{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:53:00Z","timestamp":1768891980226,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National Key Research Grant","award":["2018YFC0117004"],"award-info":[{"award-number":["2018YFC0117004"]}]},{"name":"Grants from National Natural Science Foundation of China","award":["81974479\uff0c81773329\uff0c82073447"],"award-info":[{"award-number":["81974479\uff0c81773329\uff0c82073447"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"DOI":"10.1007\/s00403-022-02498-x","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T02:02:42Z","timestamp":1670983362000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The HLA-Cw*06 allele may predict the response to methotrexate (MTX) treatment in Chinese arthritis-free psoriasis patients"],"prefix":"10.1007","author":[{"given":"Manyun","family":"Mao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehong","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menglin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kexiang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenzhi","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wangqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"issue":"2","key":"2498_CR1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/jdv.13854","volume":"31","author":"IM Michalek","year":"2017","unstructured":"Michalek IM, Loring B, John SM (2017) A systematic review of worldwide epidemiology of psoriasis. J Eur Acad Dermatol Venereol: JEADV 31(2):205\u2013212","journal-title":"J Eur Acad Dermatol Venereol: JEADV"},{"issue":"2","key":"2498_CR2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/jid.2012.339","volume":"133","author":"R Parisi","year":"2013","unstructured":"Parisi R, Symmons DP, Griffiths CE, Ashcroft DM (2013) Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol 133(2):377\u2013385","journal-title":"J Invest Dermatol"},{"issue":"1","key":"2498_CR3","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jdermsci.2011.03.002","volume":"63","author":"TF Tsai","year":"2011","unstructured":"Tsai TF, Wang TS, Hung ST, Tsai PI, Schenkel B et al (2011) Epidemiology and comorbidities of psoriasis patients in a national database in Taiwan. J Dermatol Sci 63(1):40\u201346","journal-title":"J Dermatol Sci"},{"issue":"19","key":"2498_CR4","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1001\/jama.2020.4006","volume":"323","author":"AW Armstrong","year":"2020","unstructured":"Armstrong AW, Read C (2020) Pathophysiology, clinical presentation, and treatment of psoriasis: a review. JAMA 323(19):1945\u20131960","journal-title":"JAMA"},{"issue":"5","key":"2498_CR5","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1684\/ejd.2012.1802","volume":"22","author":"X Ding","year":"2012","unstructured":"Ding X, Wang T, Shen Y, Wang X, Zhou C et al (2012) Prevalence of psoriasis in China: a population-based study in six cities. Eur J Dermatol\u202f: EJD 22(5):663\u2013667","journal-title":"Eur J Dermatol : EJD"},{"key":"2498_CR6","doi-asserted-by":"crossref","unstructured":"Bedoui Y, Guillot X, S\u00e9lambarom J, Guiraud P, Giry C et al (2019) Methotrexate an old drug with new tricks. Int J Mol Sci 20(20):5023","DOI":"10.3390\/ijms20205023"},{"issue":"2","key":"2498_CR7","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1042\/BST20190803","volume":"48","author":"AM Alqarni","year":"2020","unstructured":"Alqarni AM, Zeidler MP (2020) How does methotrexate work? Biochem Soc Trans 48(2):559\u2013567","journal-title":"Biochem Soc Trans"},{"issue":"5","key":"2498_CR8","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.jaad.2008.11.906","volume":"60","author":"RE Kalb","year":"2009","unstructured":"Kalb RE, Strober B, Weinstein G, Lebwohl M (2009) Methotrexate and psoriasis: 2009 national psoriasis foundation consensus conference. J Am Acad Dermatol 60(5):824\u2013837","journal-title":"J Am Acad Dermatol"},{"issue":"1 Suppl 1","key":"2498_CR9","doi-asserted-by":"publisher","first-page":"S59","DOI":"10.1016\/j.jaad.2005.04.031","volume":"53","author":"M Lebwohl","year":"2005","unstructured":"Lebwohl M (2005) A clinician\u2019s paradigm in the treatment of psoriasis. J Am Acad Dermatol 53(1 Suppl 1):S59-69","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"2498_CR10","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1089\/dna.2018.4583","volume":"38","author":"B Jiang","year":"2019","unstructured":"Jiang B, Yan LJ, Wu Q (2019) ABCB1 (C1236T) polymorphism affects P-glycoprotein-mediated transport of methotrexate, doxorubicin, actinomycin D, and etoposide. DNA Cell Biol 38(5):485\u2013490","journal-title":"DNA Cell Biol"},{"issue":"7","key":"2498_CR11","doi-asserted-by":"publisher","first-page":"592","DOI":"10.2174\/1389200220666190701094756","volume":"20","author":"Z Wang","year":"2019","unstructured":"Wang Z, Zhang N, Chen C, Chen S, Xu J et al (2019) Influence of the OATP polymorphism on the population pharmacokinetics of methotrexate in Chinese patients. Curr Drug Metab 20(7):592\u2013600","journal-title":"Curr Drug Metab"},{"issue":"4","key":"2498_CR12","first-page":"572","volume":"35","author":"P Ranganathan","year":"2008","unstructured":"Ranganathan P, Culverhouse R, Marsh S, Mody A, Scott-Horton TJ et al (2008) Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. J Rheumatol 35(4):572\u2013579","journal-title":"J Rheumatol"},{"issue":"9","key":"2498_CR13","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1111\/jdv.16440","volume":"34","author":"M Chen","year":"2020","unstructured":"Chen M, Chen W, Liu P, Yan K, Lv C et al (2020) The impacts of gene polymorphisms on methotrexate in Chinese psoriatic patients. J Eur Acad Dermatol Venereol: JEADV 34(9):2059\u20132065","journal-title":"J Eur Acad Dermatol Venereol: JEADV"},{"issue":"2","key":"2498_CR14","doi-asserted-by":"publisher","first-page":"S79","DOI":"10.1016\/j.jisp.2018.09.006","volume":"19","author":"F Zhou","year":"2018","unstructured":"Zhou F, Zhang X (2018) Major histocompatibility complex and psoriasis. J Investig Dermatol Symp Proc 19(2):S79-s80","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"1","key":"2498_CR15","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/bjd.15753","volume":"178","author":"LJ van Vugt","year":"2018","unstructured":"van Vugt LJ, van den Reek J, Coenen MJH, de Jong E (2018) A systematic review of pharmacogenetic studies on the response to biologics in patients with psoriasis. Br J Dermatol 178(1):86\u201394","journal-title":"Br J Dermatol"},{"issue":"4","key":"2498_CR16","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/sj.jid.5700118","volume":"126","author":"JE Gudjonsson","year":"2006","unstructured":"Gudjonsson JE, Karason A, Runarsdottir EH, Antonsdottir AA, Hauksson VB et al (2006) Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients\u2013an analysis of 1019 HLA-C- and HLA-B-typed patients. J Invest Dermatol 126(4):740\u2013745","journal-title":"J Invest Dermatol"},{"issue":"6","key":"2498_CR17","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/j.1468-3083.2007.02014.x","volume":"21","author":"X Fan","year":"2007","unstructured":"Fan X, Xiao FL, Yang S, Liu JB, Yan KL et al (2007) Childhood psoriasis: a study of 277 patients from China. J Eur Acad Dermatol Venereol: JEADV 21(6):762\u2013765","journal-title":"J Eur Acad Dermatol Venereol: JEADV"},{"issue":"6","key":"2498_CR18","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1016\/j.jaci.2018.11.038","volume":"143","author":"N Dand","year":"2019","unstructured":"Dand N, Duckworth M, Baudry D, Russell A, Curtis CJ et al (2019) HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis. J Allergy Clin Immunol 143(6):2120\u20132130","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"2498_CR19","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s40291-017-0261-4","volume":"21","author":"M Talamonti","year":"2017","unstructured":"Talamonti M, Galluzzo M, Zangrilli A, Papoutsaki M, Egan CG et al (2017) HLA-C*06:02 does not predispose to clinical response following long-term adalimumab treatment in psoriatic patients: a retrospective cohort study. Mol Diagn Ther 21(3):295\u2013301","journal-title":"Mol Diagn Ther"},{"issue":"2","key":"2498_CR20","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/jdv.12495","volume":"29","author":"R Gyulai","year":"2015","unstructured":"Gyulai R, Bagot M, Griffiths CEM, Luger T, Naldi L et al (2015) Current practice of methotrexate use for psoriasis: results of a worldwide survey among dermatologists. J Eur Acad Dermatol Venereol: JEADV 29(2):224\u2013231","journal-title":"J Eur Acad Dermatol Venereol: JEADV"},{"key":"2498_CR21","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.intimp.2019.05.042","volume":"73","author":"Q Yu","year":"2019","unstructured":"Yu Q, Tong Y, Cui L, Zhang L, Gong Y et al (2019) Efficacy and safety of etanercept combined plus methotrexate and comparison of expression of pro-inflammatory factors expression for the treatment of moderate-to-severe plaque psoriasis. Int Immunopharmacol 73:442\u2013450","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"2498_CR22","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00403-016-1618-y","volume":"308","author":"S Indhumathi","year":"2016","unstructured":"Indhumathi S, Rajappa M, Chandrashekar L, Ananthanarayanan PH, Thappa DM et al (2016) The HLA-C*06 allele as a possible genetic predisposing factor to psoriasis in South Indian Tamils. Arch Dermatol Res 308(3):193\u2013199","journal-title":"Arch Dermatol Res"},{"issue":"4","key":"2498_CR23","doi-asserted-by":"publisher","first-page":"335","DOI":"10.2340\/00015555-0253","volume":"87","author":"X Fan","year":"2007","unstructured":"Fan X, Yang S, Sun LD, Liang YH, Gao M et al (2007) Comparison of clinical features of HLA-Cw*0602-positive and -negative psoriasis patients in a Han Chinese population. Acta Derm Venereol 87(4):335\u2013340","journal-title":"Acta Derm Venereol"},{"issue":"4","key":"2498_CR24","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1111\/j.1365-2133.2012.10992.x","volume":"167","author":"JG Bergboer","year":"2012","unstructured":"Bergboer JG, Oostveen AM, de Jager ME, den Heijer M, Joosten I et al (2012) Paediatric-onset psoriasis is associated with ERAP1 and IL23R loci, LCE3C_LCE3B deletion and HLA-C*06. Br J Dermatol 167(4):922\u2013925","journal-title":"Br J Dermatol"},{"issue":"2","key":"2498_CR25","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/j.1468-3083.2008.02951.x","volume":"23","author":"Y Jin","year":"2009","unstructured":"Jin Y, Yang S, Zhang F, Kong Y, Xiao F et al (2009) Combined effects of HLA-Cw6 and cigarette smoking in psoriasis vulgaris: a hospital-based case-control study in China. J Eur Acad Dermatol Venereol: JEADV 23(2):132\u2013137","journal-title":"J Eur Acad Dermatol Venereol: JEADV"},{"key":"2498_CR26","doi-asserted-by":"publisher","first-page":"24059","DOI":"10.1038\/srep24059","volume":"6","author":"A Chandra","year":"2016","unstructured":"Chandra A, Lahiri A, Senapati S, Basu B, Ghosh S et al (2016) Increased risk of psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population. Sci Rep 6:24059","journal-title":"Sci Rep"},{"issue":"2","key":"2498_CR27","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1046\/j.1523-1747.2000.00863.x","volume":"114","author":"TG Kim","year":"2000","unstructured":"Kim TG, Lee HJ, Youn JI, Kim TY, Han H (2000) The association of psoriasis with human leukocyte antigens in Korean population and the influence of age of onset and sex. J Invest Dermatol 114(2):309\u2013313","journal-title":"J Invest Dermatol"},{"issue":"5","key":"2498_CR28","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1007\/s00403-002-0324-0","volume":"294","author":"TF Tsai","year":"2002","unstructured":"Tsai TF, Hu CY, Tsai WL, Chu CY, Lin SJ et al (2002) HLA-Cw6 specificity and polymorphic residues are associated with susceptibility among Chinese psoriatics in Taiwan. Arch Dermatol Res 294(5):214\u2013220","journal-title":"Arch Dermatol Res"},{"issue":"6","key":"2498_CR29","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1155\/2011\/682782","volume":"31","author":"G Gandhi","year":"2011","unstructured":"Gandhi G, Buttar BS, Albert L, Hasan Q, Aggarwal RK (2011) Psoriasis-associated genetic polymorphism in North Indian population in the CCHCR1 gene and in a genomic segment flanking the HLA-C region. Dis Markers 31(6):361\u2013370","journal-title":"Dis Markers"},{"issue":"4","key":"2498_CR30","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s00296-012-2472-7","volume":"33","author":"A Cibulova","year":"2013","unstructured":"Cibulova A, Zajacova M, Fojtikova M, Stolfa J, Sedova L et al (2013) The HLA-Cw*06 allele and -1149 G\/T polymorphism of extrapituitary promoter of PRL gene as a possible common genetic predisposing factors to psoriasis vulgaris and psoriatic arthritis in Czech population. Rheumatol Int 33(4):913\u2013919","journal-title":"Rheumatol Int"},{"issue":"12","key":"2498_CR31","doi-asserted-by":"publisher","first-page":"e898","DOI":"10.1111\/jdv.17544","volume":"35","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Ding X, Meng Z, Chen M, Zheng X et al (2021) A Genome-wide association study identified HLA-C associated with the effectiveness of methotrexate for psoriasis treatment. J Eur Acad Dermatol Venereol 35(12):e898\u2013e900","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"4","key":"2498_CR32","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1111\/bjd.17704","volume":"181","author":"KX Yan","year":"2019","unstructured":"Yan KX, Zhang YJ, Han L, Huang Q, Zhang ZH et al (2019) TT genotype of rs10036748 in TNIP1 shows better response to methotrexate in a Chinese population: a prospective cohort study. Br J Dermatol 181(4):778\u2013785","journal-title":"Br J Dermatol"},{"issue":"6","key":"2498_CR33","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1111\/ced.13100","volume":"42","author":"J West","year":"2017","unstructured":"West J, Ogston S, Berg J, Palmer C, Fleming C et al (2017) HLA-Cw6-positive patients with psoriasis show improved response to methotrexate treatment. Clin Exp Dermatol 42(6):651\u2013655","journal-title":"Clin Exp Dermatol"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-022-02498-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-022-02498-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-022-02498-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T02:02:50Z","timestamp":1670983370000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-022-02498-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,14]]},"references-count":33,"alternative-id":["2498"],"URL":"https:\/\/doi.org\/10.1007\/s00403-022-02498-x","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,14]]},"assertion":[{"value":"31 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was then assigned the registration number ChiCTR-OCH-14004518 in the Chinese Clinical Trial Registry.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}