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To compare the efficacy and safety between 0.01%, 0.03% bimatoprost and minoxidil 2% in gel formulations for eyebrow enhancement. Sixty eligible subjects were female or male, aged 18\u00a0years or older with eyebrow hypotrichosis, defined as either a Grade 1 or 2 on the Global Eyebrow Assessment (GEBA) scale. Patients were randomized into 3 groups using block randomization. Group a (20 patients) applied topical 0.03% bimatoprost gel once daily onto both eyebrows, group b (20 patients) applied topical 0.01% bimatoprost gel once daily onto both eyebrows while group c (20 patients) applied topical minoxidil 2% gel once daily onto both eyebrows. A significant improvement in GEBA score was reported in all the three groups after treatment (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.001); however, there was no statistically significant difference between the three groups (P1\u2009=\u20090.091; P2\u2009=\u20090.102; P3\u2009=\u20090.663). Bimatoprost is equally efficacious as minoxidil in enhancement of eyebrows with a more favorable response produced by the 0.03% concentration.<\/jats:p>","DOI":"10.1007\/s00403-023-02679-2","type":"journal-article","created":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T15:01:16Z","timestamp":1690729276000},"page":"2635-2641","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative study of the efficacy and safety of topical minoxidil 2% versus topical bimatoprost 0.01% versus topical bimatoprost 0.03% in treatment of eyebrow hypotrichosis: a randomized controlled trial"],"prefix":"10.1007","volume":"315","author":[{"given":"Mohamed S.","family":"Zaky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama A.","family":"Hashem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Mahfouz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7541-5241","authenticated-orcid":false,"given":"Mohamed L.","family":"Elsaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,30]]},"reference":[{"issue":"6","key":"2679_CR1","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1111\/jocd.13167","volume":"19","author":"P Suchonwanit","year":"2020","unstructured":"Suchonwanit P, Thammarucha S (2020) Eyebrow growth pattern analysis in patients with eyebrow hypotrichosis after receiving topical treatment: a retrospective study. 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