{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:15:19Z","timestamp":1792746919839,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T00:00:00Z","timestamp":1709337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T00:00:00Z","timestamp":1709337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"DOI":"10.1007\/s00403-024-02827-2","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T11:02:32Z","timestamp":1709377352000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Live vaccinations in dermatology for immunosuppressed patients: a narrative review"],"prefix":"10.1007","volume":"316","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1957-6622","authenticated-orcid":false,"given":"Divya M.","family":"Shan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rithi J.","family":"Chandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Fultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,2]]},"reference":[{"issue":"4","key":"2827_CR1","doi-asserted-by":"publisher","first-page":"526","DOI":"10.4103\/idoj.IDOJ_414_20","volume":"11","author":"D De","year":"2020","unstructured":"De D, Pandhi D (2020) Use of immunosuppressants\/immunomodulators in autoimmune\/inflammatory dermatologic diseases during COVID-19 pandemic\u2014general recommendation based on available evidence. Indian Dermatol Online J 11(4):526. https:\/\/doi.org\/10.4103\/idoj.IDOJ_414_20","journal-title":"Indian Dermatol Online J"},{"issue":"9","key":"2827_CR2","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1001\/jamadermatol.2015.0718","volume":"151","author":"RE Kalb","year":"2015","unstructured":"Kalb RE, Fiorentino DF, Lebwohl MG et al (2015) Risk of serious infection with biologic and systemic treatment of psoriasis: results from the psoriasis longitudinal assessment and registry (PSOLAR). JAMA Dermatol 151(9):961\u2013969. https:\/\/doi.org\/10.1001\/jamadermatol.2015.0718","journal-title":"JAMA Dermatol"},{"issue":"7","key":"2827_CR3","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1111\/ddg.14156","volume":"18","author":"S Mohme","year":"2020","unstructured":"Mohme S, Schmalzing M, M\u00fcller CSL, Vogt T, Goebeler M, Stoevesandt J (2020) Immunizations in immunocompromised patients: a guide for dermatologists. J Dtsch Dermatol Ges J Ger Soc Dermatol JDDG 18(7):699\u2013723. https:\/\/doi.org\/10.1111\/ddg.14156","journal-title":"J Dtsch Dermatol Ges J Ger Soc Dermatol JDDG"},{"key":"2827_CR4","doi-asserted-by":"publisher","DOI":"10.5070\/D327955114","author":"AJ Tan","year":"2021","unstructured":"Tan AJ, Streicher JL, Merola JF, Noe MH (2021) Vaccine considerations for adult dermatology patients on immunosuppressive and immunomodulatory therapies: a clinical review. Dermatol Online J. https:\/\/doi.org\/10.5070\/D327955114","journal-title":"Dermatol Online J"},{"issue":"1","key":"2827_CR5","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/bjd.13543","volume":"173","author":"M Sadlier","year":"2015","unstructured":"Sadlier M, Sadlier C, Alani A, Ahmad K, Bergin C, Ramsay B (2015) Poor adherence to vaccination guidelines in dermatology patients on immunosuppressive therapies: an issue that needs addressing. Br J Dermatol 173(1):288\u2013289. https:\/\/doi.org\/10.1111\/bjd.13543","journal-title":"Br J Dermatol"},{"issue":"2","key":"2827_CR6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jaad.2016.02.1240","volume":"76","author":"A Caplan","year":"2017","unstructured":"Caplan A, Fett N, Rosenbach M, Werth VP, Micheletti RG (2017) Prevention and management of glucocorticoid-induced side effects: a comprehensive review: infectious complications and vaccination recommendations. J Am Acad Dermatol 76(2):191\u2013198. https:\/\/doi.org\/10.1016\/j.jaad.2016.02.1240","journal-title":"J Am Acad Dermatol"},{"key":"2827_CR7","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/tax082","author":"F Huber","year":"2018","unstructured":"Huber F, Ehrensperger B, Hatz C, Chappuis F, B\u00fchler S, Eperon G (2018) Safety of live vaccines on immunosuppressive or immunomodulatory therapy\u2014a retrospective study in three Swiss Travel Clinics. J Travel Med. https:\/\/doi.org\/10.1093\/jtm\/tax082","journal-title":"J Travel Med."},{"issue":"4","key":"2827_CR8","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3390\/vaccines8040769","volume":"8","author":"A Chiricozzi","year":"2020","unstructured":"Chiricozzi A, Gisondi P, Bellinato F, Girolomoni G (2020) Immune response to vaccination in patients with psoriasis treated with systemic therapies. Vaccines 8(4):769. https:\/\/doi.org\/10.3390\/vaccines8040769","journal-title":"Vaccines"},{"issue":"2","key":"2827_CR9","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/ajd.12895","volume":"60","author":"M Rademaker","year":"2019","unstructured":"Rademaker M, Agnew K, Anagnostou N et al (2019) Psoriasis and infection. A clinical practice narrative. Australas J Dermatol 60(2):91\u201398. https:\/\/doi.org\/10.1111\/ajd.12895","journal-title":"Australas J Dermatol"},{"issue":"1","key":"2827_CR10","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jaad.2019.03.017","volume":"81","author":"E Baumrin","year":"2019","unstructured":"Baumrin E, Van Voorhees A, Garg A, Feldman SR, Merola JF (2019) A systematic review of herpes zoster incidence and consensus recommendations on vaccination in adult patients on systemic therapy for psoriasis or psoriatic arthritis: from the Medical Board of the National Psoriasis Foundation. J Am Acad Dermatol 81(1):102\u2013110. https:\/\/doi.org\/10.1016\/j.jaad.2019.03.017","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"2827_CR11","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1111\/pde.14631","volume":"38","author":"MA Munshi","year":"2021","unstructured":"Munshi MA, Noe MH, Chiu YE, Streicher JL (2021) Vaccines: considerations for pediatric dermatology patients on immunosuppressive agents. Pediatr Dermatol 38(5):1040\u20131046. https:\/\/doi.org\/10.1111\/pde.14631","journal-title":"Pediatr Dermatol"},{"issue":"6","key":"2827_CR12","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1111\/ijd.13140","volume":"55","author":"V Laniosz","year":"2016","unstructured":"Laniosz V, Lehman JS, Poland GA, Wetter DA (2016) Literature-based immunization recommendations for patients requiring immunosuppressive medications for autoimmune bullous dermatoses. Int J Dermatol 55(6):599\u2013607. https:\/\/doi.org\/10.1111\/ijd.13140","journal-title":"Int J Dermatol"},{"issue":"9","key":"2827_CR13","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1016\/j.vaccine.2020.01.037","volume":"38","author":"Y Uziel","year":"2020","unstructured":"Uziel Y, Moshe V, Onozo B et al (2020) Live attenuated MMR\/V booster vaccines in children with rheumatic diseases on immunosuppressive therapy are safe: multicenter, retrospective data collection. Vaccine 38(9):2198\u20132201. https:\/\/doi.org\/10.1016\/j.vaccine.2020.01.037","journal-title":"Vaccine"},{"key":"2827_CR14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.7304","author":"J Zhang","year":"2012","unstructured":"Zhang J, Xie F, Delzell E et al (2012) Association between vaccination for herpes zoster and risk of herpes zoster infection among older patients with selected immune-mediated diseases. JAMA. https:\/\/doi.org\/10.1001\/jama.2012.7304","journal-title":"JAMA"},{"issue":"1","key":"2827_CR15","first-page":"18","volume":"18","author":"KH Feli","year":"2019","unstructured":"Feli KH, Ediale CE, McMichael AJ (2019) Update in herpes zoster prevention and the role of dermatologists. J Drugs Dermatol JDD 18(1):18\u201322","journal-title":"J Drugs Dermatol JDD"},{"issue":"11","key":"2827_CR16","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.7326\/M20-6928","volume":"174","author":"JR Curtis","year":"2021","unstructured":"Curtis JR, Cofield SS, Bridges SL et al (2021) The Safety and immunologic effectiveness of the live varicella-zoster vaccine in patients receiving tumor necrosis factor inhibitor therapy: a randomized controlled trial. Ann Intern Med 174(11):1510\u20131518. https:\/\/doi.org\/10.7326\/M20-6928","journal-title":"Ann Intern Med"},{"issue":"4","key":"2827_CR17","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/jcag\/gwy069","volume":"2","author":"KA Papp","year":"2019","unstructured":"Papp KA, Haraoui B, Kumar D et al (2019) Vaccination guidelines for patients with immune-mediated disorders on immunosuppressive therapies\u2014executive summary. J Can Assoc Gastroenterol 2(4):149\u2013152. https:\/\/doi.org\/10.1093\/jcag\/gwy069","journal-title":"J Can Assoc Gastroenterol"},{"issue":"6","key":"2827_CR18","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.jaad.2013.06.046","volume":"69","author":"L Wine-Lee","year":"2013","unstructured":"Wine-Lee L, Keller SC, Wilck MB, Gluckman SJ, Van Voorhees AS (2013) From the medical board of the national psoriasis foundation: vaccination in adult patients on systemic therapy for psoriasis. J Am Acad Dermatol 69(6):1003\u20131013. https:\/\/doi.org\/10.1016\/j.jaad.2013.06.046","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"2827_CR19","doi-asserted-by":"publisher","first-page":"R174","DOI":"10.1186\/ar3497","volume":"13","author":"J Zhang","year":"2011","unstructured":"Zhang J, Delzell E, Xie F et al (2011) The use, safety, and effectiveness of herpes zoster vaccination in individuals with inflammatory and autoimmune diseases: a longitudinal observational study. Arthritis Res Ther 13(5):R174. https:\/\/doi.org\/10.1186\/ar3497","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"2827_CR20","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.abd.2018.11.001","volume":"94","author":"MH de Barros","year":"2019","unstructured":"de Barros MH, Avelleira JCR, Mendes KAP (2019) Impact of yellow fever vaccine on patients with psoriasis: preliminary results. An Bras Dermatol 94(6):757\u2013759. https:\/\/doi.org\/10.1016\/j.abd.2018.11.001","journal-title":"An Bras Dermatol"},{"issue":"6","key":"2827_CR21","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1016\/j.jaad.2021.01.047","volume":"84","author":"LM Gresham","year":"2021","unstructured":"Gresham LM, Marzario B, Dutz J, Kirchhof MG (2021) An evidence-based guide to SARS-CoV-2 vaccination of patients on immunotherapies in dermatology. J Am Acad Dermatol 84(6):1652\u20131666. https:\/\/doi.org\/10.1016\/j.jaad.2021.01.047","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"2827_CR22","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00296-013-2907-9","volume":"34","author":"D Papadopoulou","year":"2014","unstructured":"Papadopoulou D, Sipsas NV (2014) Comparison of national clinical practice guidelines and recommendations on vaccination of adult patients with autoimmune rheumatic diseases. Rheumatol Int 34(2):151\u2013163. https:\/\/doi.org\/10.1007\/s00296-013-2907-9","journal-title":"Rheumatol Int"},{"issue":"1","key":"2827_CR23","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-034886","volume":"10","author":"DJ Grint","year":"2020","unstructured":"Grint DJ, McDonald HI, Walker JL, Amirthalingam G, Andrews N, Thomas S (2020) Safety of inadvertent administration of live zoster vaccine to immunosuppressed individuals in a UK-based observational cohort analysis. BMJ Open 10(1):e034886. https:\/\/doi.org\/10.1136\/bmjopen-2019-034886","journal-title":"BMJ Open"},{"issue":"9","key":"2827_CR24","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1002\/acr.22021","volume":"65","author":"S Kern\u00e9is","year":"2013","unstructured":"Kern\u00e9is S, Launay O, Ancelle T et al (2013) Safety and immunogenicity of yellow fever 17D vaccine in adults receiving systemic corticosteroid therapy: an observational cohort study: yellow fever vaccine and corticosteroids. Arthritis Care Res 65(9):1522\u20131528. https:\/\/doi.org\/10.1002\/acr.22021","journal-title":"Arthritis Care Res"},{"issue":"1","key":"2827_CR25","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1136\/annrheumdis-2019-215882","volume":"79","author":"V Furer","year":"2020","unstructured":"Furer V, Rondaan C, Heijstek MW et al (2020) 2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Ann Rheum Dis 79(1):39\u201352. https:\/\/doi.org\/10.1136\/annrheumdis-2019-215882","journal-title":"Ann Rheum Dis"},{"key":"2827_CR26","doi-asserted-by":"publisher","DOI":"10.1590\/s1678-9946202163013","volume":"63","author":"AN Lara","year":"2021","unstructured":"Lara AN, Miyaji KT, Ibrahim KY, Lopes MH, Sartori AMC (2021) Adverse events following yellow fever vaccination in immunocompromised persons. Rev Inst Med Trop S\u00e3o Paulo 63:e13. https:\/\/doi.org\/10.1590\/s1678-9946202163013","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"issue":"2","key":"2827_CR27","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ijwd.2019.11.003","volume":"6","author":"A Worth","year":"2020","unstructured":"Worth A, Waldman RA, Dieckhaus K, Rothe MJ (2020) Art of prevention: our approach to the measles-mumps-rubella vaccine in adult patients vaccinated against measles before 1968 on biologic therapy for the treatment of psoriasis. Int J Womens Dermatol 6(2):94\u201396. https:\/\/doi.org\/10.1016\/j.ijwd.2019.11.003","journal-title":"Int J Womens Dermatol"},{"issue":"4","key":"2827_CR28","first-page":"1","volume":"52","author":"J Cono","year":"2003","unstructured":"Cono J, Casey CG, Bell DM, Centers for Disease Control and Prevention (2003) Smallpox vaccination and adverse reactions guidance for clinicians. MMWR Recomm Rep Morb Mortal Wkly Rep Recomm Rep 52(4):1\u201328","journal-title":"MMWR Recomm Rep Morb Mortal Wkly Rep Recomm Rep"},{"issue":"3","key":"2827_CR29","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s40495-023-00318-y","volume":"9","author":"S Ranjan","year":"2023","unstructured":"Ranjan S, Vashishth K, Sak K, Tuli HS (2023) The Emergence of Mpox: epidemiology and current therapeutic options. Curr Pharmacol Rep 9(3):144\u2013153. https:\/\/doi.org\/10.1007\/s40495-023-00318-y","journal-title":"Curr Pharmacol Rep"},{"issue":"22","key":"2827_CR30","doi-asserted-by":"publisher","first-page":"734","DOI":"10.15585\/mmwr.mm7122e1","volume":"71","author":"AK Rao","year":"2022","unstructured":"Rao AK, Petersen BW, Whitehill F et al (2022) Use of JYNNEOS (smallpox and monkeypox vaccine, live, nonreplicating) for preexposure vaccination of persons at risk for occupational exposure to orthopoxviruses: recommendations of the advisory committee on immunization practices\u2014United States, 2022. MMWR Morb Mortal Wkly Rep 71(22):734\u2013742. https:\/\/doi.org\/10.15585\/mmwr.mm7122e1","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"7","key":"2827_CR31","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.mayocp.2015.04.021","volume":"90","author":"TC Cheetham","year":"2015","unstructured":"Cheetham TC, Marcy SM, Tseng HF et al (2015) Risk of herpes zoster and disseminated varicella zoster in patients taking immunosuppressant drugs at the time of zoster vaccination. Mayo Clin Proc 90(7):865\u2013873. https:\/\/doi.org\/10.1016\/j.mayocp.2015.04.021","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"2827_CR32","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1186\/s12879-020-05082-8","volume":"20","author":"DR Chadwick","year":"2020","unstructured":"Chadwick DR, Sayeed L, Rose M et al (2020) Adherence to guidelines across different specialties to prevent infections in patients undergoing immunosuppressive therapies. BMC Infect Dis 20(1):359. https:\/\/doi.org\/10.1186\/s12879-020-05082-8","journal-title":"BMC Infect Dis"},{"key":"2827_CR33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ejim.2019.08.010","volume":"69","author":"H Lejri-El Euchi","year":"2019","unstructured":"Lejri-El Euchi H, Chirpaz E, Foucher A et al (2019) Vaccination against influenza and pneumococcal infections in patients with autoimmune disorders under biological therapy: coverage and attitudes in patients and physicians. Eur J Intern Med 69:25\u201331. https:\/\/doi.org\/10.1016\/j.ejim.2019.08.010","journal-title":"Eur J Intern Med"},{"issue":"9","key":"2827_CR34","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1111\/ddg.12010","volume":"11","author":"MA Radtke","year":"2013","unstructured":"Radtke MA, Rustenbach SJ, Reusch M, Str\u00f6mer K, Augustin M (2013) Influenza vaccination rate among patients with moderate to severe psoriasis: influenza vaccination in psoriasis patients. JDDG J Dtsch Dermatol Ges 11(9):837\u2013844. https:\/\/doi.org\/10.1111\/ddg.12010","journal-title":"JDDG J Dtsch Dermatol Ges"},{"issue":"3","key":"2827_CR35","doi-asserted-by":"publisher","first-page":"rkab092","DOI":"10.1093\/rap\/rkab092","volume":"5","author":"C Martin","year":"2021","unstructured":"Martin C, Muls V, Brasseur C et al (2021) ImmunoStart: preparing patients for immunosuppression. Rheumatol Adv Pract 5(3):rkab092. https:\/\/doi.org\/10.1093\/rap\/rkab092","journal-title":"Rheumatol Adv Pract"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-02827-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-024-02827-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-02827-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T17:03:14Z","timestamp":1710176594000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-024-02827-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,2]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["2827"],"URL":"https:\/\/doi.org\/10.1007\/s00403-024-02827-2","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,2]]},"assertion":[{"value":"6 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Feldman has received research, speaking, and\/or consulting support from AbbVie, Accordant, Almirall, Alvotech, Amgen, Arcutis, Arena, Argenx, Biocon, Boehringer Ingelheim, Bristol-Myers Squibb, Dermavant, Eli Lilly and Company, Eurofins, Forte, Galderma, Helsinn, Janssen, Leo Pharma, Micreos, Mylan, Novartis, Ono, Ortho Dermatology, Pfizer, Regeneron, Samsung, Sanofi, Sun Pharma, UCB, Verrica, Voluntis, and vTv Therapeutics. He is founder and part owner of Causa Research and holds stock in Sensal Health. Shan, Chandy, Fultz, and Sanders have no relevant financial or non-financial conflicts to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"96"}}