{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:06:10Z","timestamp":1740107170334,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"DOI":"10.1007\/s00403-024-03193-9","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T08:02:55Z","timestamp":1719561775000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the impact of psoriasis on liver health: does methotrexate play a villainous role?"],"prefix":"10.1007","volume":"316","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8919-3125","authenticated-orcid":false,"given":"Pelin","family":"Hizli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8628-6107","authenticated-orcid":false,"given":"I\u015f\u0131l Deniz","family":"O\u011fuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7886-1060","authenticated-orcid":false,"given":"Sevgi","family":"Kulakli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2983-065X","authenticated-orcid":false,"given":"Fatma Arzu","family":"Kili\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4738-5131","authenticated-orcid":false,"given":"Ayser","family":"Duyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"3193_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000232301","volume":"38","author":"M Meier","year":"2009","unstructured":"Meier M, Sheth PB (2009) Clinical spectrum and severity of psoriasis. Curr Probl Dermatol 38:1\u201320. https:\/\/doi.org\/10.1159\/000232301","journal-title":"Curr Probl Dermatol"},{"issue":"2","key":"3193_CR2","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/jdv.13456","volume":"30","author":"P Gisondi","year":"2016","unstructured":"Gisondi P, Barba E, Girolomoni G (2016) Non-alcoholic fatty liver disease fibrosis score in patients with psoriasis. J Eur Acad Dermatol Venereol 30(2):282\u2013287. https:\/\/doi.org\/10.1111\/jdv.13456","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"4","key":"3193_CR3","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.jhep.2009.06.008","volume":"51","author":"L Miele","year":"2009","unstructured":"Miele L, Vallone S, Cefalo C, La Torre G, Di Stasi C, Vecchio FM et al (2009) Prevalence, characteristics and severity of non-alcoholic fatty liver disease in patients with chronic plaque psoriasis. J Hepatol 51(4):778\u2013786. https:\/\/doi.org\/10.1016\/j.jhep.2009.06.008","journal-title":"J Hepatol"},{"key":"3193_CR4","doi-asserted-by":"publisher","unstructured":"Tiuca OM, Morariu SH, Mariean CR, Tiuca RA, Nicolescu AC, Cotoi OS (2023) Predictive performances of blood-count-derived inflammatory markers for liver fibrosis severity in Psoriasis Vulgaris. Int J Mol Sci 24(23). https:\/\/doi.org\/10.3390\/ijms242316898","DOI":"10.3390\/ijms242316898"},{"key":"3193_CR5","doi-asserted-by":"crossref","unstructured":"da Silva CAP, Von Kossel K, Leszczynski M, Melnik T, Riera R (2019) Methotrexate for psoriasis. Cochrane Database Syst Reviews 410.1002\/14651858.CD010498.pub2","DOI":"10.1002\/14651858.CD010498.pub2"},{"issue":"5","key":"3193_CR6","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/s0738-081x(97)00014-x","volume":"15","author":"S Said","year":"1997","unstructured":"Said S, Jeffes EW, Weinstein GD (1997) Methotrexate Clin Dermatol 15(5):781\u2013797. https:\/\/doi.org\/10.1016\/s0738-081x(97)00014-x","journal-title":"Methotrexate Clin Dermatol"},{"issue":"8","key":"3193_CR7","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.1080\/09546634.2022.2117539","volume":"33","author":"AM van Huizen","year":"2022","unstructured":"van Huizen AM, Sikkel R, Caron AGM, Menting SP, Spuls PI (2022) Methotrexate dosing regimen for plaque-type psoriasis: an update of a systematic review. J Dermatolog Treat 33(8):3104\u20133118. https:\/\/doi.org\/10.1080\/09546634.2022.2117539","journal-title":"J Dermatolog Treat"},{"key":"3193_CR8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.2147\/PTT.S141629","volume":"8","author":"HS Cheng","year":"2018","unstructured":"Cheng HS, Rademaker M (2018) Monitoring methotrexate-induced liver fibrosis in patients with psoriasis: utility of transient elastography. Psoriasis (Auckl) 8:21\u201329. https:\/\/doi.org\/10.2147\/PTT.S141629","journal-title":"Psoriasis (Auckl)"},{"key":"3193_CR9","doi-asserted-by":"publisher","unstructured":"Jr. Roenigk R HH, Auerbach, Maibach H, Weinstein G, Lebwohl M (1998) Methotrexate in psoriasis: consensus conference. J Am Acad Dermatol 38(3):478\u2013485. https:\/\/doi.org\/10.1016\/s0190-9622(98)70508-0","DOI":"10.1016\/s0190-9622(98)70508-0"},{"key":"3193_CR10","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae069","author":"P Babakinejad","year":"2024","unstructured":"Babakinejad P, Lapsley R, Forster L, McPherson S, Pearce MS, Reynolds NJ et al (2024) Cumulative methotrexate dose is not associated with liver fibrosis in patients with a history of moderate to severe psoriasis. Br J Dermatol. https:\/\/doi.org\/10.1093\/bjd\/ljae069","journal-title":"Br J Dermatol"},{"key":"3193_CR11","doi-asserted-by":"publisher","first-page":"1068157","DOI":"10.3389\/fmed.2022.1068157","volume":"9","author":"T Yongpisarn","year":"2022","unstructured":"Yongpisarn T, Namasondhi A, Iamsumang W, Rattanakaemakorn P, Suchonwanit P (2022) Liver fibrosis prevalence and risk factors in patients with psoriasis: a systematic review and meta-analysis. Front Med (Lausanne) 9:1068157. https:\/\/doi.org\/10.3389\/fmed.2022.1068157","journal-title":"Front Med (Lausanne)"},{"issue":"4","key":"3193_CR12","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1002\/cld.740","volume":"13","author":"D Berger","year":"2019","unstructured":"Berger D, Desai V, Janardhan S (2019) Con: liver biopsy remains the Gold Standard to evaluate fibrosis in patients with nonalcoholic fatty liver disease. Clin Liver Dis (Hoboken) 13(4):114\u2013116. https:\/\/doi.org\/10.1002\/cld.740","journal-title":"Clin Liver Dis (Hoboken)"},{"issue":"3","key":"3193_CR13","doi-asserted-by":"publisher","first-page":"e100","DOI":"10.1111\/ijd.15201","volume":"60","author":"E Yim","year":"2021","unstructured":"Yim E, Deutsch A, Nazarian RS, McLellan BN, Espinoza D, Wolkoff AW, Cohen SR (2021) Utilizing Fibrosis-4 score to assess risk for hepatic fibrosis in patients with psoriasis on methotrexate. Int J Dermatol 60(3):e100\u2013e1. https:\/\/doi.org\/10.1111\/ijd.15201","journal-title":"Int J Dermatol"},{"issue":"6","key":"3193_CR14","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.jhep.2015.11.004","volume":"64","author":"European Association for the Study of the L, European Association for the Study of D, European Association for the Study of O","year":"2016","unstructured":"European Association for the Study of the L, European Association for the Study of D, European Association for the Study of O (2016) EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease. J Hepatol 64(6):1388\u20131402. https:\/\/doi.org\/10.1016\/j.jhep.2015.11.004","journal-title":"J Hepatol"},{"issue":"2","key":"3193_CR15","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/liv.14669","volume":"41","author":"J Lee","year":"2021","unstructured":"Lee J, Vali Y, Boursier J, Spijker R, Anstee QM, Bossuyt PM, Zafarmand MH (2021) Prognostic accuracy of FIB-4, NAFLD fibrosis score and APRI for NAFLD-related events: a systematic review. Liver Int 41(2):261\u2013270. https:\/\/doi.org\/10.1111\/liv.14669","journal-title":"Liver Int"},{"key":"3193_CR16","doi-asserted-by":"publisher","unstructured":"Blanco-Grau A, Gabriel-Medina P, Rodriguez-Algarra F, Villena Y, Lopez-Martinez R, Augustin S et al (2021) Assessing liver fibrosis using the FIB4 index in the community setting. Diagnostics (Basel) 11(12). https:\/\/doi.org\/10.3390\/diagnostics11122236","DOI":"10.3390\/diagnostics11122236"},{"issue":"2","key":"3193_CR17","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1053\/j.gastro.2004.11.018","volume":"128","author":"L Castera","year":"2005","unstructured":"Castera L, Vergniol J, Foucher J, Le Bail B, Chanteloup E, Haaser M et al (2005) Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology 128(2):343\u2013350. https:\/\/doi.org\/10.1053\/j.gastro.2004.11.018","journal-title":"Gastroenterology"},{"issue":"3","key":"3193_CR18","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/j.1440-0960.2012.00905.x","volume":"53","author":"S Madanagobalane","year":"2012","unstructured":"Madanagobalane S, Anandan S (2012) The increased prevalence of non-alcoholic fatty liver disease in psoriatic patients: a study from South India. Australas J Dermatol 53(3):190\u2013197. https:\/\/doi.org\/10.1111\/j.1440-0960.2012.00905.x","journal-title":"Australas J Dermatol"},{"issue":"3","key":"3193_CR19","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.jaad.2013.10.044","volume":"70","author":"EA van der Voort","year":"2014","unstructured":"van der Voort EA, Koehler EM, Dowlatshahi EA, Hofman A, Stricker BH, Janssen HL et al (2014) Psoriasis is independently associated with nonalcoholic fatty liver disease in patients 55 years old or older: results from a population-based study. J Am Acad Dermatol 70(3):517\u2013524. https:\/\/doi.org\/10.1016\/j.jaad.2013.10.044","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"3193_CR20","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2340\/00015555-2161","volume":"96","author":"EA van der Voort","year":"2016","unstructured":"van der Voort EA, Koehler EM, Nijsten T, Stricker BH, Hofman A, Janssen HL et al (2016) Increased prevalence of Advanced Liver Fibrosis in patients with psoriasis: a cross-sectional analysis from the Rotterdam Study. Acta Derm Venereol 96(2):213\u2013217. https:\/\/doi.org\/10.2340\/00015555-2161","journal-title":"Acta Derm Venereol"},{"issue":"4","key":"3193_CR21","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.jhep.2009.04.020","volume":"51","author":"P Gisondi","year":"2009","unstructured":"Gisondi P, Targher G, Zoppini G, Girolomoni G (2009) Non-alcoholic fatty liver disease in patients with chronic plaque psoriasis. J Hepatol 51(4):758\u2013764. https:\/\/doi.org\/10.1016\/j.jhep.2009.04.020","journal-title":"J Hepatol"},{"issue":"5","key":"3193_CR22","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.jhep.2022.12.034","volume":"78","author":"E Atallah","year":"2023","unstructured":"Atallah E, Grove JI, Crooks C, Burden-Teh E, Abhishek A, Moreea S et al (2023) Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated. J Hepatol 78(5):989\u2013997. https:\/\/doi.org\/10.1016\/j.jhep.2022.12.034","journal-title":"J Hepatol"},{"key":"3193_CR23","doi-asserted-by":"crossref","unstructured":"Dogan S, Mente\u015fo\u011flu D, Atakan N, \u015eim\u015fek H (2019) A cross-sectional study investigating association of liver diseases in moderate to severe psoriasis patients. Turkderm-Turk Arch Dermatol Venereol 53(1)","DOI":"10.4274\/turkderm.galenos.2018.82085"},{"issue":"4","key":"3193_CR24","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1111\/jdv.12847","volume":"29","author":"R Candia","year":"2015","unstructured":"Candia R, Ruiz A, Torres-Robles R, Chavez-Tapia N, Mendez-Sanchez N, Arrese M (2015) Risk of non-alcoholic fatty liver disease in patients with psoriasis: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol 29(4):656\u2013662. https:\/\/doi.org\/10.1111\/jdv.12847","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"3193_CR25","doi-asserted-by":"crossref","unstructured":"Turner L, Bland M, Millson C, Veysey M, Hutchinson J (2020) O11 methotrexate: an innocent bystander in the development of liver fibrosis, findings of the STrATIFY study. BMJ Publishing Group","DOI":"10.1136\/gutjnl-2020-BASL.11"},{"issue":"1","key":"3193_CR26","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/bjd.12941","volume":"171","author":"CM Maybury","year":"2014","unstructured":"Maybury CM, Jabbar-Lopez ZK, Wong T, Dhillon AP, Barker JN, Smith CH (2014) Methotrexate and liver fibrosis in people with psoriasis: a systematic review of observational studies. Br J Dermatol 171(1):17\u201329. https:\/\/doi.org\/10.1111\/bjd.12941","journal-title":"Br J Dermatol"},{"issue":"4","key":"3193_CR27","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1046\/j.1365-2036.2004.01819.x","volume":"19","author":"GP Aithal","year":"2004","unstructured":"Aithal GP, Haugk B, Das S, Card T, Burt AD, Record CO (2004) Monitoring methotrexate-induced hepatic fibrosis in patients with psoriasis: are serial liver biopsies justified? Aliment Pharmacol Ther 19(4):391\u2013399. https:\/\/doi.org\/10.1046\/j.1365-2036.2004.01819.x","journal-title":"Aliment Pharmacol Ther"},{"issue":"6","key":"3193_CR28","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.jhep.2007.01.024","volume":"46","author":"P Rosenberg","year":"2007","unstructured":"Rosenberg P, Urwitz H, Johannesson A, Ros AM, Lindholm J, Kinnman N, Hultcrantz R (2007) Psoriasis patients with diabetes type 2 are at high risk of developing liver fibrosis during methotrexate treatment. J Hepatol 46(6):1111\u20131118. https:\/\/doi.org\/10.1016\/j.jhep.2007.01.024","journal-title":"J Hepatol"},{"issue":"1","key":"3193_CR29","doi-asserted-by":"publisher","first-page":"e15203","DOI":"10.1111\/dth.15203","volume":"35","author":"JHM Lee","year":"2022","unstructured":"Lee JHM, Loo CH, Tan WC, Lee CK, Jamil A, Khor YH (2022) Comparison of noninvasive screening tools for hepatic fibrosis, association with methotrexate cumulative dose, and risk factors in psoriasis patients. Dermatol Ther 35(1):e15203. https:\/\/doi.org\/10.1111\/dth.15203","journal-title":"Dermatol Ther"},{"issue":"5","key":"3193_CR30","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.jhep.2023.02.018","volume":"78","author":"V Di Martino","year":"2023","unstructured":"Di Martino V (2023) Methotrexate-induced liver fibrosis: the end of a long-held belief. J Hepatol 78(5):896\u2013897. https:\/\/doi.org\/10.1016\/j.jhep.2023.02.018","journal-title":"J Hepatol"},{"issue":"1","key":"3193_CR31","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1148\/radiol.12120224","volume":"266","author":"DC Howlett","year":"2013","unstructured":"Howlett DC, Drinkwater KJ, Lawrence D, Barter S, Nicholson T (2013) Findings of the UK national audit evaluating image-guided or image-assisted liver biopsy. Part II. Minor and major complications and procedure-related mortality. Radiology 266(1):226\u2013235. https:\/\/doi.org\/10.1148\/radiol.12120224","journal-title":"Radiology"},{"key":"3193_CR32","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/1471-230X-12-173","volume":"12","author":"M Mueller","year":"2012","unstructured":"Mueller M, Kratzer W, Oeztuerk S, Wilhelm M, Mason RA, Mao R, Haenle MM (2012) Percutaneous ultrasonographically guided liver punctures: an analysis of 1961 patients over a period of ten years. BMC Gastroenterol 12:173. https:\/\/doi.org\/10.1186\/1471-230X-12-173","journal-title":"BMC Gastroenterol"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03193-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-024-03193-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03193-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T20:37:08Z","timestamp":1725914228000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-024-03193-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,28]]},"references-count":32,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["3193"],"URL":"https:\/\/doi.org\/10.1007\/s00403-024-03193-9","relation":{},"ISSN":["1432-069X"],"issn-type":[{"type":"electronic","value":"1432-069X"}],"subject":[],"published":{"date-parts":[[2024,6,28]]},"assertion":[{"value":"11 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research was reviewed and approved by the institutional ethical committee (IEC) of Giresun University (IEC Number: KAEK-235). Informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of ethics"}},{"value":"The authors declare that they have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All participants have participated to the study providing their own written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"437"}}