{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:51:25Z","timestamp":1785876685576,"version":"3.56.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alopecia areata (AA) is a non-scarring tissue-specific autoimmune disorder. Many therapeutic modalities are available for the treatment of AA, but none has yet proven to be uniformly effective. Fractional carbon dioxide (FRCO<jats:sub>2<\/jats:sub>) laser has been introduced as a treatment modality for AA. The objective is to evaluate and compare the efficacy and safety of FRCO<jats:sub>2<\/jats:sub>laser in treatment of AA alone or in combination with betamethasone valerate cream. 30 patients were assigned to one of the following groups, Group A FRCO<jats:sub>2<\/jats:sub>, Group B FRCO<jats:sub>2<\/jats:sub>plus betamethasone valerate cream or Group C (betamethasone valerate cream). Patients received eight laser sessions 2\u00a0weeks apart, treatment period was 4\u00a0months. A statistically significant decrease in SALT score, dystrophic hair and a statistically significant increase in terminal hair was observed in all groups. Patient satisfaction level and reduction in SALT score were significantly higher among FRCO<jats:sub>2<\/jats:sub>and FRCO<jats:sub>2<\/jats:sub>plus betamethasone valerate group. However, no statistical significant difference was found between FRCO<jats:sub>2<\/jats:sub>group and FRCO<jats:sub>2<\/jats:sub>combined with betamethasone valerate cream group. FRCO<jats:sub>2<\/jats:sub>laser is a safe and effective treatment modality for AA when used alone or in combination with betamethasone valerate cream. However, it was found superior to betamethasone valerate cream monotherapy.<\/jats:p>","DOI":"10.1007\/s00403-022-02393-5","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T14:02:26Z","timestamp":1663423346000},"page":"505-511","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of fractional carbon dioxide laser alone versus its combination with betamethasone valerate in treatment of alopecia areata, a clinical and dermoscopic study"],"prefix":"10.1007","volume":"315","author":[{"given":"Dalia Abdel","family":"Halim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Nayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solwan Ibrahim","family":"El-Samanoudy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba Mohamed Abdel","family":"Raheem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4749-1981","authenticated-orcid":false,"given":"Nanis","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,17]]},"reference":[{"issue":"5","key":"2393_CR1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1002\/lsm.22358","volume":"47","author":"JM Bae","year":"2015","unstructured":"Bae JM, Jung HM, Goo B, Park YM (2015) Hair regrowth through wound healing process after ablative fractional laser treatment in a murine model. 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Ethical committee approval by the Ethical Committee, Department of Dermatology, Faculty of Medicine, Cairo University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}