{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:05:38Z","timestamp":1740107138534,"version":"3.37.3"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T00:00:00Z","timestamp":1599264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T00:00:00Z","timestamp":1599264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["552429"],"award-info":[{"award-number":["552429"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Various treatments of keratotic skin lesions and early skin cancers are performed in organ transplant recipients (OTRs) at high risk of skin malignancies but the frequency of their use is unknown. We prospectively assessed the frequency of use of cryotherapy, diathermy, and topical therapies and also investigated their associations with background incidence of histologically-confirmed squamous-cell carcinoma (SCC) and basal cell carcinoma (BCC) in a cohort of OTRs in Queensland, Australia. Median follow-up ranged from 1.7 to 3.2\u00a0years across organ transplant groups. Among 285 kidney, 125 lung and 203 liver transplant recipients [382 (62%) male, 380 (62%) immunosuppressed\u2009&gt;\u20095\u00a0years, 394 (64%) previously diagnosed with skin cancer], 306 (50%) reported treatment of skin lesions with major types of non-excision therapies during follow-up: 278 (45%) cryotherapy or diathermy; 121 (20%) topical treatments. Of these 306, 150 (49%) developed SCC at double the incidence of those who did not receive these treatments, as assessed by incidence rate ratio (IRR) adjusted for age, sex, type of organ transplant, skin color and history of skin cancer at baseline, calculated by multivariable Poisson regression (IRR<jats:sub>adj<\/jats:sub>\u2009=\u20092.1, 95% confidence interval (CI) 1.4\u20133.1). BCC incidence was not associated with these therapies. Skin lesions in OTRs that are treated with cryotherapy, diathermy, or topical treatment warrant judicious selection and careful follow-up.<\/jats:p>","DOI":"10.1007\/s00403-020-02136-4","type":"journal-article","created":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T09:02:41Z","timestamp":1599296561000},"page":"203-206","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer"],"prefix":"10.1007","volume":"314","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2753-4841","authenticated-orcid":false,"given":"Adele C.","family":"Green","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3444-1907","authenticated-orcid":false,"given":"Mandy","family":"Way","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7620-2261","authenticated-orcid":false,"given":"Mariella","family":"Oster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8846-1930","authenticated-orcid":false,"given":"Elsemieke I.","family":"Plasmeijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9677-8885","authenticated-orcid":false,"given":"Zainab","family":"Jiyad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9794-2122","authenticated-orcid":false,"given":"Peter","family":"O\u2019Rourke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-7522","authenticated-orcid":false,"given":"Kyoko","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-2151","authenticated-orcid":false,"given":"Scott","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9566-7179","authenticated-orcid":false,"given":"Nicole","family":"Isbel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9553-5870","authenticated-orcid":false,"given":"Daniel C.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3261-9345","authenticated-orcid":false,"given":"Peter","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-6419","authenticated-orcid":false,"given":"Lisa E.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-7801","authenticated-orcid":false,"given":"Marcia Batista","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2563-9559","authenticated-orcid":false,"given":"David C.","family":"Whiteman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4770-561X","authenticated-orcid":false,"given":"H. Peter","family":"Soyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4607-9060","authenticated-orcid":false,"given":"Louise","family":"Marquart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,5]]},"reference":[{"key":"2136_CR1","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1038\/sj.jid.5700776","volume":"127","author":"JN Bouwes Bavinck","year":"2007","unstructured":"Bouwes Bavinck JN, Euvrard S, Naldi L et al (2007) Keratotic skin lesions and other risk factors are associated with skin cancer in organ-transplant recipients: a case-control study in The Netherlands, United Kingdom, Germany, France, and Italy. J Investig Dermatol 127:1647\u20131656. https:\/\/doi.org\/10.1038\/sj.jid.5700776","journal-title":"J Investig Dermatol"},{"key":"2136_CR2","unstructured":"Cancer Council Australia Keratinocyte Cancers Guideline Working Party. Clinical practice guidelines for keratinocyte cancer. Sydney: Cancer Council Australia. https:\/\/wiki.cancer.org.au\/australiawiki\/index.php?oldid=208400. https:\/\/wiki.cancer.org.au\/australia\/Guidelines:Keratinocyte_carcinoma. Accessed 9 December 2019"},{"key":"2136_CR3","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1001\/jamadermatol.2016.4920","volume":"153","author":"GL Garrett","year":"2017","unstructured":"Garrett GL, Blanc PD, Boscardin J et al (2017) Incidence of and risk factors for skin cancer in organ transplant recipients in the United States. JAMA Dermatol 153:296\u2013303. https:\/\/doi.org\/10.1001\/jamadermatol.2016.4920","journal-title":"JAMA Dermatol"},{"key":"2136_CR4","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/s0190-9622(88)70270-4","volume":"19","author":"A Green","year":"1988","unstructured":"Green A, Beardmore G, Hart V, Leslie D, Marks R, Staines D (1988) Skin cancer in a Queensland population. J Am Acad Dermatol 19:1045\u20131053. https:\/\/doi.org\/10.1016\/s0190-9622(88)70270-4","journal-title":"J Am Acad Dermatol"},{"key":"2136_CR5","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1111\/ced.13211","volume":"42","author":"Z Jiyad","year":"2017","unstructured":"Jiyad Z, O\u2019Rourke P, Soyer HP, Green AC (2017) Clinical comparison of actinic changes preceding squamous cell carcinoma vs. intraepidermal carcinoma in renal transplant recipients. Clin Exp Dermatol 42:895\u2013897. https:\/\/doi.org\/10.1111\/ced.13211","journal-title":"Clin Exp Dermatol"},{"key":"2136_CR6","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1001\/jamadermatol.2015.1187","volume":"151","author":"HW Rogers","year":"2015","unstructured":"Rogers HW, Weinstock MA, Feldman SR, Coldiron BM (2015) Incidence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the U.S. population, 2012. JAMA Dermatol 151:1081\u20131086. https:\/\/doi.org\/10.1001\/jamadermatol.2015.1187","journal-title":"JAMA Dermatol"},{"key":"2136_CR7","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/bjd.18812","volume":"183","author":"M Way","year":"2020","unstructured":"Way M, Marquart L, Chambers DC et al (2020) Skin cancer multiplicity in lung transplant recipients: prospective, population-based study. Br J Dermatol 183:503\u2013508. https:\/\/doi.org\/10.1111\/bjd.18812","journal-title":"Br J Dermatol"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-020-02136-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-020-02136-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-020-02136-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T12:20:40Z","timestamp":1645014040000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-020-02136-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,5]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["2136"],"URL":"https:\/\/doi.org\/10.1007\/s00403-020-02136-4","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"type":"print","value":"0340-3696"},{"type":"electronic","value":"1432-069X"}],"subject":[],"published":{"date-parts":[[2020,9,5]]},"assertion":[{"value":"13 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Institutional ethics committees approved the study and all participants provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}