{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:34:47Z","timestamp":1788237287303,"version":"build-2803163510"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00403-020-02182-y","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T11:03:30Z","timestamp":1610535810000},"page":"815-827","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cryotherapy plus low-dose oral isotretinoin vs cryotherapy only for the treatment of anogenital warts: a randomized clinical trial"],"prefix":"10.1007","volume":"313","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5316-9307","authenticated-orcid":false,"given":"Irving Llibran","family":"Reyna-Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1637-7956","authenticated-orcid":false,"given":"Sonia","family":"Chavez-Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5496-3262","authenticated-orcid":false,"given":"Veronica","family":"Garza-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6853-8726","authenticated-orcid":false,"given":"Rodolfo","family":"Franco-Marquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-581X","authenticated-orcid":false,"given":"Gerardo","family":"Gonzalez-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0213-0031","authenticated-orcid":false,"given":"Jorge","family":"Ocampo-Candiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4783-3793","authenticated-orcid":false,"given":"Alejandra","family":"Villarreal-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"2182_CR1","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1086\/590560","volume":"47","author":"F Aubin","year":"2008","unstructured":"Aubin F, Pr\u00e9tet JL, Jacquard AC et al (2008) Human papillomavirus genotype distribution in external acuminata condylomata: a large French national study (EDiTH IV). Clin Infect Dis 47:610\u2013615. https:\/\/doi.org\/10.1086\/590560","journal-title":"Clin Infect Dis"},{"issue":"7","key":"2182_CR2","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1093\/infdis\/jiu587","volume":"211","author":"DJ Ingles","year":"2014","unstructured":"Ingles DJ, Pierce Campbell CM, Messina JA, Stoler MH, Lin HY, Fulp WJ et al (2014) Human papillomavirus virus (HPV) genotype- and age-specific analyses of external genital lesions among men in the HPV infection in men (HIM) Study. J Infec Dis. 211(7):1060\u20131067. https:\/\/doi.org\/10.1093\/infdis\/jiu587","journal-title":"J Infec Dis."},{"issue":"5","key":"2182_CR3","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1042\/CS20050369","volume":"110","author":"J Doorbar","year":"2006","unstructured":"Doorbar J (2006) Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci (Lond) 110(5):525\u2013541. https:\/\/doi.org\/10.1042\/CS20050369","journal-title":"Clin Sci (Lond)"},{"key":"2182_CR4","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1006\/viro.2000.0237","volume":"269","author":"ND Christensen","year":"2000","unstructured":"Christensen ND, Cladel NM, Reed CA, Han R (2000) Rabbit oral papillomavirus complete genome sequence and immunity following genital infection. Virology 269:451\u2013461. https:\/\/doi.org\/10.1006\/viro.2000.0237","journal-title":"Virology"},{"key":"2182_CR5","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1001\/archderm.1963.01590150022004","volume":"87","author":"AM Messing","year":"1963","unstructured":"Messing AM, Epstein WL (1963) Natural history of warts: a two year study. Arch Dermatol 87:301\u2013310. https:\/\/doi.org\/10.1001\/archderm.1963.01590150022004","journal-title":"Arch Dermatol"},{"key":"2182_CR6","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1111\/bjd.13310","volume":"171","author":"JC Sterling","year":"2014","unstructured":"Sterling JC, Gibbs S, Haque Hussain SS, Mohd Mustapa MF, Handfield-Jones SE (2014) British Association of Dermatologists\u2019 guidelines for the management of cutaneous warts 2014. Br J Dermatol 171:696\u2013712. https:\/\/doi.org\/10.1111\/bjd.13310","journal-title":"Br J Dermatol"},{"key":"2182_CR7","first-page":"266","volume":"130","author":"MA Stanley","year":"2009","unstructured":"Stanley MA (2009) Immune responses to human papilloma viruses. Indian J Med Res 130:266\u2013276","journal-title":"Indian J Med Res"},{"key":"2182_CR8","doi-asserted-by":"publisher","first-page":"e263","DOI":"10.1111\/j.1468-3083.2012.04493.x","volume":"27","author":"CJN Lacey","year":"2013","unstructured":"Lacey CJN, Woodhall SC, Wikstrom A et al (2013) 2012 European guideline for the management of anogenital warts. J Eur Acad Dermatol Venereol 27:e263\u2013e270. https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04493.x","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2182_CR9","unstructured":"Centers for Disease Control. STD treatment guidelines. Available at: http:\/\/www.cdc.gov\/std\/tg2015\/. Published 2015. Accessed on June, 22 2020."},{"issue":"3","key":"2182_CR10","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.jaad.2017.04.012","volume":"77","author":"A Bertolotti","year":"2017","unstructured":"Bertolotti A, Dupin N, Bouscarat F, Milpied B, Derancourt C (2017) Cryotherapy to treat anogenital warts in nonimmunocompromised adults: Systematic review and meta-analysis. J Am Acad Dermatol 77(3):518\u2013526. https:\/\/doi.org\/10.1016\/j.jaad.2017.04.012","journal-title":"J Am Acad Dermatol"},{"key":"2182_CR11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1073\/pnas.88.11.4582","volume":"88","author":"V Stellmach","year":"1991","unstructured":"Stellmach V, Leask A, Fuchs E (1991) Retinoid-mediated transcriptional regulation of keratin genes in human epidermal and squamous cell carcinoma cells. Proc Natl Acad Sci USA 88:45\u201382","journal-title":"Proc Natl Acad Sci USA"},{"key":"2182_CR12","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1126\/science.1145697","volume":"317","author":"D Mucida","year":"2007","unstructured":"Mucida D, Park Y, Kim G et al (2007) Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317:256\u2013260. https:\/\/doi.org\/10.1126\/science.1145697","journal-title":"Science"},{"key":"2182_CR13","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1128\/cdli.9.3.616-621.2002","volume":"9","author":"J Jason","year":"2002","unstructured":"Jason J, Archibald LK, Nwanyanwu OC (2002) Vitamin A levels and immunity in humans. Clin Diagn Lab Immunol 9:616\u2013621. https:\/\/doi.org\/10.1128\/cdli.9.3.616-621.2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"2182_CR14","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1002\/j.1460-2075.1992.tb05287.x","volume":"11","author":"D Bartsch","year":"1992","unstructured":"Bartsch D, Boye B, Baust C et al (1992) Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor beta gene in non-tumorigenic and tumorigenic HeLa hybrid cells. EMBO J 11:2283\u20132291","journal-title":"EMBO J"},{"key":"2182_CR15","first-page":"807","volume":"24","author":"Z Faluhelyi","year":"2004","unstructured":"Faluhelyi Z, Rodler I, Csejtey A et al (2004) All-trans retinoic acid (ATRA) suppresses transcription of human papillomavirus type 16 (HPV16) in a dose-dependent manner. Anticancer Res 24:807\u2013809","journal-title":"Anticancer Res"},{"key":"2182_CR16","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1177\/019459989110500404","volume":"105","author":"A Reppucci","year":"1991","unstructured":"Reppucci A, DiLorenzo T, Abramson A et al (1991) In vitro modulation of human laringuela papillota cell differentiation by retinoic acid. Otolaryngol Head Neck Surg 105:528\u2013532. https:\/\/doi.org\/10.1177\/019459989110500404","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"12","key":"2182_CR17","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1111\/ijd.14475","volume":"58","author":"F El-Esawy","year":"2019","unstructured":"El-Esawy F, Mustafa AI, El-Shimi O (2019) Serum retinol-binding protein: a novel biomarker for recalcitrant cutaneous warts. Int J Dermatol 58(12):1435\u20131438. https:\/\/doi.org\/10.1111\/ijd.14475","journal-title":"Int J Dermatol"},{"issue":"6","key":"2182_CR18","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/s0190-9622(89)70127-4","volume":"20","author":"EA Olsen","year":"1989","unstructured":"Olsen EA, Kelly FF, Vollmer RT, Buddin DA, Weck PK (1989) Comparative study of systemic interferon alfa-nl and isotretinoin in the treatment of resistant condylomata acuminata. J Am Acad Dermatol 20(6):1023\u20131030. https:\/\/doi.org\/10.1016\/s0190-9622(89)70127-4","journal-title":"J Am Acad Dermatol"},{"key":"2182_CR19","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/S0090-4295(99)80094-6","volume":"45","author":"E Cardamakis","year":"1995","unstructured":"Cardamakis E, Kotoulas IG, Relakis K, Metalinos K, Michopoulos J, Stathopoulos E et al (1995) Comparative study of systemic interferon alfa-2a plus isotretinoin versus isotretinoin in the treatment of recurrent condyloma acuminatum in men. Urology 45:857\u2013860. https:\/\/doi.org\/10.1016\/S0090-4295(99)80094-6","journal-title":"Urology"},{"key":"2182_CR20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/BF01370930","volume":"258","author":"EK Cardamakis","year":"1996","unstructured":"Cardamakis EK, Kotoulas IG, Dimopoulos DP, Stathopoulos EN, Michopoulos JT, Tzingounis VA (1996) Comparative study of systemic interferon alfa-2a with oral isotretinoin and oral isotretinoin alone in the treatment of recurrent condylomata accuminata. Arch Gynecol Obstet 258:35\u201341. https:\/\/doi.org\/10.1007\/BF01370930","journal-title":"Arch Gynecol Obstet"},{"key":"2182_CR21","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1136\/sti.2003.006841","volume":"80","author":"S Georgala","year":"2004","unstructured":"Georgala S, Katoulis AC, Georgala C, Bozi E, Mortakis A (2004) Oral isotretinoin in the treatment of recalcitrant condylomata acuminata of the cervix: a randomised placebo controlled trial. Sex Transm Infect 80:216\u2013218. https:\/\/doi.org\/10.1136\/sti.2003.006841","journal-title":"Sex Transm Infect"},{"key":"2182_CR22","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3109\/09546634.2013.869302","volume":"26","author":"MG Olgu\u00edn-Garc\u00eda","year":"2015","unstructured":"Olgu\u00edn-Garc\u00eda MG, Jurado-Santa Cruz F, Peralta-Pedrero ML, Morales-S\u00e1nchez MA (2015) A double-blind, randomized, placebo-controlled trial of oral isotretinoin in the treatment of recalcitrant facial flat warts. J Dermatolog Treat 26:78\u201382","journal-title":"J Dermatolog Treat"},{"issue":"12","key":"2182_CR23","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1111\/ijd.13727","volume":"56","author":"GJ Kaur","year":"2017","unstructured":"Kaur GJ, Brar BK, Kumar S, Brar SK, Singh B (2017) Evaluation of the efficacy and safety of oral isotretinoin versus topical isotretinoin in the treatment of plane warts: a randomized open trial. Int J Dermatol 56(12):1352\u20131358. https:\/\/doi.org\/10.1111\/ijd.13727","journal-title":"Int J Dermatol"},{"key":"2182_CR24","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1016\/s0022-5347(01)64136-3","volume":"158","author":"D Tsambaos","year":"1997","unstructured":"Tsambaos D, Georgiou S, Monastirli A, Sakkis T, Sagriotis A, Goerz G (1997) Treatment of condylomata acuminata with oral isotretinoin. J Urol 158:1810\u20131812. https:\/\/doi.org\/10.1016\/s0022-5347(01)64136-3","journal-title":"J Urol"},{"key":"2182_CR25","first-page":"267","volume":"54","author":"MG Olgu\u00edn-Garc\u00eda","year":"2010","unstructured":"Olgu\u00edn-Garc\u00eda MG, Cancela RG, Peralta-Pedrero ML (2010) Estudio preexperimental para el tratamiento de verrugas planas faciales con isotretino\u0131\u2019na oral. Dermatol Rev Mex 54:267\u2013272","journal-title":"Dermatol Rev Mex"},{"key":"2182_CR26","doi-asserted-by":"publisher","first-page":"163929","DOI":"10.5402\/2012\/163929","volume":"2012","author":"HR Al-Hamamy","year":"2012","unstructured":"Al-Hamamy HR, Salman HA, Abdulsattar NA (2012) Treatment of plane warts with a low-dose oral isotretinoin. ISRN Dermatol 2012:163929. https:\/\/doi.org\/10.5402\/2012\/163929","journal-title":"ISRN Dermatol"},{"issue":"1","key":"2182_CR27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1001\/archderm.1986.01660130021014","volume":"122","author":"RA Katz","year":"1986","unstructured":"Katz RA (1986) Isotretinoin treatment of recalcitrant warts in an immunosuppressed man. Arch Dermatol 122(1):19\u201320. https:\/\/doi.org\/10.1001\/archderm.1986.01660130021014","journal-title":"Arch Dermatol"},{"issue":"9","key":"2182_CR28","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1111\/j.1742-1241.2004.00071.x","volume":"58","author":"M Yildirim","year":"2004","unstructured":"Yildirim M, Inaloz HS, Baysal V, Kesici D, Candir O (2004) A case of condyloma acuminatum treated successfully with low-dose isotretinoin and interferon. Int J Clin Pract 58(9):889\u2013891. https:\/\/doi.org\/10.1111\/j.1742-1241.2004.00071.x","journal-title":"Int J Clin Pract"},{"issue":"1","key":"2182_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00015550510027090","volume":"1","author":"A Monastirli","year":"2005","unstructured":"Monastirli A, Matsouka P, Pasmatzi E, Melachrinou M, Georgiou S, Solomou E et al (2005) Complete remission of recalcitrant viral warts under oral isotretinoin in a patient with low-grade b-cell lymphoma. Acta Derm Venereol 1(1):1\u20131. https:\/\/doi.org\/10.1080\/00015550510027090","journal-title":"Acta Derm Venereol"},{"key":"2182_CR30","first-page":"63","volume":"21","author":"J Miljkovic","year":"2012","unstructured":"Miljkovic J (2012) A novel therapeutic approach to plane warts: a report on two cases. Acta Dermatovenerol Alp Pannonica Adriat 21:63\u201364","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"issue":"3","key":"2182_CR31","doi-asserted-by":"publisher","first-page":"249","DOI":"10.2340\/00015555-1257","volume":"92","author":"E Pasmatzi","year":"2012","unstructured":"Pasmatzi E, Kapranos N, Monastirli A, Melachrinou M, Georgiou S, Tsambaos D (2012) Large benign condyloma acuminatum: successful treatment with isotretinoin and interferon alpha. Acta Derm Venereol 92(3):249\u2013250. https:\/\/doi.org\/10.2340\/00015555-1257","journal-title":"Acta Derm Venereol"},{"issue":"2","key":"2182_CR32","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/dth.12059","volume":"27","author":"YW Yew","year":"2013","unstructured":"Yew YW, Pan JY (2013) Complete remission of recalcitrant genital warts with a combination approach of surgical debulking and oral isotretinoin in a patient with systemic lupus erythematosus. Dermatol Ther 27(2):79\u201382. https:\/\/doi.org\/10.1111\/dth.12059","journal-title":"Dermatol Ther"},{"issue":"2","key":"2182_CR33","doi-asserted-by":"publisher","first-page":"e35","DOI":"10.1016\/j.jaad.2017.08.057","volume":"78","author":"AK Jha","year":"2018","unstructured":"Jha AK, Sonthalia S, Ganguly S (2018) Oral isotretinoin as an adjunctive treatment for recurrent genital warts. J Am Acad Dermatol 78(2):e35\u2013e36. https:\/\/doi.org\/10.1016\/j.jaad.2017.08.057","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"2182_CR34","doi-asserted-by":"publisher","first-page":"227","DOI":"10.5114\/pdia.2017.70259","volume":"35","author":"A Bia\u0142ecka","year":"2018","unstructured":"Bia\u0142ecka A, M\u0119ci\u0144ska-Jundzi\u0142\u0142 K, Adamska U, Cichewicz A, Bia\u0142ecki M, Drewa G, Czajkowski R (2018) Plane warts on the back of the hand successfully treated with oral isotretinoin. Postepy Dermatol Alergol 35(2):227\u2013229. https:\/\/doi.org\/10.5114\/pdia.2017.70259","journal-title":"Postepy Dermatol Alergol"},{"key":"2182_CR35","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12803","author":"M Herold","year":"2018","unstructured":"Herold M, Nielson C, Longo MI (2018) Isotretinoin and Candida immunotherapy for recalcitrant warts in solid organ transplant recipients. Derm Ther. https:\/\/doi.org\/10.1111\/dth.12803","journal-title":"Derm Ther."},{"key":"2182_CR36","doi-asserted-by":"publisher","first-page":"569","DOI":"10.4103\/ijdvl.IJDVL_269_18","volume":"85","author":"TH Yang","year":"2019","unstructured":"Yang TH, Lee TH, Huang YC (2019) Oral isotretinoin for treating mucocutaneous human papillomavirus infections: a systematic review and meta-analysis. Indian J Dermatol Venereol Leprol 85:569\u2013577. https:\/\/doi.org\/10.4103\/ijdvl.IJDVL_269_18","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2182_CR37","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1093\/infdis\/jiu077","volume":"210","author":"ED Moreira Jr","year":"2014","unstructured":"Moreira ED Jr, Giuliano AR, Palefsky J, Flores CA, Goldstone S, Ferris D et al (2014) Incidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men. J Infect Dis 210:192\u2013199. https:\/\/doi.org\/10.1093\/infdis\/jiu077","journal-title":"J Infect Dis"},{"issue":"3","key":"2182_CR38","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1590\/abd1806-4841.20175282","volume":"92","author":"CC Camargo","year":"2017","unstructured":"Camargo CC, D\u2019Elia MPB, Miot HA (2017) Quality of life in men affected by anogenital warts. An Bras Dermatol 92(3):427\u2013429. https:\/\/doi.org\/10.1590\/abd1806-4841.20175282","journal-title":"An Bras Dermatol"},{"issue":"1","key":"2182_CR39","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1186\/s12879-019-4005-4","volume":"19","author":"R Al-Awadhi","year":"2019","unstructured":"Al-Awadhi R, Al-Mutairi N, Albatineh AN, Chehadeh W (2019) Association of HPV genotypes with external anogenital warts: a cross sectional study. BMC Infect Dis 19(1):375. https:\/\/doi.org\/10.1186\/s12879-019-4005-4","journal-title":"BMC Infect Dis"},{"key":"2182_CR40","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12836","author":"DD Dave","year":"2019","unstructured":"Dave DD, Abdelmaksoud A (2019) Low dose Isotretinoin as an adjuvant therapy for treatment of different clinical variants of warts: a case series. Dermatol Ther. https:\/\/doi.org\/10.1111\/dth.12836","journal-title":"Dermatol Ther."},{"issue":"5","key":"2182_CR41","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1093\/infdis\/jiy533","volume":"219","author":"AR Giuliano","year":"2019","unstructured":"Giuliano AR, Sirak B, Abrahamsen M, Silva RJC, Baggio ML, Galan L et al (2019) Genital wart recurrence among men residing in Brazil, Mexico, and the United States. J Infect Dis 219(5):703\u2013710. https:\/\/doi.org\/10.1093\/infdis\/jiy533","journal-title":"J Infect Dis"},{"key":"2182_CR42","doi-asserted-by":"publisher","first-page":"c5812","DOI":"10.1136\/bmj.c5812","volume":"341","author":"A Sundstr\u00f6m","year":"2010","unstructured":"Sundstr\u00f6m A, Alfredsson L, Sj\u00f6lin-Forsberg G, Gerd\u00e9n B, Bergman U, Jokinen J (2010) Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study. BMJ 341:c5812. https:\/\/doi.org\/10.1136\/bmj.c5812","journal-title":"BMJ"},{"issue":"6","key":"2182_CR43","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.jaad.2016.12.028","volume":"76","author":"YC Huang","year":"2017","unstructured":"Huang YC, Cheng YC (2017) Isotretinoin treatment for acne and risk of depression: a systematic review and meta-analysis. J Am Acad Dermatol 76(6):1068\u201376.e9. https:\/\/doi.org\/10.1016\/j.jaad.2016.12.028","journal-title":"J Am Acad Dermatol"},{"issue":"10","key":"2182_CR44","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1001\/jamadermatol.2019.1416","volume":"155","author":"S Singer","year":"2019","unstructured":"Singer S, Tkachenko E, Sharma P, Barbieri JS, Mostaghimi A (2019) Psychiatric adverse events in patients taking isotretinoin as reported in a food and drug administration database from 1997 to 2017. JAMA Dermatol 155(10):1162\u20131166. https:\/\/doi.org\/10.1001\/jamadermatol.2019.1416","journal-title":"JAMA Dermatol"},{"key":"2182_CR45","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16005","author":"C Droitcourt","year":"2019","unstructured":"Droitcourt C, Poizeau F, Kerbrat S et al (2019) Isotretinoin and risk factors for suicide attempt: a population-based comprehensive case series and nested case-control study using 2010\u20132014 French Health Insurance Data. J Eur Acad Dermatol Venereol. https:\/\/doi.org\/10.1111\/jdv.16005 (published online ahead of print, 2019 Oct 6)","journal-title":"J Eur Acad Dermatol Venereol"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-020-02182-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-020-02182-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-020-02182-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T09:26:08Z","timestamp":1635240368000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-020-02182-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,12]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2182"],"URL":"https:\/\/doi.org\/10.1007\/s00403-020-02182-y","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,12]]},"assertion":[{"value":"31 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no competing interest and therefore nothing else to declare, and have contributed significantly and take full responsibility for the manuscript. The authors of the paper are obliged to confirm that it has not been previously published.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was registered and approved (registration number: DE19-00004) by the Institutional Review Board Ethical Committee of the Dr. Jose Eleuterio Gonz\u00e1lez University Hospital of the Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Mexico (CONBIO\u00c9TICA-19-CEI-001-20160404).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from study subjects for enrollment and publication of material with the understanding that their names and initials will not be published and due efforts will be made to conceal their identity but anonymity cannot be guaranteed. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki declaration of 1975 as revised in 1983.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}