{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:40:20Z","timestamp":1780324820561,"version":"3.54.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004687","name":"Universidad de Murcia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004687","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The anatomical location of cutaneous melanoma is a relevant independent prognostic factor in melanoma. The aim of the study is to know the prognosis of lower limb cutaneous melanoma related to their location within the limb, regardless of the histological type, and if there are any other influencing variables. A real-world data observational study was developed. The lesions were divided depending on the location of the melanoma (thigh, leg and foot). Bivariate and multivariate analysis were performed, and melanoma-specific survival and disease-free survival rates were calculated. When these analysis were done, the results showed that, in melanomas of the lower limb, location on the foot presented a lower melanoma-specific survival rate compared to more proximal locations, and only the anatomical location presents statistical significance to discriminate cases with a higher mortality risk and a lower disease-free survival rate among distal melanomas (mainly on the foot). In conclusion, this study confirms that a more distal location of lower limb cutaneous melanoma is a relevant prognostic factor.<\/jats:p><jats:p>Trial registration number NCT04625491 retrospectively registered.<\/jats:p>","DOI":"10.1007\/s00403-023-02571-z","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T12:03:26Z","timestamp":1677758606000},"page":"1971-1978","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lower limb cutaneous melanoma surgery: location matters"],"prefix":"10.1007","volume":"315","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7718-8318","authenticated-orcid":false,"given":"Antonio","family":"Pi\u00f1ero-Madrona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Cerezuela-Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Ruiz-Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Mart\u00ednez-Barba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Ortiz-Reina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Mart\u00ednez-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"L\u00f3pez-\u00c1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 F.","family":"Fr\u00edas-Iniesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Viney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cabezas-Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"2571_CR1","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1111\/bjd.19010","volume":"183","author":"DD Yang","year":"2020","unstructured":"Yang DD, Salciccioli JD, Marshall DC, Sheri A, Shalhoub J (2020) Trends in malignant melanoma mortality in 31 countries from 1985 to 2015. Br J Dermatol 183:1056\u20131064","journal-title":"Br J Dermatol"},{"key":"2571_CR2","first-page":"27","volume":"21","author":"L Mervic","year":"2012","unstructured":"Mervic L (2012) Prognostic factors in patients with localized primary cutaneous melanoma. Acta Dermatovenereol APA 21:27\u201331","journal-title":"Acta Dermatovenereol APA"},{"key":"2571_CR3","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1200\/JCO.2010.31.5812","volume":"29","author":"JF Thompson","year":"2011","unstructured":"Thompson JF, Soong SJ, Balch CM, Gershemwald JE, Ding S, Ooit DG et al (2011) Prognostic significance of mitotic rate in localized primary melanoma: an analysis of patients in the multi-insitutional American Joint Committee on cancer melanoma staging database. J Clin Oncol 29:2199\u20132205","journal-title":"J Clin Oncol"},{"key":"2571_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032955","volume":"7","author":"L Mervic","year":"2012","unstructured":"Mervic L (2012) Time course and pattern of metastasis of cutaneous melanoma differ between men and women. PLoS ONE 7:e32955","journal-title":"PLoS ONE"},{"key":"2571_CR5","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1440-0960.2011.00835.x","volume":"53","author":"P Rubegni","year":"2012","unstructured":"Rubegni P, Rossi S, Nami N, Risulo M, Biaglioli M, Miracco C, Fimiani M (2012) A single centre melanoma thickness trend (1985\u20132009) in relation to skin areas accessible and non-accessible to self-inspection. Australas J Dermatol 53:32\u201336","journal-title":"Australas J Dermatol"},{"key":"2571_CR6","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s12094-017-1755-6","volume":"20","author":"F Tas","year":"2018","unstructured":"Tas F, Ertuk K (2018) Plantar melanoma is associated with certain poor prognostic histopathological factors, but not correlated with nodal involvement, recurrence, and worse survival. Clin Translat Oncol 20:607\u2013612","journal-title":"Clin Translat Oncol"},{"key":"2571_CR7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1757-1146-1-11","volume":"1","author":"IR Bristow","year":"2008","unstructured":"Bristow IR, Acland K (2008) Acral lentiginous melanoma of the food and ankle: a case series and review of the literature. J Foot Ankle Res 1:11\u201317","journal-title":"J Foot Ankle Res"},{"key":"2571_CR8","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1111\/ijd.12730","volume":"54","author":"M Sanlorenzo","year":"2015","unstructured":"Sanlorenzo M, Osella-Abate S, Ribero S, Marenco F, Nardo T, Fierro MT et al (2015) Melanoma of the lower extremities: foot site is an independent risk factor for clinical outcome. Int J Dermatol 54:1023\u20131029","journal-title":"Int J Dermatol"},{"key":"2571_CR9","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S1067-2516(03)70028-3","volume":"42","author":"SM Walsh","year":"2003","unstructured":"Walsh SM, Fisher SG, Sage RA (2003) Survival of patients with primary pedal melanoma. J Foot Ankle Surg 42:193\u2013198","journal-title":"J Foot Ankle Surg"},{"key":"2571_CR10","doi-asserted-by":"publisher","first-page":"31432","DOI":"10.1038\/srep31432","volume":"6","author":"J Lv","year":"2016","unstructured":"Lv J, Dai B, Kong Y, Shen X, Kong J (2016) Acral melanoma in Chinese: a clinicopathological and prognostic study of 142 cases. Sci Rep 6:31432","journal-title":"Sci Rep"},{"key":"2571_CR11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jss.2020.02.010","volume":"251","author":"K Huang","year":"2020","unstructured":"Huang K, Fan J, Misra S (2020) Acral lentiginous melanoma: incidence and survival in the United States, 2006\u20132015, an analysis of SEER Registry. J Surg Res 251:329\u2013339","journal-title":"J Surg Res"},{"key":"2571_CR12","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0025-7753(01)72152-5","volume":"117","author":"A Pi\u00f1ero-Madrona","year":"2001","unstructured":"Pi\u00f1ero-Madrona A, Mart\u00ednez-Escribano J, Nicol\u00e1s-Ruiz F, Mart\u00ednez-Barba E, Canteras-Jordana M, Rodriguez-Gonz\u00e1lez JM et al (2001) Sentinel node biopsy in melanoma using preoperative lymphoscintigraphy and intraoperative handheld gamma probe. Med Clin (Barc) 117:481\u2013486","journal-title":"Med Clin (Barc)"},{"key":"2571_CR13","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1177\/107110070602700908","volume":"27","author":"RJ Gray","year":"2006","unstructured":"Gray RJ, Pockaj BA, Vega ML, Connolly SM, DiCaudo DJ, File TA et al (2006) Diagnosis and treatment of malignant melanoma of the foot. Foot Ankle Int 27:696\u2013705","journal-title":"Foot Ankle Int"},{"key":"2571_CR14","doi-asserted-by":"publisher","first-page":"892","DOI":"10.2106\/00004623-199406000-00013","volume":"76","author":"BC Barnes","year":"1994","unstructured":"Barnes BC, Seigler HF, Saxby TS, Kocher MS, Harrelson JM (1994) Melanoma of the foot. J Bone Jt Surg 76:892\u2013898","journal-title":"J Bone Jt Surg"},{"key":"2571_CR15","first-page":"279","volume":"79","author":"DR Bennett","year":"1994","unstructured":"Bennett DR, Wasson D, McArthur JD, McMillen MA (1994) The effect of misdiagnosis and delay in diagnosis on clinical outcome in melanoma of the foot. J Am Coll Surg 79:279\u2013284","journal-title":"J Am Coll Surg"},{"key":"2571_CR16","doi-asserted-by":"crossref","DOI":"10.5402\/2011\/384729","volume":"2011","author":"OM Rashid","year":"2011","unstructured":"Rashid OM, Schaum JC, Wolfe LG, Brinster NK, Neifeld JP (2011) Prognostic variables and surgical management of foot melanoma: review of a 25-year institutional experience. ISRN Dermatol 2011:384729","journal-title":"ISRN Dermatol"},{"key":"2571_CR17","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1111\/j.1524-4725.2010.01632.x","volume":"36","author":"J Baumert","year":"2010","unstructured":"Baumert J, Schmidt M, Kunte C, Volkenandt M, Ruzicka T, Berking C et al (2010) Plantar melanoma: is the prognosis always bad? Dermatol Surg 36:1325\u20131327","journal-title":"Dermatol Surg"},{"key":"2571_CR18","doi-asserted-by":"publisher","first-page":"500","DOI":"10.5858\/arpa.2019-0561-RA","volume":"144","author":"DE Elder","year":"2020","unstructured":"Elder DE, Bastian BC, Cree IA, Massi D, Scolyer RA (2020) The 2018 World Health Organization classification of cutaneous, mucosal, and uveal melanoma. Arch Pathol Lab Med 144:500\u2013502","journal-title":"Arch Pathol Lab Med"},{"key":"2571_CR19","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1056\/NEJMc1512354","volume":"374","author":"M Akane","year":"2016","unstructured":"Akane M, ToshikazuO RO (2016) Melanomas and mechanical stress points of the plantar surface of the foot. N Eng J Med 374:2404\u20132406","journal-title":"N Eng J Med"},{"key":"2571_CR20","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1056\/NEJMc1706162","volume":"377","author":"CM Costello","year":"2017","unstructured":"Costello CM, Pittelkow MR, Mangold AR (2017) Acral melanoma and mechanical stress on te plantar surface of the foot. N Eng J Med 377:395\u2013396","journal-title":"N Eng J Med"},{"key":"2571_CR21","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1159\/000522492","volume":"238","author":"A Gavillero","year":"2022","unstructured":"Gavillero A, Garc\u00eda-Casado Z, Requena C, Manrique-Silva E, Traves V, Kumar R, Nagore E (2022) Differences by anat\u00f3mica site of non-aural lentiginous melanomas of the lower limb. Dermatology 238:977\u2013985","journal-title":"Dermatology"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-023-02571-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-023-02571-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-023-02571-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T04:13:14Z","timestamp":1702008794000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-023-02571-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,2]]},"references-count":21,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["2571"],"URL":"https:\/\/doi.org\/10.1007\/s00403-023-02571-z","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,2]]},"assertion":[{"value":"26 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Although this is a retrospective study, IRB approval was obtained before its development.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}