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Gonz\u00e1lez L\u00f3pez had consultation fees\/participation in company sponsored speaker\u2019s bureau from Abbvie. Dr. MA Gonzalez-Gay received grants\/research supports from Abbvie, MSD and Roche, and had consultation fees\/participation in company sponsored speaker \u0301s bureau from Pfizer, Lilly, Roche and Sanofi. Dr. R Blanco received grants\/research supports from Abbvie, MSD and Roche, and had consultation fees\/participation in company sponsored speaker \u0301s bureau from Abbvie, Pfizer, Roche, Bristol Myers, Janssen and MSD. The rest of the authors have no conflict of interest to declare regarding this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The research protocol was approved by the Ethics Committee of Cantabria (Spain). 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