{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:18:25Z","timestamp":1781756305266,"version":"3.54.5"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s00403-021-02209-y","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T17:31:17Z","timestamp":1613842277000},"page":"17-23","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Review and reappraisal of assessment parameters of second intention healing after Mohs micrographic surgery"],"prefix":"10.1007","volume":"314","author":[{"given":"Gabrielle","family":"Schwartzman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Cartron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1622-1097","authenticated-orcid":false,"given":"Amor","family":"Khachemoune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,20]]},"reference":[{"issue":"3","key":"2209_CR1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.fsc.2017.03.002","volume":"25","author":"B Mansouri","year":"2017","unstructured":"Mansouri B, Bicknell LM, Hill D, Walker GD, Fiala K, Housewright C (2017) Mohs micrographic surgery for the management of cutaneous malignancies. Fac Plast Surg Clin N Am 25(3):291\u2013301. https:\/\/doi.org\/10.1016\/j.fsc.2017.03.002","journal-title":"Fac Plast Surg Clin N Am"},{"issue":"1","key":"2209_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.fsc.2018.08.002","volume":"27","author":"E Wong","year":"2019","unstructured":"Wong E, Axibal E, Brown M (2019) Mohs micrographic surgery. Fac Plast Surg Clin N Am 27(1):15\u201334. https:\/\/doi.org\/10.1016\/j.fsc.2018.08.002","journal-title":"Fac Plast Surg Clin N Am"},{"issue":"3","key":"2209_CR3","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0190-9622(83)70150-7","volume":"9","author":"JA Zitelli","year":"1983","unstructured":"Zitelli JA (1983) Wound healing by secondary intention: a cosmetic appraisal. J Am Acad Dermatol 9(3):407\u2013415. https:\/\/doi.org\/10.1016\/S0190-9622(83)70150-7","journal-title":"J Am Acad Dermatol"},{"key":"2209_CR4","doi-asserted-by":"publisher","first-page":"S28","DOI":"10.1097\/SAP.0000000000002330","volume":"85","author":"KY Liu","year":"2020","unstructured":"Liu KY, Silvestri B, Marquez J, Huston TL (2020) Secondary intention healing after Mohs surgical excision as an alternative to surgical repair: evaluation of wound characteristics and esthetic outcomes. Ann Plast Surg 85:S28\u2013S32. https:\/\/doi.org\/10.1097\/SAP.0000000000002330","journal-title":"Ann Plast Surg"},{"issue":"7","key":"2209_CR5","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1097\/DSS.0000000000001951","volume":"45","author":"DN Trieu","year":"2019","unstructured":"Trieu DN, Drosou A, White LE, Goldberg LH (2019) Outcomes of second intention healing of the lower eyelid margin after Mohs micrographic surgery. Dermatol Surg 45(7):884\u2013889. https:\/\/doi.org\/10.1097\/DSS.0000000000001951","journal-title":"Dermatol Surg"},{"issue":"2","key":"2209_CR6","first-page":"69","volume":"2","author":"R Karel-Brant","year":"1990","unstructured":"Karel-Brant R (1990) Healing by second intention: its use in Mohs\u2019 micrographic surgery. Dermatol Nurs 2(2):69\u201372","journal-title":"Dermatol Nurs"},{"issue":"5","key":"2209_CR7","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1016\/j.jaad.2009.10.048","volume":"63","author":"S Schreml","year":"2010","unstructured":"Schreml S, Szeimies R-M, Prantl L, Landthaler M, Babilas P (2010) Wound healing in the 21st century. J Am Acad Dermatol 63(5):866\u2013881. https:\/\/doi.org\/10.1016\/j.jaad.2009.10.048","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"2209_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/cshperspect.a023267","volume":"5","author":"M Takeo","year":"2015","unstructured":"Takeo M, Lee W, Ito M (2015) Wound healing and skin regeneration. Cold Spring Harb Perspect Med 5(1):1\u201312. https:\/\/doi.org\/10.1101\/cshperspect.a023267","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"5","key":"2209_CR9","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","volume":"16","author":"S Barrientos","year":"2008","unstructured":"Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M (2008) Growth factors and cytokines in wound healing. Wound Repair Regen 16(5):585\u2013601. https:\/\/doi.org\/10.1111\/j.1524-475X.2008.00410.x","journal-title":"Wound Repair Regen"},{"issue":"5","key":"2209_CR10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1055\/s-0032-1325643","volume":"28","author":"MR Donaldson","year":"2012","unstructured":"Donaldson MR, Coldiron BM (2012) Scars after second intention healing. Fac Plast Surg 28(5):497\u2013503. https:\/\/doi.org\/10.1055\/s-0032-1325643","journal-title":"Fac Plast Surg"},{"issue":"3","key":"2209_CR11","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0738-081X(84)90023-3","volume":"2","author":"W Lambert","year":"1985","unstructured":"Lambert W, Cohen P, Klein K, Lambert M (1985) Mechanisms in selected concepts. Clin Dermatol 2(3):17\u201323","journal-title":"Clin Dermatol"},{"issue":"1","key":"2209_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.clindermatol.2006.09.007","volume":"25","author":"J Li","year":"2007","unstructured":"Li J, Chen J, Kirsner R (2007) Pathophysiology of acute wound healing. Clin Dermatol 25(1):9\u201318. https:\/\/doi.org\/10.1016\/j.clindermatol.2006.09.007","journal-title":"Clin Dermatol"},{"issue":"8","key":"2209_CR13","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1001\/archotol.1997.01900080120016","volume":"123","author":"SJ Miller","year":"1997","unstructured":"Miller SJ (1997) Healing by second intention following Mohs micrographic surgery. Arch Otolaryngol Head Neck Surg 123(8):886\u2013887. https:\/\/doi.org\/10.1001\/archotol.1997.01900080120016","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"9","key":"2209_CR14","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1111\/j.1524-4725.1987.tb00579.x","volume":"13","author":"KM Ellner","year":"1987","unstructured":"Ellner KM, Goldberg LH, Sperber J (1987) Comparison of cosmesis following healing by surgical closure and second intention. J Dermatol Surg Oncol 13(9):1016\u20131020. https:\/\/doi.org\/10.1111\/j.1524-4725.1987.tb00579.x","journal-title":"J Dermatol Surg Oncol"},{"issue":"3","key":"2209_CR15","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/0738-081X(84)90031-2","volume":"2","author":"JA Zitelli","year":"1984","unstructured":"Zitelli JA (1984) Secondary intention healing: an alternative to surgical repair. Clin Dermatol 2(3):92\u2013106","journal-title":"Clin Dermatol"},{"issue":"3","key":"2209_CR16","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1046\/j.1468-3083.2000.00046.x","volume":"14","author":"GA Moreno-Arias","year":"2000","unstructured":"Moreno-Arias GA, Izento-Menezes CM, Carrasco MA, Camps-Fresneda A (2000) Second intention healing after Mohs micrographic surgery. J Eur Acad Dermatol Venereol 14(3):159\u2013165. https:\/\/doi.org\/10.1046\/j.1468-3083.2000.00046.x","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2209_CR17","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002335","author":"C Brahe","year":"2020","unstructured":"Brahe C, Wu S, Miladi A (2020) Mucosa does not matter: successful secondary intention healing of the lip and vermilion border in Mohs surgery patients. Dermatol Surg. https:\/\/doi.org\/10.1097\/DSS.0000000000002335","journal-title":"Dermatol Surg"},{"issue":"6","key":"2209_CR18","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1067\/mjd.2002.125065","volume":"47","author":"HM Gloster","year":"2002","unstructured":"Gloster HM (2002) The use of second-intention healing for partial-thickness Mohs defects involving the vermilion and\/or mucosal surfaces of the lip. J Am Acad Dermatol 47(6):893\u2013897. https:\/\/doi.org\/10.1067\/mjd.2002.125065","journal-title":"J Am Acad Dermatol"},{"issue":"10","key":"2209_CR19","doi-asserted-by":"publisher","first-page":"497","DOI":"10.12968\/jowc.1998.7.10.497","volume":"7","author":"GD Becker","year":"1998","unstructured":"Becker GD, Adams LA, Levin BC (1998) Mohs wounds of the forehead: healing by secondary intention. J Wound Care 7(10):497\u2013500. https:\/\/doi.org\/10.12968\/jowc.1998.7.10.497","journal-title":"J Wound Care"},{"issue":"1","key":"2209_CR20","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1001\/archotol.1996.01890130051008","volume":"122","author":"BC Levin","year":"1996","unstructured":"Levin BC, Adams LA, Becker GD (1996) Healing by secondary intention of auricular defects after Mohs surgery. Arch Otolaryngol Head Neck Surg. 122(1):59\u201366. https:\/\/doi.org\/10.1001\/archotol.1996.01890130051008 ((discussion 67))","journal-title":"Arch Otolaryngol Head Neck Surg."},{"issue":"5","key":"2209_CR21","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1001\/archotol.1997.01900050085011","volume":"123","author":"BD Deutsch","year":"1997","unstructured":"Deutsch BD, Becker FF (1997) Secondary healing of Mohs defects of the forehead, temple, and lower eyelid. Arch Otolaryngol Head Neck Surg 123(5):529\u2013534. https:\/\/doi.org\/10.1001\/archotol.1997.01900050085011","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"2209_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-020-02122-w","author":"N Kibbi","year":"2020","unstructured":"Kibbi N, Khan Y, Leffell DJ, Christensen SR, Suozzi KC (2020) Predicting outcomes following second intent healing of periocular surgical defects. Arch Dermatol Res. https:\/\/doi.org\/10.1007\/s00403-020-02122-w","journal-title":"Arch Dermatol Res"},{"issue":"5","key":"2209_CR23","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.otc.2005.03.006","volume":"38","author":"DB Chandler","year":"2005","unstructured":"Chandler DB, Gausas RE (2005) Lower eyelid reconstruction. Otolaryngol Clin N Am 38(5):1033\u20131042. https:\/\/doi.org\/10.1016\/j.otc.2005.03.006","journal-title":"Otolaryngol Clin N Am"},{"issue":"3","key":"2209_CR24","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1097\/00002341-199709000-00004","volume":"13","author":"JC Lowry","year":"1997","unstructured":"Lowry JC, Bartley GB, Garrity JA (1997) The role of second-intention healing in periocular reconstruction. Ophthal Plast Reconstr Surg 13(3):174\u2013188. https:\/\/doi.org\/10.1097\/00002341-199709000-00004","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"2209_CR25","doi-asserted-by":"publisher","DOI":"10.1097\/scs.0000000000006518","author":"K Hwang","year":"2020","unstructured":"Hwang K (2020) Periorbital and perioral regions in relation to aging. J Craniofac Surg. https:\/\/doi.org\/10.1097\/scs.0000000000006518","journal-title":"J Craniofac Surg"},{"issue":"1","key":"2209_CR26","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/DSS.0000000000000208","volume":"41","author":"PC Hochwalt","year":"2015","unstructured":"Hochwalt PC, Christensen KN, Cantwell SR et al (2015) Comparison of full-thickness skin grafts versus second-intention healing for Mohs defects of the helix. Dermatol Surg 41(1):69\u201377. https:\/\/doi.org\/10.1097\/DSS.0000000000000208","journal-title":"Dermatol Surg"},{"issue":"10","key":"2209_CR27","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1001\/archotol.1996.01890220083014","volume":"122","author":"KH Calhoun","year":"1996","unstructured":"Calhoun KH, Slaughter D, Kassir R, Seikaly H, Hokanson JA (1996) Biomechanics of the helical rim advancement flap. Arch Otolaryngol Head Neck Surg 122(10):1119\u20131123. https:\/\/doi.org\/10.1001\/archotol.1996.01890220083014","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"3","key":"2209_CR28","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.fsc.2009.05.006","volume":"17","author":"DCJ Shonka","year":"2009","unstructured":"Shonka DCJ, Park SS (2009) Ear defects. Fac Plast Surg Clin N Am 17(3):429\u2013443. https:\/\/doi.org\/10.1016\/j.fsc.2009.05.006","journal-title":"Fac Plast Surg Clin N Am"},{"issue":"Suppl 1","key":"2209_CR29","doi-asserted-by":"publisher","first-page":"E884","DOI":"10.1002\/hed.24120","volume":"38","author":"SM Gore","year":"2016","unstructured":"Gore SM, Shaw D, Martin RCW et al (2016) Prospective study of sentinel node biopsy for high-risk cutaneous squamous cell carcinoma of the head and neck. Head Neck 38(Suppl 1):E884\u2013E889. https:\/\/doi.org\/10.1002\/hed.24120","journal-title":"Head Neck"},{"issue":"1","key":"2209_CR30","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/DSS.0000000000001611","volume":"45","author":"JM Donigan","year":"2019","unstructured":"Donigan JM, Millican EA (2019) Cosmetic and functional outcomes of second intention healing for Mohs defects of the lips. Dermatol Surg 45(1):26\u201335. https:\/\/doi.org\/10.1097\/DSS.0000000000001611","journal-title":"Dermatol Surg"},{"issue":"5","key":"2209_CR31","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.jaad.2006.07.030","volume":"57","author":"AL Leonard","year":"2007","unstructured":"Leonard AL, Hanke CW (2007) Second intention healing for intermediate and large postsurgical defects of the lip. J Am Acad Dermatol 57(5):832\u2013835. https:\/\/doi.org\/10.1016\/j.jaad.2006.07.030","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"2209_CR32","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.fsc.2004.11.005","volume":"13","author":"KE McCarn","year":"2005","unstructured":"McCarn KE, Park SS (2005) Lip reconstruction. Fac Plast Surg Clin N Am 13(2):301\u2013314. https:\/\/doi.org\/10.1016\/j.fsc.2004.11.005","journal-title":"Fac Plast Surg Clin N Am"},{"issue":"1","key":"2209_CR33","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.det.2004.08.009","volume":"23","author":"AL Krunic","year":"2005","unstructured":"Krunic AL, Weitzul S, Taylor RS (2005) Advanced reconstructive techniques for the lip and perioral area. Dermatol Clin 23(1):43\u201353. https:\/\/doi.org\/10.1016\/j.det.2004.08.009","journal-title":"Dermatol Clin"},{"issue":"11","key":"2209_CR34","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1288\/00005537-199511000-00007","volume":"105","author":"GD Becker","year":"1995","unstructured":"Becker GD, Adams LA, Levin BC (1995) Outcome analysis of Mohs surgery of the lip and chin: comparing secondary intention healing and surgery. Laryngoscope 105(11):1176\u20131183. https:\/\/doi.org\/10.1288\/00005537-199511000-00007","journal-title":"Laryngoscope"},{"issue":"4","key":"2209_CR35","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1111\/j.1524-4725.2011.02258.x","volume":"38","author":"R Bosley","year":"2012","unstructured":"Bosley R, Leithauser L, Turner M, Gloster HM (2012) The efficacy of second-intention healing in the management of defects on the dorsal surface of the hands and fingers after Mohs micrographic surgery. Dermatol Surg 38(4):647\u2013653. https:\/\/doi.org\/10.1111\/j.1524-4725.2011.02258.x","journal-title":"Dermatol Surg"},{"key":"2209_CR36","first-page":"1016","volume":"98","author":"LH Goldberg","year":"1987","unstructured":"Goldberg LH, Sperber JAY (1987) Cosmesis following. Healing 98:1016\u20131020","journal-title":"Healing"},{"issue":"10","key":"2209_CR37","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1001\/jamadermatol.2015.1573","volume":"151","author":"LM Dzubow","year":"2015","unstructured":"Dzubow LM (2015) Patient contribution to reconstructive decision: the purse-string closure. JAMA Dermatol 151(10):1142\u20131143. https:\/\/doi.org\/10.1001\/jamadermatol.2015.1573","journal-title":"JAMA Dermatol"},{"issue":"7","key":"2209_CR38","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1046\/j.1524-4725.2003.29180.x","volume":"29","author":"KJ Mott","year":"2003","unstructured":"Mott KJ, Clark DP, Stelljes LS (2003) Regional variation in wound contraction of Mohs surgery defects allowed to heal by second intention. Dermatol Surg 29(7):712\u2013722. https:\/\/doi.org\/10.1046\/j.1524-4725.2003.29180.x","journal-title":"Dermatol Surg"},{"key":"2209_CR39","doi-asserted-by":"crossref","unstructured":"Jaffe AT, Heymann WR, Lawrence N. Epidermal Maturation Arrest. 1999:900\u2013903.","DOI":"10.1046\/j.1524-4725.1999.99106.x"},{"issue":"12","key":"2209_CR40","first-page":"46","volume":"7","author":"MC Kessides","year":"2014","unstructured":"Kessides MC, Khachemoune A (2014) A review of epidermal maturation arrest: a unique entity or another description of persistent granulation tissue? J Clin Aesthet Dermatol 7(12):46\u201350","journal-title":"J Clin Aesthet Dermatol"},{"issue":"4","key":"2209_CR41","first-page":"20","volume":"46","author":"PE Houghton","year":"2000","unstructured":"Houghton PE, Kincaid CB, Campbell KE, Woodbury MG, Keast DH (2000) Photographic assessment of the appearance of chronic pressure and leg ulcers. Ostomy Wound Manag 46(4):20\u201326","journal-title":"Ostomy Wound Manag"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-021-02209-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-021-02209-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-021-02209-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T18:06:25Z","timestamp":1641578785000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-021-02209-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,20]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["2209"],"URL":"https:\/\/doi.org\/10.1007\/s00403-021-02209-y","relation":{},"ISSN":["0340-3696","1432-069X"],"issn-type":[{"value":"0340-3696","type":"print"},{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,20]]},"assertion":[{"value":"21 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"There are no financial disclosures, commercial associations, or any other conditions posing a conflict of interest to report for any of the above authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}