domitrovic R, Rashed K, Cvijanovic O, Vladimir-Knezevic S, Skoda M, Visnic A (2015) Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice. Chem Biol Interact 230:21\u201329","journal-title":"Chem Biol Interact"},{"issue":"1","key":"1968_CR101","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.taap.2013.04.015","volume":"271","author":"GB Sun","year":"2013","unstructured":"Sun GB, Qin M, Ye JX et al (2013) Inhibitory effects of myricitrin on oxidative stress-induced endothelial damage and early atherosclerosis in ApoE\u2212\/\u2212 mice. Toxicol Appl Pharmacol 271(1):114\u2013126","journal-title":"Toxicol Appl Pharmacol"},{"issue":"8","key":"1968_CR102","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00403-012-1249-x","volume":"304","author":"MK Jung","year":"2012","unstructured":"Jung MK, Ha S, Son JA et al (2012) Polyphenon-60 displays a therapeutic effect on acne by suppression of TLR2 and IL-8 expression via down-regulating the ERK1\/2 pathway. Arch Dermatol Res 304(8):655\u2013663","journal-title":"Arch Dermatol Res"},{"issue":"10","key":"1968_CR103","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.phymed.2013.03.002","volume":"20","author":"HM Sidahmed","year":"2013","unstructured":"Sidahmed HM, Hashim NM, Amir J et al (2013) Pyranocycloartobiloxanthone A, a novel gastroprotective compound from Artocarpus obtusus Jarret, against ethanol-induced acute gastric ulcer in vivo. Phytomedicine 20(10):834\u2013843","journal-title":"Phytomedicine"},{"issue":"5","key":"1968_CR104","doi-asserted-by":"crossref","first-page":"6071","DOI":"10.3390\/molecules17056071","volume":"17","author":"NM Hashim","year":"2012","unstructured":"Hashim NM, Rahmani M, Ee GCL et al (2012) Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from Artocarpus obtusus FM Jarrett. Molecules 17(5):6071\u20136082","journal-title":"Molecules"},{"key":"1968_CR105","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.phrs.2017.08.009","volume":"128","author":"MH Farzaei","year":"2018","unstructured":"Farzaei MH, Rahimi R, Nikfar S, Abdollahi M (2018) Effect of resveratrol on cognitive and memory performance and mood: a meta-analysis of 225 patients. Pharmacol Res 128:338\u2013344","journal-title":"Pharmacol Res"},{"issue":"2","key":"1968_CR106","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s13555-014-0063-0","volume":"4","author":"EJ Taylor","year":"2014","unstructured":"Taylor EJ, Yu Y, Champer J, Kim J (2014) Resveratrol demonstrates antimicrobial effects against propionibacterium acnes in vitro. Dermatol Ther (Heidelb) 4(2):249\u2013257","journal-title":"Dermatol Ther (Heidelb)"},{"issue":"6","key":"1968_CR107","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/jac\/dkm099","volume":"59","author":"JJ Docherty","year":"2007","unstructured":"Docherty JJ, McEwen HA, Sweet TJ, Bailey E, Booth TD (2007) Resveratrol inhibition of Propionibacterium acnes. J Antimicrob Chemother 59(6):1182\u20131184","journal-title":"J Antimicrob Chemother"},{"issue":"Pt 3","key":"1968_CR108","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1099\/jmm.0.047316-0","volume":"62","author":"S Leejae","year":"2013","unstructured":"Leejae S, Hasap L, Voravuthikunchai SP (2013) Inhibition of staphyloxanthin biosynthesis in Staphylococcus aureus by rhodomyrtone, a novel antibiotic candidate. J Med Microbiol 62(Pt 3):421\u2013428","journal-title":"J Med Microbiol"},{"key":"1968_CR109","doi-asserted-by":"crossref","first-page":"157635","DOI":"10.1155\/2013\/157635","volume":"2013","author":"J Chorachoo","year":"2013","unstructured":"Chorachoo J, Amnuaikit T, Voravuthikunchai SP (2013) Liposomal encapsulated rhodomyrtone: a novel antiacne drug. Evid Based Complement Alternat Med 2013:157635","journal-title":"Evid Based Complement Alternat Med"},{"issue":"12","key":"1968_CR110","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1099\/jmm.0.033092-0","volume":"60","author":"J. Saising","year":"2011","unstructured":"Saising J, Ongsakul M, Voravuthikunchai SP (2011) Rhodomyrtus tomentosa (Aiton) Hassk. ethanol extract and rhodomyrtone: a potential strategy for the treatment of biofilm-forming staphylococci. J Med Microbiol 60(12):1793\u20131800","journal-title":"Journal of Medical Microbiology"},{"key":"1968_CR111","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.imlet.2011.05.007","volume":"139","author":"SY Park","year":"2011","unstructured":"Park SY, Kim YH, Kim Y et al (2011) Upregulation of heme oxygenase-1 via PI3K\/Akt and Nrf-2 signaling pathways mediates the anti-inflammatory activity of Schisandrin in Porphyromonas gingivalis LPS-stimulated macrophages. Immunol Lett 139:93\u2013101","journal-title":"Immunol Lett"},{"issue":"4","key":"1968_CR112","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s12272-016-0713-0","volume":"39","author":"Z Cai","year":"2016","unstructured":"Cai Z, Liu J, Bian H, Cai J, Zhu G (2016) Suppression of P2X7\/NF-\u03baB pathways by Schisandrin B contributes to attenuation of lipopolysaccharide-induced inflammatory responses in acute lung injury. Arch Pharm Res 39(4):499\u2013507","journal-title":"Arch Pharm Res"},{"key":"1968_CR113","doi-asserted-by":"crossref","unstructured":"Ran J, Ma C, Xu K, et al (2018) Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-kappaB and MAPK signal pathways. Drug Des Devel Ther 12:1195\u20131204","DOI":"10.2147\/DDDT.S162014"},{"issue":"4","key":"1968_CR114","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/iej.12861","volume":"51","author":"JS Takanche","year":"2018","unstructured":"Takanche JS, Lee YH, Kim JS et al (2018) Anti-inflammatory and antioxidant properties of Schisandrin C promote mitochondrial biogenesis in human dental pulp cells. Int Endod J 51(4):438\u2013447","journal-title":"Int Endod J"},{"key":"1968_CR115","unstructured":"Kwon DH, Cha HJ, Choi EO, Leem SH, Kim GY, Moon SK et al (2018) Schisandrin A suppresses lipopolysaccharide-induced inflammation and oxidative stress in RAW 264.7 macrophages by suppressing the NF-kappaB, MAPKs and PI3K\/Akt pathways and activating Nrf2\/HO-1 signaling. Int J Mol Med 41(1):264\u201374"},{"key":"1968_CR116","unstructured":"Ying W, Li ZC, Li-Qing Y, Mai L, Mei T (2018) Schisandrin B alleviates acute oxidative stress via modulating Nrf2\/Keap1-mediated antioxidant pathway. Appl Physiol Nutr Metab 2018:1\u201324."},{"issue":"5","key":"1968_CR117","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s10086-013-1344-4","volume":"59","author":"AM Muddathir","year":"2013","unstructured":"Muddathir AM, Yamauchi K, Mitsunaga T (2013) Anti-acne activity of tannin-related compounds isolated from Terminalia laxiflora. J Wood Sci 59(5):426\u2013431","journal-title":"J Wood Sci"},{"issue":"5","key":"1968_CR118","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3109\/14756366.2010.546793","volume":"26","author":"N Sultana","year":"2011","unstructured":"Sultana N (2011) Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product. J Enzyme Inhib Med Chem 26(5):616\u2013642","journal-title":"J Enzyme Inhib Med Chem"},{"issue":"5","key":"1968_CR119","first-page":"7142","volume":"17","author":"Z Zhang","year":"2018","unstructured":"Zhang Z, Zhang H, Chen R, Wang Z (2018) Oral supplementation with ursolic acid ameliorates sepsis-induced acute kidney injury in a mouse model by inhibiting oxidative stress and inflammatory responses. Mol Med Rep 17(5):7142\u20137148","journal-title":"Mol Med Rep"},{"issue":"4","key":"1968_CR120","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.3892\/mmr.2016.5654","volume":"14","author":"J Peng","year":"2016","unstructured":"Peng J, Ren X, Lan T et al (2016) Renoprotective effects of ursolic acid on ischemia\/reperfusion induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NFkappaB activities. Mol Med Rep 14(4):3397\u20133402","journal-title":"Mol Med Rep"},{"issue":"3","key":"1968_CR121","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.etap.2014.03.011","volume":"37","author":"JQ Ma","year":"2014","unstructured":"Ma JQ, Ding J, Zhang L, Liu CM (2014) Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK\/NF-kappaB pathway. Environ Toxicol Pharmacol 37(3):975\u2013983","journal-title":"Environ Toxicol Pharmacol"},{"issue":"2","key":"1968_CR122","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2165\/11530630-000000000-00000","volume":"12","author":"G Fabbrocini","year":"2011","unstructured":"Fabbrocini G, Staibano S, De Rosa G et al (2011) Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study. Am J Clin Dermatol 12(2):133\u2013141","journal-title":"Am J Clin Dermatol"},{"issue":"4","key":"1968_CR123","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jphs.2015.11.005","volume":"129","author":"P Pan-In","year":"2015","unstructured":"Pan-In P, Wongsomboon A, Kokpol C, Chaichanawongsaroj N, Wanichwecharungruang S (2015) Depositing alpha-mangostin nanoparticles to sebaceous gland area for acne treatment. J Pharmacol Sci 129(4):226\u2013232","journal-title":"J Pharmacol Sci"},{"key":"1968_CR124","doi-asserted-by":"crossref","unstructured":"Lee JW, Kang YJ, Choi HK, Yoon YG (2018) Fractionated Coptis chinensis extract and its bioactive component suppress Propionibacterium acnes-stimulated inflammation in human keratinocytes. J Microbiol Biotechnol","DOI":"10.4014\/jmb.1712.12051"},{"issue":"12","key":"1968_CR125","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1038\/jid.2012.202","volume":"132","author":"M Im","year":"2012","unstructured":"Im M, Kim SY, Sohn KC, Choi DK, Lee Y, Seo YJ et al (2012) Epigallocatechin-3-gallate suppresses IGF-I-induced lipogenesis and cytokine expression in SZ95 sebocytes. J Invest Dermatol 132(12):2700\u20132708","journal-title":"J Invest Dermatol"},{"issue":"5","key":"1968_CR126","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.phymed.2011.10.005","volume":"19","author":"T Coenye","year":"2012","unstructured":"Coenye T, Brackman G, Rigole P, De Witte E, Honraet K, Rossel B et al (2012) Eradication of Propionibacterium acnes biofilms by plant extracts and putative identification of icariin, resveratrol and salidroside as active compounds. Phytomedicine 19(5):409\u2013412","journal-title":"Phytomedicine"},{"issue":"4","key":"1968_CR127","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1055\/s-2008-1034321","volume":"74","author":"MZ Sultan","year":"2008","unstructured":"Sultan MZ, Jeon YM, Moon SS (2008) Labdane-type diterpenes active against acne from pine cones (Pinus densiflora). Planta med 74(4):449\u2013452","journal-title":"Planta med"},{"key":"1968_CR128","doi-asserted-by":"crossref","unstructured":"Sharma R, Kishore N, Hussein A, Lall N (2013) Antibacterial and anti-inflammatory effects of Syzygium jambos L. (Alston) and isolated compounds on acne vulgaris. BMC Complement Altern Med 13:292","DOI":"10.1186\/1472-6882-13-292"},{"key":"1968_CR129","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.anaerobe.2016.12.002","volume":"43","author":"S Wunnoo","year":"2017","unstructured":"Wunnoo S, Saising J, Voravuthikunchai SP (2017) Rhodomyrtone inhibits lipase production, biofilm formation, and disorganizes established biofilm in Propionibacterium acnes. Anaerobe 43:61\u201368","journal-title":"Anaerobe"},{"issue":"4","key":"1968_CR130","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.anaerobe.2012.05.003","volume":"18","author":"Jongkon Saising","year":"2012","unstructured":"Saising J, Voravuthikunchai SP (2012) Anti-Propionibacterium acnes activity of rhodomyrtone, an effective compound from Rhodomyrtus tomentosa (Aiton) Hassk. leaves. Anaerobe 18(4):400\u2013404","journal-title":"Anaerobe"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-019-01968-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00403-019-01968-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-019-01968-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T23:09:27Z","timestamp":1598310567000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00403-019-01968-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,26]]},"references-count":130,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["1968"],"URL":"https:\/\/doi.org\/10.1007\/s00403-019-01968-z","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,26]]},"assertion":[{"value":"6 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}