{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:40:40Z","timestamp":1763059240315,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002744","name":"Bar-Ilan University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002744","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The association of AA with malignancies has been a scope of controversy as the current literature is highly inconsistent in this regard. To evaluate the association between AA and hematological malignancies (HMs) and solid malignancies (SMs) using a large-scale, real-life computerized database. A cross-sectional study was conducted to compare the prevalence of HMs and SMs among patients with AA relative to age-, sex-, and ethnicity-matched control subjects. Chi-square and t-tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The study included 51,561 patients with AA and 51,410 controls. AA was significantly associated with HMs (adjusted OR, 1.27; 95% CI, 1.07\u20131.51; <jats:italic>P<\/jats:italic>\u2009=\u20090.006). This association was more robust among patients with late-onset AA (\u2265\u200950 years; OR, 1.33; 95% CI, 1.04\u20131.71; <jats:italic>P<\/jats:italic>\u2009=\u20090.025). On the other hand, AA was not found to be significantly associated with SM (adjusted OR, 0.97; 95% CI, 0.88\u20131.06; <jats:italic>P<\/jats:italic>\u2009=\u20090.487), excluding among patients with alopecia totalis and universalis (OR, 2.10; 95% CI, 1.03\u20134.27; <jats:italic>P<\/jats:italic>\u2009=\u20090.036). In a granular analysis including 5 HMs and 18 SMs, non-Hodgkin lymphoma was the only malignancy that proved positively associated with AA (adjusted OR, 1.32; 95% CI, 1.03\u20131.69; <jats:italic>P<\/jats:italic>\u2009=\u20090.028). AA is associated with HMs but not SMs. Further research is warranted to validate our observations in other study cohorts.<\/jats:p>","DOI":"10.1007\/s00403-024-03385-3","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T11:02:04Z","timestamp":1728903724000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Alopecia Areata and malignancies: uncertainties clarified by a large-scale population-based study"],"prefix":"10.1007","volume":"316","author":[{"given":"Khalaf","family":"Kridin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rimma","family":"Laufer-Britva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon D.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baruch","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Lyakhovitsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Sibbald C (2023) Alopecia Areata: an updated review for 2023. 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J Eur Acad Dermatol Venereol ;20","key":"3385_CR4","DOI":"10.1111\/j.1468-3083.2006.01676.x"},{"doi-asserted-by":"crossref","unstructured":"Huang KP, Mullangi S, Guo Y, Qureshi AA (2013) Autoimmune, atopic, and mental health comorbid conditions associated with Alopecia Areata in the United States. JAMA Dermatol ;149","key":"3385_CR5","DOI":"10.1001\/jamadermatol.2013.3049"},{"doi-asserted-by":"crossref","unstructured":"Chu SY, Chen YJ, Tseng WC et al (2011) Comorbidity profiles among patients with Alopecia Areata: the importance of onset age, a nationwide population-based study. J Am Acad Dermatol ;65","key":"3385_CR6","DOI":"10.1016\/j.jaad.2010.08.032"},{"doi-asserted-by":"crossref","unstructured":"Conic RZ, Miller R, Piliang M, Bergfeld W (2017) Atanaskova Mesinkovska N. Comorbidities in patients with Alopecia Areata. J Am Acad Dermatol ;76","key":"3385_CR7","DOI":"10.1016\/j.jaad.2016.12.007"},{"doi-asserted-by":"crossref","unstructured":"Miller R, Conic RZ, Bergfeld W, Mesinkovska NA (2015) Prevalence of Comorbid Conditions and Sun-Induced Skin Cancers in Patients with Alopecia Areata. Journal of Investigative Dermatology Symposium Proceedings. ;17","key":"3385_CR8","DOI":"10.1038\/jidsymp.2015.44"},{"doi-asserted-by":"crossref","unstructured":"Chen CC, Chang YT, Liu HN, Chen YJ (2018) Cancer risk in patients with Alopecia Areata: a nationwide population-based matched cohort study. Cancer Med ;7","key":"3385_CR9","DOI":"10.1002\/cam4.1448"},{"doi-asserted-by":"crossref","unstructured":"George P, Jagun O, Liu Q et al (2023) Incidence Rates of Infections, malignancies, Thromboembolism, and Cardiovascular events in an Alopecia Areata Cohort from a US claims database. Dermatol Ther (Heidelb) ;13","key":"3385_CR10","DOI":"10.1007\/s13555-023-00937-9"},{"doi-asserted-by":"crossref","unstructured":"Lee JH, Song Y, Do Han K et al (2018) Cancer risk by the subtype of alopecia. Sci Rep ;8","key":"3385_CR11","DOI":"10.1038\/s41598-018-28142-1"},{"doi-asserted-by":"crossref","unstructured":"Mostaghimi A, Qureshi S, Joyce C, Guo Y, Huang KP (2016) Reduced incidence of skin cancer in patients with alopecia areata: a retrospective cohort study. Cancer Epidemiol ;41","key":"3385_CR12","DOI":"10.1016\/j.canep.2016.02.009"},{"doi-asserted-by":"crossref","unstructured":"Seo HM, Han SS, Kim JS (2018) Cancer risks among patients with Alopecia Areata: a population-based case-control study in Korea. J Am Acad Dermatol ;78","key":"3385_CR13","DOI":"10.1016\/j.jaad.2017.08.011"},{"doi-asserted-by":"crossref","unstructured":"GONG J, LIM SW (2014) Alopecia Areata as a paraneoplastic syndrome of Hodgkin\u2019s lymphoma: a case report. 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J Chronic Dis 40:373\u2013383","journal-title":"J Chronic Dis"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03385-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-024-03385-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03385-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T16:05:50Z","timestamp":1732205150000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-024-03385-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,14]]},"references-count":25,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3385"],"URL":"https:\/\/doi.org\/10.1007\/s00403-024-03385-3","relation":{},"ISSN":["1432-069X"],"issn-type":[{"type":"electronic","value":"1432-069X"}],"subject":[],"published":{"date-parts":[[2024,10,14]]},"assertion":[{"value":"13 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"678"}}