{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:55:04Z","timestamp":1783133704862,"version":"3.54.6"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100022025","name":"South Valley University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100022025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitiligo is considered an autoimmune disease, and its treatment is challenging. We assessed and compared the effect of fractional erbium:yttrium\u2013aluminum\u2013garnet (Er:YAG) laser-assisted delivery of platelet-rich plasma versus microneedling (Mn) with platelet-rich plasma (PRP) in enhancing skin repigmentation in localized stable vitiligo patients. In total, 40 patients with localized stable vitiligo were selected in a random manner into two similar groups (20 each). Group (A) was subjected to fractional Er:YAG laser combined with platelet-rich plasma and Group (B) was subjected to microneedling combined with platelet-rich plasma. The procedure was repeated every 2\u00a0weeks for up to 6\u00a0months. Each individual was assessed clinically utilizing Vitiligo Area Scoring Index (VASI). Fractional Er:YAG\u2009+\u2009PRP group achieved better pigmentation100% (excellent 30%, very good 15%, good 30% and satisfactory 25%) which is comparable to Mn\u2009+\u2009PRP where 80% of cases demonstrate repigmentation (20% very good, 10% good and 50% mild). When comparing the VASI scores for both groups after therapy to the baseline VASI, there was a statistically significant decrease [p\u2009=\u20090.001 for group(A) and 0.003 for group(B)]. Regarding the treatment side effects, there was significantly (p\u2009=\u20090.048) side effects among cases treated with microneedling group(B) (25%) than those fractional Er:Yag laser therapy group(A) (5%). Both forms of therapy demonstrated induction of repigmentation of vitiligo, but fractional Er:YAG laser efficacy is greater when combined with platelet-rich plasma.<\/jats:p><jats:p>Clinical trials.gov identifier: NCT05511493.<\/jats:p>","DOI":"10.1007\/s00403-024-03035-8","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T11:01:34Z","timestamp":1718449294000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effectiveness of fractional erbium\u2013YAG laser, microneedling, platelet-rich plasma in localized stable vitiligo patients: randomized clinical trial"],"prefix":"10.1007","volume":"316","clinical-trial-number":[{"clinical-trial-number":"nct05511493","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5394-6033","authenticated-orcid":false,"given":"Soheir","family":"Abdel-Hamid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-3302","authenticated-orcid":false,"given":"Hassan M.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya M.","family":"Hameed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8638-0427","authenticated-orcid":false,"given":"Eisa M.","family":"Hegazy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,15]]},"reference":[{"key":"3035_CR1","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1111\/jocd.16274","volume":"23","author":"N Atefi","year":"2024","unstructured":"Atefi N, Ziaeifar E, Seirafianpour F, Sadeghzadeh Bazargan A, Amin NG, Mozafarpoor S et al (2024) Evaluation of efficacy and safety of vitiligo treatment with micro-needling combined with N-Acetylcysteine and micro-needling alone: a double-blinded randomized controlled clinical trial. J Cosmet Dermatol 23:2220\u20132230","journal-title":"J Cosmet Dermatol"},{"issue":"1","key":"3035_CR2","doi-asserted-by":"publisher","DOI":"10.1002\/ski2.317","volume":"4","author":"A Al Hammadi","year":"2023","unstructured":"Al Hammadi A, de Castro CCS, Parmar NV, Ubogui J, Hatatah N, Ahmed HM et al (2023) Prevalence and burden of vitiligo in Africa, the Middle East and Latin America. Skin Health Dis. 4(1):e317","journal-title":"Skin Health Dis."},{"issue":"4","key":"3035_CR3","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.abd.2021.09.008","volume":"97","author":"HZ Marchioro","year":"2022","unstructured":"Marchioro HZ, de Castro CCS, Fava VM, Sakiyama PH, Dellatorre G, Miot HA (2022) Update on the pathogenesis of vitiligo. An Bras Dermatol 97(4):478\u2013490","journal-title":"An Bras Dermatol"},{"issue":"5","key":"3035_CR4","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1111\/bjd.14356","volume":"174","author":"M Whitton","year":"2016","unstructured":"Whitton M, Pinart M, Batchelor J, Leonardi-Bee J, Gonzalez U, Jiyad Z et al (2016) Evidence-based management of vitiligo: summary of a Cochrane systematic review. Br J Dermatol 174(5):962\u2013969","journal-title":"Br J Dermatol"},{"issue":"8","key":"3035_CR5","first-page":"28","volume":"13","author":"M-Y Lin","year":"2020","unstructured":"Lin MY, Lin C-S, Hu S, Chung WH (2020) Progress in the use of platelet-rich plasma in aesthetic and medical dermatology. J Clin Aesthet Dermatol 13(8):28","journal-title":"J Clin Aesthet Dermatol"},{"issue":"6","key":"3035_CR6","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15159","volume":"34","author":"E Ziaeifar","year":"2021","unstructured":"Ziaeifar E, Ziaeifar F, Mozafarpoor S, Goodarzi A (2021) Applications of microneedling for various dermatologic indications with a special focus on pigmentary disorders: a comprehensive review study. Dermatol Ther 34(6):e15159","journal-title":"Dermatol Ther"},{"issue":"1","key":"3035_CR7","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/lsm.23125","volume":"52","author":"R Shavit","year":"2020","unstructured":"Shavit R, Dierickx C (2020) A new method for percutaneous drug delivery by thermo-mechanical fractional injury. Lasers Surg Med 52(1):61\u201369","journal-title":"Lasers Surg Med"},{"issue":"6","key":"3035_CR8","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1002\/lsm.22260","volume":"46","author":"J Helou","year":"2014","unstructured":"Helou J, Maatouk I, Obeid G, Moutran R, St\u00e9phan F, Tomb R (2014) Fractional laser for vitiligo treated by 10,600 nm ablative fractional carbon dioxide laser followed by sun exposure. Lasers Surg Med 46(6):443\u2013448","journal-title":"Lasers Surg Med"},{"issue":"2","key":"3035_CR9","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/BF03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul F, Erdfelder E, Lang AG, Buchner AG (2007) G\u2217Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39(2):175\u2013191","journal-title":"Behav Res Methods"},{"issue":"4","key":"3035_CR10","doi-asserted-by":"publisher","first-page":"424","DOI":"10.5021\/ad.2011.23.4.424","volume":"23","author":"DH Kim","year":"2011","unstructured":"Kim DH, Je YJ, Kim CD, Lee YH, Seo YJ, Lee JH et al (2011) Can platelet-rich plasma be used for skin rejuvenation? Evaluation of effects of platelet-rich plasma on human dermal fibroblast. Ann Dermatol 23(4):424\u2013431","journal-title":"Ann Dermatol"},{"issue":"5","key":"3035_CR11","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/jocd.12440","volume":"17","author":"M Mina","year":"2018","unstructured":"Mina M, Elgarhy L, Al-Saeid H, Ibrahim Z (2018) Comparison between the efficacy of microneedling combined with 5-fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo. J Cosmet Dermatol 17(5):744\u2013751","journal-title":"J Cosmet Dermatol"},{"key":"3035_CR12","doi-asserted-by":"crossref","unstructured":"Nugroho H, Fadzil MHA, Yap VV, Norashikin S, Suraiya HH (2007) Determination of skin repigmentation progression. In: 29th Annual international conference of the IEEE engineering in medicine and biology society, FrP2B3.3, pp. 3442\u20133445","DOI":"10.1109\/IEMBS.2007.4353071"},{"issue":"6","key":"3035_CR13","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1001\/archderm.140.6.677","volume":"140","author":"I Hamzavi","year":"2004","unstructured":"Hamzavi I, Jain H, McLean D, Shapiro J, Zeng H, Lui H (2004) Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. Arch Dermatol 140(6):677\u2013683","journal-title":"Arch Dermatol"},{"issue":"8","key":"3035_CR14","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1126\/science.28.706.49","volume":"2","author":"GH Hardy","year":"1908","unstructured":"Hardy GH (1908) Mendelian proportions in a mixed population. Science 2(8):49\u201350","journal-title":"Science"},{"key":"3035_CR15","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1534\/genetics.106.057042","volume":"174","author":"AE Stark","year":"2006","unstructured":"Stark AE (2006) A clarification of the Hardy-Weinberg law. Genetics 174:1695\u20131697","journal-title":"Genetics"},{"issue":"2","key":"3035_CR16","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1111\/jocd.12704","volume":"18","author":"ZA Ibrahim","year":"2019","unstructured":"Ibrahim ZA, Hassan GF, Elgendy HY, Al-Shenawy HA (2019) Evaluation of the efficacy of transdermal drug delivery of calcipotriol plus betamethasone versus tacrolimus in the treatment of vitiligo. J Cosmet Dermatol 18(2):581\u2013588","journal-title":"J Cosmet Dermatol"},{"issue":"2","key":"3035_CR17","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/jocd.12373","volume":"17","author":"F Mokhtari","year":"2018","unstructured":"Mokhtari F, Bostakian A, Shahmoradi Z, Jafari-Koshki T, Iraji F, Faghihi G et al (2018) Potential emerging treatment in vitiligo using Er:YAG in combination with 5FU and clobetasol. J Cosmet Dermatol 17(2):165\u2013170","journal-title":"J Cosmet Dermatol"},{"issue":"4","key":"3035_CR18","doi-asserted-by":"publisher","first-page":"207","DOI":"10.22317\/jcms.v4i4.486","volume":"4","author":"M Al-Dhalimi","year":"2018","unstructured":"Al-Dhalimi M, Al-Sabak H, Hussain A (2018) Treatment of resistant acral vitiligo with fractional Er:YAG laser. J Contemp Med Sci 4(4):207\u2013210","journal-title":"J Contemp Med Sci"},{"issue":"3","key":"3035_CR19","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/jocd.12397","volume":"17","author":"R Abdelghani","year":"2018","unstructured":"Abdelghani R, Ahmed NA, Darwish HM (2018) Combined treatment with fractional carbon dioxide laser, autologous platelet-rich plasma, and narrow band ultraviolet B for vitiligo in different body sites: a prospective, randomized comparative trial. J Cosmet Dermatol 17(3):365\u2013372","journal-title":"J Cosmet Dermatol"},{"issue":"9","key":"3035_CR20","first-page":"600","volume":"39","author":"A Botsali","year":"2021","unstructured":"Botsali A, Caliskan E (2021) Safety and efficacy of high-dose fractional erbium: yttrium aluminium garnet laser in stable vitiligo. Photobiomodul Photomed Laser Surg 39(9):600\u2013606","journal-title":"Photobiomodul Photomed Laser Surg"},{"issue":"5","key":"3035_CR21","first-page":"9854","volume":"8","author":"MR Abdelaty","year":"2021","unstructured":"Abdelaty MR (2021) Efficacy of platelet rich plasma after skin needling in the treatment of vitiligo. Br J Res 8(5):9854\u20139861","journal-title":"Br J Res"},{"issue":"6","key":"3035_CR22","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1111\/jocd.13152","volume":"19","author":"E Attwa","year":"2020","unstructured":"Attwa E, Khashaba S, Ezzat N (2020) Evaluation of additional effect of topical 5-fluorouracil needling treatment of localized vitiligo. J Cosmet Dermatol 19(6):1473\u20131478","journal-title":"J Cosmet Dermatol"},{"issue":"4","key":"3035_CR23","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1111\/jocd.13304","volume":"19","author":"H Ebrahim","year":"2020","unstructured":"Ebrahim H, Albalate W (2020) Efficacy of microneedling combined with tacrolimus versus either one alone for vitiligo treatment. J Cosmet Dermatol 19(4):855\u2013862","journal-title":"J Cosmet Dermatol"},{"issue":"3","key":"3035_CR24","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4103\/JCAS.JCAS_103_22","volume":"16","author":"S Ahlawat","year":"2023","unstructured":"Ahlawat S, Kothiwala R, Meherda A (2023) A comparative study to evaluate the efficacy of fractional CO2 laser + PRP vs. fractional CO2 laser alone in patients with vitiligo. J Cutan Aesthet Surg 16(3):186\u2013191","journal-title":"J Cutan Aesthet Surg"},{"key":"3035_CR25","doi-asserted-by":"publisher","first-page":"551","DOI":"10.2147\/CCID.S178817","volume":"11","author":"MO Kadry","year":"2018","unstructured":"Kadry MO, Tawfik A, Abdallah N, Badawi A, Shokeir H (2018) Platelet rich plasma versus combined fractional carbon dioxide laser with platelet-rich plasma in the treatment of vitiligo: a comparative study. Clin Cosmet Investig Dermatol 11:551\u2013559","journal-title":"Clin Cosmet Investig Dermatol"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03035-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-024-03035-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03035-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T20:32:32Z","timestamp":1725913952000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-024-03035-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,15]]},"references-count":25,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["3035"],"URL":"https:\/\/doi.org\/10.1007\/s00403-024-03035-8","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,15]]},"assertion":[{"value":"25 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"399"}}