{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:14:47Z","timestamp":1791263687135,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Pfizer\u2019s Global Medical Grants program","award":["87970425"],"award-info":[{"award-number":["87970425"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"DOI":"10.1007\/s00403-024-03154-2","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T11:01:34Z","timestamp":1718449294000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Paeoniflorin regulates RhoA\/ROCK1 and Nrf2 pathways in PDLIM1-dependent or independent manners in oxidative stressed melanocytes"],"prefix":"10.1007","volume":"316","author":[{"given":"Jin-Ping","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Yao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Zhe","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Song","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Qun","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Duo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,15]]},"reference":[{"key":"3154_CR1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1159\/000528180","volume":"239","author":"R Patel","year":"2023","unstructured":"Patel R, Pandya AG, Sikirica V et al (2023) Prevalence of Vitiligo among children and adolescents in the United States. Dermatology 239:227\u2013234. https:\/\/doi.org\/10.1159\/000528180","journal-title":"Dermatology"},{"key":"3154_CR2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1046\/j.1365-2133.1997.18011894.x","volume":"137","author":"IC Le Poole","year":"1997","unstructured":"Le Poole IC, van den Wijngaard RM, Westerhof W, Das PK (1997) Tenascin is overexpressed in vitiligo lesional skin and inhibits melanocyte adhesion. Br J Dermatol 137:171\u2013178. https:\/\/doi.org\/10.1046\/j.1365-2133.1997.18011894.x","journal-title":"Br J Dermatol"},{"key":"3154_CR3","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/j.1600-0625","volume":"21","author":"AS Ricard","year":"2012","unstructured":"Ricard AS, Pain C, Daubos A et al (2012) Study of CCN3 (NOV) and DDR1 in normal melanocytes and vitiligo skin. Exp Dermatol 21:411\u2013416. https:\/\/doi.org\/10.1111\/j.1600-06252012.01473.x","journal-title":"Exp Dermatol"},{"key":"3154_CR4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1046\/j.1365-2133.2003.05024.x","volume":"148","author":"Y Gauthier","year":"2003","unstructured":"Gauthier Y, Cario-Andre M, Lepreux S et al (2003) Melanocyte detachment after skin friction in non lesional skin of patients with generalized vitiligo. Br J Dermatol 148:95\u2013101. https:\/\/doi.org\/10.1046\/j.1365-2133.2003.05024.x","journal-title":"Br J Dermatol"},{"key":"3154_CR5","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1034\/j.1600-0749.2003.00070.x","volume":"16","author":"Y Gauthier","year":"2003","unstructured":"Gauthier Y, Cario Andre M, Ta\u0131\u00ebb A (2003) A critical appraisal of vitiligo etiologic theories: is melanocyte loss a melanocytor-rhagy? Pigment Cell Res 16:322\u2013332. https:\/\/doi.org\/10.1034\/j.1600-0749.2003.00070.x","journal-title":"Pigment Cell Res"},{"key":"3154_CR6","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1038\/jid.2015.25","volume":"135","author":"RY Wagner","year":"2015","unstructured":"Wagner RY, Luciani F, Cario-Andre\u00b4 M et al (2015) Altered E-cadherin levels and distribution in melanocytes precede clinical manifestations of vitiligo. J Invest Dermatol 135:1810\u20131819. https:\/\/doi.org\/10.1038\/jid.2015.25","journal-title":"J Invest Dermatol"},{"key":"3154_CR7","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1083\/jcb.143.7.1899","volume":"143","author":"X Wu","year":"1998","unstructured":"Wu X, Bowers B, Rao K, Wei Q, Hammer JA (1998) Visualization of melanosome dynamics within wild-type and dilute melanocytes suggests a paradigm for myosin V function in vivo. J Cell Biol 143:1899\u20131918. https:\/\/doi.org\/10.1083\/jcb.143.7.1899","journal-title":"J Cell Biol"},{"key":"3154_CR8","first-page":"905","volume":"45","author":"G Lambert, Vancoillie","year":"1999","unstructured":"Lambert, Vancoillie G, Naeyaert JM (1999) Molecular motors and their role in pigmentation. Cell Mol Biol (Noisy-le-grand) 45:905\u2013991","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"3154_CR9","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1080\/15548627.2016","volume":"12","author":"Y Shang","year":"2016","unstructured":"Shang Y, Wang H, Jia P et al (2016) Autophagy regulates spermatid differentiation via degradation of PDLIM1. Autophagy 12:1575\u20131592. https:\/\/doi.org\/10.1080\/15548627.2016","journal-title":"Autophagy"},{"key":"3154_CR10","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1100\/tsw.2007.232","volume":"7","author":"AJW te Velthuis","year":"2007","unstructured":"te Velthuis AJW, Bagowski CP (2007) PDZ and LIM domain encoding genes: molecular interactions and their role in Development. Sci World J 7:1470\u20131149. https:\/\/doi.org\/10.1100\/tsw.2007.232","journal-title":"Sci World J"},{"key":"3154_CR11","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1080\/15548627.2016.1159377","volume":"12","author":"C Liu","year":"2016","unstructured":"Liu C, Wang H, Shang Y et al (2016) Autophagy is required for ectoplasmic specialization assembly in sertoli cells. Autophagy 12:814\u2013832. https:\/\/doi.org\/10.1080\/15548627.2016.1159377","journal-title":"Autophagy"},{"key":"3154_CR12","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1034\/j.1600-0749.2002.02056.x","volume":"15","author":"G Scott","year":"2002","unstructured":"Scott G (2002) Rac and rho: the story behind melanocyte dendrite formation. Pigment Cell Res 15:322\u2013330. https:\/\/doi.org\/10.1034\/j.1600-0749.2002.02056.x","journal-title":"Pigment Cell Res"},{"key":"3154_CR13","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/jcp.1041510210","volume":"151","author":"JP Lacour","year":"1992","unstructured":"Lacour JP, Gordon PR, Eller M et al (1992) Cytoskeletal events underlying dendrite formation by cultured pigment cells. J Cell Physiol 151:287\u2013299. https:\/\/doi.org\/10.1002\/jcp.1041510210","journal-title":"J Cell Physiol"},{"key":"3154_CR14","doi-asserted-by":"publisher","first-page":"e29846","DOI":"10.4161\/sgtp.29846","volume":"5","author":"L Julian","year":"2014","unstructured":"Julian L, Olson MF (2014) Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions. Small GTPases 5:e29846. https:\/\/doi.org\/10.4161\/sgtp.29846","journal-title":"Small GTPases"},{"key":"3154_CR15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/cancers12010033","volume":"12","author":"H Liu","year":"2019","unstructured":"Liu H, Seynhaeve ALB, Brouwer RWW et al (2019) CREPT promotes Melanoma Progression through Accelerated Proliferation and enhanced Migration by RhoA-Mediated actin filaments and focal adhesion formation. Cancers (Basel) 12:33. https:\/\/doi.org\/10.3390\/cancers12010033","journal-title":"Cancers (Basel)"},{"key":"3154_CR16","doi-asserted-by":"publisher","unstructured":"Wang JS, Huang Y, Zhang SP et al (2019) A protective role of Paeoniflorin in Fluctuant Hyperglycemia Induced Vascular Endothelial Injuries through Antioxidative and Anti-inflammatory effects and reduction of PKC\u03b21. Oxid Med Cell Longev 5647219. https:\/\/doi.org\/10.1155\/2019\/5647219","DOI":"10.1155\/2019\/5647219"},{"key":"3154_CR17","first-page":"1199","volume":"46","author":"F Shen","year":"2019","unstructured":"Shen F, Zheng Q, Xie SQ et al (2019) Effect of total glucosides combined with NB-UVB for Vitiligo. Liaoning J Traditional Chin Med 46:1199\u20131201. 10.13192 \/j. issn.1000-1719.2019.06.026","journal-title":"Liaoning J Traditional Chin Med"},{"key":"3154_CR18","first-page":"155","volume":"12","author":"R Ye","year":"2013","unstructured":"Ye R, Nie LP, Hu XP et al (2013) Clinical effect and relevant experimental study in patients with sporadic vitiligo by the combination of total glucosides of Paeony and Pimecrolimus. Chin J Dermatol Venerol Integ Trad W Med 12:155\u2013157. doi: 1672-0709(2013)03-0155-03","journal-title":"Chin J Dermatol Venerol Integ Trad W Med"},{"key":"3154_CR19","doi-asserted-by":"publisher","first-page":"536","DOI":"10.3389\/fphar.2020.00536","volume":"11","author":"J Yuan","year":"2020","unstructured":"Yuan J, Lu Y, Wang H et al (2020) Paeoniflorin resists H2O2-Induced oxidative stress in melanocytes by JNK\/Nrf2\/HO-1 pathway. Front Pharmacol 11:536. https:\/\/doi.org\/10.3389\/fphar.2020.00536","journal-title":"Front Pharmacol"},{"key":"3154_CR20","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s11626-997-0021-6","volume":"33","author":"IC Le Poole","year":"1997","unstructured":"Le Poole IC, van den Berg FM, van den Wijngaard RM et al (1997) Generation of a human melanocyte cell line by introduction of HPV16 E6 and E7 genes. Vitro Cell Dev Biol Anim 33:42\u201349. https:\/\/doi.org\/10.1007\/s11626-997-0021-6","journal-title":"Vitro Cell Dev Biol Anim"},{"key":"3154_CR21","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1290\/1071-2690(2000)036<0309:PAIHVM>2.0.CO;2","volume":"36","author":"IC Le Poole","year":"2000","unstructured":"Le Poole IC, Boissy RE, Sarangarajan R et al (2000) PIG3V, an immortalized human vitiligo melanocyte cell line, expresses dilated endoplasmic reticulum. Vitro Cell Dev Biol Anim 36:309\u2013319. https:\/\/doi.org\/10.1290\/1071-2690(2000)036%3C0309:PAIHVM%3E2.0.CO;2","journal-title":"Vitro Cell Dev Biol Anim"},{"key":"3154_CR22","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/cdd.2015.117","volume":"23","author":"Q Shi","year":"2016","unstructured":"Shi Q, Zhang W, Guo S et al (2016) Oxidative stress-induced overexpression of miR-25: the mechanism underlying the degeneration of melanocytes in vitiligo. Cell Death Differ 23:496\u2013508. https:\/\/doi.org\/10.1038\/cdd.2015.117","journal-title":"Cell Death Differ"},{"key":"3154_CR23","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1038\/jid.2011.56","volume":"131","author":"Z Jian","year":"2011","unstructured":"Jian Z, Li K, Liu L et al (2011) Heme Oxygenase-1 protects human melanocytes from H2O2-Induced oxidative stress via the Nrf2-ARE pathway. J Invest Dermatol 131:1420\u20131427. https:\/\/doi.org\/10.1038\/jid.2011.56","journal-title":"J Invest Dermatol"},{"key":"3154_CR24","doi-asserted-by":"publisher","first-page":"11100","DOI":"10.1074\/jbc.275.15.11100","volume":"275","author":"T Vallenius","year":"2000","unstructured":"Vallenius T, Luukko K, M\u00e4kel\u00e4 TP (2000) CLP-36 PDZ-LIM protein associates with nonmuscle a-actinin-1 and a-actinin-4. J Biol Chem 275:11100\u201311105. https:\/\/doi.org\/10.1074\/jbc.275.15.11100","journal-title":"J Biol Chem"},{"key":"3154_CR25","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1242\/jcs.064964","volume":"124","author":"ST Sit","year":"2011","unstructured":"Sit ST, Manser E (2011) Rho GTPases and their role in organizing the actin cytoskeleton. J Cell Sci 124:679\u2013683. https:\/\/doi.org\/10.1242\/jcs.064964","journal-title":"J Cell Sci"},{"key":"3154_CR26","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s12016-021-08868-z","volume":"61","author":"YH Wang","year":"2021","unstructured":"Wang YH, Li SL, Li CY (2021) Clinical features, immunopathogenesis, and therapeutic strategies in Vitiligo. Clin Rev Allergy Immunol 61:299\u2013323. https:\/\/doi.org\/10.1007\/s12016-021-08868-z","journal-title":"Clin Rev Allergy Immunol"},{"key":"3154_CR27","doi-asserted-by":"publisher","first-page":"104416","DOI":"10.1016\/j.fitote.2019.104416","volume":"140","author":"M Hu","year":"2020","unstructured":"Hu M, Chen C, Liu J et al (2020) The melanogenic effects and underlying mechanism of paeoniflorin in human melanocytes and vitiligo mice. Fitoterapia 140:104416. https:\/\/doi.org\/10.1016\/j.fitote.2019.104416","journal-title":"Fitoterapia"},{"key":"3154_CR28","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1038\/jid.2011.413","volume":"132","author":"H Ando","year":"2012","unstructured":"Ando H, Niki Y, Ito M et al (2012) Melanosomes are transferred from melanocytes to keratinocytes through the processes of packaging, release, uptake, and dispersion. J Invest Dermatol 132:1222\u20131229. https:\/\/doi.org\/10.1038\/jid.2011.413","journal-title":"J Invest Dermatol"},{"key":"3154_CR29","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1242\/jcs.107.4.983","volume":"107","author":"A Tang","year":"1994","unstructured":"Tang A, Eller MS, Hara M et al (1994) E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro. J Cell Sci 107:983\u2013992. https:\/\/doi.org\/10.1242\/jcs.107.4.983","journal-title":"J Cell Sci"},{"key":"3154_CR30","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1038\/jid.2014.152","volume":"134","author":"Z Jian","year":"2014","unstructured":"Jian Z, Li K, Song P et al (2014) Impaired activation of the Nrf2-ARE signaling pathway undermines H2O2-Induced oxidative stress response: a possible mechanism for Melanocyte Degeneration in Vitiligo. J Invest Dermatol 134:2221\u20132230. https:\/\/doi.org\/10.1038\/jid.2014.152","journal-title":"J Invest Dermatol"},{"key":"3154_CR31","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.jaad.2022.05.012","volume":"88","author":"S Ramadan","year":"2023","unstructured":"Ramadan S, Zeid OA, Esmat S et al (2023) Combination of Acitretin with NB-UVB for the treatment of Vitiligo: a New Treatment modality with an impact on tissue E-Cadherin expression. J AM Acad Dermatol 88:241\u2013243. https:\/\/doi.org\/10.1016\/j.jaad.2022.05.012","journal-title":"J AM Acad Dermatol"},{"key":"3154_CR32","first-page":"181","volume":"28","author":"FG Zuo","year":"2008","unstructured":"Zuo FG, Xiang LH (2008) Regulation of rho small GTPases on dendricity and cell adhension in melanocytes. Int J Pathol Clin Med 28:181\u2013184","journal-title":"Int J Pathol Clin Med"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03154-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-024-03154-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03154-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T20:33:01Z","timestamp":1725913981000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-024-03154-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,15]]},"references-count":32,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["3154"],"URL":"https:\/\/doi.org\/10.1007\/s00403-024-03154-2","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,15]]},"assertion":[{"value":"18 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"401"}}