{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:38:57Z","timestamp":1790959137150,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s00403-021-02256-5","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:19:51Z","timestamp":1624061991000},"page":"553-561","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Efficacy assessments of tretinoin-loaded nano lipid carriers in acne vulgaris: a double blind, split-face randomized clinical study"],"prefix":"10.1007","volume":"314","author":[{"given":"Aniseh","family":"Samadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohre","family":"Sartipi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7384-6686","authenticated-orcid":false,"given":"Saman","family":"Ahmad Nasrollahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behjat","family":"Sheikholeslami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour","family":"Nassiri Kashani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Rouini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rassoul","family":"Dinarvand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Firooz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,19]]},"reference":[{"key":"2256_CR1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/978-3-540-78814-0_34","volume-title":"Therapy of skin diseases","author":"CC Zouboulis","year":"2010","unstructured":"Zouboulis CC, Abdel-Naser MB (2010) Acne and its variants. In: Krieg T, Bickers D, Miyacki Y (eds) Therapy of skin diseases. Springer, Berlin, pp 359\u2013373"},{"issue":"4","key":"2256_CR2","doi-asserted-by":"publisher","first-page":"201","DOI":"10.2165\/00128071-200001040-00001","volume":"1","author":"EA Eady","year":"2000","unstructured":"Eady EA, Cove JH (2000) Is acne an infection of blocked pilosebaceous follicles? Implications for antimicrobial treatment. Am J Clin Dermatol 1(4):201\u2013209","journal-title":"Am J Clin Dermatol"},{"issue":"1","key":"2256_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4103\/0019-5154.77543","volume":"56","author":"S Rathi","year":"2011","unstructured":"Rathi S (2011) Acne vulgaris treatment: the current scenario. Indian J Dermatol 56(1):7\u201313","journal-title":"Indian J Dermatol"},{"issue":"5","key":"2256_CR4","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1590\/abd1806-4841.20177003","volume":"92","author":"E Bagatin","year":"2017","unstructured":"Bagatin E, Florez-White M, Arias-Gomez MI et al (2017) Algorithm for acne treatment: Ibero-Latin American consensus. An Bras Dermatol 92(5):689\u2013693","journal-title":"An Bras Dermatol"},{"issue":"4","key":"2256_CR5","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1111\/jocd.12381","volume":"16","author":"DH McDaniel","year":"2017","unstructured":"McDaniel DH, Mazur C, Wortzman MS et al (2017) Efficacy and tolerability of a double-conjugated retinoid cream vs 1.0% retinol cream or 0.025% tretinoin cream in subjects with mild to severe photoaging. J Cosmet Dermatol 16(4):542\u2013548","journal-title":"J Cosmet Dermatol"},{"key":"2256_CR6","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1517\/14656566.9.16.2931","volume":"9","author":"MB Abdel-Naser","year":"2008","unstructured":"Abdel-Naser MB, Zouboulis CC (2008) Clindamycin phosphate \/ tretinoin gel formulation in the treatment of acne vulgaris. Expert Opin Pharmacother 9:2931\u20132937","journal-title":"Expert Opin Pharmacother"},{"key":"2256_CR7","doi-asserted-by":"publisher","first-page":"S15","DOI":"10.1111\/j.1610-0387.2008.06741_suppx.x","volume":"1","author":"A Thielitz","year":"2010","unstructured":"Thielitz A, Abdel-Naser MB, Fluhr JW et al (2010) Topical retinoids in acne\u2013an evidence-based overview. J Dtsch Dermatol Ges 1:S15-23","journal-title":"J Dtsch Dermatol Ges"},{"issue":"2","key":"2256_CR8","first-page":"31","volume":"3","author":"M Tabbakhian","year":"2008","unstructured":"Tabbakhian M, Sharifian A (2008) Preparation and in vitro characterization of tretinoin-containing. Res Pharmaceut Sci 3(2):31\u201340","journal-title":"Res Pharmaceut Sci"},{"issue":"1\u20132","key":"2256_CR9","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0378-5173(02)00701-9","volume":"253","author":"C Duclairoir","year":"2003","unstructured":"Duclairoir C, Orecchioni AM, Depraetere P et al (2003) Evaluation of gliadins nanoparticles as drug delivery systems: a study of three different drugs. Int J Pharm 253(1\u20132):133\u2013144","journal-title":"Int J Pharm"},{"key":"2256_CR10","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0378-5173(94)00090-5","volume":"1994","author":"D Amdidouche","year":"1994","unstructured":"Amdidouche D, Montassier P, Poelman MC et al (1994) Evaluation by laser Doppler velocimetry of the attenuation of tretinoin induced skin irritation by \u03b2-cyclodextrin complexation. Int J Pharmaceut 1994:111\u2013116","journal-title":"Int J Pharmaceut"},{"issue":"3","key":"2256_CR11","doi-asserted-by":"publisher","first-page":"305","DOI":"10.15171\/apb.2015.043","volume":"5","author":"N Naseri","year":"2015","unstructured":"Naseri N, Valizadeh H, Zakeri-Milani P (2015) Solid lipid nanoparticles and nanostructured lipid carriers: structure. Prep Appl Adv Pharm Bull 5(3):305\u2013313","journal-title":"Prep Appl Adv Pharm Bull"},{"key":"2256_CR12","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.molcatb.2006.02.011","volume":"2006","author":"S Falcocchio","year":"2006","unstructured":"Falcocchio S, Ruiz C, Javier PFI et al (2006) Propionibacterium acnes GehA lipase, an enzyme involved in acne development, can be successfully inhibited by defined natural substances. J Mol Catal B: Enzym 2006:132\u2013137","journal-title":"J Mol Catal B: Enzym"},{"issue":"1","key":"2256_CR13","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ijpharm.2013.08.019","volume":"456","author":"K Raza","year":"2013","unstructured":"Raza K, Singh B, Lohan S et al (2013) Nano-lipoidal carriers of tretinoin with enhanced percutaneous absorption, photostability, biocompatibility and anti-psoriatic. Int J Pharm 456(1):65\u201372","journal-title":"Int J Pharm"},{"issue":"1","key":"2256_CR14","first-page":"73","volume":"35","author":"R Sanad","year":"2014","unstructured":"Sanad R (2014) Lipid nanoparticles (SLNs and NLCs): wide range of application. J Drug Res Egypt 35(1):73\u201379","journal-title":"J Drug Res Egypt"},{"issue":"2","key":"2256_CR15","first-page":"705","volume":"4","author":"A Dubey","year":"2012","unstructured":"Dubey A, Prabhu P, Kamath J (2012) Nano structured lipid carriers: a novel. Int J PharmTech Res 4(2):705\u2013714","journal-title":"Int J PharmTech Res"},{"key":"2256_CR16","doi-asserted-by":"publisher","first-page":"575","DOI":"10.2174\/1567201813666160512145954","volume":"14","author":"SA Nasrollahi","year":"2017","unstructured":"Nasrollahi SA, Hassanzade H, Moradi A et al (2017) Safety assessment of tretinoin loaded nano emulsion and nanostructured lipid carriers: a non-invasive trial on human volunteers. Curr Drug Deliv 14:575\u2013580","journal-title":"Curr Drug Deliv"},{"issue":"6","key":"2256_CR17","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.addr.2007.05.004","volume":"59","author":"MR Gasco","year":"2007","unstructured":"Gasco MR (2007) Lipid nanoparticles: perspectives and challenges. Adv Drug Deliv Rev 59(6):377\u2013378","journal-title":"Adv Drug Deliv Rev"},{"issue":"6","key":"2256_CR18","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1159\/000488993","volume":"31","author":"M Sabouri","year":"2018","unstructured":"Sabouri M, Samadi A, Ahmad Nasrollahi S et al (2018) Tretinoin loaded nanoemulsion for acne vulgaris: fabrication, physicochemical and clinical efficacy assessments. Skin Pharmacol Physiol 31(6):316\u2013323","journal-title":"Skin Pharmacol Physiol"},{"key":"2256_CR19","first-page":"221","volume":"2017","author":"A Moradi","year":"2017","unstructured":"Moradi A, Farboud ES, Ahmad-Nasrollahi S et al (2017) Tretinoin Loaded nanostructured lipid carrier (NLC): safe and effective drug delivery system. Nanosci Nanotechnol Asia 2017:221\u2013229","journal-title":"Nanosci Nanotechnol Asia"},{"key":"2256_CR20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3390\/pharmaceutics9040037","volume":"9","author":"CM Nastiti","year":"2017","unstructured":"Nastiti CM, Ponto T, Abd E et al (2017) Topical nano and microemulsions for skin delivery. Pharmaceutics 9:37","journal-title":"Pharmaceutics"},{"issue":"1\u20132","key":"2256_CR21","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.ijpharm.2006.12.045","volume":"337","author":"W Weyenberg","year":"2007","unstructured":"Weyenberg W, Filev P, Van den Plas D et al (2007) Cytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal application. Int J Pharm 337(1\u20132):291\u2013298","journal-title":"Int J Pharm"},{"issue":"11","key":"2256_CR22","first-page":"10","volume":"24","author":"G Latter","year":"2019","unstructured":"Latter G, Grice JE, Mohammed Y et al (2019) Targeted topical delivery of retinoids in the management of acne vulgaris: current formulations and novel delivery systems. Pharmaceutics 24(11):10","journal-title":"Pharmaceutics"},{"key":"2256_CR23","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.ejpb.2018.10.017","volume":"133","author":"A Gordillo-Galeano","year":"2018","unstructured":"Gordillo-Galeano A, Mora-Huertas CE (2018) Solid lipid nanoparticles and nanostructured lipid carriers: a review emphasizing on particle structure and drug release. Eur J Pharm Biopharm 133:285\u2013308","journal-title":"Eur J Pharm Biopharm"},{"issue":"2","key":"2256_CR24","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.ijpharm.2010.08.014","volume":"416","author":"R Shegokar","year":"2011","unstructured":"Shegokar R, Singh KK, M\u00fcller RH (2011) Production & stability of stavudine solid lipid nanoparticles\u2014from lab to industrial scale. Int J Pharm 416(2):461\u2013470","journal-title":"Int J Pharm"},{"key":"2256_CR25","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.chemphyslip.2013.07.010","volume":"175","author":"S Khurana","year":"2013","unstructured":"Khurana S, Bedi P, Jain N (2013) Preparation and evaluation of solid lipid nanoparticles based nanogel for dermal delivery of meloxicam. Chem Phys Lipids 175:65\u201372","journal-title":"Chem Phys Lipids"},{"key":"2256_CR26","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ifset.2013.03.002","volume":"19","author":"F Tamjidi","year":"2013","unstructured":"Tamjidi F, Shahedi M, Varshosaz J et al (2013) Nanostructured lipid carriers (NLC): a potential delivery system for bioactive food molecules. Innov Food Sci Emerg Technol 19:29\u201343","journal-title":"Innov Food Sci Emerg Technol"},{"key":"2256_CR27","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.colsurfa.2013.12.023","volume":"444","author":"AB Kova\u010devi\u0107","year":"2014","unstructured":"Kova\u010devi\u0107 AB, Muller RH, Savi\u0107 SD et al (2014) Solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants: preparation, characterization and physical stability investigation. Colloids Surf A Physicochem Eng Asp 444:15\u201325","journal-title":"Colloids Surf A Physicochem Eng Asp"},{"issue":"4","key":"2256_CR28","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.3109\/10717544.2015.1041578","volume":"23","author":"SA Rahman","year":"2016","unstructured":"Rahman SA, Abdelmalak NS, Badawi A et al (2016) Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients. Drug Deliv 23(4):1184\u20131193","journal-title":"Drug Deliv"},{"key":"2256_CR29","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/1476-511X-11-159","volume":"11","author":"S Selvamuthukumar","year":"2012","unstructured":"Selvamuthukumar S, Velmurugan R (2012) Nanostructured lipid carriers: a potential drug carrier for cancer chemotherapy. Lipids Health Dis 11:159","journal-title":"Lipids Health Dis"},{"key":"2256_CR30","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s40089-015-0161-8","volume":"5","author":"M Almousallam","year":"2015","unstructured":"Almousallam M, Moia C, Huijun Z (2015) Development of nanostructured lipid carrier for dacarbazine delivery. Int Nano Lett 5:241\u2013248","journal-title":"Int Nano Lett"},{"key":"2256_CR31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ijpharm.2005.11.045","volume":"311","author":"M Manconi","year":"2006","unstructured":"Manconi M, Sinico C, Valenti D et al (2006) Niosomes as carriers for tretinoin: III. A study into the in vitro cutaneous delivery of vesicle-incorporated tretinoin. Int J Pharm 311:11\u201319","journal-title":"Int J Pharm"},{"key":"2256_CR32","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jconrel.2004.11.020","volume":"103","author":"C Sinico","year":"2005","unstructured":"Sinico C, Manconi M, Peppi M et al (2005) Liposomes as carriers for dermal delivery of tretinoin: in vitro evaluation of drug permeation and vesicle\u2013skin interaction. J Control Release 103:123\u2013136","journal-title":"J Control Release"},{"key":"2256_CR33","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1208\/s12249-010-9553-2","volume":"11","author":"NS Sanad","year":"2010","unstructured":"Sanad NS, Tabdelmalak TS, Elbayoomy A (2010) Formulation of a novel oxybenzone-loaded nanostructured lipid carriers (NLCs). AAPS PharmSciTech 11:1684\u20131694","journal-title":"AAPS PharmSciTech"},{"key":"2256_CR34","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jfoodeng.2015.10.005","volume":"171","author":"N Dan","year":"2016","unstructured":"Dan N (2016) Compound release from nanostructured lipid carriers (NLCs). J Food Eng 171:37\u201343","journal-title":"J Food Eng"},{"key":"2256_CR35","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.ejpb.2016.07.026","volume":"108","author":"VM Ghate","year":"2016","unstructured":"Ghate VM, Lewis SA, Prabhu P et al (2016) Nanostructured lipid carriers for the topical delivery of tretinoin. Eur J Pharm Biopharm 108:253\u2013261","journal-title":"Eur J Pharm Biopharm"},{"key":"2256_CR36","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1200\/JCO.1995.13.5.1238","volume":"13","author":"PC Adamson","year":"1995","unstructured":"Adamson PC, Bailey J, Pluda J et al (1995) Pharmacokinetics of all- trans-retinoic acid administered on an intermittent schedule. J Clin Oncol 13:1238\u20131240","journal-title":"J Clin Oncol"},{"issue":"5","key":"2256_CR37","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1067\/mjd.2003.175","volume":"48","author":"K Lynn","year":"2003","unstructured":"Lynn K, Joel L, Judy L et al (2003) Assessment of dermatopharmacokinetic approach in the bioequivalence determination of topical tretinoin gel products. JAAD 48(5):740\u2013751","journal-title":"JAAD"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-021-02256-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-021-02256-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-021-02256-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T13:24:00Z","timestamp":1656077040000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-021-02256-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,19]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["2256"],"URL":"https:\/\/doi.org\/10.1007\/s00403-021-02256-5","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,19]]},"assertion":[{"value":"18 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study was approved by the Ethics Committee of Tehran University of Medical Sciences under the registration code IR.TUMS.REC.1394.1771. The study protocol was approved by the Committee of Iranian Registry of Clinical Trials on 3\/1\/2016 under the registration code IRCT20161207031288N2. Data were generated, recorded and processed in accordance with the Declaration of Helsinki and principles of Good Clinical Practice. The method of study was explained to all volunteers, and a written informed consent was obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of Ethics"}}]}}