{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:28:34Z","timestamp":1785554914618,"version":"3.56.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"DOI":"10.1007\/s00403-024-02906-4","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T15:02:49Z","timestamp":1716562969000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Assessing outcomes of topical 5-fluorouracil as primary and adjuvant therapy for squamous cell carcinoma in-situ"],"prefix":"10.1007","volume":"316","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5665-102X","authenticated-orcid":false,"given":"Dawn","family":"Queen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-1627","authenticated-orcid":false,"given":"Megan H.","family":"Trager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily R.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0595-1457","authenticated-orcid":false,"given":"Faramarz H.","family":"Samie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"issue":"1","key":"2906_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1365-2133.2006.07610.x","volume":"156","author":"NH Cox","year":"2007","unstructured":"Cox NH, Eedy DJ, Morton CA (2007) Guidelines for management of Bowen\u2019s disease: 2006 update. Br J Dermatol 156(1):11\u201321","journal-title":"Br J Dermatol"},{"issue":"2","key":"2906_CR2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1177\/120347540300700201","volume":"7","author":"H Bargman","year":"2003","unstructured":"Bargman H, Hochman J (2003) Topical treatment of Bowen\u2019s disease with 5-Fluorouracil. J Cutan Med Surg 7(2):101\u2013105","journal-title":"J Cutan Med Surg"},{"key":"2906_CR3","doi-asserted-by":"crossref","unstructured":"Connolly SM, Baker DR, Coldiron BM, Fazio MJ, Storrs PA, Vidimos AT, Zalla MJ, Brewer JD, Smith Begolka W, Berger TG, Bigby M, Bolognia JL, Brodland DG, Collins S, Cronin TA Jr., Dahl MV, Grant-Kels JM, Hanke CW, Hruza GJ, James WD, Lober CW, McBurney EI, Norton SA, Roenigk RK, Wheeland RG, Wisco OJ (2012) AAD\/ACMS\/ASDSA\/ASMS 2012 appropriate use criteria for Mohs micrographic surgery: a report of the American Academy of Dermatology, American College of Mohs Surgery, American Society for Dermatologic Surgery Association, and the American Society for Mohs Surgery, J Am Acad Dermatol 67(4) 531\u2009\u2013\u200950","DOI":"10.1016\/j.jaad.2012.06.009"},{"issue":"5","key":"2906_CR4","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.jaad.2016.06.047","volume":"75","author":"JJ Leitenberger","year":"2016","unstructured":"Leitenberger JJ, Rogers H, Chapman JC, Maher IA, Fox MC, Harmon CB, Bailey EC, Odland P, Wysong A, Johnson T, Wisco OJ (2016) Defining recurrence of nonmelanoma skin cancer after Mohs micrographic surgery: report of the American College of Mohs Surgery Registry and Outcomes Committee. J Am Acad Dermatol 75(5):1022\u20131031","journal-title":"J Am Acad Dermatol"},{"key":"2906_CR5","unstructured":"Jarett Casale PP (2023) Fluorouracil, Jan ed.2024."},{"issue":"2","key":"2906_CR6","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s13555-021-00668-9","volume":"12","author":"E Stockfleth","year":"2022","unstructured":"Stockfleth E, B\u00e9geault N, Delarue A (2022) Intensity of local skin reactions during 5-Fluorouracil Treatment related to the number of Actinic Keratosis lesions: a Post Hoc, exploratory analysis. Dermatol Ther (Heidelb) 12(2):467\u2013479","journal-title":"Dermatol Ther (Heidelb)"},{"issue":"2","key":"2906_CR7","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.jaad.2021.08.045","volume":"87","author":"H Neale","year":"2022","unstructured":"Neale H, Michelon M, Jacob S, Pinkston M, Ukaegbu R, Zamor W, Morrison E, Deng A, Levin NA (2022) Topical 5% 5-fluorouracil versus procedural modalities for squamous cell carcinoma in situ and superficial basal cell carcinoma: a retrospective cohort analysis. J Am Acad Dermatol 87(2):423\u2013425","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"2906_CR8","first-page":"433","volume":"33","author":"K Gross","year":"2007","unstructured":"Gross K, Kircik L, Kricorian G (2007) 5% 5-Fluorouracil cream for the treatment of small superficial basal cell carcinoma: efficacy, tolerability, cosmetic outcome, and patient satisfaction. Dermatol Surg 33(4):433\u2013439 discussion 440","journal-title":"Dermatol Surg"},{"issue":"1","key":"2906_CR9","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jaad.2021.07.067","volume":"87","author":"JR Stewart","year":"2022","unstructured":"Stewart JR, Lang ME, Brewer JD (2022) Efficacy of nonexcisional treatment modalities for superficially invasive and in situ squamous cell carcinoma: a systematic review and meta-analysis. J Am Acad Dermatol 87(1):131\u2013137","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"2906_CR10","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1046\/j.1365-2133.2003.05033.x","volume":"148","author":"A Salim","year":"2003","unstructured":"Salim A, Leman JA, McColl JH, Chapman R, Morton CA (2003) Randomized comparison of photodynamic therapy with topical 5-fluorouracil in Bowen\u2019s disease. Br J Dermatol 148(3):539\u2013543","journal-title":"Br J Dermatol"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-02906-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-024-02906-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-02906-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T11:29:42Z","timestamp":1719401382000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-024-02906-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,24]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["2906"],"URL":"https:\/\/doi.org\/10.1007\/s00403-024-02906-4","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,24]]},"assertion":[{"value":"7 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional or regional) and with the Helsinki Declaration of 1975, as revised in 1983.This study was IRB approved (IRB AAAU4123). The patients in this manuscript have given written informed consent to publication of their case details.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement\/IRB approval status"}},{"value":"None of the authors have conflict of interest pertaining to this submission. The use of fluorouracil 5% cream for SCCis is an off-label use of this medication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"220"}}