{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:29:57Z","timestamp":1789414197453,"version":"build-2803163510"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T00:00:00Z","timestamp":1715385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T00:00:00Z","timestamp":1715385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100022025","name":"South Valley University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100022025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is a chronic, immune-mediated, hyperproliferative skin disease. Etiopathogenesis of psoriasis is not well understood. Plexin B2 was found to have effects on CD100-mediated T-cell morphology and expressed in the immune system. It may play a role in the pathogenesis of psoriasis. To assess the tissue level of plexin-B2 and plexin B2 related gene polymorphism\u00a0which is\u00a0signal regulatory protein gamma (SIRP\u03b3-rs71212732) in psoriatic patients before and after NB-UVB, acitretin therapy alone or in combination and to detect correlation between level of tissue plexin B2 and disease severity and improvement. This single blinded randomized controlled trial was carried on 50 psoriatic patients and 50 healthy controls. Psoriasis Area and Severity Index score (PASI) was used to evaluate the disease severity. Tissue plexin-b2 level was measured using ELISA and SIRP\u03b3-rs71212732 (T\\C) was assessed using TaqMan\u2122 assays and real-time PCR. A significant lower tissue plexin-B2 level was observed in control group (2.9\u2009\u00b1\u20090.6\u00a0pg\/g) than cases (25.8\u2009\u00b1\u20092.8, pg\/g) (p\u2009&lt;\u20090.001). Also, a significantly higher tissue plexin-B2 level was observed in sever psoriasis (32.7\u2009\u00b1\u20093.8\u00a0pg\/ml) in than moderate psoriasis (13.6\u2009\u00b1\u20092.1\u00a0pg\/ml, p\u2009=\u20090.001). Tissue plexin B2 was positively correlated with diseases severity. Significantly higher (TC&amp; TT) genotypes and mutant (C) allele among patients compared to the controls, p\u2009&lt;\u20090.001 for all. Tissue plexin-b2 level was high in psoriasis vulgaris with positive correlation with disease severity and decreased after treatment. This may indicate a role of plexin-b2 in psoriasis vulgaris pathogenesis.<\/jats:p>","DOI":"10.1007\/s00403-024-02880-x","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T17:01:21Z","timestamp":1715446881000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Plexin B2 tissue expression and related gene polymorphisms in psoriasis and their relation to NB-UVB and Acitretin therapy"],"prefix":"10.1007","volume":"316","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8638-0427","authenticated-orcid":false,"given":"Eisa Mohamed","family":"Hegazy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustafa A. 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The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Institutional Review Board-Ethics committee of the Faculty of Medicine, South Valley University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"A written consent was obtained and signed by every subject in the study for agreement to publish study data, including photos and other materials.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for participation"}},{"value":"Written informed consent was obtained for publication from the subject.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"162"}}