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While physical destruction may be associated with scarring, immunotherapy may be effective in treating warts through stimulating body immune response. The objective of the study was to compare the efficacy, safety, and outcome of <jats:italic>Candida<\/jats:italic> antigen vs diphencyprone (DPCP) in the treatment of warts. Fifty patients were randomly assigned to receive either intralesional <jats:italic>Candida<\/jats:italic> antigen every 3\u00a0weeks or weekly DPCP application. Both treatments were applied only to the mother wart. Lesions\u2019 clearance and associated side effects were observed up to 4\u00a0weeks after treatment. Two blinded physicians evaluated photos of warts before and 4\u00a0weeks after the end of treatment. Both modalities granted wart clearance and\/or improvement with no statistically significant difference; however, <jats:italic>Candida<\/jats:italic> antigen was significantly better in clearing adjacent untreated warts (<jats:italic>p<\/jats:italic>\u2009=\u20090.046). Fewer side effects were observed among the <jats:italic>Candida<\/jats:italic> antigen group. The response was duration associated in the <jats:italic>Candida<\/jats:italic> groups only. Intralesional <jats:italic>Candida<\/jats:italic> antigen injection and DPCP treatments for warts yielded improvement with superiority of <jats:italic>Candida<\/jats:italic> injection in eradicating distant lesions and fewer side effects. A shorter wart duration may be associated with a better therapeutic response with <jats:italic>Candida<\/jats:italic> antigen.<\/jats:p>","DOI":"10.1007\/s00403-022-02402-7","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T03:15:16Z","timestamp":1665976516000},"page":"583-591","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The efficacy and safety of intralesional Candida vaccine versus topical diphencyproprobenone in immunotherapy of verruca vulgaris: A randomized comparative study"],"prefix":"10.1007","volume":"315","author":[{"given":"Mohamed H. 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