{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:48:47Z","timestamp":1792889327123,"version":"4.5.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002352","name":"Ain Shams University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treating nail psoriasis is often a time-consuming challenge with an unsecure outcome. Response to the treatment is variable and relapses are common. Systemic treatments have multiple systemic side effects and lack of the patient compliance makes intra-lesional therapies not the best choice for treatment of nail psoriasis. We aimed to evaluate and compare the efficacy and side effects of methotrexate versus calcipotriol plus betamethasone two-compound formula when applied topically to psoriatic nails after fractional CO<jats:sub>2<\/jats:sub> laser. This comparative pilot study included 20 patients with nail psoriasis. One side was treated with fractional CO<jats:sub>2<\/jats:sub> laser followed by the application of topical methotrexate (Group A) and the other side with fractional CO<jats:sub>2<\/jats:sub> laser followed by topical (Calcipotriol 0.05\u00a0mg\/gm\u2009+\u2009Betamethasone 0.5\u00a0mg\/gm) (Group B). 4 sessions were done, once every 2\u00a0weeks. There was a high statistical significant decrease in total NAPSI score in group A at 1(<jats:italic>P<\/jats:italic>\u2009=\u20090.000) and 2\u00a0months (<jats:italic>P<\/jats:italic>\u2009=\u20090.000). There was a high statistical significant decrease in total NA<jats:italic>P<\/jats:italic>SI score in group B at 1(<jats:italic>P<\/jats:italic>\u2009=\u20090.001) and 2\u00a0months (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). There was no statistical significant difference regarding total NA<jats:italic>P<\/jats:italic>SI score between both group A and B at 0 (<jats:italic>P<\/jats:italic>\u2009=\u20090.271), 1(<jats:italic>P<\/jats:italic>\u2009=\u20090.513) and 2\u00a0months (<jats:italic>P<\/jats:italic>\u2009=\u20090.647). Combined fractional CO<jats:sub>2<\/jats:sub> laser with either topical MTX or topical betamethasone plus calcipotriol two-compound formula is effective treatment for nail psoriasis.\n<\/jats:p>","DOI":"10.1007\/s00403-023-02574-w","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T20:13:12Z","timestamp":1677010392000},"page":"1705-1715","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fractional CO2 laser in the treatment of nail psoriasis: how can it help?"],"prefix":"10.1007","volume":"315","author":[{"given":"Ahmed Abdelfattah","family":"Afify","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha Adel","family":"Shaheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Gamal","family":"El-Banna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"issue":"3","key":"2574_CR1","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1111\/bjd.14811","volume":"176","author":"JG Schlager","year":"2017","unstructured":"Schlager JG, Rosumeck S, Werner RN, Jacobs A, Schmitt J, Schlager C, Nast A (2017) Topical treatments for scalp psoriasis: summary of a cochrane systematic review. Br J Dermatol 176(3):604\u2013614","journal-title":"Br J Dermatol"},{"issue":"8","key":"2574_CR2","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1111\/jdv.13678","volume":"30","author":"EL Maranda","year":"2016","unstructured":"Maranda EL, Nguyen AH, Lim VM, Hafeez F, Jimenez JJ (2016) Laser and light therapies for the treatment of nail psoriasis. J Eur Acad Dermatol Venerol 30(8):1278\u20131284","journal-title":"J Eur Acad Dermatol Venerol"},{"issue":"3","key":"2574_CR3","first-page":"193","volume":"5","author":"A Afshar","year":"2017","unstructured":"Afshar A, Tabrizi A (2017) Nail psoriasis triggered by the reconstruction of syndactyly. Arch Bone Jt Surg 5(3):193\u2013195","journal-title":"Arch Bone Jt Surg"},{"issue":"2","key":"2574_CR4","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.det.2014.12.001","volume":"33","author":"M Lorizzo","year":"2015","unstructured":"Lorizzo M (2015) Tips to treat the 5 most common nail disorders. Dermatol clin 33(2):175\u2013183","journal-title":"Dermatol clin"},{"issue":"1","key":"2574_CR5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.5978\/islsm.14-RE-01","volume":"23","author":"T Omi","year":"2014","unstructured":"Omi T, Numano K (2014) The role of the CO2 laser and fractional CO2 laser in dermatology. Laser Ther 23(1):49\u201360","journal-title":"Laser Ther"},{"issue":"5","key":"2574_CR6","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1046\/j.1468-3083.2000.00058.x","volume":"14","author":"UF Haustein","year":"2000","unstructured":"Haustein UF, Rytter M (2000) Methotrexate in psoriasis: 26 years\u2019 experience with low-dose long-term treatment. 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Eur J Mol Clin Med 8(4):852\u2013856","journal-title":"Eur J Mol Clin Med"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-023-02574-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-023-02574-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-023-02574-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T16:08:26Z","timestamp":1689178106000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-023-02574-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,21]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["2574"],"URL":"https:\/\/doi.org\/10.1007\/s00403-023-02574-w","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,21]]},"assertion":[{"value":"29 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"No competing interests and no funding source.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Before the start of the study, all participants signed a written consent form. The study followed instructions of the Ain Shams University Research Ethics Committee (FMASU MS 71\/2019), and the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}