{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:07:28Z","timestamp":1790381248441,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2024A1515012768"],"award-info":[{"award-number":["2024A1515012768"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Dermatol Res"],"DOI":"10.1007\/s00403-024-03433-y","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T10:02:14Z","timestamp":1728900134000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Exploring the association between skin microbiota and inflammatory skin diseases: a two-sample Mendelian randomization analysis"],"prefix":"10.1007","volume":"316","author":[{"given":"Lingfeng","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoshuai","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jikang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"3433_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nrmicro.2017.157","volume":"16","author":"AL Byrd","year":"2018","unstructured":"Byrd AL, Belkaid Y, Segre JA (2018) The human skin microbiome. Nat Rev Microbiol 16:143\u2013155. https:\/\/doi.org\/10.1038\/nrmicro.2017.157","journal-title":"Nat Rev Microbiol"},{"key":"3433_CR2","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.tim.2013.10.001","volume":"21","author":"NN Schommer","year":"2013","unstructured":"Schommer NN, Gallo RL (2013) Structure and function of the human skin microbiome. Trends Microbiol 21:660\u2013668. https:\/\/doi.org\/10.1016\/j.tim.2013.10.001","journal-title":"Trends Microbiol"},{"key":"3433_CR3","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1101\/gr.075549.107","volume":"18","author":"EA Grice","year":"2008","unstructured":"Grice EA, Kong HH, Renaud G, Young AC, Bouffard GG, NISC Comparative Sequencing Program et al (2008) A diversity profile of the human skin microbiota. Genome Res 18:1043\u20131050. https:\/\/doi.org\/10.1101\/gr.075549.107","journal-title":"Genome Res"},{"key":"3433_CR4","doi-asserted-by":"publisher","first-page":"688","DOI":"10.3390\/life14060688","volume":"14","author":"M-A Ionescu","year":"2024","unstructured":"Ionescu M-A, Tatu AL, Busila C, Axente ER, Badalato N, Feuilloley MGJ et al (2024) Microbiome modulation in acne patients and clinical correlations. Life Basel Switz 14:688. https:\/\/doi.org\/10.3390\/life14060688","journal-title":"Life Basel Switz"},{"key":"3433_CR5","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1097\/QCO.0000000000000814","volume":"35","author":"E Bouza","year":"2022","unstructured":"Bouza E, Burillo A (2022) Current international and national guidelines for managing skin and soft tissue infections. Curr Opin Infect Dis 35:61\u201371. https:\/\/doi.org\/10.1097\/QCO.0000000000000814","journal-title":"Curr Opin Infect Dis"},{"key":"3433_CR6","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S0140-6736(11)60321-8","volume":"379","author":"HC Williams","year":"2012","unstructured":"Williams HC, Dellavalle RP, Garner S (2012) Acne vulgaris. Lancet Lond Engl 379:361\u2013372. https:\/\/doi.org\/10.1016\/S0140-6736(11)60321-8","journal-title":"Lancet Lond Engl"},{"key":"3433_CR7","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1101\/gr.131029.111","volume":"22","author":"HH Kong","year":"2012","unstructured":"Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA et al (2012) Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res 22:850\u2013859. https:\/\/doi.org\/10.1101\/gr.131029.111","journal-title":"Genome Res"},{"key":"3433_CR8","doi-asserted-by":"publisher","first-page":"e808","DOI":"10.1542\/peds.2008-2217","volume":"123","author":"JT Huang","year":"2009","unstructured":"Huang JT, Abrams M, Tlougan B, Rademaker A, Paller AS (2009) Treatment of Staphylococcus aureus colonization in atopic dermatitis decreases disease severity. Pediatrics 123:e808-814. https:\/\/doi.org\/10.1542\/peds.2008-2217","journal-title":"Pediatrics"},{"key":"3433_CR9","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nrg3182","volume":"13","author":"I Cho","year":"2012","unstructured":"Cho I, Blaser MJ (2012) The human microbiome: at the interface of health and disease. Nat Rev Genet 13:260\u2013270. https:\/\/doi.org\/10.1038\/nrg3182","journal-title":"Nat Rev Genet"},{"key":"3433_CR10","doi-asserted-by":"publisher","first-page":"3250","DOI":"10.1167\/iovs.11-9295","volume":"53","author":"N O\u2019Reilly","year":"2012","unstructured":"O\u2019Reilly N, Gallagher C, Reddy Katikireddy K, Clynes M, O\u2019Sullivan F, Kavanagh K (2012) Demodex-associated Bacillus proteins induce an aberrant wound healing response in a corneal epithelial cell line: possible implications for corneal ulcer formation in ocular rosacea. Invest Ophthalmol Vis Sci 53:3250\u20133259. https:\/\/doi.org\/10.1167\/iovs.11-9295","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3433_CR11","doi-asserted-by":"publisher","first-page":"4703","DOI":"10.1038\/s41467-019-12253-y","volume":"10","author":"N Fyhrquist","year":"2019","unstructured":"Fyhrquist N, Muirhead G, Prast-Nielsen S, Jeanmougin M, Olah P, Skoog T et al (2019) Microbe-host interplay in atopic dermatitis and psoriasis. Nat Commun 10:4703. https:\/\/doi.org\/10.1038\/s41467-019-12253-y","journal-title":"Nat Commun"},{"key":"3433_CR12","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nrcardio.2017.78","volume":"14","author":"MV Holmes","year":"2017","unstructured":"Holmes MV, Ala-Korpela M, Smith GD (2017) Mendelian randomization in cardiometabolic disease: challenges in evaluating causality. Nat Rev Cardiol 14:577\u2013590. https:\/\/doi.org\/10.1038\/nrcardio.2017.78","journal-title":"Nat Rev Cardiol"},{"key":"3433_CR13","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k601","volume":"362","author":"NM Davies","year":"2018","unstructured":"Davies NM, Holmes MV, Davey SG (2018) Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ 362:k601. https:\/\/doi.org\/10.1136\/bmj.k601","journal-title":"BMJ"},{"key":"3433_CR14","doi-asserted-by":"publisher","first-page":"6204","DOI":"10.1038\/s41467-022-33906-5","volume":"13","author":"L Moitinho-Silva","year":"2022","unstructured":"Moitinho-Silva L, Degenhardt F, Rodriguez E, Emmert H, Juzenas S, M\u00f6bus L et al (2022) Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota. Nat Commun 13:6204. https:\/\/doi.org\/10.1038\/s41467-022-33906-5","journal-title":"Nat Commun"},{"key":"3433_CR15","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/bjd.20072","volume":"185","author":"L Moitinho-Silva","year":"2021","unstructured":"Moitinho-Silva L, Boraczynski N, Emmert H, Baurecht H, Szymczak S, Schulz H et al (2021) Host traits, lifestyle and environment are associated with human skin bacteria. Br J Dermatol 185:573\u2013584. https:\/\/doi.org\/10.1111\/bjd.20072","journal-title":"Br J Dermatol"},{"key":"3433_CR16","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"MI Kurki","year":"2023","unstructured":"Kurki MI, Karjalainen J, Palta P, Sipil\u00e4 TP, Kristiansson K, Donner KM et al (2023) FinnGen provides genetic insights from a well-phenotyped isolated population. Nature 613:508\u2013518. https:\/\/doi.org\/10.1038\/s41586-022-05473-8","journal-title":"Nature"},{"key":"3433_CR17","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1038\/s41588-021-00931-x","volume":"53","author":"S Sakaue","year":"2021","unstructured":"Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S et al (2021) A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet 53:1415\u20131424. https:\/\/doi.org\/10.1038\/s41588-021-00931-x","journal-title":"Nat Genet"},{"key":"3433_CR18","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.3390\/microorganisms11102586","volume":"11","author":"J Long","year":"2023","unstructured":"Long J, Gu J, Yang J, Chen P, Dai Y, Lin Y et al (2023) Exploring the association between gut microbiota and inflammatory skin diseases: a two-sample Mendelian randomization analysis. Microorganisms 11:2586. https:\/\/doi.org\/10.3390\/microorganisms11102586","journal-title":"Microorganisms"},{"key":"3433_CR19","doi-asserted-by":"publisher","first-page":"1231848","DOI":"10.3389\/fimmu.2023.1231848","volume":"14","author":"R Mao","year":"2023","unstructured":"Mao R, Yu Q, Li J (2023) The causal relationship between gut microbiota and inflammatory dermatoses: a Mendelian randomization study. Front Immunol 14:1231848. https:\/\/doi.org\/10.3389\/fimmu.2023.1231848","journal-title":"Front Immunol"},{"key":"3433_CR20","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14231","author":"Y Gu","year":"2024","unstructured":"Gu Y, Zhang W, Zhao W, Zeng X (2024) Investigating causal relationships between the gut microbiota and inflammatory skin diseases: a Mendelian randomization study. Australas J Dermatol. https:\/\/doi.org\/10.1111\/ajd.14231","journal-title":"Australas J Dermatol"},{"key":"3433_CR21","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/ije\/dyr036","volume":"40","author":"S Burgess","year":"2011","unstructured":"Burgess S, Thompson SG, CRP CHD Genetics Collaboration (2011) Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol 40:755\u2013764. https:\/\/doi.org\/10.1093\/ije\/dyr036","journal-title":"Int J Epidemiol"},{"key":"3433_CR22","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/gepi.21758","volume":"37","author":"S Burgess","year":"2013","unstructured":"Burgess S, Butterworth A, Thompson SG (2013) Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol 37:658\u2013665. https:\/\/doi.org\/10.1002\/gepi.21758","journal-title":"Genet Epidemiol"},{"key":"3433_CR23","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","volume":"44","author":"J Bowden","year":"2015","unstructured":"Bowden J, Davey Smith G, Burgess S (2015) Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol 44:512\u2013525. https:\/\/doi.org\/10.1093\/ije\/dyv080","journal-title":"Int J Epidemiol"},{"key":"3433_CR24","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.21965","volume":"40","author":"J Bowden","year":"2016","unstructured":"Bowden J, Davey Smith G, Haycock PC, Burgess S (2016) Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol 40:304\u2013314. https:\/\/doi.org\/10.1002\/gepi.21965","journal-title":"Genet Epidemiol"},{"key":"3433_CR25","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.ajhg.2021.05.014","volume":"108","author":"H Xue","year":"2021","unstructured":"Xue H, Shen X, Pan W (2021) Constrained maximum likelihood-based Mendelian randomization robust to both correlated and uncorrelated pleiotropic effects. Am J Hum Genet 108:1251\u20131269. https:\/\/doi.org\/10.1016\/j.ajhg.2021.05.014","journal-title":"Am J Hum Genet"},{"key":"3433_CR26","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck M, Chen C-Y, Neale B, Do R (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 50:693\u2013698. https:\/\/doi.org\/10.1038\/s41588-018-0099-7","journal-title":"Nat Genet"},{"key":"3433_CR27","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s10654-015-0011-z","volume":"30","author":"S Burgess","year":"2015","unstructured":"Burgess S, Scott RA, Timpson NJ, Davey Smith G, Thompson SG, EPIC-InterAct Consortium (2015) Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol 30:543\u2013552. https:\/\/doi.org\/10.1007\/s10654-015-0011-z","journal-title":"Eur J Epidemiol"},{"key":"3433_CR28","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1136\/ebmental-2019-300085","volume":"22","author":"P Pagoni","year":"2019","unstructured":"Pagoni P, Dimou NL, Murphy N, Stergiakouli E (2019) Using Mendelian randomisation to assess causality in observational studies. Evid Based Ment Health 22:67\u201371. https:\/\/doi.org\/10.1136\/ebmental-2019-300085","journal-title":"Evid Based Ment Health"},{"key":"3433_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007081","volume":"13","author":"G Hemani","year":"2017","unstructured":"Hemani G, Tilling K, Davey SG (2017) Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet 13:e1007081. https:\/\/doi.org\/10.1371\/journal.pgen.1007081","journal-title":"PLoS Genet"},{"key":"3433_CR30","doi-asserted-by":"publisher","first-page":"1297240","DOI":"10.3389\/fimmu.2024.1297240","volume":"15","author":"Y Zhong","year":"2024","unstructured":"Zhong Y, Wang F, Meng X, Zhou L (2024) The associations between gut microbiota and inflammatory skin diseases: a bi-directional two-sample Mendelian randomization study. Front Immunol 15:1297240. https:\/\/doi.org\/10.3389\/fimmu.2024.1297240","journal-title":"Front Immunol"},{"key":"3433_CR31","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s40257-020-00531-1","volume":"21","author":"B Dr\u00e9no","year":"2020","unstructured":"Dr\u00e9no B, Dagnelie MA, Khammari A, Corvec S (2020) The skin microbiome: a new actor in inflammatory acne. Am J Clin Dermatol 21:18\u201324. https:\/\/doi.org\/10.1007\/s40257-020-00531-1","journal-title":"Am J Clin Dermatol"},{"key":"3433_CR32","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s40257-018-00417-3","volume":"20","author":"H Xu","year":"2019","unstructured":"Xu H, Li H (2019) Acne, the skin microbiome, and antibiotic treatment. Am J Clin Dermatol 20:335\u2013344. https:\/\/doi.org\/10.1007\/s40257-018-00417-3","journal-title":"Am J Clin Dermatol"},{"key":"3433_CR33","doi-asserted-by":"publisher","first-page":"adv00164","DOI":"10.2340\/00015555-3514","volume":"100","author":"SM Edslev","year":"2020","unstructured":"Edslev SM, Agner T, Andersen PS (2020) Skin microbiome in atopic dermatitis. Acta Derm Venereol 100:adv00164. https:\/\/doi.org\/10.2340\/00015555-3514","journal-title":"Acta Derm Venereol"},{"key":"3433_CR34","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.alit.2021.11.001","volume":"71","author":"LF Koh","year":"2022","unstructured":"Koh LF, Ong RY, Common JE (2022) Skin microbiome of atopic dermatitis. Allergol Int Off J Jpn Soc Allergol 71:31\u201339. https:\/\/doi.org\/10.1016\/j.alit.2021.11.001","journal-title":"Allergol Int Off J Jpn Soc Allergol"},{"key":"3433_CR35","doi-asserted-by":"publisher","first-page":"eaah4680","DOI":"10.1126\/scitranslmed.aah4680","volume":"9","author":"T Nakatsuji","year":"2017","unstructured":"Nakatsuji T, Chen TH, Narala S, Chun KA, Two AM, Yun T et al (2017) Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Sci Transl Med 9:eaah4680. https:\/\/doi.org\/10.1126\/scitranslmed.aah4680","journal-title":"Sci Transl Med"},{"key":"3433_CR36","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.idc.2020.10.002","volume":"35","author":"RJ Bystritsky","year":"2021","unstructured":"Bystritsky RJ (2021) Cellulitis. Infect Dis Clin North Am 35:49\u201360. https:\/\/doi.org\/10.1016\/j.idc.2020.10.002","journal-title":"Infect Dis Clin North Am"},{"key":"3433_CR37","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/S0140-6736(14)60763-7","volume":"386","author":"K Ezzedine","year":"2015","unstructured":"Ezzedine K, Eleftheriadou V, Whitton M, van Geel N (2015) Vitiligo. Lancet Lond Engl 386:74\u201384. https:\/\/doi.org\/10.1016\/S0140-6736(14)60763-7","journal-title":"Lancet Lond Engl"},{"key":"3433_CR38","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1001\/jamadermatol.2021.1688","volume":"157","author":"TM LeWitt","year":"2021","unstructured":"LeWitt TM, Kundu RV (2021) Vitiligo. JAMA Dermatol 157:1136. https:\/\/doi.org\/10.1001\/jamadermatol.2021.1688","journal-title":"JAMA Dermatol"},{"key":"3433_CR39","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s13671-017-0178-5","volume":"6","author":"D Yan","year":"2017","unstructured":"Yan D, Issa N, Afifi L, Jeon C, Chang HW, Liao W (2017) The role of the skin and gut microbiome in psoriatic disease. Curr Dermatol Rep 6:94\u2013103. https:\/\/doi.org\/10.1007\/s13671-017-0178-5","journal-title":"Curr Dermatol Rep"}],"container-title":["Archives of Dermatological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03433-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00403-024-03433-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00403-024-03433-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T16:05:44Z","timestamp":1732205144000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00403-024-03433-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,14]]},"references-count":39,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3433"],"URL":"https:\/\/doi.org\/10.1007\/s00403-024-03433-y","relation":{},"ISSN":["1432-069X"],"issn-type":[{"value":"1432-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,14]]},"assertion":[{"value":"3 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"677"}}